Vitamin B12 Metabolism (Bos taurus)

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116, 132, 187, 241, 263...70180, 24427, 61, 113, 132Negative EffectBiomarker forSelenium statusOther proteinsCleavageProcess or metabolism involved in Se PathwayCofactorsConversionNitrogen CompundsNecessary stimulationBindingFrom intracellular part to the plasmaInhibitionSelenoproteinsMetabolitesEnzymesStimulationTranscription factorReactionProtein with polymorphismProtein*MicronutrientsLEGENDCofactor conversionCatalysisOverarching processis composed ofIntracellularPlasmaPGF2aF2-IsoprostaneLipoprotein metabolismThromboxane B2TCN2Prostaglandin metabolismCCL2a-TocopherolPGF2aPGE2LRP2CCL2F2-IsoprostaneRELALipid peroxidationThromboxane B2GIFThromboxane A2a-TocopherolPGE1CUBNTCN1Thromboxane B2NFKB2PGE2DNA Oxidation8-Isoprostaglandin F2aTCN28-Isoprostaglandin F2aNFKB1PGE1Protein tyrosine nitration87, 92, 164, 175, 195...15, 130, 16051, 114, 125, 219130, 246, 296130, 28051, 114, 21911, 51, 97, 114, 143...3001551, 114, 136, 207, 219...15153188, 267171170, 254130, 246, 29615310, 21315387, 92, 164, 175, 195...42, 231188, 267130, 28011, 51, 97, 114, 120...51, 136, 2221542, 207, 231153MAT1ASHMT2MCEEMM-CoA-HCBRMMABMTRMTRRMUT6617, 261101120, 12651, 117114126, 278114, 123, 127, 168, 218CBS84NADP+NADHNADP+NADP+MPO19, 27, 203CysteineSERPINE1PLATF7F2PLGPLATPLGF2F7SERPINE16712, 3434, 13312, 346734, 13367676767H2O25,10-Methylene-THF17, 2285-methyl-THF5-methyl-THFCreatinineCreatinine146, 148110, 180, 211, 218, 228...110, 180, 211, 218, 228...146, 148SOD3SOD3CTHTHF228NADPHNADPHNADPHNADMTHFR127, 228HomocysteineHomocysteine42, 49, 99, 110, 132...42, 49, 99, 110, 132...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate110, 211, 267110, 211, 267SerineSerine17, 26117, 261APOA1APOESCARB1CholesterolCholesterolAPOA1HDLLDL/APOBVLDL-TAGAPOBoxLDLVLDLVLDL/APOBHDLAPOA1HDL-CLDLTAGLDLRSAA4SERPINA3-7ABCA1SAA1LDLSAA2HDL-CSERPINA3-7TAGVLDL-TAGHDL/SAAHDL/APOA1VLDLoxLDLAPOBLDL-CLDL-CSAA310, 164, 231107, 17480, 159, 25610, 164, 23180, 159, 256107, 174159, 256264174174174140, 18426, 238144264264264140, 264174, 23210, 164, 231174107, 17417444, 264226107, 144, 17410, 164, 231174, 231, 23226, 238264174144, 17444, 26426, 184140, 264174107, 174Vitamin B12/CobalaminCob(I)alaminAdenosylcobalaminMethylcob(III)alaminVitamin B12/CobalaminMethylcob(III)alaminAdenosylcobalamin8-OHdGCob(II)alaminFAD8-OHdG114, 126, 180, 244171114, 117114, 126114, 117114, 126, 180, 244171114, 126, 28951, 80, 99, 110, 114...41, 51, 80, 99, 110...Chlorinevitamin Dvitamin DChlorine8080CystathionineSOD2ZincZincO3NOHOClNO2HNO2NO3-N2O123, 16819, 49, 123, 203CCL5FibrinTNFALBIL1BIL6IL1BTNFHBAINSICAM1IL6IFNGHbA1cFibrinogenIFNGINSRHbA1cFibrinogenD-dimerALBFibrinCCL5CRPINSHBGD-dimer429447, 128, 185207, 26367, 2147, 13635, 41, 132, 1823, 4767, 21412, 6735, 211, 291132, 241, 246435, 211, 2917, 13635, 13220647, 132, 206207, 26347, 128, 185294104, 164, 170, 182, 206...132, 24112, 674447, 119, 132, 206, 246RiboflavinRiboflavin80, 20580, 205O2L-Methylmalonyl-CoA Methylmalonic acid S-AdenosylhomocysteineCbl/HCCbl/TC S-AdenosylmethionineMethionineCbl/IFMethionine Methylmalonic acid S-AdenosylhomocysteineCbl/TC S-AdenosylmethionineD-Methylmalonyl-CoA Succinyl-CoA51, 114, 2191, 218, 22851, 114, 146, 21951, 11751, 114, 219100, 228101, 126, 228, 290101, 126, 228, 29051, 114, 219100, 22851, 11799, 1171, 218, 22811751, 117NitrotyrosineONOO-ONOOH300FructosamineGlucoseGlucoseFructosamine4, 1854, 18577Ascorbic acidAscorbic acidAscorbic acid58, 87, 22458, 87, 22458, 87, 224


