Allantoin Degradation (Saccharomyces cerevisiae)

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1, 2(S)-ureidoglycolateureaglyoxylateDUR1,2allantoinallantoateDAL1CO2urea-1-carboxylateH2ODAL3ADPureaDAL2DUR1,2ATPphosphateH2OH2O2 NH3H2OCO2


The allantoin degradation pathway, which converts allantoin to ammonia and carbon dioxide, allows S. cerevisiae to use allantoin as a sole nitrogen source. Conversion of allantoin to ammonia is carried out by the DAL1, DAL2, and DAL3 gene products, which work sequentially to generate urea (CITS: [3915539]). Urea is then degraded to ammonia in a two-step process by the DUR1,2 protein, a multifunctional single enzyme originally thought to be encoded by two tightly-linked genes (hence the name DUR1,2; (CITS: [6105114]). The allantoin catabolic pathway genes are regulated by a general signal that responds to the availability of readily utilizable nitrogen sources, and also by pathway-specific induction by allantoin or the intermediate allophanate. These regulatory effects are mediated by cis-acting DNA elements and the trans-acting factors Gln3p, Gat1p, Dal80p, Dal81p, and Dal82p (CITS: [10488154])(CITS: [12062797])(CITS: [10702289])(CITS: [7899074]). SOURCE: SGD pathways,


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  1. Cooper TG, Lam C, Turoscy V; ''Structural analysis of the dur loci in S. cerevisiae: two domains of a single multifunctional gene.''; Genetics, 1980 PubMed Europe PMC Scholia
  2. Wong S, Wolfe KH; ''Birth of a metabolic gene cluster in yeast by adaptive gene relocation.''; Nat Genet, 2005 PubMed Europe PMC Scholia


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107257view14:35, 17 September 2019MaintBotChEBI identifier normalization
71348view18:02, 17 October 2013MaintBotAutomated update of data sources
70086view17:05, 12 July 2013KhanspersOntology Term : 'nitrogen metabolic pathway' added !
70068view08:27, 12 July 2013Mkutmonfixing unconnected lines
70067view08:22, 12 July 2013MkutmonPeriodical save, work in progress
70066view08:20, 12 July 2013Mkutmonfixing unconnected lines (work in progress)
69853view17:11, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69633view20:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
41869view04:52, 2 March 2011MaintBotRemoved redundant pathway information and comments
36633view22:35, 9 April 2010MaintBotDescription and bibliography added from SGD
35534view14:04, 12 February 2010MichielAdded ref
21369view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Allantoin Degradation]] moved to [[Pathway:WP328]]: Moved to stable identifier
12651view07:56, 17 May 2008MaintBotautomated metabolite conversion
8639view14:05, 7 January 2008MaintBotAdded to category $category
8637view14:05, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
(S)-ureidoglycolateMetaboliteCHEBI:57296 (ChEBI)
2 NH3Metabolite
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
DAL1GeneProductS000001466 (SGD)
DAL2GeneProductS000001468 (SGD)
DAL3GeneProductS000001471 (SGD)
DUR1,2GeneProductS000000412 (SGD)
allantoateMetaboliteCHEBI:17536 (ChEBI)
allantoinMetabolite97-59-6 (CAS)
phosphateMetabolite14265-44-2 (CAS)
urea-1-carboxylateMetaboliteCHEBI:15832 (ChEBI)
ureaMetabolite57-13-6 (CAS)

Annotated Interactions

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