SUMOylation of DNA damage response and repair proteins (Homo sapiens)

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7, 9, 18, 23, 27...8, 19, 28, 31, 626, 15, 16, 492212, 15, 19, 6325, 46, 5015, 451025, 36, 46, 635847, 561, 5, 11, 34, 49...35, 66, 68552, 30, 42, 59, 631, 5, 16, 34, 49...384, 15, 58, 6311, 16, 44222611, 13, 17, 40, 5216, 6315, 21, 40, 633, 14, 49nucleoplasmSUMO1-K330-TDG STAG1 UBE2I-G97-SUMO1 SUMO1-K65,160,490-PML CBX8 SUMO2-C93-UBE2I WRNUBE2I:SUMO2,UBE2I:SUMO33SUMO1:WRNSUMO2,3-K330-TDGSUMO3:UBE2IUBE2I,HDAC7K356-WRN-G97-SUMO1 SUMO2-C93-UBE2I PMLSUMO1-K411,K412,K414-RAD52 SUMO2,3-CETN2UBE2IUBE2I-G92-SUMO3 UBE2I:SUMO2,UBE2I:SUMO3SUMO1-K203,K486-PARP1 UBE2I-G93-SUMO2 RPA1NUP93 SUMO1-K210-XRCC4 XRCC4-G97-SUMO1 SUMO1-C93-UBE2I RNF168UBE2ISUMO1:C93-UBE2IUBE2I-G93-SUMO2 UBE2I-G93-SUMO2 UBE2I:SUMO2,UBE2I:SUMO3SUMO1-K297-SP100 RANBP2 BMI1 SUMO1:C93-UBE2ISMC1A NUP88 UBE2I:SUMO2,UBE2I:SUMO3UBE2I-G97-SUMO1 K411-RAD52-G97-SUMO1 SMC6 SUMO3-C93-UBE2I UBE2I-G97-SUMO1 UBE2ISUMO3-C93-UBE2I SUMO1:MDC1HDAC7 4SUMO2,3-BLMPIAS1 PIAS4SMC5 PHC1 NUP160 NUP58-2 SUMO2,3-K449,K577-RPA1SUMO1-K1840-MDC1 K203-PARP1-G97-SUMO1 XPCSP100-G97-SUMO1 UBE2I-G92-SUMO3 UBE2I-G97-SUMO1 SUMO1-C93-UBE2I SUMO2-C93-UBE2I PIAS1 PRC1 complexSUMO2:UBE2IUBE2I:SUMO2,UBE2I:SUMO3UBE2I-G93-SUMO2 NUP37 SEH1L-1 PIAS1,2-1UBE2ISUMO3-K65,K160,K490-PMLSUMO1-RNF168 UBE2I-G97-SUMO1 HERC2STAG2-G97-SUMO1 UBE2I-G97-SUMO1 3SUMO1:PML2SUMO1:PARP1PCGF2 SUMO3-C93-UBE2I SUMO2,3-K203,K486-PARP1SUMO1:C93-UBE2ISUMO1:C93-UBE2IPIAS4 SUMO2-C93-UBE2I SUMO1:HERC2NUP62 UBE2ISUMO1:C93-UBE2IUBE2I-G92-SUMO3 SUMO1-C93-UBE2I PIAS2-1 SUMO1:SP100SUMO1:C93-UBE2IMDC1NUP54 PARP1SP100SEC13 UBE2INUP210 SUMO3-C93-UBE2I K490-PML-G97-SUMO1 SUMO1:C93-UBE2INUP205 CBX2 UBE2INUP58-1 SEH1L-2 SUMO1-C93-UBE2I SUMO1-C93-UBE2I NSMCE2 UBE2I-G93-SUMO2 UBE2I:SUMO2,UBE2I:SUMO3UBE2I-G93-SUMO2 NSMCE1 3SUMO1:RAD52SMC3 NUP155 SUMO1-K109-BRCA1 SUMO2,3-K1840-MDC1NSMCE3 SUMO2:UBE2IUBE2IPHC2 SUMO1-K-STAG2 SUMO1-C93-UBE2I NUP188 UBE2I-G92-SUMO3 SUMO1-C93-UBE2I CBX4 UBE2ISUMO1:C93-UBE2INUP50 UBE2I-G97-SUMO1 UBE2IEID3 K412-RAD52-G97-SUMO1 UBE2I-G97-SUMO1 RAD52NUP35 UBE2IPOM121C NUP43 UBE2I-G93-SUMO2 SUMO2-C93-UBE2I UBE2I-G92-SUMO3 UBE2I-G97-SUMO1 UBE2IK496-WRN-G97-SUMO1 K898-WRN-G97-SUMO1 STAG1 UBE2I-G97-SUMO1 SUMO1-C93-UBE2I SUMO2,3-BRCA1CETN2SCMH1-2 NSMCE4A SUMO1:C93-UBE2ISUMO3-C93-UBE2I NUP85 NUP153 UBE2IPIAS4K65-PML-G97-SUMO1 UBE2I RNF168-SUMO1 NUP98-4 RING1 RAD21 K160-PML-G97-SUMO1 SUMO2-K65,K160,K490-PMLBRCA1-G97-SUMO1 p14ARFUBE2IRNF2 AAAS UBE2IPOM121 SUMO1-C93-UBE2I BRCA1UBE2I-G97-SUMO1 SUMO1:C93-UBE2ISMC3 SUMO2-C93-UBE2I SUMO1-K-RAD21 HERC2-SUMO1 UBE2I-G97-SUMO1 SUMO1:RNF168SUMO3-C93-UBE2I SMC1A SUMOylated CohesinUBE2I-G92-SUMO3 SUMO1:BRCA1NUP98-5 K414-RAD52-G97-SUMO1 NUP98-3 