trans-Golgi Network Vesicle Budding (Homo sapiens)

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20311411, 246, 9, 12, 13, 253, 15, 23, 27, 309, 26, 299, 26, 2966, 7, 92, 4, 17, 1991, 10, 16, 21, 286, 7, 99, 229, 226, 9, 12, 13, 256, 85, 1810cytoplasmic vesicle membraneGolgi lumenendosome lumenlysosomal lumensecretory granule membranecytosolVAMP8NAPA GNS TFRC(1-760) Vamp8:SNAP23:Syn4Secretory granuledocking and fusioncomplexVAMP2BLOC1S1AP1S3 PUM1AP4M1 AP1B1 AP3S1 AP1S1 SORT1 AP1M1 AP1B1 AP4B1 GTP CTSZ VAMP2 ACBD3AP1G1 Ferritin ComplexDNASE2 PIK3C2A HSPA8 OCRL CTSZ GTP RAB5C AP1S3 SNX5 GTPVAMP2 GAK SORT1 BLOC1S6VampTGOLN2 VAMP7GTP AP1B1 Golgi-associatedVesicle DestinedCargoAP1S2 SNX2 VAMP2 ACBD3 BLOC1S1 ARRB1 SNX2 PICALM SH3GL2Arf1-GDPPiAP1S3 AP4B1 Clathrin TriskelionAP1M2 AP3S1 AP1M2 SH3GL2 TGOLN2 GOLGB1 homodimerAP4E1 CPD Clathrin light chain IGF2R ARRB1 AP1S2 Clathrin TriskelionHIP1R TXNDC5 VAMP2 LysosomeDestinedCargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin ComplexARF1 SNX2 AP1M2 VAMP7AP4E1 GAK DNAJC6 VAMP8 AP1G1 CLTC SNX5 PIK3C2A CLINT1 AP1G1 IGF2R AP1S1 PICALM DTNBP1BLOC1S1 BLOC1S1 TFRC(1-760) CLVS2 NECAP1 SH3GL2 AP4B1 VAMP8 CLTC-1 PUM1 AP1S2 CPD SNAP23AP4:APPNAPAAP3S1 Lysosome DestinedCargoClathrin light chain CLTC-1 AP1S1 ADPVAMP7 SNX5 AP1M2 FTH1 ARRB1 TPD52 M6PR SORT1 STX4 AP1S1 HGS ARRB1CLTB Vamp2:SNAP23:Syn4Secretory granuledocking and fusioncomplexAP1M1 CLINT1YIPF6 AP1B1 AP1S1 AP1M1 AP1B1 AP1G2AP1B1 SNAPIN PI(3,5)P2ARF1 SNAP23 BLOC1S4 ACBD3:GOLGB1 dimerHGSAP1S3 CHMP2AARRB1 AP1S3 NECAP1 VAMP7 VAMP8AP4E1 Clathrin light chain AP4B1 AP1M2 AP3B1 PIK3C2A Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp ComplexCLVS2 AP1S1 Clathrin TriskelionDNM2 HSC70:AuxillinComplexAP1G1 AP4B1 VAMP8 STX4 IGF2R IGF2R AP4:APPARF1 BLOC1S1 AP1S2 AP1M1 CLTB SNX9 TPD52L1 ARF1 BLOC1S1 VampDNASE2 AP1S2 SNAP23 DNASE2 ARF1 AP1M2 GOLGB1 Lysosome CargoCLTC VAMP8 ARF1 APP(18-770) OCRL ATPAP3S1 DTNBP1 M6PR CLAT:AP1:CLVSArf1-GDPTPD52L1 AP1B1 SNAPIN VAMP7 AP4E1 TPD52 LysosomeCargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp ComplexAP1M2 TGOLN2 SNX5 APP(18-770) VAMP7 TXNDC5 AP1G1 ARRB1 DNAJC6 SORT1 AP1S2 Lysosome CargoGolgi-associatedVesicle CargoSNX9 SORT1 GTPAP1M2 AP4M1 TPD52 VAMP8 AP1S2 TGOLN2 BLOC1S1 GOLGB1 AP1M2 GAK AP1G1 VAMP7 Lysosome DestinedCargoAP1S3 CLTC-1 RAB5C TPD52 AP4E1 SNX9 RAB5C CLVS1 Clathrin light chain AP1M1 VAMP7 GDP RAB5C AP1S3 DNM2AP4S1 PI(3,5)P2 TBC1D8B AP3B1 YIPF6 AP4B1 AP3S1 AP1S2 DNASE2 AP1B1 VAMP2 AP1G2 CLTC-1 AP1M1 PiGDP STX4GDPPIK3C2A SNAPIN SH3D19GAK VAMP8 PICALM VAMP7 STX4AP3B1 CHMP2A AP-1 ComplexRAB5C TBC1D8B AP1B1 CPD VAMP7 AP1S3 FTH1 OCRL SNAP23 AP1S2 Vamp7:SNAP23:Syn4Plasma membranevesicle docking andfusion complexDNASE2 TPD52L1 AP1S1 VAMP2 AP4B1 AP1M2 SNX2 Arf1-GTPATPCLAT:AP1:CLVS:PI(3,5)P2AP1G1 TPD52 AP4S1 LysosomeDestinedCargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp ComplexPiFTL PICALM VAMP8 TBC1D8B DNM2SNAP23YIPF6 OCRL AP1M1 CLTC-1 TPD52L1 AP1B1 BLOC1S4AP1M2 NECAP1 DNM2 M6PR FTL CTSZ TBC1D8B GNS TXNDC5 ARRB1TXNDC5 PiAP4B1 YIPF6 ADPAP1G1 AP-1 ComplexArf1-GDPHSC70:AuxillinComplexAP1G1 BLOC1S3 AP4VAMP8 AP1S1 AP1S3 TFRC(1-760) ARRB1PIK3C2A SNX9 NECAP1 CPD AP1S1 NECAP1 AP1S2 SNAPIN CLTC-1 TXNDC5AP-1 ComplexAP4E1 SH3GL2TBC1D8B M6PR GDPGAK VAMP8 PiVAMP7 CTSZ AP1M1 CLVS1 AP4E1 VAMP2AP4S1 SNX2 AP4M1 AP1M1 TFRC(1-760) M6PR SNX5 CLTC-1 APP(18-770)AP4E1 GTP AP1B1 TXNDC5 Clathrin light chain BLOC1S3AP1M1 Clathrin light chain Golgi-associatedvesicle interactingproteinsVAMP8 Golgi-associatedVesicle CargoArf1-GTPSTX4 SH3D19 AP3B1 AP1G1 CLTA GDP VAMP2 AP1G1 GBF1SNX9 Clathrin light chain SNAPIN Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp ComplexGTPYIPF6 CLTA AP1S3 Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin ComplexHSPA8 GNS AP1M1 TPD52L1 AP1G2:HGS:CHMP2AVAMP2 TXNDC5 HIP1R HIP1R CPD GDPAP1S1 HIP1R AP1S3 VAMP2 TGOLN2 AP1S2 BLOC-1 ComplexHIP1R VAMP7 VAMP2 GNS ARF1 AP3B1 AP1S1 Golgi-associatedVesicle DestinedCargoIGF2R VampOCRL ARRB1 PICALM CTSZ GNS SNAP23TFRC(1-760) BLOC1S6


