Methionine Biosynthesis (Saccharomyces cerevisiae)

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1, 2L-aspartyl-4-P5-methyltetrahydropteroyltri-L-glutamateH+L-aspartateH2SL-aspartate-semialdehydetetrahydropteroyltri-L-glutamateO-acetyl-L-homoserineNADPCoenzyme AL-methionineNADPADPhomocysteinehomoserineMET17NADPHNADPHMET6HOM2acetyl-CoAacetateATPHOM6phosphateHOM3MET2


S. cerevisiae synthesizes the essential amino acid L-lysine via the L-alpha-aminoadipic acid pathway instead of the diaminopmelate pathway (CITS: [10714900]). Originally proposed to be characteristic of fungi, recent studies suggest prokaryotes also synthesize lysine via the alpha-aminoadipic acid pathway (CITS: [11029074]). Intermediates in this pathway are often incorporated into secondary metabolites. For example, it has been well- studied that alpha-aminoadipate is required for penicillin production (CITS: [10714900]). Regulation of the lysine biosynthetic pathway in S. cerevisiae is an interaction between general amino acid control (via Gcn4p) (CITS: [Hinnebusch]), feedback inhibition of homocitrate synthase activity by lysine (CITS: [10103047]), and induction of Lys14p by alpha-aminoadipate semialdehyde (CITS: [10975256]). SOURCE: SGD pathways,


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  1. Cherest H, Thomas D, Surdin-Kerjan Y; ''Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae.''; J Biol Chem, 2000 PubMed Europe PMC
  2. Mountain HA, Byström AS, Larsen JT, Korch C; ''Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae.''; Yeast, 1991 PubMed Europe PMC


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90089view07:33, 13 October 2016EgonwFixed a weird char in a reference.
90088view07:25, 13 October 2016EgonwReplace the CAS numbers of the salt with that of just the metabolite.
73853view00:55, 26 February 2014MaintBotupdated schema
67459view11:04, 26 June 2013DdiglesOntology Term : 'methionine biosynthetic pathway' added !
41885view04:52, 2 March 2011MaintBotRemoved redundant pathway information and comments
36657view22:44, 9 April 2010MaintBot
36612view22:30, 9 April 2010MaintBotDescription and bibliography added from SGD
34365view22:34, 9 December 2009MaintBotAutomatic update of empty xrefs
30205view10:18, 14 July 2009NeilswainstonReplaced label representing NADP with annotated metabolite.
21383view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Methionine Biosynthesis]] moved to [[Pathway:WP335]]: Moved to stable identifier
12780view08:02, 17 May 2008MaintBotautomated metabolite conversion
8825view14:10, 7 January 2008MaintBotAdded to category $category
8823view14:10, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
Coenzyme AMetabolite64885-97-8 (CAS)
HOM2GeneProductS000002565 (SGD)
HOM3GeneProductS000000854 (SGD)
HOM6GeneProductS000003900 (SGD)
L-methionineMetabolite63-68-3 (CAS)
MET17GeneProductS000004294 (SGD)
MET2GeneProductS000005221 (SGD)
MET6GeneProductS000000893 (SGD)
NADPMetaboliteCHEBI:25523 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
acetateMetabolite64-19-7 (CAS)
acetyl-CoAMetabolite72-89-9 (CAS)
homocysteineMetabolite6027-13-0 (CAS)
homoserineMetabolite672-15-1 (CAS)
phosphateMetabolite14265-44-2 (CAS)

Annotated Interactions

No annotated interactions
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