UBE2IXRCC4SUMO1:TDGSUMO3-C93-UBE2I STAG2 RAD21-G97-SUMO1 SUMO2-C93-UBE2I SUMO2-C93-UBE2I NUPL2 SUMO1-C93-UBE2I SUMO1:C93-UBE2ITDG-G97-SUMO1 MDC1-G97-SUMO1 Cohesin ComplexSUMO1:XPCSUMO1:C93-UBE2IK486-PARP1-G97-SUMO1 XPC-G97-SUMO1 SUMO1-HERC2 SUMO1:XRCC4NUP214 Nuclear Pore Complex(NPC)SMC5-SMC6 ComplexSUMO1-C93-UBE2I SUMO1-K356,K496,K898-WRN BLMSUMO1-C93-UBE2I UBE2I-G93-SUMO2 NUP133 UBE2I:SUMO2,UBE2I:SUMO3SUMO2-C93-UBE2I UBE2I-G93-SUMO2 PIAS4UBE2I-G92-SUMO3 UBE2I-G92-SUMO3 PIAS1,4TDGSUMO2-K297-SP100NDC1 UBE2I-G97-SUMO1 TPR SUMO1:C93-UBE2ISUMO3-C93-UBE2I RAE1 SUMO1-K655-XPC PHC3 SUMO1-C93-UBE2I NUP107 25, 46, 502912, 15, 63261, 7029, 616329353, 15, 492929, 6129292935, 6822225529, 6115, 21, 40, 6329, 61715829, 613, 142915, 58, 6329, 6117, 40, 5232, 33, 41, 54, 60...19, 31, 622438226329, 6163431529, 612929, 6147, 5622201, 70


Description

Several factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferrari 2013, Flotho and Melchior 2013, Jackson and Durocher 2013). SUMOylation can alter enzymatic activity and protein stability or it can serve to recruit additional factors. For example, SUMOylation of Thymine DNA glycosylase (TDG) causes TDG to lose affinity for its product, an abasic site opposite a G residue, and thus increases turnover of the enzyme. During repair of double-strand breaks SUMO1, SUMO2, SUMO3, and the SUMO E3 ligases PIAS1 and PIAS4 accumulate at double-strand breaks where BRCA1, HERC1, RNF168, MDC1, and TP53BP1 are SUMOylated. SUMOylation of BRCA1 may increase its ubiquitin ligase activity while SUMOylation of MDC1 and HERC2 appears to play a role in recruitment of proteins such as RNF4 and RNF8 to double strand breaks. Similarly SUMOylation of RPA1 (RPA70) recruits RAD51 in the homologous recombination pathway. View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 3108214
Reactome-version 
Reactome version: 75
Reactome Author 
Reactome Author: May, Bruce

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
114993view16:52, 25 January 2021ReactomeTeamReactome version 75
113437view11:51, 2 November 2020ReactomeTeamReactome version 74
112640view16:02, 9 October 2020ReactomeTeamReactome version 73
101555view11:42, 1 November 2018ReactomeTeamreactome version 66
101091view21:25, 31 October 2018ReactomeTeamreactome version 65
100620view19:59, 31 October 2018ReactomeTeamreactome version 64
100171view16:44, 31 October 2018ReactomeTeamreactome version 63
99721view15:11, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99295view12:46, 31 October 2018ReactomeTeamreactome version 62
93901view13:43, 16 August 2017ReactomeTeamreactome version 61
93474view11:24, 9 August 2017ReactomeTeamreactome version 61
88418view11:53, 5 August 2016FehrhartOntology Term : 'sumoylation pathway' added !
