IL-1 Signaling Pathway (Rattus norvegicus)

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DEndosomeDephosphorylationDeubiquitinationECDesumoylationCytoplasmDActivationReaction through unknown mechanisms/molecules(Protein-protein interaction)InhibitionAutophosphorylationTranslocationMolecule in the pathwayDExtracellularMolecular associationPalmitoylationMTMitochondriaCY -> NUDENDemethylationPlasma membraneDLigandDPhosphorylationEnzyme complexRecruitmentNUPMDeacetylationProteins in a complex interactionProteolytic cleavageDMethylationCY -> NUSumoylationCYNucleusControlCY -> NUUbiquitinationAcetylationGlycosylationGolgi apparatusCY->EXGOReceptorPM -> CYAccession Number: NetPath 13PM -> CYCY->EXRELAMAP3K7MAP3K7IP2Irak2MAP3K7IP2NFKBIAIrak1Il1aIRAK4Il1rnIl1bTraf6Traf6IRAK4IKBKAPIrak1Il1bIRAK3Traf6MAP3K7IP1PLCG1Il1bIl1rapIl1aIl1r1SQSTM1Il1bIl1r1MAP3K7MAP3K7IP2MAP3K7IP1MAP3K7TOLLIPNFKB1MAP3K7IP2TOLLIPIl1rnMAP3K14Ptpns1MAP3K7IP1Irak1MAP3K7PTPN11CHUKCAPN1Traf6AKT1MAP3K7IP2PELI1MAPK1Il1rapMAP2K1MAP3K7RELACHUKMAP3K7IP2Ptpns1Myd88Il1aGene SymbolMAP3K14Traf6CAPNS1MAPK3MAPK8Irak1Irak4PTPN11Il1r1NFKBIBNFKBIAIrak1Traf6Il1aCASP1Il1r2Il1r2Il1r2PELI1MAPK1Irak1PRKCZMAP3K7


Description

The interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor, IL1R2. Upon binding to the ligands, interleukin-1 alpha or beta, IL1R1 interacts with IL-1 receptor accessory protein (IL1RAP) to activate the MAPK/JNK signaling modules. The MAPK pathway leads to activation of NFkB complex. As both IL-1 and TNF alpha stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_13

Comments

GenMAPP notes 
NetPath 13: IL-1 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
79334view12:02, 21 March 2015EgonwReplaced another gene name with its Entrez Gene identifier.
78052view12:52, 23 November 2014EgonwReplaced label Entrez Genes identifiers by their numeric IDs.
69338view18:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
67364view10:42, 26 June 2013Christine ChichesterOntology Term : 'interleukin-1 signaling pathway' added !
41650view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
35779view06:18, 13 February 2010MaintBotAdded description
21423view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:IL-1 NetPath 13]] moved to [[Pathway:WP355]]: Moved to stable identifier
8162view13:46, 7 January 2008MaintBot[[Pathway:Rat:IL-1 NetPath 13]] moved to [[Pathway:Rattus norvegicus:IL-1 NetPath 13]]: Renaming species
7701view16:10, 18 December 2007MaintBotfixed category names
7240view12:41, 4 November 2007MaintBotAdded categories to GPML
6558view22:20, 22 May 2007A.Pandeygpml file for [[Rat:IL-1_NetPath_13]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct24185 (Entrez Gene)
CAPN1GeneProduct29153 (Entrez Gene)
CAPNS1GeneProduct29156 (Entrez Gene)
CASP1GeneProduct25166 (Entrez Gene)
CHUKGeneProduct309361 (Entrez Gene)
Gene SymbolGeneProduct
IKBKAPGeneProduct140934 (Entrez Gene)
IRAK3GeneProduct314870 (Entrez Gene)
IRAK4GeneProduct300177 (Entrez Gene)
Il1aGeneProduct24493 (Entrez Gene)
Il1bGeneProduct24494 (Entrez Gene)
Il1r1GeneProduct25663 (Entrez Gene)
Il1r2GeneProduct117022 (Entrez Gene)
Il1rapGeneProduct25466 (Entrez Gene)
Il1rnGeneProduct60582 (Entrez Gene)
Irak1GeneProduct363520 (Entrez Gene)
Irak2GeneProduct362418 (Entrez Gene)
Irak4GeneProduct300177 (Entrez Gene)
MAP2K1GeneProduct170851 (Entrez Gene)
MAP3K14GeneProduct360640 (Entrez Gene)
MAP3K7GeneProduct313121 (Entrez Gene)
MAP3K7IP1GeneProduct315139 (Entrez Gene)
MAP3K7IP2GeneProduct
MAPK1GeneProduct116590 (Entrez Gene)
MAPK3GeneProduct50689 (Entrez Gene)
MAPK8GeneProduct116554 (Entrez Gene)
Myd88GeneProduct301059 (Entrez Gene)
NFKB1GeneProduct81736 (Entrez Gene)
NFKBIAGeneProduct25493 (Entrez Gene)
NFKBIBGeneProduct81525 (Entrez Gene)
PELI1GeneProduct305549 (Entrez Gene)
PLCG1GeneProduct25738 (Entrez Gene)
PRKCZGeneProduct25522 (Entrez Gene)
PTPN11GeneProduct25622 (Entrez Gene)
Ptpns1GeneProduct25528 (Entrez Gene)
RELAGeneProduct309165 (Entrez Gene)
SQSTM1GeneProduct113894 (Entrez Gene)
TOLLIPGeneProduct361677 (Entrez Gene)
Traf6GeneProduct311245 (Entrez Gene)

Annotated Interactions

No annotated interactions
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