TOR Signaling (Bos taurus)

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1-3, 54high AMP:ATPAmino acidsmTORC1mTORC2HypoxiaSurvivalAmino acid transporterAMPKPRKAB2EIF4EBP1RHEBPRKAB1DDIT4LPRKAG1ULK1RAC1RapamycinPRKCAMAPKAP1ULK2DDIT4PRKAG3CDC42PRKAA1RRAGBRRAGCActin OrganizationPRKAG2ULK3Cytoskeletal dynamicsMLST8Insulin signalingPRR5LRICTORMTORRRAGAInsulin signalingmRNA translationRPS6KB1TSC1FKBP1AAKT1TSC2PRR5AKT1S1PRKAA2RRAGDMLST8Ribosome biogenesisAutophagyMTORRPTOR


Description

TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1471(70031) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Corradetti MN, Guan KL; ''Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?''; Oncogene, 2006 PubMed Europe PMC Scholia
  2. Wullschleger S, Loewith R, Hall MN; ''TOR signaling in growth and metabolism.''; Cell, 2006 PubMed Europe PMC Scholia
  3. Inoki K, Guan KL; ''Complexity of the TOR signaling network.''; Trends Cell Biol, 2006 PubMed Europe PMC Scholia
  4. Sancak Y, Sabatini DM; ''Rag proteins regulate amino-acid-induced mTORC1 signalling.''; Biochem Soc Trans, 2009 PubMed Europe PMC Scholia
  5. Yang Q, Guan KL; ''Expanding mTOR signaling.''; Cell Res, 2007 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
111150view09:00, 20 July 2020L DupuisConverted interaction line to graphical lines in representation of membrane
97055view15:17, 26 April 2018Mick EikelhofFixed unconnected lines
80895view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142208
AKT1S1GeneProductENSBTAG00000005763 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204673
Actin OrganizationPathway
Amino acidsMetaboliteCHEBI:33709 (ChEBI)
AutophagyPathway
CDC42GeneProductENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831
Cytoskeletal dynamicsPathway
DDIT4GeneProductENSBTAG00000000163 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168209
DDIT4LGeneProductENSBTAG00000010610 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145358
EIF4EBP1GeneProductENSBTAG00000027654 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187840
FKBP1AGeneProductENSBTAG00000032651 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000088832
Insulin signalingPathwayWP481 (WikiPathways)
MAPKAP1GeneProductENSBTAG00000010271 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119487
MLST8GeneProductENSBTAG00000009928 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167965
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793
PRKAA1GeneProductENSBTAG00000000013 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132356
PRKAA2GeneProductENSBTAG00000018747 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162409
PRKAB1GeneProductENSBTAG00000005940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111725
PRKAB2GeneProductENSBTAG00000014387 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131791
PRKAG1GeneProductENSBTAG00000014426 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181929
PRKAG2GeneProductENSBTAG00000002917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106617
PRKAG3GeneProductENSBTAG00000013492 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115592
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
PRR5GeneProductENSBTAG00000039784 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186654
PRR5LGeneProductENSBTAG00000021029 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135362
RAC1GeneProductENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136238
RHEBGeneProductENSBTAG00000031861 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106615
RICTORGeneProductENSBTAG00000006697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164327
RPS6KB1GeneProductENSBTAG00000016851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108443
RPTORGeneProductENSBTAG00000002883 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141564
RRAGAGeneProductENSBTAG00000038064 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155876
RRAGBGeneProductENSBTAG00000012980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000083750
RRAGCGeneProductENSBTAG00000009368 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116954
RRAGDGeneProductENSBTAG00000018438 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000025039
RapamycinMetabolite5497196 (PubChem-compound)
Ribosome biogenesisPathway
TSC1GeneProductENSBTAG00000005190 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165699
TSC2GeneProductENSBTAG00000020617 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103197
ULK1GeneProductENSBTAG00000012987 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177169
ULK2GeneProductENSBTAG00000030977 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000083290
ULK3GeneProductENSBTAG00000005838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140474
mRNA translationPathwayWP107 (WikiPathways)

Annotated Interactions

No annotated interactions
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