Myometrial Relaxation and Contraction Pathways (Bos taurus)

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1-3Predicted Cxn43PKC inhibitor 1IP3Mg2+AP-1 complexTR GbgMyometrial ContractionSRPredicted OT-RCamk2Transcriptional RegulationPhospholipase-CRegulators of G-proteinsignaling (RGS)Phospholipase-CMAPKPLPACamk2Ca2+Pge2PKC inhibitor 1Transcription FactorsNa+Na+Calcium MobilizationDAGIGFBPCa2+TRPi + TRAdenylyl CyclasesAdenylyl CyclasesRGSEts complexGbgPathways of Myometrial RelaxationActivation via CRH and cAMPPKCNOPathways of Myometrial ContractionCell GrowthMyometrial RelaxationGbgPKCNucleusPip2Calcium InfluxIGFBPGSTO1RLN1ACTBATPCyclic AMPRGS17GNG13ADCY2GABPB1ATP2A2YWHAQGNB4RGS6OXTATP2A3RAMP1ADCY4RAMP3OXTRRGS11PRKAR2ASFNGNB5GNG12CNN2GPR182CALM2CTITPR3ADPRGS9GNB2PRKCARGS2MYLK2IGFBP4GNG5RGS4RXFP2GRK5PLCG2ATPCALM1PKIBRGS5RXFP1GNG8IL1BPRKCEYWHAGITPR2Cyclic AMPCALM3GNB3CAMK2BYWHAHRGS20CREB1GUCA2AYWHAENOS3ACTA2PRKCQACTG1GNG2PRKCDATF3GNG7PRKACBADCY5GNAQRGS19ADPPLCB3RGS10ACTC1ETS2GUCY2ECAMK2GIGFBP3CNN1ACTA1PRKD1IGFBP2Cyclic GMPPKIGSLC8A1NFKB1OXTRGNG11RYR2IGFBP6YWHAZMYL2GNB1GNG3ADCY7JUNGABPAPRKAR1ACALD1ADCY3GUCY1A1ARRB2NOS1MAFFPRKCBATF4PLCG1YWHABGRK6GRK4CRHR1CRCPPRKACAPRKCHGJA1RYR1ADCY1PRKAR2BGRK4GNG4GRK5IL6ATF2SP1RGS16RGS3PKIAIGFBP1PLCD1MYLK2RGS1RGS18FOSMYL4GNASGNGT1CRHGUCA2BARRB1PRKCGLPAR1ATF5PDE4DPRKCZRAMP2RGS7CXCR7ARRB2CACNB3ATF1CAMK2DITPR1PDE4BPRKAR1BRGS14RYR3ATF6BCAMK2AARRB1CREB3IGFBP5ADCY9ADMCORINDGKZADCY8GRK6ADCY6


