p38 MAPK Signaling Pathway (Mus musculus)

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1-8DNA transcription???TranslationStress: Osmotic shockg-radiation, AnisomycinFASL, InflammatoryCytokines, UV, etc.Cytokines Production,Apoptosis, etc.Growth Factors, UVTrophic Factors, etc.??Creb1Mef2dPla2g4aShc1ApoptosisStat1Ddit3HrasRps6ka5Ripk1Mapkapk2Cdc42Grb2Traf2MycElk1Map2k4TraddHspb1Mapk14Map3k9MaxHmgn1Rasgrf1Mapkapk2DaxxTgfbr1Mapk14Map3k7Map3k5Rac1Map2k6Mknk1Atf2Gm42878Tgfb2Map3k1Transcription factors


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP400 (r95117) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  2. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  3. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  4. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia
  5. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  6. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  7. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  8. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
95744view13:50, 19 January 2018MkutmonHomology conversion update
95233view19:17, 26 November 2017DeSlOntology Term : 'cytokine mediated signaling pathway' added !
95211view12:04, 24 November 2017Mkutmonadded homology converter comment source
70038view02:05, 12 July 2013AlexanderPicoModified title
69208view18:25, 8 July 2013MaintBotUpdated to 2013 gpml schema
67570view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
41398view00:30, 2 March 2011MaintBotRemoved redundant pathway information and comments
38354view05:20, 2 September 2010KhanspersPeriodical save, work in progress
38236view21:14, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38235view21:14, 27 August 2010Khanspers
35698view23:07, 12 February 2010KhanspersDescription and Bibliography
33044view21:36, 7 October 2009MaintBotadded xrefs
32405view17:03, 15 August 2009MaintBotFixed text labels
32060view13:33, 14 August 2009MaintBotFixed group labels
31435view21:03, 13 August 2009MaintBotFixed text labels
30871view00:14, 30 July 2009MaintBotConverted from Homo sapiens
21413view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:p38 MAPK signaling pathway]] moved to [[Pathway:WP350]]: Moved to stable identifier
8326view13:46, 7 January 2008MaintBot[[Pathway:Mouse:p38 MAPK signaling pathway]] moved to [[Pathway:Mus musculus:p38 MAPK signaling pathway]]: Renaming species
7781view16:17, 18 December 2007MaintBotfixed category names
7323view12:42, 4 November 2007MaintBotAdded categories to GPML
6512view22:19, 22 May 2007S.Burelgpml file for [[Mouse:p38_MAPK_signaling_pathway]]

External references

DataNodes

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NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
Atf2GeneProductENSMUSG00000027104 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1386
Cdc42GeneProductENSMUSG00000006699 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:998
Creb1GeneProductENSMUSG00000025958 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1385
DaxxGeneProductENSMUSG00000002307 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1616
Ddit3GeneProductENSMUSG00000025408 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1649
Elk1GeneProductENSMUSG00000009406 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2002
Gm42878GeneProductENSMUSG00000105340 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8550
Grb2GeneProductENSMUSG00000059923 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2885
Hmgn1GeneProductENSMUSG00000040681 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3150
HrasGeneProductENSMUSG00000025499 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3265
Hspb1GeneProductENSMUSG00000004951 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3315
Map2k4GeneProductENSMUSG00000033352 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416
Map2k6GeneProductENSMUSG00000020623 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5608
Map3k1GeneProductENSMUSG00000021754 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4214
Map3k5GeneProductENSMUSG00000071369 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4217
Map3k7GeneProductENSMUSG00000028284 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6885
Map3k9GeneProductENSMUSG00000042724 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4293
Mapk14GeneProductENSMUSG00000053436 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1432
Mapkapk2GeneProductENSMUSG00000016528 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9261
MaxGeneProductENSMUSG00000059436 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4149
Mef2dGeneProductENSMUSG00000001419 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4209
Mknk1GeneProductENSMUSG00000028708 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8569
MycGeneProductENSMUSG00000022346 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4609
Pla2g4aGeneProductENSMUSG00000056220 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5321
Rac1GeneProductENSMUSG00000001847 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5879
Rasgrf1GeneProductENSMUSG00000032356 (Ensembl)
  • PDZ domain containing guanine nucleotide exchange
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5923
Ripk1GeneProductENSMUSG00000021408 (Ensembl)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8737
Rps6ka5GeneProductENSMUSG00000021180 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9252
Shc1GeneProductENSMUSG00000042626 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6464
Stat1GeneProductENSMUSG00000026104 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6772
Tgfb2GeneProductENSMUSG00000039239 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7042
Tgfbr1GeneProductENSMUSG00000007613 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7046
TraddGeneProductENSMUSG00000031887 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8717
Traf2GeneProductENSMUSG00000026942 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7186

Annotated Interactions

No annotated interactions
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