RAC1/PAK1/p38/MMP2 Pathway (Homo sapiens)

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1NucleusERK1ANG2MSH2ANG4PIK3/p85ABIN-2PXNPI3K/p110IKBNFKB1MAPK13ProteasomedegradationEIF4EBP1ERK1TIE1TEKVaculogenesisIKK1MYCERBB2NOS1MAPK14PIP3MAPK11ANG1RELAMAPK12HRASRS1YAP1KRASRAC1EGFRIKBKGRasGAPSTAT3MAPK1AKTFKHRFN1CASP7PAK1Regulation of Actin CytoskeletonCASP9ERK2TP53Pck(s)SOS1IKK2GRB14Cell migration,survival and cell-cell interactionSTAT5ASAPKRAD51MAPK8MAPK14DOKRBADBAXSHP2JNKABIN-1SurvivinSRCCTNNB1ERK2PIP2IntegrinMapkANG3GRB7STMN1NRASNCK1PIK3RABIN-3PPPGRB2CRKPPAK1STAT5BNFKB1IKBPFAKNOS2AngiogenesisMMP2


Description

Interplay of RAC1, p38 MAPK, PAK1 and MMP2 in cell signaling pathways downstream of TEK receptor activity related to tumor growth, angiogenesis, and cell proliferation. These processes are reduced in RAC1 inactivated models of ovarian cancer. Gonzalez-Villasana, et al. Clin Cancer Res, 2015.

Quality Tags

Ontology Terms

 

Bibliography

  1. Gonzalez-Villasana V, Fuentes-Mattei E, Ivan C, Dalton HJ, Rodriguez-Aguayo C, Fernandez-de Thomas RJ, Aslan B, Del C Monroig P, Velazquez-Torres G, Previs RA, Pradeep S, Kahraman N, Wang H, Kanlikilicer P, Ozpolat B, Calin G, Sood AK, Lopez-Berestein G; ''Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer.''; Clin Cancer Res, 2015 PubMed

History

View all...
CompareRevisionActionTimeUserComment
96971view01:57, 24 April 2018AlexanderPicoadded MMP2 and bolded main axis
96970view01:53, 24 April 2018AlexanderPicoOntology Term : 'ovarian cancer' added !
96969view01:53, 24 April 2018AlexanderPicoModified title
96968view01:52, 24 April 2018AlexanderPicoModified description
94281view18:48, 30 August 2017KhanspersOntology Term : 'signaling pathway' added !
94280view18:48, 30 August 2017KhanspersModified description
94279view18:47, 30 August 2017Khanspersminor layout change
87628view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
83781view15:34, 4 December 2015SusanChanged ID and name of NEMO
81655view21:21, 21 August 2015Khanspers
81652view19:12, 21 August 2015MaintBotModified description
81307view23:49, 17 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABIN-1GeneProductENSG00000145901 (Ensembl)
ABIN-2GeneProductENSG00000168884 (Ensembl)
ABIN-3GeneProductENSG00000050730 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ANG1GeneProductENSG00000154188 (Ensembl)
ANG2GeneProductENSG00000091879 (Ensembl)
ANG3GeneProductENSG00000116194 (Ensembl)
ANG4GeneProductENSG00000101280 (Ensembl)
AngiogenesisPathwayWP1539 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CRKGeneProductENSG00000167193 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Cell migration,

survival and

cell-cell interaction
Pathway
DOKRGeneProductENSG00000147443 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4EBP1GeneProductENSG00000187840 (Ensembl)
ERBB2GeneProductENSG00000141736 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FKHRGeneProductENSG00000150907 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
GRB14GeneProductENSG00000115290 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GRB7GeneProductENSG00000141738 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IKBGeneProductENSG00000100906 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IKK1GeneProductENSG00000213341 (Ensembl)
IKK2GeneProductENSG00000104365 (Ensembl)
IntegrinGeneProductENSG00000150093 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MapkGeneProduct
NCK1GeneProductENSG00000158092 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS1GeneProductENSG00000089250 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PI3K/p110GeneProductENSG00000121879 (Ensembl)
PIK3/p85GeneProductENSG00000145675 (Ensembl)
PIK3RGeneProductENSG00000145675 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PIP3MetaboliteHMDB04249 (HMDB)
PXNGeneProductENSG00000089159 (Ensembl)
Pck(s)GeneProduct
Proteasome degradationPathwayWP183 (WikiPathways)
RAC1GeneProductENSG00000136238 (Ensembl)
RAD51GeneProductENSG00000051180 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RS1GeneProductENSG00000102104 (Ensembl)
RasGAPGeneProductENSG00000145715 (Ensembl)
Regulation of Actin CytoskeletonPathwayWP51 (WikiPathways)
SAPKGeneProduct5601 (Entrez Gene)
SHP2GeneProductENSG00000179295 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
STMN1GeneProductENSG00000117632 (Ensembl)
SurvivinGeneProductENSG00000089685 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl)
TIE1GeneProductENSG00000066056 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
VaculogenesisPathway
YAP1GeneProductENSG00000137693 (Ensembl)

Annotated Interactions

No annotated interactions

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