Focal Adhesion (Bos taurus)

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1-17+p+pIntegrin alphaWnt Signalingsignaling system+p+p+pDNA+p+p+p-pRAFITGAFilopodia Lamellipodia formationCell SurvivalCell MotilityStress Fiber-FA formation+p+pERKCell Proliferation+p+p+p+p+p+pDNA+pMEKFA turnoverActin Polymerization+p+pApoptosisPKCPhosphatidylinositiolReceptor Tyrosine KinasesCytokine-cytokine receptor interactionsRegulation ofCell CycleECM-receptor interactions-p+pITGB+p+pactin cytoskeleton+p-p+p+p+p+pIntegrin betaPDGFRBITGAVHRASPAK4CHADIGF1RTNRBIRC4RAC3FN1BRAFITGAXGRB2RAPGEF1ARHGAP5PIK3R2BLKTNXBMAP2K1ACTG1ITGA3SRMSVEGFACCND3PTK6COL3A1ITGA5MYL6EGFAKT3THBS4Crk1COL5A1CCND2SRCITGB5VASPPDGFBPTENPIK3CGPIK3R4FYNHCKITGA4SHC3MAP2K3RAF1COL4A4PAK1VWFMAPK7PDGFCITGB6BADCOL11A1PXNMAP2K5CAV1SPP1ITGB1MYLKMAP2K6FARP2ITGADITGAMCOL4A6ERBB2ITGA6BIRC3MAPK12IGF-ITNK1EGFRRHOBRAP1BCOL1A2LAMC1DIAPH1ITGB4LAMA1LAMC1ELK1TNCCOL11A2CRKITGA10PDPK1MAPK8COL5A2INTB3PIK3R5ROCK1MAPK4FLNAMAPK1ROCK2TXKPIP2LAMB1PDGFAITGA9ARAFITGAEPAK3PIK3CAPIP3AKT1PTK2CDC42PARVBACTN1LAMA2LAMA4THBS3CAV2MAPK6ITGA2BSHC1ILKPGFTHBS1RAC2RHOAITGALTESK2VTNCOL5A3ACTBKDRBCL2COL2A1MAPK9C-METBCAR1ITGA8MYLK2PDGFDVAV1THBS2PIK3CDCAPN1COL4A2ITGA7PAK7RAP1ADOCK1MAP2K2PELOSTYK1TNK2GSK3BLAMA3COL4A1VEGFCCOL6A2LAMC3LAMC2LAMA5FIGFCAV3PDGFRAVCLITGB8HGFITGA11VEGFBITGA2FLT1PPP1R12ATLN1CTNNB1CCND1RAC1LAMB3PIK3R1ITGB7PAK2COMPJUNIBSPZYXSEPP1PIK3CBCOL1A1RELNTNNPAK6BIRC2ITGB2FGRAKT2BRAFPIP5K1CSOS1


Description

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Source: KEGG http://www.genome.jp/kegg/pathway/hsa/hsa04510.html

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP306(80308) with a 94.0% conversion rate.

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Bibliography

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  1. Berman AE, Kozlova NI, Morozevich GE; ''Integrins: structure and signaling.''; Biochemistry (Mosc), 2003 PubMed Europe PMC
  2. Turner CE; ''Paxillin and focal adhesion signalling.''; Nat Cell Biol, 2000 PubMed Europe PMC
  3. Guo W, Giancotti FG; ''Integrin signalling during tumour progression.''; Nat Rev Mol Cell Biol, 2004 PubMed Europe PMC
  4. Oloumi A, McPhee T, Dedhar S; ''Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.''; Biochim Biophys Acta, 2004 PubMed Europe PMC
  5. Lee JW, Juliano R; ''Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.''; Mol Cells, 2004 PubMed Europe PMC
  6. Stupack DG, Cheresh DA; ''Get a ligand, get a life: integrins, signaling and cell survival.''; J Cell Sci, 2002 PubMed Europe PMC
  7. Petit V, Thiery JP; ''Focal adhesions: structure and dynamics.''; Biol Cell, 2000 PubMed Europe PMC
  8. Nicholson KM, Anderson NG; ''The protein kinase B/Akt signalling pathway in human malignancy.''; Cell Signal, 2002 PubMed Europe PMC
  9. Danen EH, Yamada KM; ''Fibronectin, integrins, and growth control.''; J Cell Physiol, 2001 PubMed Europe PMC
  10. Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed Europe PMC
  11. Hlobilkovأƒآ، A, Knillovأƒآ، J, Bأƒآ،rtek J, Lukأƒآ،s J, Kolأƒآ،r Z; ''The mechanism of action of the tumour suppressor gene PTEN.''; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2003 PubMed Europe PMC
  12. Mitra SK, Hanson DA, Schlaepfer DD; ''Focal adhesion kinase: in command and control of cell motility.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC
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History