Description

Vitamin B12 is a water soluble, organic compound and essential nutrient involved in the everyday functioning of the nervous system and the brain.

Vitamin B12 is involved in the preservation and regeneration of the myelin shealth - the protective fatty layer that acts as an insulator in nerve axons.

Animals store vitamin B12 in liver and muscle and therefore eggs, milk, meat, liver are sources of the vitamin.

Problems in metabolism of vitamin B12 lead to "persistent" lack of energy to perform every day tasks.

The genes and pathways highlighted above describe several routes through which genes and metabolites involved in B12 metabolism are interconnected.

Central B12 metabolism nodes include folate metabolism and the synthesis of the citric acid cycle intermediates and succinyl-CoA, cyanocobalamin into methylcobalamin conversion, tyrosine nitration and riboflavin pathways.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP1533_96310 with a 81.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Schöneich C; ''Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.''; Biochim Biophys Acta, 2005 PubMed Europe PMC
  2. Packer L, Witt EH, Tritschler HJ; ''alpha-Lipoic acid as a biological antioxidant.''; Free Radic Biol Med, 1995 PubMed Europe PMC
  3. Videla LA, Rodrigo R, Araya J, Poniachik J; ''Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.''; Trends Mol Med, 2006 PubMed Europe PMC
  4. Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ; ''Hemoglobin variants and determination of glycated hemoglobin (HbA1c).''; Diabetes Metab Res Rev, 2001 PubMed Europe PMC
  5. Edmondson DE, Newton-Vinson P; ''The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction.''; Antioxid Redox Signal, 2001 PubMed Europe PMC
  6. Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, Tommasino M, Vlach J; ''Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC
  7. Youssef D, El Abbassi A, Jordan RM, Peiris AN; ''Fructosamine--an underutilized tool in diabetes management: case report and literature review.''; Tenn Med, 2008 PubMed Europe PMC
  8. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone''; Prostaglandins., 1982 PubMed Europe PMC
  9. Waterham HR, Wijburg FA, Hennekam RC, Vreken P, Poll-The BT, Dorland L, Duran M, Jira PE, Smeitink JA, Wevers RA, Wanders RJ; ''Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.''; Am J Hum Genet, 1998 PubMed Europe PMC
  10. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.''; Clin Rev Allergy Immunol, 2009 PubMed Europe PMC
  11. Swanson DA, Pangilinan F, Mills JL, Kirke PN, Conley M, Weiler A, Frey T, Parle-McDermott A, O'Leary VB, Seltzer RR, Moynihan KA, Molloy AM, Burke H, Scott JM, Brody LC; ''Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population.''; Birth Defects Res A Clin Mol Teratol, 2005 PubMed Europe PMC
  12. Weisel JW; ''Fibrinogen and fibrin.''; Adv Protein Chem, 2005 PubMed Europe PMC
  13. Penning TM, Jin Y, Steckelbroeck S, Lanisnik Rizner T, Lewis M; ''Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC
  14. Hammarström S; ''Leukotrienes.''; Annu Rev Biochem, 1983 PubMed Europe PMC
  15. Reilly IA, FitzGerald GA; ''Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.''; Blood, 1987 PubMed Europe PMC
  16. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr, 1999 PubMed Europe PMC
  17. Lucock M; ''Folic acid: nutritional biochemistry, molecular biology, and role in disease processes.''; Mol Genet Metab, 2000 PubMed Europe PMC
  18. Gao Y, Feng HC, Walder K, Bolton K, Sunderland T, Bishara N, Quick M, Kantham L, Collier GR; ''Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein.''; FEBS Lett, 2004 PubMed Europe PMC
  19. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM; ''Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.''; Biochemistry, 2006 PubMed Europe PMC
  20. Chen D, Zhang XY, Shi Y; ''Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.''; Biochem J, 2006 PubMed Europe PMC
