mir-124 predicted interactions with cell cycle and differentiation (Homo sapiens)

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1Neuronal differentiationhsa-miR-124aAMPKSIX4STRADBPTBPKLB1SCP1Cell polarityand differentiationCell cycle progression


Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.

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  1. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, Purinton S, Wang Y, Ivan C, Kim HS, Borkowski RJ, Khan S, Rodriguez-Aguayo C, Lopez-Berestein G, Lea J, Gazdar A, Baggerly KA, Sood AK, White MA; ''A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.''; Mol Syst Biol, 2015 PubMed Europe PMC Scholia


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89883view12:59, 6 October 2016MkutmonModified description
87701view09:00, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
84854view21:53, 28 March 2016Khanspersupdated interactions
83894view00:16, 23 December 2015KhanspersModified description
83889view00:06, 23 December 2015KhanspersNew pathway
83890view00:05, 23 December 2015KhanspersModified description

External references


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NameTypeDatabase referenceComment
AMPKGeneProductENSG00000132356 (Ensembl)
KLB1GeneProductENSG00000118046 (Ensembl)
PTBPGeneProductENSG00000011304 (Ensembl)
SCP1GeneProductENSG00000144579 (Ensembl)
SIX4GeneProductENSG00000100625 (Ensembl)
STRADBGeneProductENSG00000082146 (Ensembl)
hsa-miR-124aRnaMIMAT0000422 (miRBase mature sequence)

Annotated Interactions

No annotated interactions

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