CompareRevisionActionTimeUserComment
80784view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTBGeneProductENSBTAG00000026199 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60
ACTG1GeneProductENSBTAG00000006189 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71
ACTN1GeneProductENSBTAG00000018255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:87
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
AKT2GeneProductENSBTAG00000001400 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208
AKT3GeneProductENSBTAG00000017788 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10000
ARAFGeneProductENSBTAG00000005039 (Ensembl)
  • ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:369
ARHGAP5GeneProductENSBTAG00000027024 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:394
BADGeneProductENSBTAG00000012511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:572
BCAR1GeneProductENSBTAG00000012002 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9564
BCL2GeneProductENSBTAG00000019302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
BIRC2GeneProductENSBTAG00000035735 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:329
BIRC3GeneProductENSBTAG00000024918 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:330
BIRC4GeneProduct
BLKGeneProductENSBTAG00000005049 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:640
BRAFGeneProductENSBTAG00000021761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
C-METGeneProductENSBTAG00000006161 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233
CAPN1GeneProductENSBTAG00000010230 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:823
CAV1GeneProductENSBTAG00000017869 (Ensembl)
  • CAV1; caveolin 1 caveolae protein 22kD
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:857
CAV2GeneProductENSBTAG00000045584 (Ensembl)
  • CAV2; caveolin 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:858
CAV3GeneProductENSBTAG00000022699 (Ensembl)
  • CAV3; caveolin 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:859
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CCND2GeneProductENSBTAG00000016649 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CCND3GeneProductENSBTAG00000010106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CDC42GeneProductENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
CHADGeneProductENSBTAG00000021302 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1101
COL11A1GeneProductENSBTAG00000021217 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1301
COL11A2GeneProductENSBTAG00000000601 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1302
COL1A1GeneProductENSBTAG00000013103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1277
COL1A2GeneProductENSBTAG00000013472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1278
COL2A1GeneProductENSBTAG00000013155 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1280
COL3A1GeneProductENSBTAG00000021466 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1281
COL4A1GeneProductENSBTAG00000012849 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1282
COL4A2GeneProductENSBTAG00000025210 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1284
COL4A4GeneProductENSBTAG00000021310 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1286
COL4A6GeneProductENSBTAG00000013760 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1288
COL5A1GeneProductENSBTAG00000047998 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1289
COL5A2GeneProductENSBTAG00000027020 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1290
COL5A3GeneProductENSBTAG00000010179 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50509
COL6A2GeneProductENSBTAG00000019269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1292
COMPGeneProductENSBTAG00000004630 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1311
CRKGeneProductENSBTAG00000005665 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
Crk1GeneProduct
DIAPH1GeneProductENSBTAG00000030499 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1729
DOCK1GeneProductENSBTAG00000031890 (Ensembl)
  • DOCK1; dedicator of cyto-kinesis
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1793
EGFGeneProduct
EGFRGeneProductENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
ELK1GeneProductENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ERBB2GeneProductENSBTAG00000021798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064
FARP2GeneProduct
FGRGeneProductENSBTAG00000011784 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2268
FIGFGeneProductENSBTAG00000009476 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2277
FLNAGeneProductENSBTAG00000011190 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2316
FLT1GeneProductENSBTAG00000016915 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2321
FN1GeneProductENSBTAG00000008300 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2335
FYNGeneProductENSBTAG00000011851 (Ensembl)
  • FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
GRB2GeneProductENSBTAG00000004736 (Ensembl)
  • GRB2; growth factor receptor-bound protein 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
GSK3BGeneProductENSBTAG00000048057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
HCKGeneProductENSBTAG00000007932 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3055
HGFGeneProductENSBTAG00000017664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3082
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IBSPGeneProductENSBTAG00000000470 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3381
IGF-IGeneProductENSBTAG00000011082 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3479
IGF1RGeneProductENSBTAG00000021527 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3480
ILKGeneProductENSBTAG00000000696 (Ensembl)