Description

This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP289(80212) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. M����hats C, Tanguy G, Dallot E, Cabrol D, Ferr���� F, Leroy MJ; ''Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium?''; J Clin Endocrinol Metab, 2001 PubMed Europe PMC Scholia
  2. Aggelidou E, Hillhouse EW, Grammatopoulos DK; ''Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
  3. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR; ''Identifying genetic networks underlying myometrial transition to labor.''; Genome Biol, 2005 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
105928view11:46, 16 August 2019MaintBotHMDB identifier normalization
89455view13:09, 15 September 2016Mkutmonremoved invalid ontology term
89079view07:36, 22 August 2016EgonwOntology Term : 'signaling pathway' added !
80929view15:31, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTA1GeneProductENSBTAG00000046332 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58
ACTA2GeneProductENSBTAG00000014614 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:59
ACTBGeneProductENSBTAG00000026199 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60
ACTC1GeneProductENSBTAG00000005714 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:70
ACTG1GeneProductENSBTAG00000006189 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71
ADCY1GeneProductENSBTAG00000009520 (Ensembl)
  • CYA1 HUMAN
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:107
ADCY2GeneProductENSBTAG00000019210 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108
ADCY3GeneProductENSBTAG00000018705 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109
ADCY4GeneProductENSBTAG00000018419 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:196883
ADCY5GeneProductENSBTAG00000018777 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:111
ADCY6GeneProductENSBTAG00000005464 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112
ADCY7GeneProductENSBTAG00000006208 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:113
ADCY8GeneProductENSBTAG00000014600 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114
ADCY9GeneProductENSBTAG00000016629 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:115
ADMGeneProductENSBTAG00000021048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:133
ADPMetabolite58-64-0 (CAS)
ARRB1GeneProductENSBTAG00000020485 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:408
ARRB2GeneProductENSBTAG00000035587 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:409
ATF1GeneProductENSBTAG00000018131 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:466
ATF2GeneProductENSBTAG00000002295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1386
ATF3GeneProductENSBTAG00000008545 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:467
ATF4GeneProductENSBTAG00000017462 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:468
ATF5GeneProductENSBTAG00000003457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22809
ATF6BGeneProductENSBTAG00000008794 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1388
ATPMetabolite1927-31-7 (CAS)
ATP2A2GeneProductENSBTAG00000001398 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:488
ATP2A3GeneProductENSBTAG00000014806 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:489
CACNB3GeneProductENSBTAG00000021808 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:784
CALD1GeneProductENSBTAG00000013953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:800
CALM1GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000001575;En:ENSBTAG00000025644;
CALM2GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000001575;En:ENSBTAG00000025644;
CALM3GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000001575;En:ENSBTAG00000025644;
CAMK2AGeneProductENSBTAG00000020087 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:815
CAMK2BGeneProductENSBTAG00000012653 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:816
CAMK2DGeneProductENSBTAG00000014463 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:817
CAMK2GGeneProductENSBTAG00000012667 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:818
CNN1GeneProductENSBTAG00000011207 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1264
CNN2GeneProductENSBTAG00000020764 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1265
CORINGeneProductENSBTAG00000002199 (Ensembl)
  • MGI:97367
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10699
CRCPGeneProductENSBTAG00000037489 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27297
CREB1GeneProductENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
CREB3GeneProductENSBTAG00000011429 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10488
CRHGeneProductENSBTAG00000033128 (Ensembl)
  • CRF HUMAN PMID: 11854458
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1392
CRHR1GeneProductENSBTAG00000002749 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1394
CTGeneProductENSBTAG00000047380 (Ensembl)
  • CRF HUMAN PMID: 11854458
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:796
CXCR7GeneProductENSBTAG00000018424 (Ensembl)
  • PMID: 10614663
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57007
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
Cyclic GMPMetaboliteHMDB0001314 (HMDB)
DGKZGeneProductENSBTAG00000013636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8525
ETS2GeneProductENSBTAG00000009214 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2114
FOSGeneProductENSBTAG00000004322 (Ensembl)
  • PMID: 10218980 PMID: 7628395 [
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
GABPAGeneProductENSBTAG00000019043 (Ensembl)
  • Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.

    Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.

    PMID: 10218980
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2551
GABPB1GeneProductENSBTAG00000022801 (Ensembl)
  • Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.

    Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.

    PMID: 10218980
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2553
GJA1GeneProductENSBTAG00000001835 (Ensembl)
  • Endogenous nitric oxide suppresses rat myometrial connexin 43 gap junction protein expression during pregnancy.

    Sladek SM, Westerhausen-Larson A, Roberts JM.

    PMID: 10377025
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2697
GNAQGeneProductENSBTAG00000009789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
GNASGeneProductENSBTAG00000017475 (Ensembl)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
GNB1GeneProductENSBTAG00000000215 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782
GNB2GeneProductENSBTAG00000006495 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2783
GNB3GeneProductENSBTAG00000016043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2784
GNB4GeneProductENSBTAG00000002767 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:59345
GNB5GeneProductENSBTAG00000003762 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10681
GNG11GeneProductENSBTAG00000000820 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2791
GNG12GeneProductENSBTAG00000035697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55970
GNG13GeneProductENSBTAG00000033526 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51764
GNG2GeneProductENSBTAG00000003043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54331
GNG3GeneProductENSBTAG00000002508 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2785
GNG4GeneProductENSBTAG00000002908 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2786
GNG5GeneProductENSBTAG00000008122 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2787
GNG7GeneProductENSBTAG00000007644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2788
GNG8GeneProductENSBTAG00000017762 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:94235
GNGT1GeneProductENSBTAG00000002674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2792
GPR182GeneProductENSBTAG00000039157 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11318
GRK4GeneProductENSBTAG00000001505 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2868
GRK5GeneProductENSBTAG00000007981 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2869
GRK6GeneProductENSBTAG00000043994 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2870
GSTO1GeneProductENSBTAG00000003989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9446
GUCA2AGeneProductENSBTAG00000007195 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2980
GUCA2BGeneProductENSBTAG00000007194 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2981
GUCY1A1GeneProductENSBTAG00000014576 (Ensembl)
  • PMID: 11854458
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2982
GUCY2EGeneProductPMID: 11854458
IGFBP1GeneProductENSBTAG00000046768 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3484
IGFBP2GeneProductENSBTAG00000005596 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3485
IGFBP3GeneProductENSBTAG00000003994 (Ensembl)
  • Relaxin is a member of the Insulin Growth Factor family of proteins. IGFBP-3 binds IGFII preferentially. (SwissProt).
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3486
IGFBP4GeneProductENSBTAG00000008611 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3487
IGFBP5GeneProductENSBTAG00000007062 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3488
IGFBP6GeneProductENSBTAG00000021467 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3489
IL1BGeneProductENSBTAG00000001321 (Ensembl)
  • Structure, characterization, and expression of the rat oxytocin receptor gene.