Description

After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 199992
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Gillespie, Marc E

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Aguilar RC, Boehm M, Gorshkova I, Crouch RJ, Tomita K, Saito T, Ohno H, Bonifacino JS.; ''Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4.''; PubMed
  2. Döring T, Gotthardt K, Stieler J, Prange R.; ''γ2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits.''; PubMed
  3. Suzuki K, Verma IM.; ''Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.''; PubMed
  4. Rost M, Mann S, Lambert C, Döring T, Thomé N, Prange R.; ''Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation.''; PubMed
  5. Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW.; ''Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis.''; PubMed
  6. Borner GH, Harbour M, Hester S, Lilley KS, Robinson MS.; ''Comparative proteomics of clathrin-coated vesicles.''; PubMed
  7. Hirst J, Lindsay MR, Robinson MS.; ''GGAs: roles of the different domains and comparison with AP-1 and clathrin.''; PubMed
  8. Starcevic M, Dell'Angelica EC.; ''Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).''; PubMed
  9. Bryant NJ, Govers R, James DE.; ''Regulated transport of the glucose transporter GLUT4.''; PubMed
  10. Burgos PV, Mardones GA, Rojas AL, daSilva LL, Prabhu Y, Hurley JH, Bonifacino JS.; ''Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.''; PubMed
  11. Zhu Y, Traub LM, Kornfeld S.; ''ADP-ribosylation factor 1 transiently activates high-affinity adaptor protein complex AP-1 binding sites on Golgi membranes.''; PubMed
  12. Ungewickell E, Ungewickell H, Holstein SE, Lindner R, Prasad K, Barouch W, Martin B, Greene LE, Eisenberg E.; ''Role of auxilin in uncoating clathrin-coated vesicles.''; PubMed
  13. Lee DW, Zhao X, Zhang F, Eisenberg E, Greene LE.; ''Depletion of GAK/auxilin 2 inhibits receptor-mediated endocytosis and recruitment of both clathrin and clathrin adaptors.''; PubMed
  14. Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y.; ''Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin.''; PubMed
  15. Puri N, Roche PA.; ''Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis.''; PubMed
  16. Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck G, Ekici A, Brockschmidt FF, Nöthen MM, Munnich A, Strom TM, Reis A, Colleaux L.; ''Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature.''; PubMed
  17. Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K.; ''Identification and characterization of novel clathrin adaptor-related proteins.''; PubMed
  18. Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R.; ''A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function.''; PubMed
  19. Hartmann-Stühler C, Prange R.; ''Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein.''; PubMed
  20. Kirchhausen T.; ''Three ways to make a vesicle.''; PubMed
  21. Hirst J, Bright NA, Rous B, Robinson MS.; ''Characterization of a fourth adaptor-related protein complex.''; PubMed
  22. Musacchio A, Smith CJ, Roseman AM, Harrison SC, Kirchhausen T, Pearse BM.; ''Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography.''; PubMed
  23. Salinas E, Quintanar-Stephano A, Córdova LE, Ouintanar JL.; ''Allergen-sensitization increases mast-cell expression of the exocytotic proteins SNAP-23 and syntaxin 4, which are involved in histamine secretion.''; PubMed
  24. Seaman MN, Sowerby PJ, Robinson MS.; ''Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network.''; PubMed
  25. Acton SL, Wong DH, Parham P, Brodsky FM, Jackson AP.; ''Alteration of clathrin light chain expression by transfection and gene disruption.''; PubMed
  26. Maier O, Knoblich M, Westermann P.; ''Dynamin II binds to the trans-Golgi network.''; PubMed
  27. Wesolowski J, Paumet F.; ''Escherichia coli exposure inhibits exocytic SNARE-mediated membrane fusion in mast cells.''; PubMed
  28. Verkerk AJ, Schot R, Dumee B, Schellekens K, Swagemakers S, Bertoli-Avella AM, Lequin MH, Dudink J, Govaert P, van Zwol AL, Hirst J, Wessels MW, Catsman-Berrevoets C, Verheijen FW, de Graaff E, de Coo IF, Kros JM, Willemsen R, Willems PJ, van der Spek PJ, Mancini GM.; ''Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy.''; PubMed
  29. Farsad K, Ringstad N, Takei K, Floyd SR, Rose K, De Camilli P.; ''Generation of high curvature membranes mediated by direct endophilin bilayer interactions.''; PubMed
  30. Guo Z, Turner C, Castle D.; ''Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells.''; PubMed
  31. Katoh Y, Ritter B, Gaffry T, Blondeau F, Höning S, McPherson PS.; ''The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology.''; PubMed

