Transcription factor regulation in adipogenesis (Homo sapiens)

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Nucleus243, 82443278387833, 8821, 68521222383, 82GlucocorticoidsLipids/FA oxidationERAdipocyte Secretory ProductsROSLipidsGenes involved in:Mitochondrial uncouplingFA Beta-oxidationOxidative phosphorylationTCA cycleGlycolysisMitochondriaINSR2RXRA1, 6LPIN15PCK21, 6CEBPA3, 8GLUT47PPARG1, 3, 6, 8CREB18CEBPBCEBPDNR3C18NRIP17IRS1IRS22ADIPOQLEP3JNK2FOXO1A8TWIST14PPARGC1A4TNFIL64NRIP1772


The transcription factors involved in adipogenesis are shown in the current pathway. Adipogensis is the biological proces of cell differentation in which preadipocytes are converted into adipocytes. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Ontology Terms



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  1. Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM; ''PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene.''; Mol Cell Biol, 1995 PubMed Europe PMC Scholia
  2. Hotamisligil GS; ''Inflammation and metabolic disorders.''; Nature, 2006 PubMed Europe PMC Scholia
  3. Lowe CE, O'Rahilly S, Rochford JJ; ''Adipogenesis at a glance.''; J Cell Sci, 2011 PubMed Europe PMC Scholia
  4. Dobrian AD; ''A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue.''; Front Endocrinol (Lausanne), 2012 PubMed Europe PMC Scholia
  5. Miranda M, Escoté X, Alcaide MJ, Solano E, Ceperuelo-Mallafré V, Hernández P, Wabitsch M, Vendrell J; ''Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolyticgenes.''; Am J Physiol Endocrinol Metab, 2010 PubMed Europe PMC Scholia
  6. Beale EG, Forest C, Hammer RE; ''Regulation of cytosolic phosphoenolpyruvate carboxykinase gene expression in adipocytes.''; Biochimie, 2003 PubMed Europe PMC Scholia
  7. Rosell M, Jones MC, Parker MG; ''Role of nuclear receptor corepressor RIP140 in metabolic syndrome.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  8. Siersbæk R, Nielsen R, Mandrup S; ''Transcriptional networks and chromatin remodeling controlling adipogenesis.''; Trends Endocrinol Metab, 2012 PubMed Europe PMC Scholia


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105845view23:13, 15 August 2019KhanspersModified description
104860view15:05, 20 June 2019FehrhartCEBPA stimulates expression of LEP (8)
104857view14:58, 20 June 2019Fehrhart
88581view19:16, 11 August 2016Mkutmonfix unconnected lines
85185view14:36, 23 April 2016EgonwReplaced a mim-conversion with Arrow.
84770view09:29, 18 March 2016EgonwGave Glucocorticoids an identifier (semantic meaning).
84378view06:02, 18 February 2016EgonwOntology Term : 'fat cell' added !
84377view05:52, 18 February 2016EgonwOntology Term : 'signaling pathway pertinent to development' added !
84365view19:45, 16 February 2016KhanspersConnected interactions
84133view15:53, 18 January 2016Mkutmonupdated layout
84023view10:07, 11 January 2016SusanConnect lines
84022view10:04, 11 January 2016SusanModified description
83984view19:19, 7 January 2016Ingrid.felicidadeModified title
83983view19:17, 7 January 2016Ingrid.felicidadeNew pathway

External references


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NameTypeDatabase referenceComment
ADIPOQGeneProductENSG00000181092 (Ensembl)
CEBPAGeneProductENSG00000245848 (Ensembl)
CEBPBGeneProductENSG00000172216 (Ensembl)
CEBPDGeneProductENSG00000221869 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
FOXO1AGeneProductENSG00000150907 (Ensembl)
GLUT4GeneProductENSG00000181856 (Ensembl)
GlucocorticoidsMetaboliteCHEBI:24261 (ChEBI)
IL6GeneProductENSG00000136244 (Ensembl)
INSRGeneProductENSG00000171105 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
LEPGeneProductENSG00000174697 (Ensembl)
LPIN1GeneProductENSG00000134324 (Ensembl)
NR3C1GeneProductENSG00000113580 (Ensembl)
NRIP1GeneProductENSG00000180530 (Ensembl)
PCK2GeneProductENSG00000100889 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TWIST1GeneProductENSG00000122691 (Ensembl)

Annotated Interactions

No annotated interactions

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