    Rozen F, Russo C, Banville D, Zingg HH PMID: 7816817 quote: The presence of APREs in the OTR gene promoter suggests that the acute induction of OTR expression at the onset of parturition may be a phenomenon mechanistically similar to the fast induction of acute phase response genes. This notion is strengthened by the observation that the uterus is populated by macrophages and other specific lymphocytes (19,20). Specifically, at term, nearly half of the decidual cells are of bone marrow origin (20). IL-1beta released from macrophages stimulates the production and release of IL-6 by uterine stromal cells (21,22). Moreover, IL- is a central pathophysiological mediator of infection-induced premature delivery (23), and preterm delivery can be prevented by an IL-1 antagonist in mice (24). We speculate that under physiological as well as phathophysiological conditions, inflammatory cytokines are important inducers of labor and that this mechanism involves the cytokine-induced transcriptional activation of the OTR gene. :end quote

    19. Hunt, J.S. (1994) Biol. Reprod. 50, 461-466 20. Vince, G.S., et al. (1990) J. Immunol. Methods 132, 181-189. 21. Tabibzadeh, S. (1991) Endocr. Rev, 12, 272-290. 22. Dudley, D.Jl, et. Al. (1992) J. Clin. Endocrinol. Metab. 74, 884-889

    23. Romero, R., et. Al, Am. J. Obstet. Gynecol. 167, 863-872.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL6GeneProductENSBTAG00000014921 (Ensembl)
  • Structure, characterization, and expression of the rat oxytocin receptor gene.

    Rozen F, Russo C, Banville D, Zingg HH PMID: 7816817 quote: The presence of APREs in the OTR gene promoter suggests that the acute induction of OTR expression at the onset of parturition may be a phenomenon mechanistically similar to the fast induction of acute phase response genes. This notion is strengthened by the observation that the uterus is populated by macrophages and other specific lymphocytes (19,20). Specifically, at term, nearly half of the decidual cells are of bone marrow origin (20). IL-1beta released from macrophages stimulates the production and release of IL-6 by uterine stromal cells (21,22). Moreover, IL- is a central pathophysiological mediator of infection-induced premature delivery (23), and preterm delivery can be prevented by an IL-1 antagonist in mice (24). We speculate that under physiological as well as phathophysiological conditions, inflammatory cytokines are important inducers of labor and that this mechanism involves the cytokine-induced transcriptional activation of the OTR gene. :end quote

    19. Hunt, J.S. (1994) Biol. Reprod. 50, 461-466 20. Vince, G.S., et al. (1990) J. Immunol. Methods 132, 181-189. 21. Tabibzadeh, S. (1991) Endocr. Rev, 12, 272-290. 22. Dudley, D.Jl, et. Al. (1992) J. Clin. Endocrinol. Metab. 74, 884-889

