NOTCH1 regulation of human endothelial cell calcification (Homo sapiens)

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1Flow / Shear stressValve endotheliumInterstitial CellExtracellular MatrixCALUVEGFSAT1ALPLFGFR3MGPPAR1ITGA1SOX6NOTCH1GJA5Secreted proteinsPLATCalcificationPTHrPDLL1DLL3DLL4JAG1JAG2


Description

Model of NOTCH1 regulation of human endothelial cell calcification.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D; ''NOTCH1 regulates matrix gla protein and calcificationgene networks in human valve endothelium.''; J Mol Cell Cardiol, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106657view21:17, 12 September 2019KhanspersModified description
105658view05:15, 10 August 2019KhanspersModified description
87953view13:07, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
87385view11:05, 22 July 2016MaintBotadded missing graphids
82217view20:45, 15 September 2015Khanspersupdates
81814view06:06, 1 September 2015KhanspersModified description
81813view06:04, 1 September 2015KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ALPLGeneProductENSG00000162551 (Ensembl)
CALUGeneProductENSG00000128595 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DLL3GeneProductENSG00000090932 (Ensembl)
DLL4GeneProductENSG00000128917 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
GJA5GeneProduct2702 (Entrez Gene)
ITGA1GeneProductENSG00000213949 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
JAG2GeneProductENSG00000184916 (Ensembl)
MGPProteinENSG00000111341 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PAR1GeneProductENSG00000198121 (Ensembl)
PLATProteinENSG00000104368 (Ensembl)
PTHrPProteinENSG00000104368 (Ensembl)
SAT1GeneProductENSG00000130066 (Ensembl)
SOX6GeneProductENSG00000110693 (Ensembl)
VEGFGeneProductENSG00000112715 (Ensembl)

Annotated Interactions

No annotated interactions

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