86571view09:21, 11 July 2016ReactomeTeamreactome version 56
83291view10:40, 18 November 2015ReactomeTeamVersion54
81424view12:57, 21 August 2015ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
2SUMO1:PARP1ComplexR-HSA-4551687 (Reactome)
3SUMO1:PMLComplexR-HSA-3730883 (Reactome)
3SUMO1:RAD52ComplexR-HSA-4568880 (Reactome)
3SUMO1:WRNComplexR-HSA-4568903 (Reactome)
4SUMO2,3-BLMProteinP54132 (Uniprot-TrEMBL)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
BLMProteinP54132 (Uniprot-TrEMBL)
BMI1 ProteinP35226 (Uniprot-TrEMBL)
BRCA1-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
CBX2 ProteinQ14781 (Uniprot-TrEMBL)
CBX4 ProteinO00257 (Uniprot-TrEMBL)
CBX8 ProteinQ9HC52 (Uniprot-TrEMBL)
CETN2ProteinP41208 (Uniprot-TrEMBL)
Cohesin ComplexComplexR-HSA-1641505 (Reactome)
EID3 ProteinQ8N140 (Uniprot-TrEMBL)
HDAC7 ProteinQ8WUI4 (Uniprot-TrEMBL)
HERC2-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
HERC2ProteinO95714 (Uniprot-TrEMBL)
K160-PML-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K203-PARP1-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K356-WRN-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K411-RAD52-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K412-RAD52-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K414-RAD52-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K486-PARP1-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K490-PML-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K496-WRN-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K65-PML-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K898-WRN-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
MDC1-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
MDC1ProteinQ14676 (Uniprot-TrEMBL)
NDC1 ProteinQ9BTX1 (Uniprot-TrEMBL)
NSMCE1 ProteinQ8WV22 (Uniprot-TrEMBL)
NSMCE2 ProteinQ96MF7 (Uniprot-TrEMBL)
NSMCE3 ProteinQ96MG7 (Uniprot-TrEMBL)
NSMCE4A ProteinQ9NXX6 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188 ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205 ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP58-1 ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUP58-2 ProteinQ9BVL2-2 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)
NUP93 ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-3 ProteinP52948-3 (Uniprot-TrEMBL)
NUP98-4 ProteinP52948-4 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
NUPL2 ProteinO15504 (Uniprot-TrEMBL)
Nuclear Pore Complex (NPC)ComplexR-HSA-157689 (Reactome)
PARP1ProteinP09874 (Uniprot-TrEMBL)
PCGF2 ProteinP35227 (Uniprot-TrEMBL)
PHC1 ProteinP78364 (Uniprot-TrEMBL)
PHC2 ProteinQ8IXK0 (Uniprot-TrEMBL)
PHC3 ProteinQ8NDX5 (Uniprot-TrEMBL)
PIAS1 ProteinO75925 (Uniprot-TrEMBL)
PIAS1,2-1ComplexR-HSA-4090382 (Reactome)
PIAS1,4ComplexR-HSA-2997694 (Reactome)
PIAS2-1 ProteinO75928-1 (Uniprot-TrEMBL)
PIAS4 ProteinQ8N2W9 (Uniprot-TrEMBL)
PIAS4ProteinQ8N2W9 (Uniprot-TrEMBL)
PMLProteinP29590 (Uniprot-TrEMBL)
POM121 ProteinQ96HA1 (Uniprot-TrEMBL)
