Initiation of transcription and translation elongation at the HIV-1 LTR (Homo sapiens)

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NFATC4PNFATC3PNFATC2P1HIV-1 LTRDSIF5'Calcineurin complexHDACDegradationNucleusNELFASUPT4H1p300HistonesHMBACBPPPP3R2PPP3R1HDACSP1RNA Pol IINELFBHDAC1PPP3CCPPP3CASUPT5HHEXIM1TatPPP3CBCDK9CycT1AcIKBANFATC1PRELANFATC4ProstratinNFATC3UbiquitinNFATC2NFATC1p50NFATC4NFATC3NFATC2NFATC13'CytoplasmIKBAPPRELAp50RELAp50RELAp50RELAp50NFATC4NFATC3NFATC2NFATC1p50p50CBPp300HistonesAcCDK9CycT1TatTatNELFCDNELFECDK9CycT1TatSP1SP1HDAC2HDAC3HDAC4HDAC5HDAC7HDAC8HDAC9


Description

Following cellular activation or drug treatment, NFAT and NF-kB translocate to the nucleus and bind sites at the HIV-1 LTR. NFAT and NF-kB recruit p300/CBP to the LTR, resulting in acetylation of histone tails and transcriptional activation. In the case of NF-kB, proteosomal degradation of IkBa permits NF-kB translocation and displacement of the p50 homodimers. This is followed by Tat- dependent elongation in which Tat recruits the P-TEFb complex to TAR. Cdk9 phosphorylates the CTD of RNA Pol II, resulting in increased processivity. P-TEFb phosphorylates DSIF and NELF, resulting in removal of NELF from Pol II and converting DSIF into a positive elongation factor, thereby promoting productive elongation.

Data nodes in blue represent HIV proteins.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Ruelas DS, Greene WC; ''An integrated overview of HIV-1 latency.''; Cell, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106735view13:21, 17 September 2019MaintBotHMDB identifier normalization
106616view20:44, 12 September 2019KhanspersModified description
105625view05:01, 10 August 2019KhanspersModified description
97633view12:33, 31 May 2018AMTanOntology Term : 'human immunodeficiency virus infectious disease' added !
87386view11:05, 22 July 2016MaintBotadded missing graphids
82252view23:18, 16 September 2015Khanspersnew version
81816view06:09, 1 September 2015KhanspersModified description
81815view06:06, 1 September 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CBPGeneProductENSG00000005339 (Ensembl)
CDK9GeneProductENSG00000136807 (Ensembl)
CycT1GeneProductENSG00000129315 (Ensembl)
HDACGeneProduct
HDAC1GeneProductENSG00000116478 (Ensembl)
HDAC2GeneProductENSG00000196591 (Ensembl)
HDAC3GeneProductENSG00000171720 (Ensembl)
HDAC4GeneProductENSG00000068024 (Ensembl)
HDAC5GeneProductENSG00000108840 (Ensembl)
HDAC7GeneProductENSG00000061273 (Ensembl)
HDAC8GeneProduct55869 (Entrez Gene)
HDAC9GeneProductENSG00000048052 (Ensembl)
HEXIM1GeneProductENSG00000186834 (Ensembl)
HMBAMetaboliteHMDB0041901 (HMDB)
HistonesGeneProduct
IKBAGeneProductENSG00000100906 (Ensembl)
NELFAGeneProductENSG00000185049 (Ensembl)
NELFBGeneProductENSG00000188986 (Ensembl)
NELFCDGeneProductENSG00000101158 (Ensembl)
NELFEGeneProduct7936 (Entrez Gene)
NFATC1GeneProductENSG00000131196 (Ensembl)
NFATC2GeneProductENSG00000101096 (Ensembl)
NFATC3GeneProductENSG00000072736 (Ensembl)
NFATC4GeneProductENSG00000100968 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl)
PPP3CBGeneProductENSG00000107758 (Ensembl)
PPP3CCGeneProductENSG00000120910 (Ensembl)
PPP3R1GeneProductENSG00000221823 (Ensembl)
PPP3R2GeneProductENSG00000188386 (Ensembl)
ProstratinMetabolite399975 (Chemspider)
RELAGeneProductENSG00000173039 (Ensembl)
RNA Pol IIGeneProduct
SP1GeneProductENSG00000185591 (Ensembl)
SUPT4H1GeneProductENSG00000213246 (Ensembl)
SUPT5HGeneProductENSG00000196235 (Ensembl)
TatGeneProduct
UbiquitinGeneProduct
p300GeneProductENSG00000100393 (Ensembl)
p50GeneProductENSG00000109320 (Ensembl)

Annotated Interactions

No annotated interactions

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