Acetylcholine Synthesis (Rattus norvegicus)

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1*Cytosol**Synaptic Cleft*PhosphatidylethanolamineAcetylcholinePhosphorylcholineAhsgAchePdha1Acetyl-CoAAcetatePemtPhosphatidylcholineCytidine Diphosphate CholinePcyt1aCholineGlycerophosphocholinePyruvate from GlycolysisCholinePdha2Chat


Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.


GenMAPP notes 
MAPP converted from mouse to rat by NASA ARS/UMDNJ

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Ontology Terms



  1. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.''; Science, 1983 PubMed Europe PMC


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109384view15:35, 16 March 2020L DupuisConverted interactions to graphical lines
107241view14:33, 17 September 2019MaintBotChEBI identifier normalization
106983view13:44, 17 September 2019MaintBotHMDB identifier normalization
85050view10:31, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
71290view16:56, 17 October 2013MaintBotAutomated update of data sources
69325view18:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
67027view09:56, 26 June 2013Christine ChichesterOntology Term : 'acetylcholine metabolic pathway' added !
62841view05:03, 3 May 2013MaintBotUpdated UniProt data source
54705view13:34, 7 December 2012Andra
54704view13:32, 7 December 2012Andra
41636view02:33, 2 March 2011MaintBotRemoved redundant pathway information and comments
35062view11:12, 11 February 2010ThomasModified description
35061view11:11, 11 February 2010Thomasadded literature, connected lines, fixed annotations
34396view22:56, 9 December 2009KhanspersAdded conectors and metabolites
21433view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Acetylcholine Synthesis]] moved to [[Pathway:WP360]]: Moved to stable identifier
7882view13:46, 7 January 2008MaintBot[[Pathway:Rat:Acetylcholine Synthesis]] moved to [[Pathway:Rattus norvegicus:Acetylcholine Synthesis]]: Renaming species
7566view16:00, 18 December 2007MaintBotfixed category names
7327view12:42, 4 November 2007MaintBotAdded categories to GPML
19368view22:19, 22 May 2007M.Ramirezgpml file for [[Rat:Acetylcholine_Synthesis]]
6514view22:19, 22 May 2007A.Kwagpml file for [[Rat:Acetylcholine_Synthesis]]

External references


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NameTypeDatabase referenceComment
AcetateMetaboliteCHEBI:30089 (ChEBI)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
AcetylcholineMetaboliteHMDB0000895 (HMDB)
AcheGeneProduct83817 (Entrez Gene)
AhsgGeneProduct25373 (Entrez Gene)
ChatGeneProductCLAT (Uniprot-TrEMBL)
CholineMetaboliteHMDB0000097 (HMDB)
Cytidine Diphosphate CholineMetaboliteCHEBI:16436 (ChEBI)
GlycerophosphocholineMetaboliteCHEBI:16870 (ChEBI)
Pcyt1aGeneProduct140544 (Entrez Gene)
Pdha1GeneProduct29554 (Entrez Gene)
Pdha2GeneProduct117098 (Entrez Gene)
PemtGeneProduct25511 (Entrez Gene)
PhosphatidylcholineMetaboliteCHEBI:49183 (ChEBI)
PhosphatidylethanolamineMetaboliteCHEBI:16038 (ChEBI)
PhosphorylcholineMetaboliteHMDB0001565 (HMDB)
Pyruvate from GlycolysisMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions
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