POM121C ProteinA8CG34 (Uniprot-TrEMBL)
PRC1 complexComplexR-HSA-389114 (Reactome)
RAD21 ProteinO60216 (Uniprot-TrEMBL)
RAD21-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
RAD52ProteinP43351 (Uniprot-TrEMBL)
RAE1 ProteinP78406 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
RING1 ProteinQ06587 (Uniprot-TrEMBL)
RNF168-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
RNF168ProteinQ8IYW5 (Uniprot-TrEMBL)
RNF2 ProteinQ99496 (Uniprot-TrEMBL)
RPA1ProteinP27694 (Uniprot-TrEMBL)
SCMH1-2 ProteinQ96GD3-2 (Uniprot-TrEMBL)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEH1L-1 ProteinQ96EE3-1 (Uniprot-TrEMBL)
SEH1L-2 ProteinQ96EE3-2 (Uniprot-TrEMBL)
SMC1A ProteinQ14683 (Uniprot-TrEMBL)
SMC3 ProteinQ9UQE7 (Uniprot-TrEMBL)
SMC5 ProteinQ8IY18 (Uniprot-TrEMBL)
SMC5-SMC6 ComplexComplexR-HSA-2993768 (Reactome)
SMC6 ProteinQ96SB8 (Uniprot-TrEMBL)
SP100-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
SP100ProteinP23497 (Uniprot-TrEMBL)
STAG1 ProteinQ8WVM7 (Uniprot-TrEMBL)
STAG2 ProteinQ8N3U4 (Uniprot-TrEMBL)
STAG2-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
SUMO1-C93-UBE2I ProteinP63279 (Uniprot-TrEMBL)
SUMO1-HERC2 ProteinO95714 (Uniprot-TrEMBL)
SUMO1-K-RAD21 ProteinO60216 (Uniprot-TrEMBL)
SUMO1-K-STAG2 ProteinQ8N3U4 (Uniprot-TrEMBL)
SUMO1-K109-BRCA1 ProteinP38398 (Uniprot-TrEMBL)
SUMO1-K1840-MDC1 ProteinQ14676 (Uniprot-TrEMBL)
SUMO1-K203,K486-PARP1 ProteinP09874 (Uniprot-TrEMBL)
SUMO1-K210-XRCC4 ProteinQ13426 (Uniprot-TrEMBL)
SUMO1-K297-SP100 ProteinP23497 (Uniprot-TrEMBL)
SUMO1-K330-TDG ProteinQ13569 (Uniprot-TrEMBL)
SUMO1-K356,K496,K898-WRN ProteinQ14191 (Uniprot-TrEMBL)
SUMO1-K411,K412,K414-RAD52 ProteinP43351 (Uniprot-TrEMBL)
SUMO1-K65,160,490-PML ProteinP29590 (Uniprot-TrEMBL)
SUMO1-K655-XPC ProteinQ01831 (Uniprot-TrEMBL)
SUMO1-RNF168 ProteinQ8IYW5 (Uniprot-TrEMBL)
SUMO1:BRCA1ComplexR-HSA-3730747 (Reactome)
SUMO1:C93-UBE2IComplexR-HSA-2993783 (Reactome)
SUMO1:HERC2ComplexR-HSA-4551752 (Reactome)
SUMO1:MDC1ComplexR-HSA-4570497 (Reactome)
SUMO1:RNF168ComplexR-HSA-4551657 (Reactome)
SUMO1:SP100ComplexR-HSA-3730791 (Reactome)
SUMO1:TDGComplexR-HSA-4551594 (Reactome)
SUMO1:XPCComplexR-HSA-4570501 (Reactome)
SUMO1:XRCC4ComplexR-HSA-4568891 (Reactome)
SUMO2,3-BRCA1ProteinP38398 (Uniprot-TrEMBL)
SUMO2,3-CETN2ProteinP41208 (Uniprot-TrEMBL)
SUMO2,3-K1840-MDC1ProteinQ14676 (Uniprot-TrEMBL)
SUMO2,3-K203,K486-PARP1ProteinP09874 (Uniprot-TrEMBL)
SUMO2,3-K330-TDGProteinQ13569 (Uniprot-TrEMBL)
SUMO2,3-K449,K577-RPA1ProteinP27694 (Uniprot-TrEMBL)
SUMO2-C93-UBE2I ProteinP63279 (Uniprot-TrEMBL)
SUMO2-K297-SP100ProteinP23497 (Uniprot-TrEMBL)
SUMO2-K65,K160,K490-PMLProteinP29590 (Uniprot-TrEMBL)
SUMO2:UBE2IComplexR-HSA-2993778 (Reactome)
SUMO3-C93-UBE2I ProteinP63279 (Uniprot-TrEMBL)
SUMO3-K65,K160,K490-PMLProteinP29590 (Uniprot-TrEMBL) Fu et al. (2005) report that only lysine-160 is conjugated to SUMO3. Gong and Yeh (2006) report that lysine-65, lysine-160, and lysine-490 are conjugated to SUMO3.