  • ILK; integrin-linked kinase [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3611
INTB3GeneProductENSBTAG00000009987 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
ITGA10GeneProductENSBTAG00000008373 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8515
ITGA11GeneProductENSBTAG00000008380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22801
ITGA2BGeneProductENSBTAG00000008165 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3674
ITGA2GeneProductENSBTAG00000019289 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3673
ITGA3GeneProductENSBTAG00000019498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3675
ITGA4GeneProductENSBTAG00000009256 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3676
ITGA5GeneProductENSBTAG00000013745 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3678
ITGA6GeneProductENSBTAG00000017266 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655
ITGA7GeneProductENSBTAG00000012897 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3679
ITGA8GeneProductENSBTAG00000007602 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8516
ITGA9GeneProductENSBTAG00000016566 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3680
ITGADGeneProductENSBTAG00000019524 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3681
ITGAEGeneProductENSBTAG00000015264 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3682
ITGALGeneProductENSBTAG00000007103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3683
ITGAMGeneProductENSBTAG00000047238 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3684
ITGAVGeneProductENSBTAG00000019929 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3685
ITGAXGeneProduct
ITGB1GeneProductENSBTAG00000015910 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
ITGB2GeneProductENSBTAG00000017060 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3689
ITGB4GeneProductENSBTAG00000018169 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691
ITGB5GeneProductENSBTAG00000013755 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3693
ITGB6GeneProductENSBTAG00000009080 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694
ITGB7GeneProductENSBTAG00000018993 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3695
ITGB8GeneProductENSBTAG00000003709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3696
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
KDRGeneProductENSBTAG00000000782 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3791
LAMA1GeneProductENSBTAG00000018160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:284217
LAMA2GeneProductENSBTAG00000010229 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3908
LAMA3GeneProductENSBTAG00000027181 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3909
LAMA4GeneProductENSBTAG00000008817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3910
LAMA5GeneProductENSBTAG00000003061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3911
LAMB1GeneProductENSBTAG00000011412 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3912
LAMB3GeneProductENSBTAG00000016542 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3914
LAMC1GeneProductENSBTAG00000011966 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3915
LAMC1GeneProductENSBTAG00000022635 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3913
LAMC2GeneProductENSBTAG00000000793 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3918
LAMC3GeneProduct
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)
  • MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K3GeneProductENSBTAG00000010576 (Ensembl)
  • MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K5GeneProductENSBTAG00000000218 (Ensembl)
  • MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
MAP2K6GeneProductENSBTAG00000001609 (Ensembl)
  • MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAPK12GeneProductENSBTAG00000019574 (Ensembl)
  • MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6300
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK4GeneProductENSBTAG00000009907 (Ensembl)
  • MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596
MAPK6GeneProductENSBTAG00000005865 (Ensembl)
  • MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5597
MAPK7GeneProductENSBTAG00000001014 (Ensembl)
  • MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPK9GeneProductENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
MYL6GeneProductENSBTAG00000010799 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4637
MYLK2GeneProductENSBTAG00000014930 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85366
MYLKGeneProductENSBTAG00000014567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4638
PAK1GeneProductENSBTAG00000010191 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
PAK2GeneProductENSBTAG00000047856 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062
PAK3GeneProductENSBTAG00000015670 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5063
PAK4GeneProductENSBTAG00000013958 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10298
PAK6GeneProductENSBTAG00000019076 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56924
PAK7GeneProductENSBTAG00000017679 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57144
PARVBGeneProductENSBTAG00000021978 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29780
PDGFAGeneProductENSBTAG00000014541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5154
PDGFBGeneProductENSBTAG00000021697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5155
PDGFCGeneProductENSBTAG00000043959 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56034
PDGFDGeneProductENSBTAG00000034827 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80310
PDGFRAGeneProductENSBTAG00000007173 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5156
