miR-517 relationship with ARCN1 and USP1 (Homo sapiens)

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1Cell viabilityID1hsa-miR-517a-3pp21ARCN1ID2USP1Cell cycle progression


Schematic summarizing predicted miR-517a relationships with ARCN1 and USP1.

A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-517a targets a common vulnerability, primarily via its target ARCN1.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Ontology Terms



  1. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, Purinton S, Wang Y, Ivan C, Kim HS, Borkowski RJ, Khan S, Rodriguez-Aguayo C, Lopez-Berestein G, Lea J, Gazdar A, Baggerly KA, Sood AK, White MA; ''A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.''; Mol Syst Biol, 2015 PubMed Europe PMC Scholia


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105860view23:20, 15 August 2019KhanspersModified description
89884view13:01, 6 October 2016MkutmonModified description
87706view09:05, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
84855view21:54, 28 March 2016Khanspersupdated interactions
83893view00:15, 23 December 2015KhanspersModified description
83891view00:15, 23 December 2015KhanspersNew pathway
83892view00:14, 23 December 2015KhanspersModified description

External references


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NameTypeDatabase referenceComment
ARCN1GeneProductENSG00000095139 (Ensembl)
ID1GeneProductENSG00000125968 (Ensembl)
ID2GeneProductENSG00000115738 (Ensembl)
USP1GeneProductENSG00000162607 (Ensembl)
hsa-miR-517a-3pRnaMIMAT0002852 (miRBase mature sequence)
p21GeneProductENSG00000124762 (Ensembl)

Annotated Interactions

No annotated interactions

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