SUMO3:UBE2IComplexR-HSA-2993782 (Reactome)
SUMOylated CohesinComplexR-HSA-3108231 (Reactome)
TDG-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
TDGProteinQ13569 (Uniprot-TrEMBL)
TPR ProteinP12270 (Uniprot-TrEMBL)
UBE2I ProteinP63279 (Uniprot-TrEMBL)
UBE2I,HDAC7ComplexR-HSA-3000385 (Reactome)
UBE2I-G92-SUMO3 ProteinP55854 (Uniprot-TrEMBL)
UBE2I-G93-SUMO2 ProteinP61956 (Uniprot-TrEMBL)
UBE2I-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
UBE2I:SUMO2,UBE2I:SUMO3ComplexR-HSA-3899312 (Reactome)
UBE2IProteinP63279 (Uniprot-TrEMBL)
WRNProteinQ14191 (Uniprot-TrEMBL)
XPC-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
XPCProteinQ01831 (Uniprot-TrEMBL)
XRCC4-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
XRCC4ProteinQ13426 (Uniprot-TrEMBL)
p14ARFProteinQ8N726 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
2SUMO1:PARP1ArrowR-HSA-4551604 (Reactome)
3SUMO1:PMLArrowR-HSA-3000383 (Reactome)
3SUMO1:PMLArrowR-HSA-5228508 (Reactome)
3SUMO1:RAD52ArrowR-HSA-4568863 (Reactome)
3SUMO1:WRNArrowR-HSA-4568846 (Reactome)
4SUMO2,3-BLMArrowR-HSA-4568914 (Reactome)
BLMR-HSA-4568914 (Reactome)
BRCA1R-HSA-2997616 (Reactome)
BRCA1R-HSA-2997709 (Reactome)
CETN2R-HSA-4570463 (Reactome)
Cohesin ComplexR-HSA-3108212 (Reactome)
HERC2R-HSA-4551724 (Reactome)
MDC1R-HSA-4570553 (Reactome)
MDC1R-HSA-4570554 (Reactome)
Nuclear Pore Complex (NPC)mim-catalysisR-HSA-3000348 (Reactome)
Nuclear Pore Complex (NPC)mim-catalysisR-HSA-3000399 (Reactome)
Nuclear Pore Complex (NPC)mim-catalysisR-HSA-3000411 (Reactome)
Nuclear Pore Complex (NPC)mim-catalysisR-HSA-5228508 (Reactome)
PARP1R-HSA-4551604 (Reactome)
PARP1R-HSA-4551768 (Reactome)
PIAS1,2-1mim-catalysisR-HSA-4568848 (Reactome)
PIAS1,4mim-catalysisR-HSA-2997616 (Reactome)
PIAS1,4mim-catalysisR-HSA-2997709 (Reactome)
PIAS4mim-catalysisR-HSA-4551604 (Reactome)
PIAS4mim-catalysisR-HSA-4551661 (Reactome)
PIAS4mim-catalysisR-HSA-4551724 (Reactome)
PIAS4mim-catalysisR-HSA-4551768 (Reactome)
PMLR-HSA-3000383 (Reactome)
PMLR-HSA-3000411 (Reactome)
PMLR-HSA-3000433 (Reactome)
PMLR-HSA-5228508 (Reactome)
PRC1 complexmim-catalysisR-HSA-4570463 (Reactome)
R-HSA-2997616 (Reactome) PIAS1,4 SUMOylate BRCA1 with SUMO2,3 (Galanty et al. 2009, Morris et al. 2009, Vialter et al. 2011, Hendriks et al. 2014). More SUMO2,3-BRCA1 than SUMO1-BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009). SUMOylation with SUMO2,3 increases in response to oxidative stress (Vialter et al. 2011). SUMOylation of BRCA1 increases its ubiquitin ligase activity (Morris et al. 2009).
R-HSA-2997709 (Reactome) PIAS1,4 SUMOylate BRCA1 with SUMO1 at lysine-109 (Morris et al. 2009, Xu et al. 2009). SUMOylation occurs in response to genotoxic stress and double-strand breaks to which PIAS1 and PIAS4 are recruited (Galanty et al. 2009). SUMOylation enhances the ability of BRCA1 to bind and modulate ESR1 (ERalpha) transcriptional activity (Xu et al. 2009). More SUMO2:BRCA1 than SUMO1:BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009).
R-HSA-3000348 (Reactome) RANBP2 of the nuclear pore complex SUMOylates SP100 with SUMO2 at lysine-297 (Tatham et al. 2005, Hendriks et al. 2014). RANBP2 binds UBE2I (UBC9) to facilitate the transfer of SUMO2 from SUMO2:UBE2I to SP100 (Tatham et al. 2005).
R-HSA-3000383 (Reactome) UBE2I (UBC9) alone and in association with HDAC7 can SUMOylate PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999, Knipscheer et al. 2008). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). Knockdown of HDAC7 reduces the number of PML bodies (Gao et al. 2008).
