Serotonin Receptor 4/6/7 and NR3C Signaling (Bos taurus)

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72, 8077, 1018250, 784, 91118, 21, 59, 62, 737, 13, 24, 35, 55...67, 741488, 9320, 5430, 60, 65, 70, 974456, 10536, 8711, 25, 32, 37, 47...8, 10, 12, 29, 43...8546, 5289, 9479, 986, 9, 16, 19, 23...53, 71, 76, 1002717, 39, 48, 51, 58...44, 4538, 963, 28, 31, 33, 42...14, 41, 49, 75, 90...6664, 81, 865, 1528322, 40922CREB1RAP1AMAP2K1MAPK3GNASATF1MAPK1MAPKAPK2RPS6KA5serotoninELK1RPS6KCyclic AMPBRAFMAP2K2HTR7ADCYHTR4GR-APKAEGR1ELK4SRFHTR6


This pathway is courtesy of Ariadne Genomics Pathway Studio.


This pathway was inferred from Homo sapiens pathway WP734(74438) with a 86.0% conversion rate.

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  37. Ebina T, Kawabe J, Katada T, Ohno S, Homcy CJ, Ishikawa Y; ''Conformation-dependent activation of type II adenylyl cyclase by protein kinase C.''; J Cell Biochem, 1997 PubMed Europe PMC
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  40. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A; ''MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.''; J Biol Chem, 1999 PubMed Europe PMC
  41. Chen KD, Chen LY, Huang HL, Lieu CH, Chang YN, Chang MD, Lai YK; ''Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells.''; J Biol Chem, 1998 PubMed Europe PMC
  42. Tanimura S, Nomura K, Ozaki K, Tsujimoto M, Kondo T, Kohno M; ''Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility.''; J Biol Chem, 2002 PubMed Europe PMC
  43. Morgan MA, Dolp O, Reuter CW; ''Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling.''; Blood, 2001 PubMed Europe PMC
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  58. Papin C, Eych�ne A, Brunet A, Pag�s G, Pouyss�gur J, Calothy G, Barnier JV; ''B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.''; Oncogene, 1995 PubMed Europe PMC
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  60. Zhou B, Zhang ZY; ''The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.''; J Biol Chem, 2002 PubMed Europe PMC
  61. Saji M, Levine MA, Zeiger MA; ''An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.''; Surgery, 1994 PubMed Europe PMC
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  65. Lum H, Roebuck KA; ''Oxidant stress and endothelial cell dysfunction.''; Am J Physiol Cell Physiol, 2001 PubMed Europe PMC
  66. Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M; ''Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins.''; Mol Pharmacol, 2002 PubMed Europe PMC
  67. Casper-Lindley C, Dahlbeck D, Clark ET, Staskawicz BJ; ''Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC
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  69. Yan Z, Yang DC, Jett M; ''Cholera toxin induces tumor necrosis factor alpha production in human monocytes.''; Mol Cell Biol Res Commun, 1999 PubMed Europe PMC
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  71. Waas WF, Dalby KN; ''Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2.''; J Biol Chem, 2002 PubMed Europe PMC
  72. Duan WR, Ito M, Park Y, Maizels ET, Hunzicker-Dunn M, Jameson JL; ''GnRH regulates early growth response protein 1 transcription through multiple promoter elements.''; Mol Endocrinol, 2002 PubMed Europe PMC
  73. Traub O, Monia BP, Dean NM, Berk BC; ''PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC
  74. Peters EP, Wilderspin AF, Wood SP, Zvelebil MJ, Sezer O, Danchin A; ''A pyruvate-stimulated adenylate cyclase has a sequence related to the fes/fps oncogenes and to eukaryotic cyclases.''; Mol Microbiol, 1991 PubMed Europe PMC
  75. Wesselborg S, Bauer MK, Vogt M, Schmitz ML, Schulze-Osthoff K; ''Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.''; J Biol Chem, 1997 PubMed Europe PMC
  76. Guha M, O'Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, Stern D, Mackman N; ''Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.''; Blood, 2001 PubMed Europe PMC
  77. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G; ''Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).''; EMBO J, 2003 PubMed Europe PMC
  78. Chibalin AV, Lopina OD, Petukhov SP, Vasilets LA; ''Phosphorylation of the Na,K-ATPase by Ca,phospholipid-dependent and cAMP-dependent protein kinases. Mapping of the region phosphorylated by Ca,phospholipid-dependent protein kinase.''; J Bioenerg Biomembr, 1993 PubMed Europe PMC
  79. Paine E, Palmantier R, Akiyama SK, Olden K, Roberts JD; ''Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway.''; J Biol Chem, 2000 PubMed Europe PMC
  80. Lee HJ, Mignacca RC, Sakamoto KM; ''Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.''; J Biol Chem, 1995 PubMed Europe PMC
  81. Ino H, Chiba T; ''Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo.''; J Neurosci, 2001 PubMed Europe PMC
  82. Rolli M, Kotlyarov A, Sakamoto KM, Gaestel M, Neininger A; ''Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner.''; J Biol Chem, 1999 PubMed Europe PMC
  83. Andrews MH, Kostaki A, Setiawan E, McCabe L, Owen D, Banjanin S, Matthews SG; ''Developmental regulation of the 5-HT7 serotonin receptor and transcription factor NGFI-A in the fetal guinea-pig limbic system: influence of GCs.''; J Physiol, 2004 PubMed Europe PMC
  84. Barry OP, Mullan B, Sheehan D, Kazanietz MG, Shanahan F, Collins JK, O'Sullivan GC; ''Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent.''; J Biol Chem, 2001 PubMed Europe PMC
  85. Bourdon DM, Camden JM, Landon LA, Levy FO, Turner JT; ''Identification of the adenylyl cyclase-activating 5-hydroxytryptamine receptor subtypes expressed in the rat submandibular gland.''; Br J Pharmacol, 2000 PubMed Europe PMC
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  87. Russell DL, Doyle KM, Gonzales-Robayna I, Pipaon C, Richards JS; ''Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1,and early growth response factor-1.''; Mol Endocrinol, 2003 PubMed Europe PMC
  88. Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD; ''Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.''; Mol Cell Biol, 2005 PubMed Europe PMC
  89. Hassler M, Richmond TJ; ''The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.''; EMBO J, 2001 PubMed Europe PMC
  90. Pomerance M, Abdullah HB, Kamerji S, Correze C, Blondeau JP; ''Thyroid-stimulating hormone and cyclic AMP activate p38 mitogen-activated protein kinase cascade. Involvement of protein kinase A, rac1, and reactive oxygen species.''; J Biol Chem, 2000 PubMed Europe PMC
  91. Chen JK, Heckert LL; ''Dmrt1 expression is regulated by follicle-stimulating hormone and phorbol esters in postnatal Sertoli cells.''; Endocrinology, 2001 PubMed Europe PMC
  92. Morrison PF, Morishige GM, Beagles KE, Heyes MP; ''Quinolinic acid is extruded from the brain by a probenecid-sensitive carrier system: a quantitative analysis.''; J Neurochem, 1999 PubMed Europe PMC
  93. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS; ''Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells.''; Endocrinology, 1998 PubMed Europe PMC
  94. Mo Y, Ho W, Johnston K, Marmorstein R; ''Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.''; J Mol Biol, 2001 PubMed Europe PMC
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  96. Ravanti L, Heino J, L�pez-Ot�n C, K�h�ri VM; ''Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.''; J Biol Chem, 1999 PubMed Europe PMC
  97. Chung KC, Sung JY, Ahn W, Rhim H, Oh TH, Lee MG, Ahn YS; ''Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells.''; J Biol Chem, 2001 PubMed Europe PMC
  98. Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M; ''Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.''; J Biol Chem, 1995 PubMed Europe PMC
  99. Sung JY, Shin SW, Ahn YS, Chung KC; ''Basic fibroblast growth factor-induced activation of novel CREB kinase during the differentiation of immortalized hippocampal cells.''; J Biol Chem, 2001 PubMed Europe PMC
  100. Vasilevskaya IA, O'Dwyer PJ; ''Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells.''; Cancer Res, 1999 PubMed Europe PMC
  101. Tokunou T, Ichiki T, Takeda K, Funakoshi Y, Iino N, Takeshita A; ''cAMP response element-binding protein mediates thrombin-induced proliferation of vascular smooth muscle cells.''; Arterioscler Thromb Vasc Biol, 2001 PubMed Europe PMC
  102. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyss�gur J; ''Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.''; EMBO J, 1999 PubMed Europe PMC
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  105. Rossant CJ, Pinnock RD, Hughes J, Hall MD, McNulty S; ''Corticotropin-releasing factor type 1 and type 2alpha receptors regulate phosphorylation of calcium/cyclic adenosine 3',5'-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase.''; Endocrinology, 1999 PubMed Europe PMC
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101988view06:34, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
101982view20:36, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
80922view15:31, 30 June 2015MkutmonNew pathway

