let-7 inhibition of ES cell reprogramming (Homo sapiens)

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1Differentiationlet-7 miRNAsc-MYCEGR1LIN-41MIRLET7A1SOX2KLF4OCT4PluripotencyMIRLET7A2MIRLET7A3MIRLET7CMIRLET7DMIRLET7EMIRLET7F1MIRLET7F2MIRLET7GMIRLET7I


Description

Four transcription factors (OCT4, KLF4, SOX2, and c-MYC) reprogram adult cells into stem cells. MicroRNA let-7 is a barrier to reprogramming that inhibits LIN-41, a strong reprogramming factor that is expressed in pluripotent embryonic stem cells. LIN-41 inhibits the transcription factor EGR1, which promotes cell differentiation and is another barrier to reprogramming. (Description from Worringer et al)

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Ontology Terms

 

Bibliography

  1. Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S; ''The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.''; Cell Stem Cell, 2014 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
88676view15:40, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
81230view19:12, 6 August 2015KhanspersModified description
81229view19:09, 6 August 2015Khansperslayout change
81228view19:08, 6 August 2015KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
EGR1GeneProductENSG00000120738 (Ensembl)
KLF4GeneProductENSG00000136826 (Ensembl)
LIN-41GeneProductENSG00000206557 (Ensembl)
MIRLET7A1GeneProductENSG00000199165 (Ensembl)
MIRLET7A2GeneProductENSG00000198975 (Ensembl)
MIRLET7A3GeneProductENSG00000198986 (Ensembl)
MIRLET7CGeneProductENSG00000199030 (Ensembl)
MIRLET7DGeneProductENSG00000199133 (Ensembl)
MIRLET7EGeneProductENSG00000198972 (Ensembl)
MIRLET7F1GeneProductENSG00000199072 (Ensembl)
MIRLET7F2GeneProductENSG00000208012 (Ensembl)
MIRLET7GGeneProductENSG00000199150 (Ensembl)
MIRLET7IGeneProductENSG00000199179 (Ensembl)
OCT4GeneProduct5460 (Entrez Gene)
SOX2GeneProductENSG00000181449 (Ensembl)
c-MYCGeneProductENSG00000136997 (Ensembl)

Annotated Interactions

No annotated interactions

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