R-HSA-3000399 (Reactome) RANBP2 SUMOylates SP100 with SUMO1 at lysine-297 (Pichler et al. 2002, Tatham et al. 2005). RANBP2 has a binding site for SUMO1 and a binding site for UBE2I (UBC9) which may recruit the SUMO1:UBE2I (SUMO1:UBC9) complex (Tatham et al. 2005). RANBP2 is located on the cytoplasmic filaments of the nuclear pore so that SUMOylation may occur during nuclear import of SP100 (Pichler et al. 2002)
R-HSA-3000411 (Reactome) RANBP2 of the nuclear pore complex SUMOylates PML with SUMO2 at lysine-65, lysine-160, and lysine-490 (Kamitani et al. 1998, Tatham et al. 2005). RANBP2 contains both a binding site for SUMO1 and a binding site for UBE2I (Tatham et al. 2005). The binding site for UBE2I participates in SUMOylation of PML with SUMO2. SUMO2 colocalizes significantly with PML bodies (Vertegaal et al. 2004).
R-HSA-3000433 (Reactome) PML is observed to be SUMOylated with SUMO3 at lysine-65, lysine-160, and lysine-490 (Kamitani et al. 1998). SUMO3 is almost identical with SUMO2 therefore the same E3 ligase (RANBP2) that SUMOylate PML with SUMO2 may also be active with SUMO3, but this has not been proven. PML colocalizes with SUMO3 in nuclear bodies and disruption of SUMO3 expression reduces the number of nuclear bodies (Fu et al. 2005).
R-HSA-3108212 (Reactome) The NSMCE2 (NSE2, MMS21) subunit of the SMC5/6 complex SUMOylates the RAD21 and STAG2 subunits of cohesin with SUMO1 (Potts et al. 2006 supplementary data, reviewed in Stephan et al 2011). RAD21 (SCC1) is SUMOylated at several lysines (Wu et al. 2012). SUMOylation of RAD21 occurs during DNA damage repair and is necessary for sister chromatid recombination (Wu et al. 2012).
R-HSA-4551604 (Reactome) PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO1 (Martin et al. 2009, Matafora et al. 2009, Messner et al. 2009, Zilio et al. 2013, Impens et al. 2014). SUMOylation abrogates acetylation of PARP1 by p300 (Messner et al. 2009). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). PARP1 is SUMOylated in response to heat shock and SUMOylation is required for full activation of the HSP70.1 promoter (Martin et al 2009).
R-HSA-4551616 (Reactome) RPA1 (RPA70) is SUMOylated at lysine-449 and lysine-577 with SUMO2,3 (Dou et al. 2010, Tammsalu et al. 2014). SUMOylation of RPA1 recruits RAD51 to sites of DNA damage to initiate repair through homologous recombination.
R-HSA-4551648 (Reactome) TDG is SUMOylated at lysine-330 with SUMO1 by UBE2I (Hardeland et al. 2002, Baba et al. 2005, Steinacher et al. 2005, Knipscheer et al. 2008, Smet-Nocca et al. 2011). Conjugation of SUMO1 to TDG induces dissociation of TDG from its product, an abasic site, and increases turnover of TDG with G:U substrate but abolishes activity with G:T substrate (Hardeland et al. 2002).
R-HSA-4551661 (Reactome) PIAS4 SUMOylates RNF168 at an unknown lysine residue (Danielsen et al. 2012). Both RNF168 and HERC2 are SUMOylated at double-strand breaks in DNA. SUMOylation of RNF168 is required for its retention at double-strand breaks.
R-HSA-4551724 (Reactome) PIAS4 SUMOylates HERC2 at an unknown lysine residue with SUMO1 (Danielsen et al. 2012). HERC2 binds SUMO1 and is then SUMOylated. SUMOylation of HERC2 promotes binding to RNF8 at double-strand breaks in DNA.
R-HSA-4551738 (Reactome) TDG is SUMOylated at lysine-330 with SUMO2,3 by UBE2I and perhaps another E3 ligase (Hardeland et al. 2002, Baba et al. 2006, Hendriks et al. 2014, Tammsalu et al. 2014). SUMOylation increases turnover of TDG with G:U substrate and abolishes activity with G:T substrate (Hardeland et al. 2002).
R-HSA-4551768 (Reactome) PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO2,3 in response to heat shock (Martin et al. 2009, Lamoliatte et al. 2013, Hendriks et al. 2014, Tammsalu et al. 2014). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). SUMOylation of PARP1 is required for full activation of the HSP70.1 promoter (Martin et al. 2009).