External references


View all...
NameTypeDatabase referenceComment
ADCYGeneProductAdenylate cyclase
ATF1GeneProductENSBTAG00000018131 (Ensembl)
  • activating transcription factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:466
BRAFGeneProductENSBTAG00000021761 (Ensembl)
  • v-raf murine sarcoma viral oncogene homolog B1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CREB1GeneProductENSBTAG00000005474 (Ensembl)
  • cAMP response element-binding protein 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
Cyclic AMPMetabolite60-92-4 (CAS)
EGR1GeneProductENSBTAG00000010069 (Ensembl)
  • early growth response protein
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1958
ELK1GeneProductENSBTAG00000015817 (Ensembl)
  • ELK1, member of ETS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ELK4GeneProductENSBTAG00000004953 (Ensembl)
  • ETS domain-containing protein Elk-4 (SRF accessory protein 1)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
GNASGeneProductENSBTAG00000017475 (Ensembl)
  • GNAS (guanine nucleotide binding protein, alpha stimulating)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
GR-AGeneProductENSBTAG00000019472 (Ensembl)
  • nuclear receptor, subfamily 3, group C, member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2908
HTR4GeneProductENSBTAG00000010837 (Ensembl)
  • 5 hydroxytryptamine (serotonin) receptor 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3360
HTR6GeneProductENSBTAG00000007996 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3362
HTR7GeneProductENSBTAG00000008783 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 7
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3363
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • mitogen activated protein kinase kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)
  • mitogen activated protein kinase kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • mitogen activated protein kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK1
MAPK3GeneProductENSBTAG00000016156 (Ensembl)
  • mitogen activated protein kinase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl)
  • MAP kinase-activated protein kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261
PKAGeneProductcAMP-dependent protein kinase, protein kinase A
RAP1AGeneProductENSBTAG00000014710 (Ensembl)
  • RAS-related protein-1a
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RPS6KGeneProductribosomal protein S6 kinase
RPS6KA5GeneProductENSBTAG00000010906 (Ensembl)
  • ribosomal protein S6 kinase, polypeptide 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252
SRFGeneProductENSBTAG00000012777 (Ensembl)
  • serum response factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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