  21. Schumm K, Rocha S, Caamano J, Perkins ND; ''Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit.''; EMBO J, 2006 PubMed Europe PMC
  22. Araya Z, Wikvall K; ''6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes.''; Biochim Biophys Acta, 1999 PubMed Europe PMC
  23. Holleran WM, Williams ML, Gao WN, Elias PM; ''Serine-palmitoyl transferase activity in cultured human keratinocytes.''; J Lipid Res, 1990 PubMed Europe PMC
  24. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.''; J Biol Chem, 2001 PubMed Europe PMC
  25. Zamocky M, Furtmüller PG, Obinger C; ''Evolution of catalases from bacteria to humans.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  26. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC
  27. Klebanoff SJ; ''Myeloperoxidase: friend and foe.''; J Leukoc Biol, 2005 PubMed Europe PMC
  28. Lu J, Holmgren A; ''Selenoproteins.''; J Biol Chem, 2009 PubMed Europe PMC
  29. Neumann D, Kollewe C, Resch K, Martin MU.; ''The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC
  30. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, Raz A; ''Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.''; Biochem J, 2002 PubMed Europe PMC
  31. Jeong D, Kim TS, Chung YW, Lee BJ, Kim IY; ''Selenoprotein W is a glutathione-dependent antioxidant in vivo.''; FEBS Lett, 2002 PubMed Europe PMC
  32. Kimura M, Okuno E, Inada J, Ohyama H, Kido R; ''Purification and characterization of amino-acid N-choloyltransferase from human liver.''; Hoppe Seylers Z Physiol Chem, 1983 PubMed Europe PMC
  33. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.''; Circulation, 2000 PubMed Europe PMC
  34. Adams RL, Bird RJ; ''Review article: Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants.''; Nephrology (Carlton), 2009 PubMed Europe PMC
  35. Esmon CT; ''Does inflammation contribute to thrombotic events?''; Haemostasis, 2000 PubMed Europe PMC
  36. Deo AK, Bandiera SM; ''Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.''; Drug Metab Dispos, 2008 PubMed Europe PMC
  37. Betsholtz IH, Wikvall K; ''Cytochrome P450 CYP27-catalyzed oxidation of C27-steroid into C27-acid.''; J Steroid Biochem Mol Biol, 1995 PubMed Europe PMC
  38. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, Urade Y; ''Mechanism of metal activation of human hematopoietic prostaglandin D synthase.''; Nat Struct Biol, 2003 PubMed Europe PMC
  39. Sakurai T, Yamamoto Y, Baba N, Nakano M; ''Phospholipase A(2) activity in non-glycated and glycated low density lipoproteins.''; Biochim Biophys Acta, 1996 PubMed Europe PMC
  40. Grumolato L, Ghzili H, Montero-Hadjadje M, Gasman S, Lesage J, Tanguy Y, Galas L, Ait-Ali D, Leprince J, Guérineau NC, Elkahloun AG, Fournier A, Vieau D, Vaudry H, Anouar Y; ''Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion.''; FASEB J, 2008 PubMed Europe PMC
  41. Politis A, Olgiati P, Malitas P, Albani D, Signorini A, Polito L, De Mauro S, Zisaki A, Piperi C, Stamouli E, Mailis A, Batelli S, Forloni G, De Ronchi D, Kalofoutis A, Liappas I, Serretti A; ''Vitamin B12 levels in Alzheimer's disease: association with clinical features and cytokine production.''; J Alzheimers Dis, 2010 PubMed Europe PMC
  42. Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS; ''Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.''; Clin Immunol, 2009 PubMed Europe PMC
  43. Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, Adachi M; ''Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells.''; Clin Exp Allergy, 2006 PubMed Europe PMC
  44. Kamagate A, Dong HH; ''FoxO1 integrates insulin signaling to VLDL production.''; Cell Cycle, 2008 PubMed Europe PMC
  45. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.''; Am J Clin Nutr, 2009 PubMed Europe PMC
  46. Franken PA, Van den Berg L, Huang J, Gunyuzlu P, Lugtigheid RB, Verheij HM, De Haas GH; ''Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide.''; Eur J Biochem, 1992 PubMed Europe PMC
  47. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y; ''A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.''; J Biol Chem, 1997 PubMed Europe PMC
