Osteoblast signaling (Homo sapiens)

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PDGF_Ra/b complexOsteoblastavb3 integrin complexNucleusPDGF-BB complexFGF-23Vitamin DOsteoprotegerinPDGFRBRANK ligandNa+NPT3Parathyroid hormoneParathyroid hormoneSoluble RANK ligandNa+OsteocalcinCollagen 1Bone sialoproteinITGB3PDGF RaPTH receptorITGAVPDGFBBone sialoproteinPTH receptorFGF-23Vitamin DPDGFBPDGFRAPhosphateOsteoprotegerinPDGF RbPDGFBPDGFBPDGF-BB complex


Osteoblasts are specialized, terminally differentiated cell of mesenchymal origin. They create dense, crosslinked collagen and also specialized proteins, including osteocalcin and osteopontin. This pathway illustrates various signaling pathways in osteoblasts relevant to collagen and protein production. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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117584view11:24, 21 May 2021EweitzModified title
107607view22:16, 23 October 2019KhanspersModified description
106732view13:21, 17 September 2019MaintBotHMDB identifier normalization
106573view21:21, 6 September 2019KhanspersModified description
105766view19:37, 15 August 2019KhanspersModified description
97829view06:20, 10 June 2018EgonwUndo revision 97751 by [[Special:Contributions/Teacup|Teacup]] ([[User talk:Teacup|Talk]])
97751view13:12, 7 June 2018TeacupModified description
90527view00:02, 22 November 2016Khanspersfixed typo and updated PDGFB complex
79496view14:33, 23 March 2015ZariChanged uniprot ID to entrez ID for Osteocalcin
79329view11:32, 21 March 2015EgonwSplitted up "PDGF Ra/b" because it had two associated Entrez Gene identifiers.
74192view08:08, 4 April 2014EgonwReplaced an InChI with a more traditional identifier.
74152view11:43, 1 April 2014EgonwReplaced an InChI with a more traditional identifier.
71995view11:34, 24 October 2013MkutmonChanged Unknown -> GeneProduct for annotated PDGF Ra/b
71257view21:13, 16 October 2013MaintBotAutomated update of data sources
67554view11:25, 26 June 2013DdiglesOntology Term : 'signaling pathway pertinent to development' added !
61679view21:42, 16 April 2013MaintBotupdated data source swissprot to unitprot
53892view14:18, 15 November 2012EgonwReplaced InChIkey with InChI.
53517view12:34, 8 November 2012EgonwRDF tidy
53516view12:30, 8 November 2012EgonwRDF tidy
48244view06:13, 17 May 2012MaintBotUpdating PubChem xrefs
48218view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45323view20:11, 7 October 2011KhanspersOntology Term : 'signaling pathway' added !
45322view20:11, 7 October 2011KhanspersOntology Term : 'osteoblast' added !
41124view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
39761view07:34, 17 January 2011AlexanderPicomore specific title
38790view00:39, 24 September 2010AlexanderPico
38789view00:38, 24 September 2010AlexanderPicobeautification
32048view13:30, 14 August 2009MaintBotFixed group labels
21357view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Osteoblasts]] moved to [[Pathway:WP322]]: Moved to stable identifier
14745view22:45, 23 May 2008EhsiaoConnected!
10488view19:50, 1 February 2008AlexanderPicoupdated author info
10487view19:46, 1 February 2008AlexanderPicoadded author info
10389view02:13, 25 January 2008AlexanderPicolabeled complexes
10355view02:59, 23 January 2008AlexanderPicoModified categories
10354view02:57, 23 January 2008AlexanderPicoupdated datanode types
10353view02:48, 23 January 2008169.230.76.4updated protein and small molecule identifiers
10345view01:48, 23 January 2008AlexanderPico[[Pathway:Homo sapiens:Osteoblast]] moved to [[Pathway:Homo sapiens:Osteoblasts]]
10333view01:31, 23 January 2008EhsiaoGPML Import (Author=Grant Yang)

External references


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NameTypeDatabase referenceComment
Bone sialoproteinProtein3381 (Entrez Gene)
Collagen 1Protein1277 (Entrez Gene)
FGF-23Protein8074 (Entrez Gene)
ITGAVProtein3685 (Entrez Gene)
ITGB3Protein3690 (Entrez Gene)
NPT3Protein10246 (Entrez Gene)
Na+MetaboliteCHEBI:29101 (ChEBI)
OsteocalcinProtein632 (Entrez Gene)
OsteoprotegerinProtein4982 (Entrez Gene)
PDGF RaGeneProduct5156 (Entrez Gene)
PDGF RbGeneProduct5155 (Entrez Gene)
PDGFBProtein5155 (Entrez Gene)
PDGFRAProtein5156 (Entrez Gene)
PDGFRBProtein5159 (Entrez Gene)
PTH receptorProtein5745 (Entrez Gene)
Parathyroid hormoneProtein5741 (Entrez Gene)
PhosphateMetabolite1061 (PubChem-compound)
RANK ligandProtein8600 (Entrez Gene)
Soluble RANK ligandProtein8600 (Entrez Gene)
Vitamin DMetaboliteHMDB0000876 (HMDB)

Annotated Interactions

No annotated interactions

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