History

View all...
CompareRevisionActionTimeUserComment
101511view11:37, 1 November 2018ReactomeTeamreactome version 66
101047view21:19, 31 October 2018ReactomeTeamreactome version 65
100578view19:52, 31 October 2018ReactomeTeamreactome version 64
100127view16:37, 31 October 2018ReactomeTeamreactome version 63
99677view15:07, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99270view12:45, 31 October 2018ReactomeTeamreactome version 62
93989view13:49, 16 August 2017ReactomeTeamreactome version 61
93594view11:28, 9 August 2017ReactomeTeamreactome version 61
88363view16:41, 1 August 2016FehrhartOntology Term : 'pathway pertinent to protein folding, sorting, modification, translocation and degradation' added !
86701view09:24, 11 July 2016ReactomeTeamreactome version 56
83468view12:32, 18 November 2015ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACBD3 ProteinQ9H3P7 (Uniprot-TrEMBL)
ACBD3:GOLGB1 dimerComplexR-HSA-8874975 (Reactome)
ACBD3ProteinQ9H3P7 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
AP-1 ComplexComplexR-HSA-167717 (Reactome)
AP1B1 ProteinQ10567 (Uniprot-TrEMBL)
AP1G1 ProteinO43747 (Uniprot-TrEMBL)
AP1G2 ProteinO75843 (Uniprot-TrEMBL)
AP1G2:HGS:CHMP2AComplexR-HSA-5671700 (Reactome)
AP1G2ProteinO75843 (Uniprot-TrEMBL)
AP1M1 ProteinQ9BXS5 (Uniprot-TrEMBL)
AP1M2 ProteinQ9Y6Q5 (Uniprot-TrEMBL)
AP1S1 ProteinP61966 (Uniprot-TrEMBL)
AP1S2 ProteinP56377 (Uniprot-TrEMBL)
AP1S3 ProteinQ96PC3 (Uniprot-TrEMBL)
AP3B1 ProteinO00203 (Uniprot-TrEMBL)
AP3S1 ProteinQ92572 (Uniprot-TrEMBL)
AP4:APPComplexR-HSA-5229081 (Reactome)
AP4:APPComplexR-HSA-5229085 (Reactome)
AP4B1 ProteinQ9Y6B7 (Uniprot-TrEMBL)
AP4E1 ProteinQ9UPM8 (Uniprot-TrEMBL)
AP4M1 ProteinO00189 (Uniprot-TrEMBL)
AP4ComplexR-HSA-5229123 (Reactome)
AP4S1 ProteinQ9Y587 (Uniprot-TrEMBL)
APP(18-770) ProteinP05067 (Uniprot-TrEMBL)
APP(18-770)ProteinP05067 (Uniprot-TrEMBL)
ARF1 ProteinP84077 (Uniprot-TrEMBL)
ARRB1 ProteinP49407 (Uniprot-TrEMBL)
ARRB1ProteinP49407 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Arf1-GDPComplexR-HSA-201340 (Reactome)
Arf1-GTPComplexR-HSA-199981 (Reactome)
BLOC-1 ComplexComplexR-HSA-429825 (Reactome)
BLOC1S1 ProteinP78537 (Uniprot-TrEMBL)
BLOC1S1ProteinP78537 (Uniprot-TrEMBL)
BLOC1S3 ProteinQ6QNY0 (Uniprot-TrEMBL)
BLOC1S3ProteinQ6QNY0 (Uniprot-TrEMBL)
BLOC1S4 ProteinQ9NUP1 (Uniprot-TrEMBL)
BLOC1S4ProteinQ9NUP1 (Uniprot-TrEMBL)
BLOC1S6 ProteinQ9UL45 (Uniprot-TrEMBL)
BLOC1S6ProteinQ9UL45 (Uniprot-TrEMBL)
CHMP2A ProteinO43633 (Uniprot-TrEMBL)
CHMP2AProteinO43633 (Uniprot-TrEMBL)
CLAT:AP1:CLVS:PI(3,5)P2ComplexR-HSA-5334658 (Reactome)
CLAT:AP1:CLVSComplexR-HSA-5333673 (Reactome)
