Fatty Acid Biosynthesis (Homo sapiens)

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Acetyl-ACPMitochondrionAcetoacetyl-ACPCytosolMalonyl-ACPPalmitoyl-ACPpyruvate6 iterationsLong-Chain fatty acidtrans-delta2-enoyl-CoA3-ketoacyl-CoAOxaloacetateCitrate3-L-Hydroxyacyl-CoAless than 6 iterationsTCA Cyclebeta-hydroxybutyrylPalmitateButyryl-ACPCrotonoyl-ACPFatty acyl CoAAcetyl-synthaseACSL6FASNACSL3Malonyl-CoAAcyl-CoA (n+2)MECRFASNACLYFASNFASNPCTriacylglyceride Synthesis pathwayAcetyl-CoADECR1FASNACACBECHS1ACAS2ECHDC1HADHSCECHDC2ACSL1ECHDC3FASNACSL5FASNSCDPECRACSL4ACACAACAA2ECH1FASN


Fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid synthases. This process takes place in the cytoplasm of the cell. Most of the acetyl-CoA which is converted into fatty acids is derived from carbohydrates via the glycolytic pathway. Source: Wikipedia

Pathway based on Kam Dahlquist's original. Edited by Magali Jaillard, Marijke Vermeer, Michiel Adrieans, Ron Schormans and Chris Evelo.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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View all...
110772view21:30, 3 June 2020Khanspersremoved stray gene
106416view21:59, 28 August 2019KhanspersModified description
105595view04:47, 10 August 2019KhanspersModified description
98551view18:05, 16 September 2018AlexanderPicoupdated outdated chebi
98530view20:27, 14 September 2018Khanspersoverall update
98529view20:06, 14 September 2018KhanspersModified description
98528view20:05, 14 September 2018Khanspersremoved GenMAPP comments
98527view20:04, 14 September 2018KhanspersModified description
98526view20:04, 14 September 2018KhanspersModified description
98056view06:36, 13 July 2018Fehrhartadded ID for ACSS2 (Acetyl-(CoA) synthase)
94197view14:43, 25 August 2017Mkutmonadded some metabolite identifiers
85181view07:04, 23 April 2016EgonwConverted the remaining metabolite labels into Metabolite DataNodes.
70641view10:21, 20 August 2013EgonwAdded a ChEBI id for 'long chain fatty acid'.
70640view10:18, 20 August 2013EgonwConverted a IUPAC-named Label into a Chemspider-backed Metabolite DataNode.
69014view17:47, 8 July 2013MaintBotUpdated to 2013 gpml schema
45261view18:44, 7 October 2011AlexanderPicoOntology Term : 'fatty acid biosynthetic pathway' added !
41186view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
39781view14:51, 18 January 2011MartijnVanIerselpathway link added
38814view08:58, 24 September 2010Jildaucompartment
38673view15:08, 23 September 2010BassetfrogAdded link to Triacylglyceride Synthesis pathway
32875view22:22, 16 September 2009MaintBotchanged type for metabolites
32064view13:34, 14 August 2009MaintBotFixed group labels
30271view20:19, 25 July 2009AlexanderPicofixed unsupported characters in Comment Source "GenMAPP notes"
21427view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Fatty Acid Synthesis BiGCaT]] moved to [[Pathway:WP357]]: Moved to stable identifier
14593view06:32, 23 May 2008AlexanderPicoupdated pathway reference
14144view14:59, 21 May 2008MichielConnected genes to reaction arrows
14142view14:54, 21 May 2008MichielPeriodical save, work in progress
14138view14:40, 21 May 2008MichielConnected arrows
14136view14:30, 21 May 2008Michiel
14134view14:30, 21 May 2008MichielCreated groups of genes
13068view11:13, 17 May 2008MaintBotautomated metabolite conversion
8052view13:46, 7 January 2008MaintBot[[Pathway:Human:Fatty Acid Synthesis BiGCaT]] moved to [[Pathway:Homo sapiens:Fatty Acid Synthesis BiGCaT]]: Renaming species
7648view16:07, 18 December 2007MaintBotfixed category names
7357view12:42, 4 November 2007MaintBotAdded categories to GPML
19460view22:17, 22 May 2007Evelogpml file for [[Human:Fatty_Acid_Synthesis_BiGCaT]]
6318view22:17, 22 May 2007Kdahlquistgpml file for [[Human:Fatty_Acid_Synthesis_BiGCaT]]

External references


View all...
NameTypeDatabase referenceComment
3-ketoacyl-CoAMetaboliteCHEBI:57347 (ChEBI)
ACAA2GeneProduct10449 (Entrez Gene)
ACACAGeneProduct31 (Entrez Gene)
ACACBGeneProduct32 (Entrez Gene)
ACAS2GeneProduct55902 (Entrez Gene)
ACLYGeneProduct47 (Entrez Gene)
ACSL1GeneProduct2180 (Entrez Gene)
ACSL3GeneProduct2181 (Entrez Gene)
ACSL4GeneProduct2182 (Entrez Gene)
ACSL5GeneProduct51703 (Entrez Gene)
ACSL6GeneProduct23305 (Entrez Gene)
Acetoacetyl-ACPMetaboliteCHEBI:2393 (ChEBI)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
Acetyl-synthaseGeneProductENSG00000131069 (Ensembl)
Acyl-CoA (n+2)Metabolite9029-97-4 (CAS)
Butyryl-ACPMetaboliteCHEBI:3247 (ChEBI)
CitrateMetabolite29081 (Chemspider)
DECR1GeneProduct1666 (Entrez Gene)
ECH1GeneProduct1891 (Entrez Gene)
ECHDC1GeneProduct55862 (Entrez Gene)
ECHDC2GeneProduct55268 (Entrez Gene)
ECHDC3GeneProduct79746 (Entrez Gene)
ECHS1GeneProduct1892 (Entrez Gene)
FASNGeneProduct2194 (Entrez Gene)
Fatty acyl CoAMetabolite
HADHSCGeneProduct3033 (Entrez Gene)
Long-Chain fatty acidMetaboliteCHEBI:15904 (ChEBI)
MECRGeneProduct51102 (Entrez Gene)
Malonyl-CoAMetabolite524-14-1 (CAS)
OxaloacetateMetaboliteCHEBI:30744 (ChEBI)
PCGeneProduct5091 (Entrez Gene)
PECRGeneProduct55825 (Entrez Gene)
PalmitateMetabolite440215 (Chemspider)
SCDGeneProduct6319 (Entrez Gene)
TCA CyclePathwayWP78 (WikiPathways)
Triacylglyceride Synthesis pathwayPathwayWP325 (WikiPathways)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions

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