Butyrate-induced histone acetylation (Bos taurus)

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21Acetylated HistoneCitrateAcetyl CoACitrateGlucoseButyrateBeta oxidationAcetyl CoAHDACsTCAcycleAKT1ButyrateACLYLipidbiosynthesisButyrateButyrate


Metabolism of butyrate is suggested to be an energy source for histone acetylation.


This pathway was inferred from Homo sapiens pathway WP2366(73980) with a 66.0% conversion rate.

Quality Tags

Ontology Terms



  1. Davie JR; ''Inhibition of histone deacetylase activity by butyrate.''; J Nutr, 2003 PubMed Europe PMC
  2. Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ; ''The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation.''; Mol Cell, 2012 PubMed Europe PMC


102130view21:15, 1 December 2018EgonwReplaced Wikipedia with Wikidata identifiers.
89151view03:06, 23 August 2016AriuttaOntology Term : 'classic metabolic pathway' added !
80881view15:29, 30 June 2015MkutmonNew pathway

External references


View all...
NameTypeDatabase referenceComment
ACLYProteinENSBTAG00000016740 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53396
AKT1ProteinENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P31749
Acetyl CoAMetaboliteCHEBI:15351 (ChEBI)
Acetylated HistoneComplexQ36293 (Wikidata)
ButyrateMetaboliteCHEBI:17968 (ChEBI)
CitrateMetaboliteCHEBI:35808 (ChEBI)
GlucoseMetaboliteCHEBI:17634 (ChEBI)
Lipid biosynthesisPathwayWP357 (WikiPathways)
TCA cyclePathwayWP78 (WikiPathways)

Annotated Interactions

No annotated interactions
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