Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)

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18, 20, 21208, 20212121208, 2018, 2018, 202020nucleoplasmcytosolHIST1H2BC HIST2H2BE KLK2,KLK3O2H2AFB1 6-Dehydrotestosterone KLK3 Gene TEST HIST1H2BA androst-4-en-3,17-dione HIST1H2BJ HIST1H2BM ADPKLK2 Gene androst-4-en-3,17-dione H2AFB1 H2BFS HIST1H4 HIST2H2AA3 H2AFV HIST2H2AA3 HIST1H2AC 6-Dehydrotestosterone TEST KLK2 Gene H2AFZ HIST1H2BC HIST1H2AJ HIST1H2BA p-T774-PKN1 ATPHIST1H2BA DHTEST androst-4-en-3,17-dione HIST1H2BJ p-T12-HIST2H3A AR HIST1H2AD SUCCAandrost-4-en-3,17-dione KLK2 Gene HIST1H2BJ HIST1H2BH HIST2H2AC androst-4-en-3,17-dione H2AFX H2AFZ HIST1H2BK H2AFB1 KDM1Ap-T774-PKN1 H2BFS HIST1H2BH HIST1H2AD TEST H2AFZ p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4CHIST1H2BC HIST1H2AJ HIST1H2AB H2AFV HIST2H2AA3 HIST2H2AA3 KDM4Cp-T12, Me2K-10-HIST2H3A HIST1H2BN HIST1H2BC HIST1H2BD H2AFJ HIST1H2BA HIST1H2AC HIST1H2BA HIST1H2BN HIST1H2BL KLK2 Gene HIST1H4 AR HIST1H2BB DHTEST KLK2 Gene KLK2 Gene p-T12, Me3K-10-HIST2H3A HIST1H2AC p-T12, Me3K-10-HIST1H3A 6-Dehydrotestosterone CH2OHIST2H2BE HIST1H2AB HIST1H2AC HIST1H2AC H2AFJ HIST1H2BJ HIST1H2BN 6-Dehydrotestosterone H2BFS HIST1H4 KLK3 Gene HIST1H2BO HIST1H2BB HIST1H2BD HIST1H2AB HIST1H2BJ HIST1H2BD HIST1H2BH HIST1H2BO CO2HIST1H2AC 6-Dehydrotestosterone HIST1H2BJ p-T774-PKN1HIST2H2AA3 HIST1H2BM O2HIST1H2BO AR HIST1H2BB Me3K-10-H3F3A H2AFB1 p-T12,Me3K-10-H3F3A HIST1H2BN HIST2H2AC HIST1H2BO SUCCAKLK3 Gene p-T12, Me2K-10-HIST1H3A HIST1H2BK 6-Dehydrotestosterone AR H2AFX Me3K-10-H3F3A p-T774-PKN1 HIST2H2AC HIST1H2BM HIST3H2BB KLK2 Gene HIST1H2BM HIST1H2BH HIST1H2AB HIST1H2BL HIST1H2BL p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3p-T12, Me2K-10-H3F3A HIST2H2AA3 HIST3H2BB HIST1H2BD KLK2 HIST1H2AJ p-T12, Me3K-10-HIST2H3A H2AFJ HIST1H2AJ HIST1H2BO HIST1H4 HIST1H2BJ H2AFX HIST1H2BJ KLK2 Gene H2BFS KLK3 p-T12,Me3K-10-H3F3A androst-4-en-3,17-dione KLK3 Gene H2AFX 2OGH2AFX KLK3 Gene p-T12, Me3K-10-HIST1H3A H2BFS HIST2H2BE CO2HIST1H2AD HIST2H2AC H2AFV HIST1H2BK 6-Dehydrotestosterone DHTEST AR HIST1H2BM HIST1H2BL HIST1H2AJ H2AFB1 HIST2H2AA3 HIST1H2BD KLK2,3Gene:Nucleosomewith Me3K-10-H3p-T12-HIST1H3A HIST2H2AC HIST1H2BK AR AR p-T12,MeK-HIST2H3A KLK3 Gene HIST1H2BC androst-4-en-3,17-dione AR NCOA2HIST1H2AD p-T12, Me2K-10-H3F3A H2BFS HIST2H2AC KLK2,3 genesHIST1H4 HIST1H2BA H2AFZ HIST1H2AD HIST1H2BN HIST1H2BO HIST1H2BN HIST1H2BN SUCCAHIST2H2AC HIST1H2BC KLK2 Gene KDM4C HIST1H2BH H2AFX RHO GTPases activatePKNsTEST KLK3 Gene