Evolocumab Mechanism (Homo sapiens)

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1LDL-C degradedLDLR is recycled tocell surface to bindand extract more LDL-CPCSK9LDLRLDL-CholesterolEvolocumabPCSK9LDLRLDL-CholesterolPCSK9LDLRLDL-CholesterolLDLRLDL-CholesterolLDLRLDL-CholesterolLDL-C degraded alongwith LDLR and PCSK9


Evolocumab (Repatha) is an injectable monoclonal antibody that effectively reduces LDL-Cholesterol levels. A limited quantity of LDL-Cholesterol is extracted from circulative blood when PCSK9-bound LDLR is degraded upon internalization in Liver cells. Evolocumab competitively bind PCSK9 away from LDLR complexes, which allows LDLR to be recycled, returning to the surface and clearing additional molecules of LDL-Cholesterol.

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Ontology Terms



  1. Dorey, Emma; ''Cholesterol-budting PCSK9 drugs''; The Pharmaceutical Journal, 2015


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105111view13:06, 8 July 2019DeSlOntology Term : 'hepatocyte' added !
105110view13:05, 8 July 2019DeSlOntology Term : 'altered cholesterol biosynthetic pathway' added !
105109view13:05, 8 July 2019DeSlOntology Term : 'altered cholesterol transport pathway' added !
105108view12:55, 8 July 2019DeSlConverted DataNode type for Evolocumab from protein to metabolite.
88049view13:44, 25 July 2016SusanOntology Term : 'drug pathway' added !
81714view18:08, 25 August 2015MaintBotfixed typo in lit ref
81680view09:59, 23 August 2015EgonwAdded an xref for Evolocumab (which links to at least a CAS registry number).
81671view22:33, 22 August 2015AlexanderPicofixing multiline label
81670view22:32, 22 August 2015AlexanderPicofixing multiline label
81669view22:24, 22 August 2015AlexanderPicoQuick edit to datanode annotation or property
81668view22:22, 22 August 2015AlexanderPicoAdded lit ref
81667view22:13, 22 August 2015AlexanderPicoModified description
81666view22:05, 22 August 2015AlexanderPicoNew pathway

External references


NameTypeDatabase referenceComment
EvolocumabMetaboliteQ15623825 (Wikidata)
LDL-CholesterolMetaboliteCHEBI:47774 (ChEBI)
LDLRGeneProductENSG00000130164 (Ensembl)
PCSK9GeneProductENSG00000169174 (Ensembl)

Annotated Interactions

No annotated interactions

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