Septum site determination (Escherichia coli)

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1E.coli cytoplasmcell membraneMinDADP ATP PhosphateMinEMinDMinDMinDMinDMinEMinEATP ATP ATP


In Escherichia coli, division site selection is regulated in part by the Min-protein system. Oscillations of the Min proteins from pole to pole every approximately 40 sec have been revealed by in vivo studies of GFP fusions. The dynamic oscillatory structures produced by the Min proteins, including a ring of MinE protein, compact polar zones of MinD, and zebra-striped oscillations in filamentous cells, remain unexplained. We show that the Min oscillations, including mutant phenotypes, can be accounted for by in vitro-observed interactions involving MinD and MinE, with a crucial role played by the rate of nucleotide exchange. Recent discoveries suggest that protein oscillations may play a general role in proper chromosome and plasmid partitioning. (Huang KC et al. 2003)

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Ontology Terms



  1. Huang KC, Meir Y, Wingreen NS; ''Dynamic structures in Escherichia coli: spontaneous formation of MinE rings and MinD polar zones.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC


106103view12:01, 16 August 2019MaintBotHMDB identifier normalization
87655view08:55, 25 July 2016LindarieswijkOntology Term : 'regulatory pathway' added !
84322view16:16, 5 February 2016FehrhartModified description
82927view14:22, 13 November 2015FehrhartNew pathway

External references


NameTypeDatabase referenceComment
ADP MetaboliteHMDB0001341 (HMDB)
ATP MetaboliteHMDB0000538 (HMDB)
MinDProteinP0AEZ3 (Uniprot-TrEMBL)
MinEProteinP0A734 (Uniprot-TrEMBL)
PhosphateMetaboliteHMDB0001429 (HMDB)

Annotated Interactions

No annotated interactions

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