Integrated Breast Cancer Pathway (Bos taurus)

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632010181661126168124191716925162151324222151623BASC ComplexCell CycleMG1G2S7, 12, 14NAB1JUNApoptosisAQP73RPP38CDK2ATMPIAS1E-CADHERINTestosteroneProteinBADUSP15P13KCYP19A1DCAKDBleomycinQ8NBS1EstradiolMSH6ARATRDexamethasoneSELKCDC25BPlicamycinAmpicillinCDC25ATetradecanoylphorbol AcetateCancer DevelopmentDNABAK1JAK1PTENMRE11AHydrocortisoneTGFBR2JUNNF1EDARODC1MAP3K13MAXABL1AKT1BACH1SMARCA4PIK3R2C9JNK1BRCA1Cell Cycle arrestbta-mir-21RHEBTPRTRADDGDI1CDC42FADDTamoxifenHDAC1CCNB1IP1WEE1TFPIRASGEF1ANCOA3MitomycinCycloheximideSTK11TCF/LEFDHTKD1TP53AnastrozoleTSC1PMLExemstaneCell SurvivalKRASFAUMDM2CDK7C9JNK1CDK4CDK2B5MEC1SMAD7RAD54LRRASSIRT1STAT1TP53MAP3K7IP1CHUKARAFSMAD6UBE2FRALAFOSL1NCOA3ANXA1bta-mir-21TSC1Penicillin GMTORFILIP1ATMCTNB1 degradationBMPRIITGFBR1RRASERAL1EGFRBID2EP300RASGRP3SMAD2BRCA1MSH2TSC2FlutamideC9JNK1CREB1PIGRCERKBADGRNUSP38DonepezilProteasomeTranscriptionSMAD7Anti-ApoptosisHDAC1HydroxyureaLithium ChlorideRaloxifeneRAD50CERKPHBSMAD2PLK3CASP9Gene ExpressionNOXA1MYCRHOATF1MIR29B1USP21RAP1AGARNL1RAC1SMEK1NUP85SMAD4DAG1ZMIZ1E2F1BLMMAPK1SMEK2CSNK1DRRASBMPR-IALapatnibCASP8ESR1MMP1AURKAFOXO1RB1ALKBH1ATRCell proliferationGSK3ABARD1CorticosteroneBRAFBRCA2DihydrotestosteroneApoptosisIMPA1CDC25AGADD45APKIACASP3CERKB3KP27AHRCHEK1CERKBARD1MDM2LetrozoleSMEK1MYT1APOBEC3AP13HDAC1Proliferative genesCTNNB1C1H21ORF7XRCC3USP21RHOCASP3FOSL1CHUKAngiogenesisHMGCRPaclitaxelCHEK2ZMYND8NFKB1ATRSMAD1HIPK2CCND1JAKMIP1FADDE2F1Conjugated Estrogenscyc-DIRS1FulvestrantCell survival and ProliferationPLK1PLK3MYCBP2NocodazoleAKT1RAD51Methyl MethanesulfonateWEE1SMAD4FERBAXVEGFAITPKCBCL2FluoxymesteronePAK1SP1bta-mir-21USP16MYC1MIR29B2


Description

This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1984(80445) with a 91.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

CompareRevisionActionTimeUserComment
108100view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106468view08:08, 1 September 2019EgonwAdded CID for compound with the stereo correct, that was missing.
105916view11:45, 16 August 2019MaintBotHMDB identifier normalization
80901view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProductENSBTAG00000017976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000097007
AHRGeneProductENSBTAG00000007746 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106546
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P31749
ALKBH1ProteinENSBTAG00000008133 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13686
ANXA1GeneProductENSBTAG00000015978 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135046
APOBEC3AProteinENSBTAG00000037800 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9HC16
AQP73Protein
ARAFProteinENSBTAG00000005039 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10398
ARProteinENSBTAG00000022255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10275
ATF1ProteinENSBTAG00000018131 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P18846
ATMProteinENSBTAG00000003111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13315
ATRProteinENSBTAG00000011529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13535
AURKAGeneProductENSBTAG00000013009 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087586
AmpicillinMetabolite6249 (PubChem-compound)
AnastrozoleMetabolite2102 (Chemspider)
Angiogenesis
Anti-Apoptosis
Apoptosis
B3KP27Protein
B5MEC1Protein
BACH1ProteinENSBTAG00000004139 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O14867
BADProteinENSBTAG00000012511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92934
BAK1ProteinENSBTAG00000000428 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q16611
BARD1GeneProductENSBTAG00000033690 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:580
BAXGeneProductENSBTAG00000013340 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087088
BCL2ProteinENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10415
BID2ProteinENSBTAG00000013988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P55957
BLMProteinENSBTAG00000020301 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P54132
BMPR-IAGeneProductENSBTAG00000000231 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107779
BMPRIIProteinENSBTAG00000006420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13873
BRAFProteinENSBTAG00000021761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P15056
BRCA1ProteinENSBTAG00000022520 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P38398
BRCA2GeneProductENSBTAG00000000988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139618
BleomycinMetabolite456190 (PubChem-compound)
C1H21ORF7ProteinENSBTAG00000007444 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P57077
C9JNK1Protein
CASP3GeneProductENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164305
CASP8GeneProductENSBTAG00000015718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064012
CASP9GeneProductENSBTAG00000002472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132906
CCNB1IP1ProteinENSBTAG00000008466 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9NPC3
CCND1ProteinENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P24385
CDC25AProteinENSBTAG00000009586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P30304
CDC25BProteinENSBTAG00000008436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P30305
CDC42GeneProductENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831