CLINT1 ProteinQ14677 (Uniprot-TrEMBL)
CLINT1ProteinQ14677 (Uniprot-TrEMBL)
CLTA ProteinP09496 (Uniprot-TrEMBL)
CLTB ProteinP09497 (Uniprot-TrEMBL)
CLTC ProteinQ00610 (Uniprot-TrEMBL)
CLTC-1 ProteinQ00610-1 (Uniprot-TrEMBL)
CLVS1 ProteinQ8IUQ0 (Uniprot-TrEMBL)
CLVS2 ProteinQ5SYC1 (Uniprot-TrEMBL)
CPD ProteinO75976 (Uniprot-TrEMBL)
CTSZ ProteinQ9UBR2 (Uniprot-TrEMBL)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp ComplexComplexR-HSA-432669 (Reactome)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp ComplexComplexR-HSA-351198 (Reactome)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin ComplexComplexR-HSA-350825 (Reactome)
Clathrin TriskelionComplexR-HSA-350827 (Reactome)
Clathrin light chain ProteinP09496-1 (Uniprot-TrEMBL)
DNAJC6 ProteinO75061 (Uniprot-TrEMBL)
DNASE2 ProteinO00115 (Uniprot-TrEMBL)
DNM2 ProteinP50570 (Uniprot-TrEMBL)
DNM2ProteinP50570 (Uniprot-TrEMBL)
DTNBP1 ProteinQ96EV8 (Uniprot-TrEMBL)
DTNBP1ProteinQ96EV8 (Uniprot-TrEMBL)
FTH1 ProteinP02794 (Uniprot-TrEMBL)
FTL ProteinP02792 (Uniprot-TrEMBL)
Ferritin ComplexComplexR-HSA-434350 (Reactome) The ferritin complex is an oligomer of 24 subunits with light and heavy chains. The structural features of ferritin arise from the combination in various ratios of two subunits, H and L, which differ in size, amino acid composition, surface charge, and immunoreactivity. A corollary related differences in ferritin iron content to the functional efficiency of one of the two subunits for storing iron. In humans the H subunit is associated with a lower pI and lower iron content, and predominates in heart tissue, whereas the L subunit is associated with a higher pI and higher iron content, and predominates in the liver.
The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Iron metabolism provides a useful example of gene expression translational control. Increased iron levels stimulate the synthesis of the iron-binding protein, ferritin, without any corresponding increase in the amount of ferritin mRNA. The 5'-UTR of both ferritin heavy chain mRNA and light chain mRNA contain a single iron-response element (IRE), a specific cis-acting regulatory sequence which forms a hairpin structure.
GAK ProteinO14976 (Uniprot-TrEMBL)
GBF1ProteinQ92538 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GNS ProteinP15586 (Uniprot-TrEMBL)
GOLGB1 ProteinQ14789 (Uniprot-TrEMBL)
GOLGB1 homodimerComplexR-HSA-6810505 (Reactome)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
Golgi-associated Vesicle CargoComplexR-HSA-432672 (Reactome)
Golgi-associated Vesicle CargoComplexR-HSA-435029 (Reactome)
Golgi-associated