p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3p-T774-PKN1:AR:Androgenp-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3H2AFX HIST1H2BH H2AFV p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1AH2AFB1 Me3K-10-HIST2H3A TEST H2AFJ TEST H2AFB1 HIST1H2AJ p-T774-PKN1 HIST1H2AD HIST1H2BB HIST1H2BO H2AFZ HIST1H2BD HIST1H2BH HIST1H2AJ HIST1H2BD p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1AHIST1H2AC KDM1A androst-4-en-3,17-dione HIST1H2BB HIST1H2AB 2OGH2AFZ H2AFJ HIST3H2BB DHTEST p-T774-PKN1 HIST1H2AB p-T12,MeK-10-HIST1H3A p-T774-PKN1 HIST3H2BB HIST1H2AD HIST1H2BK DHTEST p-T12,MeK-H3F3A H2AFZ HIST1H2BL HIST1H2BK 6-Dehydrotestosterone HIST1H2BB HIST3H2BB HIST1H2AJ HIST1H2BC HIST1H2BK HIST2H2BE DHTEST HIST1H2AC p-T774-PKN1:AR:Androgen:NCOA26-Dehydrotestosterone HIST1H2BM p-T12, Me2K-10-HIST2H3A H2BFS HIST1H2BB H2AFV HIST1H2AB DHTEST CH2OTEST p-T774-PKN1:AR:AndrogenHIST2H2BE H2AFJ HIST2H2BE TEST H2AFZ HIST2H2BE HIST1H2BL HIST2H2AA3 6-Dehydrotestosterone HIST1H2BK H2AFX HIST1H2AD KDM1A HIST1H2BN AR:Androgenp-T12, Me2K-10-HIST1H3A H2AFB1 DHTEST TEST HIST1H2BL 2OGH2AFV DHTEST HIST1H2BM p-T774-PKN1 HIST1H4 HIST1H2BL HIST1H2BO CO2AR HIST2H2BE HIST1H2BA 6-Dehydrotestosterone Me3K-10-HIST2H3A HIST1H2BA DHTEST AR TEST HIST1H2BM p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3CH2OMe3K-10-HIST1H3A O2HIST1H4 HIST2H2AC HIST3H2BB NCOA2 KLK3 Gene AR Me3K-10-HIST1H3A HIST1H2BC androst-4-en-3,17-dione HIST3H2BB DHTEST p-T774-PKN1 HIST1H4 HIST1H2BB H2AFV p-T12-H3F3A HIST1H2AB HIST3H2BB H2AFV H2AFJ androst-4-en-3,17-dione H2BFS TEST HIST1H2BH androst-4-en-3,17-dione HIST1H2BD KLK3 Gene p-T774-PKN1 H2AFJ p-T774-PKN1 211-7, 9-17, 19202020212120202020


PKN1, activated by phosphorylation at threonine T774, binds activated AR (androgen receptor) and promotes transcription from AR-regulated promoters. On one hand, phosphorylated PKN1 promotes the formation of a functional complex of AR with the transcriptional coactivator NCOA2 (TIF2) (Metzger et al. 2003). On the other hand, binding of phosphorylated PKN1, in complex with the activated AR, to androgen-reponsive promoters of KLK2 and KLK3 (PSA) genes, leads to PKN1-mediated histone phosphorylation. PKN1-phosphorylated histones recruit histone demethylases KDM4C (JMJD2C) and KDM1A (LSD1), and the ensuing demethylation of histones associated with the promoter regions of KLK2 and KLK3 genes increases their transcription (Metzger et al. 2005, Metzger et al. 2008). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 5625886
Reactome version: 61
Reactome Author 
Reactome Author: Orlic-Milacic, Marija

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