eIF5A regulation in response to inhibition of the nuclear export system (Homo sapiens)

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1SINE: Selective inhibitors of nuclear exportSINENucleusApoptosisEIF5AEXP4IGF2BP1EIF5AEIF5AEXP4EIF5ACytoplasmIGF2BP1CRM1EIF5AIGF2BP1CRM1


Model of eIF5A regulation in response to inhibition of the nuclear export system. Under normal conditions, IGF2BP1 is exported by XPO1 and binds to eIF5A in cytoplasm. The binding with IGF2BP1 prevents eIF5A from accumulating in mitochondria. SINE (Selective Inhibitors of Nuclear Export) inhibits the nuclear export of IGF2BP1, resulting in decreased cytoplasmic IGF2BP1. Unbound eIF5A accumulates in mitochondria and induces apoptosis.

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  1. Miyake T, Pradeep S, Wu SY, Rupaimoole R, Zand B, Wen Y, Gharpure KM, Nagaraja AS, Hu W, Cho MS, Dalton HJ, Previs RA, Taylor ML, Hisamatsu T, Kang Y, Liu T, Shacham S, McCauley D, Hawke DH, Wiktorowicz JE, Coleman RL, Sood AK; ''XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.''; Clin Cancer Res, 2015 PubMed


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87966view13:14, 25 July 2016SusanOntology Term : 'nuclear protein transport pathway' added !
87384view11:05, 22 July 2016MaintBotadded missing graphids
81679view23:42, 22 August 2015AlexanderPicoAdded pathway node for Apoptosis
81297view00:10, 15 August 2015MaintBotModified description
81296view00:04, 15 August 2015KhanspersNew pathway

External references


NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
CRM1GeneProductENSG00000082898 (Ensembl)
EIF5AGeneProductENSG00000132507 (Ensembl)
EXP4GeneProductENSG00000132953 (Ensembl)
IGF2BP1GeneProductENSG00000159217 (Ensembl)

Annotated Interactions

No annotated interactions

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