    23. Romero, R., et. Al, Am. J. Obstet. Gynecol. 167, 863-872.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
ITPR1GeneProductENSBTAG00000020455 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708
ITPR2GeneProductENSBTAG00000002313 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3709
ITPR3GeneProductENSBTAG00000013245 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3710
JUNGeneProductENSBTAG00000004037 (Ensembl)
  • PMID: 10218980
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
LPAR1GeneProductENSBTAG00000009654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1902
MAFFGeneProductENSBTAG00000021435 (Ensembl)
  • OMIM: Inoue et al. (1994) demonstrated that the US-2 element in the promoter of the human oxytocin receptor gene (OXTR; 167055) binds specifically nuclear proteins from human myometrium at parturition. Using the US-2 element in a yeast 1-hybrid system to screen a human myometrium cDNA library, Kimura et al. (1999) isolated a full-length cDNA encoding the homolog of chicken MafF. Human MAFF encodes a deduced 164-amino acid protein with a predicted molecular mass of 17.8 kD. Like other small MAF proteins (e.g., MAFG, 602020), it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. Northern blot analysis showed a strong 2.6-kb signal in mRNA from term myometrium and from kidney, but not from nonpregnant myometrium. The MAFF protein is also preferentially expressed in term myometrium. The authors concluded that MAFF plays a role in OXTR gene upregulation at term.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23764
MYL2GeneProductENSBTAG00000018369 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4633
MYL4GeneProductENSBTAG00000021916 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4635
MYLK2GeneProductENSBTAG00000014930 (Ensembl)
  • KML2 MOUSE
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85366
NFKB1GeneProductENSBTAG00000020270 (Ensembl)
  • Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE. PMID: 10421804
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NOS1GeneProductENSBTAG00000002023 (Ensembl)
  • PMID: 11854458
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
NOS3GeneProductENSBTAG00000017680 (Ensembl)
  • PMID: 11854458
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4846
OXTGeneProductENSBTAG00000008026 (Ensembl)
  • MGI:97453
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5020
OXTRGeneProductENSBTAG00000019772 (Ensembl)
  • Sladek SM, Westerhausen-Larson A, Roberts JM. PMID: 10377025
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5021
PDE4BGeneProductENSBTAG00000008636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5142
PDE4DGeneProductENSBTAG00000000494 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144
PKIAGeneProductENSBTAG00000008150 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5569
PKIBGeneProductENSBTAG00000004394 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5570
PKIGGeneProductENSBTAG00000005275 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11142
PLCB3GeneProductENSBTAG00000012510 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5331
PLCD1GeneProductENSBTAG00000037726 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5333
PLCG1GeneProductENSBTAG00000017584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335
PLCG2GeneProductENSBTAG00000002103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5336
PRKACAGeneProductENSBTAG00000006642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566
PRKACBGeneProductENSBTAG00000011953 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5567
PRKAR1AGeneProductENSBTAG00000008621 (Ensembl)
  • KAP0 HUMAN
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5573
PRKAR1BGeneProductENSBTAG00000046142 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5575
PRKAR2AGeneProductENSBTAG00000014205 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5576
PRKAR2BGeneProductENSBTAG00000014958 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5577
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKCBGeneProductENSBTAG00000020921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PRKCDGeneProductENSBTAG00000008719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PRKCEGeneProductENSBTAG00000020614 (Ensembl)
  • This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
PRKCGGeneProductENSBTAG00000013550 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
PRKCHGeneProductENSBTAG00000003276 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583
PRKCQGeneProductENSBTAG00000010664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588
PRKCZGeneProductENSBTAG00000014119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
PRKD1GeneProductENSBTAG00000012789 (Ensembl)
  • KPCM HUMAN
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
RAMP1GeneProductENSBTAG00000011534 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10267
RAMP2GeneProductENSBTAG00000019903 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10266
RAMP3GeneProductENSBTAG00000020704 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10268
RGS10GeneProductENSBTAG00000002647 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6001
RGS11GeneProductENSBTAG00000016574 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8786
RGS14GeneProductENSBTAG00000008497 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10636
RGS16GeneProductENSBTAG00000004305 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6004
RGS17GeneProductENSBTAG00000009277 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26575
RGS18GeneProductENSBTAG00000013064 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64407
RGS19GeneProductENSBTAG00000021837 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10287
RGS1GeneProductENSBTAG00000021672 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5996
RGS20GeneProductENSBTAG00000003454 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8601
RGS2GeneProductENSBTAG00000034366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5997
RGS3GeneProductENSBTAG00000004499 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5998
RGS4GeneProductENSBTAG00000046277 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5999
RGS5GeneProductENSBTAG00000016341 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8490
RGS6GeneProductENSBTAG00000014189 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9628
RGS7GeneProductENSBTAG00000005410 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6000
RGS9GeneProductENSBTAG00000017751 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8787
RLN1GeneProduct
RXFP1GeneProductENSBTAG00000010306 (Ensembl)
  • PMID: 11809971
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:59350
RXFP2GeneProductENSBTAG00000015132 (Ensembl)
  • PMID: 11809971 LGR8 MOUSE
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:122042
RYR1GeneProductENSBTAG00000006999 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6261
RYR2GeneProductENSBTAG00000022886 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6262
RYR3GeneProductENSBTAG00000025642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6263
SFNGeneProductENSBTAG00000009223 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2810
SLC8A1GeneProductENSBTAG00000013861 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6546
SP1GeneProductENSBTAG00000003021 (Ensembl)
  • Promoter activity of the rat connexin 43 gene in NRK cells.

    Fernandez-Cobo M, Stewart D, Drujan D, De Maio A.

    Division of Pediatric Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

    PMID: 11255234
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667
YWHABGeneProductENSBTAG00000016846 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7529
YWHAEGeneProductENSBTAG00000005664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7531
YWHAGGeneProductENSBTAG00000004077 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7532
YWHAHGeneProductENSBTAG00000011631 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7533
YWHAQGeneProductENSBTAG00000002108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10971
YWHAZGeneProductENSBTAG00000000236 (Ensembl)
  • PMID: 9861170 PMID: 1317796
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7534

Annotated Interactions

No annotated interactions
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