R-HSA-4568846 (Reactome) CDKN2A (p14-ARF) SUMOylates WRN at lysine-356, lysine-496, and lysine-898 with SUMO1 (Woods et al. 2004). SUMOylation of WRN causes it to be released from the nucleolus.
R-HSA-4568848 (Reactome) PIAS1,2-1 SUMOylate XRCC4 at lysine-210 with SUMO1 (Yurchenko et al. 2006). SUMOylation causes localization of XRCC4 to the nucleus. (An unSUMOylatable mutant of XRCC4 is localized to the cytosol.)
R-HSA-4568863 (Reactome) RAD52 is SUMOylated at lysine-411, lysine-412, and lysine-414 with SUMO1. SUMOylation is important for localization of RAD52 to the nucleus.
R-HSA-4568914 (Reactome) BLM is SUMOylated at lysine-317, lysine-331, lysine-344, and lysine-347 with SUMO2,3 (Eladad et al. 2005, Zhu et al. 2008, Ouyang et al. 2009, Ouyang et al. 2013, Hendriks et al. 2014). SUMOylation causes BLM to localize to PML bodies (Eladad et al. 2005). SUMOylated BLM recruits RAD51, which directly binds SUMO, and facilitates the substitution of RAD51 for RPA at stalled replication forks (Ouyang et al. 2009, 2013).
R-HSA-4570463 (Reactome) CBX4 (Pc2) in the PRC1 complex SUMOylates CETN2 at an unknown residue with SUMO2,3 (Klein and Nigg 2009). SUMOylation of CETN2 enhances its nuclear localization. Interaction with XPC is also required for nuclear localization of CETN2.
R-HSA-4570528 (Reactome) XPC is SUMOylated at lysine-655 with SUMO1 (Wang et al. 2005, 2007). SUMOylation occurs after UV irradiation and may target XPC for destruction (Wang et al. 2007).
R-HSA-4570553 (Reactome) MDC1 is SUMOylated at lysine-1840 with SUMO2,3 (Luo et al. 2012, Hendriks et al. 2014, Tammsalu et al. 2014). SUMOylation is required for degradation of MDC1. SUMOylation of MDC1 is required for recruitment of RNF4 (Yin et al. 2012), which is believed to ubiquitinylate MDC1, resulting in degradation of MDC1.
R-HSA-4570554 (Reactome) MDC1 is SUMOylated at lysine-1840 with SUMO1. SUMOyation of MDC1 is required for its degradation, which is thought to be directed by ubiquitinylation by RNF4 (Luo et al. 2012).
R-HSA-5228508 (Reactome) RANBP2 of the nuclear pore complex SUMOylates PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). RANBP2 contains both a binding site for SUMO1 and a binding site for UBE2I (Tatham et al. 2005). The binding site for SUMO1 may play a role in SUMOylation of PML with SUMO1. Knockdown of RANBP2 reduces the number of PML bodies (Saitoh et al. 2006).
RAD52R-HSA-4568863 (Reactome)
RNF168R-HSA-4551661 (Reactome)
RPA1R-HSA-4551616 (Reactome)
SMC5-SMC6 Complexmim-catalysisR-HSA-3108212 (Reactome)
SP100R-HSA-3000348 (Reactome)
SP100R-HSA-3000399 (Reactome)
SUMO1:BRCA1ArrowR-HSA-2997709 (Reactome)
SUMO1:C93-UBE2IR-HSA-2997709 (Reactome)
SUMO1:C93-UBE2IR-HSA-3000383 (Reactome)
SUMO1:C93-UBE2IR-HSA-3000399 (Reactome)
SUMO1:C93-UBE2IR-HSA-3108212 (Reactome)
SUMO1:C93-UBE2IR-HSA-4551604 (Reactome)
SUMO1:C93-UBE2IR-HSA-4551648 (Reactome)
SUMO1:C93-UBE2IR-HSA-4551661 (Reactome)
SUMO1:C93-UBE2IR-HSA-4551724 (Reactome)
SUMO1:C93-UBE2IR-HSA-4568846 (Reactome)
SUMO1:C93-UBE2IR-HSA-4568848 (Reactome)
SUMO1:C93-UBE2IR-HSA-4568863 (Reactome)
SUMO1:C93-UBE2IR-HSA-4570528 (Reactome)
