Threonine Biosynthesis (Saccharomyces cerevisiae)

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1, 2NADPO-phospho-L-homoserineL-Aspartate-semialdehydeH+L-AspartateL-Aspartyl-4-PH2ONADPhomoserineTHR1THR4NADPHL-threoninephosphateADPATPHOM2HOM3HOM6phosphateADPATPNADPH


Threonine biosynthesis as shown here covers the process of converting L-Aspartate into threonine. This pathway is regulated at multiple points by its end product, both via enzyme inhibition and attenuation. There is a three-step pathway that converts L-aspartate into homoserine. Two of the three enzymes that catalyze the first step in this pathway are bifunctional, also serving to catalyze the later step in the pathway. Homoserine feeds into biosynthetic pathways for both threonine and methionine. Fittingly, this pathway is regulated by the outputs of both of those pathways. SOURCE: SGD pathways,


GenMAPP remarks 
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Ontology Terms



  1. Schultes NP, Ellington AD, Cherry JM, Szostak JW; ''Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases.''; Gene, 1990 PubMed Europe PMC
  2. Ramos C, Calderón IL; ''Biochemical evidence that the Saccharomyces cerevisiae THR4 gene encodes threonine synthetase.''; FEBS Lett, 1994 PubMed Europe PMC


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107019view13:47, 17 September 2019MaintBotHMDB identifier normalization
103636view20:46, 22 March 2019AlexanderPicoModified description
102461view05:47, 24 December 2018EgonwFixed a encoding issue.
102460view05:45, 24 December 2018EgonwReplaced secondary ChEBI IDs with primary IDs.
102445view13:47, 23 December 2018DeSlAnnotated metabolites which where previously text labels.
102444view13:42, 23 December 2018DeSlLayout
102443view13:41, 23 December 2018DeSlConnected side metabolites properly
102442view13:39, 23 December 2018DeSlConnected enzymes with MIMcatalysis
102441view13:37, 23 December 2018DeSlChanged main interactions from arrow to MIMconversion; connected lines to main metabolites
102440view13:36, 23 December 2018DeSlChanged labels to metabolite nodes
89663view05:45, 24 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
70271view21:50, 15 July 2013MaintBotupdated to 2013 schema
69854view17:12, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67699view11:51, 26 June 2013DdiglesOntology Term : 'threonine biosynthetic pathway' added !
41857view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
36659view22:50, 9 April 2010MaintBot
36619view22:32, 9 April 2010MaintBotDescription and bibliography added from SGD
21375view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Threonine Biosynthesis]] moved to [[Pathway:WP331]]: Moved to stable identifier
12869view08:06, 17 May 2008MaintBotautomated metabolite conversion
8957view14:13, 7 January 2008MaintBotAdded to category $category
8955view14:13, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
H+MetaboliteCHEBI:15378 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HOM2ProteinS000002565 (SGD)
HOM3ProteinS000000854 (SGD)
HOM6ProteinS000003900 (SGD)
L-Aspartate-semialdehydeMetaboliteHMDB0012249 (HMDB)
L-AspartateMetaboliteCHEBI:17053 (ChEBI)
L-Aspartyl-4-PMetaboliteCHEBI:15836 (ChEBI)
L-threonineMetabolite72-19-5 (CAS)
NADPHMetabolite53-57-6 (CAS)
NADPMetaboliteHMDB0000217 (HMDB)
O-phospho-L-homoserineMetaboliteCHEBI:15961 (ChEBI)
THR1ProteinS000001067 (SGD)
THR4ProteinS000000649 (SGD)
homoserineMetabolite672-15-1 (CAS)
phosphateMetabolite14265-44-2 (CAS)

Annotated Interactions

No annotated interactions
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