Vesicle Destined

Cargo
ComplexR-HSA-432674 (Reactome)
Golgi-associated

Vesicle Destined

Cargo
ComplexR-HSA-435032 (Reactome)
Golgi-associated

vesicle interacting

proteins
ComplexR-HSA-434351 (Reactome)
HGS ProteinO14964 (Uniprot-TrEMBL)
HGSProteinO14964 (Uniprot-TrEMBL)
HIP1R ProteinO75146 (Uniprot-TrEMBL)
HSC70:Auxillin ComplexComplexR-HSA-351175 (Reactome)
HSPA8 ProteinP11142 (Uniprot-TrEMBL)
IGF2R ProteinP11717 (Uniprot-TrEMBL)
Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp ComplexComplexR-HSA-432691 (Reactome)
Lysosome

Destined

Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex
ComplexR-HSA-432700 (Reactome)
Lysosome

Destined

Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex
ComplexR-HSA-432704 (Reactome)
Lysosome CargoComplexR-HSA-432697 (Reactome)
Lysosome CargoComplexR-HSA-435030 (Reactome)
Lysosome Destined CargoComplexR-HSA-432690 (Reactome)
Lysosome Destined CargoComplexR-HSA-435031 (Reactome)
M6PR ProteinP20645 (Uniprot-TrEMBL)
NAPA ProteinP54920 (Uniprot-TrEMBL)
NAPAProteinP54920 (Uniprot-TrEMBL)
NECAP1 ProteinQ8NC96 (Uniprot-TrEMBL)
OCRL ProteinQ01968 (Uniprot-TrEMBL)
PI(3,5)P2 MetaboliteCHEBI:16851 (ChEBI)
PI(3,5)P2MetaboliteCHEBI:16851 (ChEBI)
PICALM ProteinQ13492 (Uniprot-TrEMBL)
PIK3C2A ProteinO00443 (Uniprot-TrEMBL)
PUM1 ProteinQ14671 (Uniprot-TrEMBL)
PUM1ProteinQ14671 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RAB5C ProteinP51148 (Uniprot-TrEMBL)
SH3D19 ProteinQ5HYK7 (Uniprot-TrEMBL)
SH3D19ProteinQ5HYK7 (Uniprot-TrEMBL)
SH3GL2 ProteinQ99962 (Uniprot-TrEMBL)
SH3GL2ProteinQ99962 (Uniprot-TrEMBL)
SNAP23 ProteinO00161 (Uniprot-TrEMBL)
SNAP23ProteinO00161 (Uniprot-TrEMBL)
SNAPIN ProteinO95295 (Uniprot-TrEMBL)
SNX2 ProteinO60749 (Uniprot-TrEMBL)
SNX5 ProteinQ9Y5X3 (Uniprot-TrEMBL)
SNX9 ProteinQ9Y5X1 (Uniprot-TrEMBL)
SORT1 ProteinQ99523 (Uniprot-TrEMBL)
STX4 ProteinQ12846 (Uniprot-TrEMBL)
STX4ProteinQ12846 (Uniprot-TrEMBL)
TBC1D8B ProteinQ0IIM8 (Uniprot-TrEMBL)
TFRC(1-760) ProteinP02786 (Uniprot-TrEMBL)
TGOLN2 ProteinO43493 (Uniprot-TrEMBL)
TPD52 ProteinP55327 (Uniprot-TrEMBL)
TPD52L1 ProteinQ16890 (Uniprot-TrEMBL)
TXNDC5 ProteinQ8NBS9 (Uniprot-TrEMBL)
TXNDC5ProteinQ8NBS9 (Uniprot-TrEMBL)
VAMP2 ProteinP63027 (Uniprot-TrEMBL)
VAMP2ProteinP63027 (Uniprot-TrEMBL)
VAMP7 ProteinP51809 (Uniprot-TrEMBL)
VAMP7ProteinP51809 (Uniprot-TrEMBL)
VAMP8 ProteinQ9BV40 (Uniprot-TrEMBL)
VAMP8ProteinQ9BV40 (Uniprot-TrEMBL)
Vamp2:SNAP23:Syn4