PDGFRBGeneProductENSBTAG00000002804 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5159
PDPK1GeneProductENSBTAG00000034436 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PELOGeneProductENSBTAG00000003268 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53918
PGFGeneProductENSBTAG00000013688 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5228
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PIK3CBGeneProductENSBTAG00000006909 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5291
PIK3CDGeneProductENSBTAG00000018984 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5293
PIK3CGGeneProductENSBTAG00000020848 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294
PIK3R1GeneProductENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3R2GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;
PIK3R4GeneProductENSBTAG00000020787 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:30849
PIK3R5GeneProductENSBTAG00000005978 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23533
PIP2GeneProduct
PIP3GeneProduct
PIP5K1CGeneProductENSBTAG00000000710 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23396
PPP1R12AGeneProductENSBTAG00000014609 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4659
PTENGeneProductENSBTAG00000009498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728
PTK2GeneProductENSBTAG00000009578 (Ensembl)
  • PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
PTK6GeneProductENSBTAG00000044091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5753
PXNGeneProductENSBTAG00000018108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829
RAC1GeneProductENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAC2GeneProductENSBTAG00000011043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5880
RAC3GeneProductENSBTAG00000022927 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5881
RAF1GeneProductENSBTAG00000045748 (Ensembl)
  • RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RAP1AGeneProductENSBTAG00000014710 (Ensembl)
  • RAP1A; RAP1A member of RAS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RAP1BGeneProductENSBTAG00000008967 (Ensembl)
  • RAP1B; RAP1B member of RAS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
RAPGEF1GeneProductENSBTAG00000020791 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889
RELNGeneProductENSBTAG00000046817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5649
RHOAGeneProductENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
RHOBGeneProductENSBTAG00000046054 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:388
ROCK1GeneProductENSBTAG00000008403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
ROCK2GeneProductENSBTAG00000005847 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9475
SEPP1GeneProductSEPP1; selenoprotein P plasma
SHC1GeneProductENSBTAG00000019838 (Ensembl)
  • SHC1; SHC (Src homology 2 domain containing) transforming protein 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SHC3GeneProductENSBTAG00000011375 (Ensembl)
  • SHC3; neuronal Sh
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53358
SOS1GeneProductENSBTAG00000011643 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
SPP1GeneProductENSBTAG00000005260 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6696
SRCGeneProductENSBTAG00000008938 (Ensembl)
  • SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
SRMSGeneProductENSBTAG00000001985 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6725
STYK1GeneProductENSBTAG00000015351 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55359
TESK2GeneProductENSBTAG00000011244 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10420
THBS1GeneProductENSBTAG00000002006 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
THBS2GeneProductENSBTAG00000018810 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7058
THBS3GeneProductENSBTAG00000000057 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7059
THBS4GeneProductENSBTAG00000012866 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7060
TLN1GeneProductENSBTAG00000025868 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7094
TNCGeneProductENSBTAG00000000575 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3371
TNK1GeneProductENSBTAG00000017739 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8711
TNK2GeneProductENSBTAG00000021364 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10188
TNNGeneProductENSBTAG00000015650 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:63923
TNRGeneProductENSBTAG00000011706 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7143
TNXBGeneProductENSBTAG00000001444 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7148
TXKGeneProductENSBTAG00000005055 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7294
VASPGeneProductENSBTAG00000019604 (Ensembl)
  • VASP; vasodilator-stimulated phosphoprotein
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7408
VAV1GeneProductENSBTAG00000039160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409
VCLGeneProductENSBTAG00000021879 (Ensembl)
  • VCL; vinculin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7414
VEGFAGeneProductENSBTAG00000047561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7422
VEGFBGeneProductENSBTAG00000047567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7423
VEGFCGeneProductENSBTAG00000014737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7424
VTNGeneProductENSBTAG00000016151 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7448
VWFGeneProductENSBTAG00000012265 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7450
ZYXGeneProductENSBTAG00000017970 (Ensembl)
  • ZYX; zyxin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7791

Annotated Interactions

No annotated interactions
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