SUMO1:C93-UBE2IR-HSA-4570554 (Reactome)
SUMO1:C93-UBE2IR-HSA-5228508 (Reactome)
SUMO1:C93-UBE2Imim-catalysisR-HSA-4551648 (Reactome)
SUMO1:C93-UBE2Imim-catalysisR-HSA-4568863 (Reactome)
SUMO1:C93-UBE2Imim-catalysisR-HSA-4570528 (Reactome)
SUMO1:C93-UBE2Imim-catalysisR-HSA-4570554 (Reactome)
SUMO1:HERC2ArrowR-HSA-4551724 (Reactome)
SUMO1:MDC1ArrowR-HSA-4570554 (Reactome)
SUMO1:RNF168ArrowR-HSA-4551661 (Reactome)
SUMO1:SP100ArrowR-HSA-3000399 (Reactome)
SUMO1:TDGArrowR-HSA-4551648 (Reactome)
SUMO1:XPCArrowR-HSA-4570528 (Reactome)
SUMO1:XRCC4ArrowR-HSA-4568848 (Reactome)
SUMO2,3-BRCA1ArrowR-HSA-2997616 (Reactome)
SUMO2,3-CETN2ArrowR-HSA-4570463 (Reactome)
SUMO2,3-K1840-MDC1ArrowR-HSA-4570553 (Reactome)
SUMO2,3-K203,K486-PARP1ArrowR-HSA-4551768 (Reactome)
SUMO2,3-K330-TDGArrowR-HSA-4551738 (Reactome)
SUMO2,3-K449,K577-RPA1ArrowR-HSA-4551616 (Reactome)
SUMO2-K297-SP100ArrowR-HSA-3000348 (Reactome)
SUMO2-K65,K160,K490-PMLArrowR-HSA-3000411 (Reactome)
SUMO2:UBE2IR-HSA-3000348 (Reactome)
SUMO2:UBE2IR-HSA-3000411 (Reactome)
SUMO3-K65,K160,K490-PMLArrowR-HSA-3000433 (Reactome)
SUMO3:UBE2IR-HSA-3000433 (Reactome)
SUMO3:UBE2Imim-catalysisR-HSA-3000433 (Reactome)
SUMOylated CohesinArrowR-HSA-3108212 (Reactome)
TDGR-HSA-4551648 (Reactome)
TDGR-HSA-4551738 (Reactome)
UBE2I,HDAC7mim-catalysisR-HSA-3000383 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3R-HSA-2997616 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3R-HSA-4551616 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3R-HSA-4551738 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3R-HSA-4551768 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3R-HSA-4568914 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3R-HSA-4570463 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3R-HSA-4570553 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3mim-catalysisR-HSA-4551616 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3mim-catalysisR-HSA-4551738 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3mim-catalysisR-HSA-4568914 (Reactome)
UBE2I:SUMO2,UBE2I:SUMO3mim-catalysisR-HSA-4570553 (Reactome)
UBE2IArrowR-HSA-2997616 (Reactome)
UBE2IArrowR-HSA-2997709 (Reactome)
UBE2IArrowR-HSA-3000348 (Reactome)
UBE2IArrowR-HSA-3000383 (Reactome)
UBE2IArrowR-HSA-3000399 (Reactome)
UBE2IArrowR-HSA-3000411 (Reactome)
UBE2IArrowR-HSA-3000433 (Reactome)
UBE2IArrowR-HSA-3108212 (Reactome)
UBE2IArrowR-HSA-4551604 (Reactome)
UBE2IArrowR-HSA-4551616 (Reactome)
UBE2IArrowR-HSA-4551648 (Reactome)
UBE2IArrowR-HSA-4551661 (Reactome)
UBE2IArrowR-HSA-4551724 (Reactome)
UBE2IArrowR-HSA-4551738 (Reactome)
UBE2IArrowR-HSA-4551768 (Reactome)
UBE2IArrowR-HSA-4568846 (Reactome)
UBE2IArrowR-HSA-4568848 (Reactome)
UBE2IArrowR-HSA-4568863 (Reactome)
UBE2IArrowR-HSA-4568914 (Reactome)
UBE2IArrowR-HSA-4570463 (Reactome)
UBE2IArrowR-HSA-4570528 (Reactome)
UBE2IArrowR-HSA-4570553 (Reactome)
UBE2IArrowR-HSA-4570554 (Reactome)
UBE2IArrowR-HSA-5228508 (Reactome)
WRNR-HSA-4568846 (Reactome)
XPCR-HSA-4570528 (Reactome)
XRCC4R-HSA-4568848 (Reactome)
p14ARFmim-catalysisR-HSA-4568846 (Reactome)
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