Secretory granule docking and fusion

complex
ComplexR-HSA-376372 (Reactome)
Vamp7:SNAP23:Syn4

Plasma membrane vesicle docking and

fusion complex
ComplexR-HSA-376340 (Reactome)
Vamp8:SNAP23:Syn4

Secretory granule docking and fusion

complex
ComplexR-HSA-376367 (Reactome)
VampComplexR-HSA-432668 (Reactome)
VampComplexR-HSA-432673 (Reactome)
VampComplexR-HSA-432694 (Reactome)
YIPF6 ProteinQ96EC8 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ACBD3:GOLGB1 dimerArrowR-HSA-8874979 (Reactome)
ACBD3R-HSA-8874979 (Reactome)
ADPArrowR-HSA-421836 (Reactome)
ADPArrowR-HSA-432688 (Reactome)
AP-1 ComplexArrowR-HSA-421836 (Reactome)
AP-1 ComplexArrowR-HSA-432688 (Reactome)
AP-1 ComplexR-HSA-421833 (Reactome)
AP-1 ComplexR-HSA-432712 (Reactome)
AP1G2:HGS:CHMP2AArrowR-HSA-5671702 (Reactome)
AP1G2R-HSA-5671702 (Reactome)
AP4:APPArrowR-HSA-5229111 (Reactome)
AP4:APPArrowR-HSA-5229132 (Reactome)
AP4:APPR-HSA-5229111 (Reactome)
AP4:APPmim-catalysisR-HSA-5229111 (Reactome)
AP4R-HSA-5229132 (Reactome)
APP(18-770)R-HSA-5229132 (Reactome)
ARRB1ArrowR-HSA-421836 (Reactome)
ARRB1ArrowR-HSA-432688 (Reactome)
ARRB1R-HSA-421833 (Reactome)
ARRB1R-HSA-432712 (Reactome)
ATPR-HSA-421836 (Reactome)
ATPR-HSA-432688 (Reactome)
Arf1-GDPArrowR-HSA-421831 (Reactome)
Arf1-GDPArrowR-HSA-432706 (Reactome)
Arf1-GDPR-HSA-350769 (Reactome)
Arf1-GTPArrowR-HSA-350769 (Reactome)
Arf1-GTPR-HSA-421833 (Reactome)
Arf1-GTPR-HSA-432712 (Reactome)
BLOC-1 ComplexArrowR-HSA-429815 (Reactome)
BLOC1S1R-HSA-429815 (Reactome)
BLOC1S3R-HSA-429815 (Reactome)
BLOC1S4R-HSA-429815 (Reactome)
BLOC1S6R-HSA-429815 (Reactome)
CHMP2AR-HSA-5671702 (Reactome)
CLAT:AP1:CLVS:PI(3,5)P2ArrowR-HSA-5333658 (Reactome)
CLAT:AP1:CLVSR-HSA-5333658 (Reactome)
CLINT1R-HSA-434362 (Reactome)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp ComplexArrowR-HSA-421833 (Reactome)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp ComplexR-HSA-421831 (Reactome)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp ComplexArrowR-HSA-421835 (Reactome)
Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp ComplexR-HSA-421836 (Reactome)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin ComplexArrowR-HSA-421831 (Reactome)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin ComplexR-HSA-421835 (Reactome)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complexmim-catalysisR-HSA-421835 (Reactome)
Clathrin TriskelionArrowR-HSA-421836 (Reactome)
Clathrin TriskelionArrowR-HSA-432688 (Reactome)
Clathrin TriskelionR-HSA-421831 (Reactome)
Clathrin TriskelionR-HSA-432706 (Reactome)
DNM2ArrowR-HSA-421835 (Reactome)
DNM2ArrowR-HSA-432707 (Reactome)
DNM2R-HSA-421831 (Reactome)
DNM2R-HSA-432706 (Reactome)
DTNBP1R-HSA-429815 (Reactome)
Ferritin ComplexR-HSA-434362 (Reactome)
GBF1mim-catalysisR-HSA-350769 (Reactome)
GDPArrowR-HSA-350769 (Reactome)