Synaptic Vesicle Pathway (Bos taurus)

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MonoaminesSynapsin P+CytoskeletonVesicle ReleaseDopamineL-GlutamineATPRAB3ASYN1SYN2SYN3SYT1VAMP2Early Vesicle TraffickingAnterograde Transportfrom the Trans-GolgiNetworkPresynaptic membraneSTX1BSTX2STX1ASTX3SNAP25Active Zone T-SNARESRIMS1STXBP1RAB3ADockingUNC13CPrimingUNC13BUNC13ACPLX3CPLX2CPLX1NSF Attachment ProteinsNAPANSFCa2+CACNA1ACACNA1BRAB3ASynaptic cleft(upon deplolarization)ADPFusionSYPPoreFormationCa2+DNM1DNM1LDNM2DNM3CLTACLTCCLTCL1AP2S1AP2A1AP2A2AP2B1AP2M1EndocytosisSLC32A1SLC17A8SLC17A7SLC17A6SLC18A1SLC18A2SLC18A3Neurotransmitter UptakeNeurotransmitterSLC32A1SLC22A3SLC38A1PARK7SLC1A3CLN8SerotoninSLC6A4SLC25A4GlutamateATP1A2Neurotransmitter


Description

Pathway depicting synaptic transmission of neurotransmitters from the presynaptic nerve terminal to the synaptic cleft upon depolarization. Synaptotagmin mediated transport along the nerve cell cytoskeleton indicates the initial step of this process. Originally created by Joanna S. Fong and Nathan Salomonis in the Bruce Conklin laboratory 5/12/2000 for use in GenMAPP. Genes associated with neurotransmitter reuptake from the synaptic left were obtained from the Gene Ontology term GO:0001504. For additional information see: http://en.wikipedia.org/wiki/Synaptic_vesicle

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2267(78595) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

CompareRevisionActionTimeUserComment
105943view11:47, 16 August 2019MaintBotHMDB identifier normalization
80828view15:27, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADPMetabolite
AP2A1GeneProductENSBTAG00000019180 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196961
AP2A2GeneProductENSBTAG00000009915 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183020
AP2B1GeneProductENSBTAG00000020316 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006125
AP2M1GeneProductENSBTAG00000020106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161203
AP2S1GeneProductENSBTAG00000010584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000042753
ATPMetabolite
ATP1A2GeneProductENSBTAG00000010551 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000018625
CACNA1AGeneProductENSBTAG00000014828 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141837
CACNA1BGeneProductENSBTAG00000007882 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148408
CLN8GeneProductENSBTAG00000008584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182372
CLTAGeneProductENSBTAG00000001137 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122705
CLTCGeneProductENSBTAG00000016708 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141367
CLTCL1GeneProduct
CPLX1GeneProduct
CPLX2GeneProductENSBTAG00000013741 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145920
CPLX3GeneProductENSBTAG00000021426 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213578
DNM1GeneProductENSBTAG00000011307 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106976
DNM1LGeneProductENSBTAG00000011395 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087470
DNM2GeneProductENSBTAG00000013362 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079805
DNM3GeneProductENSBTAG00000014319 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197959
DopamineMetaboliteHMDB0000073 (HMDB)
GlutamateMetabolite
L-GlutamineMetaboliteHMDB0000641 (HMDB)
NAPAGeneProductENSBTAG00000013084 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105402
NSFGeneProductENSBTAG00000008442 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073969
PARK7GeneProductENSBTAG00000020518 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116288
RAB3AGeneProductENSBTAG00000010635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105649
RIMS1GeneProductENSBTAG00000020238 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079841
SLC17A6GeneProductENSBTAG00000038347 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091664
SLC17A7GeneProductENSBTAG00000007036 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104888
SLC17A8GeneProductENSBTAG00000001088 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179520
SLC18A1GeneProductENSBTAG00000020788 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000036565
SLC18A2GeneProductENSBTAG00000004739 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165646
SLC18A3GeneProductENSBTAG00000014990 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187714
SLC1A3GeneProductENSBTAG00000018245 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079215
SLC22A3GeneProductENSBTAG00000039080 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146477
SLC25A4GeneProductENSBTAG00000013208 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151729
SLC32A1GeneProductENSBTAG00000047894 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101438
SLC38A1GeneProductENSBTAG00000000859 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111371
SLC6A4GeneProductENSBTAG00000019349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108576
SNAP25GeneProductENSBTAG00000008323 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132639
STX1AGeneProductENSBTAG00000017075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106089
STX1BGeneProductENSBTAG00000002349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099365
STX2GeneProductENSBTAG00000007988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111450
STX3GeneProductENSBTAG00000012820 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166900
STXBP1GeneProductENSBTAG00000003525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136854
SYN1GeneProductENSBTAG00000005042 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000008056
SYN2GeneProductENSBTAG00000020260 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157152
SYN3GeneProductENSBTAG00000020636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185666
SYPGeneProductENSBTAG00000016096 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102003
SYT1GeneProductENSBTAG00000034693 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067715
SerotoninMetaboliteHMDB0000259 (HMDB)
UNC13AGeneProductENSBTAG00000012682 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130477
UNC13BGeneProductENSBTAG00000011397 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198722
UNC13CGeneProductENSBTAG00000025522 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137766
VAMP2GeneProductENSBTAG00000003891 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000220205

Annotated Interactions

No annotated interactions
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