  48. Bailey JM, Bryant RW, Whiting J, Salata K; ''Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells.''; J Lipid Res, 1983 PubMed Europe PMC
  49. Jakubowski H; ''Molecular basis of homocysteine toxicity in humans.''; Cell Mol Life Sci, 2004 PubMed Europe PMC
  50. Chatterjee S, Castiglione E; ''UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.''; Biochim Biophys Acta, 1987 PubMed Europe PMC
  51. Whitehead VM; ''Acquired and inherited disorders of cobalamin and folate in children.''; Br J Haematol, 2006 PubMed Europe PMC
  52. Puig-Kröger A, Sierra-Filardi E, Domí­nguez-Soto A, Samaniego R, Corcuera MT, Gómez-Aguado F, Ratnam M, Sánchez-Mateos P, Corbí­ AL; ''Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.''; Cancer Res, 2009 PubMed Europe PMC
  53. Brigelius-Flohé R; ''Glutathione peroxidases and redox-regulated transcription factors.''; Biol Chem, 2006 PubMed Europe PMC
  54. Whanger PD; ''Selenoprotein expression and function-Selenoprotein W.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  55. Shimojo T, Akino T, Miura Y, Schroepfer GJ Jr; ''Sphingolipid base metabolism. Stereospecific uptake of proton in the enzymatic conversion of sphinganine 1-phosphate to ethanolamine 1-phosphate.''; J Biol Chem, 1976 PubMed Europe PMC
  56. Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM; ''NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.''; J Leukoc Biol, 2007 PubMed Europe PMC
  57. Baker CH, Matsuda SP, Liu DR, Corey EJ; ''Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.''; Biochem Biophys Res Commun, 1995 PubMed Europe PMC
  58. Verrax J, Calderon PB; ''The controversial place of vitamin C in cancer treatment.''; Biochem Pharmacol, 2008 PubMed Europe PMC
  59. Banning A, Florian S, Deubel S, Thalmann S, Müller-Schmehl K, Jacobasch G, Brigelius-Flohé R; ''GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  60. Hoyos B, Ballard DW, Böhnlein E, Siekevitz M, Greene WC; ''Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression.''; Science, 1989 PubMed Europe PMC
  61. Schöneich C; ''Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.''; Biochim Biophys Acta, 2005 PubMed Europe PMC
  62. Guan ZZ, Wang YN, Xiao KQ, Hu PS, Liu JL; ''Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.''; Neurochem Int, 1999 PubMed Europe PMC
  63. Lu C, Qiu F, Zhou H, Peng Y, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett, 2006 PubMed Europe PMC
  64. Eberhardt C, Gray PW, Tjoelker LW; ''Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3.''; J Biol Chem, 1997 PubMed Europe PMC
  65. Olivier LM, Chambliss KL, Gibson KM, Krisans SK; ''Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.''; J Lipid Res, 1999 PubMed Europe PMC
  66. Kovachy RJ, Copley SD, Allen RH; ''Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase.''; J Biol Chem, 1983 PubMed Europe PMC
  67. Lijnen HR; ''Elements of the fibrinolytic system.''; Ann N Y Acad Sci, 2001 PubMed Europe PMC
  68. Ferré P; ''The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity.''; Diabetes, 2004 PubMed Europe PMC
  69. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL; ''A new human selenium-containing protein. Purification, characterization, and cDNA sequence.''; J Biol Chem, 1998 PubMed Europe PMC
  70. Schäfer M, Werner S; ''Oxidative stress in normal and impaired wound repair.''; Pharmacol Res, 2008 PubMed Europe PMC
  71. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ; ''Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.''; J Biol Chem, 1997 PubMed Europe PMC
  72. Pesch J, Brehm U, Staib C, Grummt F; ''Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53.''; J Interferon Cytokine Res, 1996 PubMed Europe PMC
  73. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.''; Clin Rev Allergy Immunol, 2009 PubMed Europe PMC
  74. Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P; ''A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.''; J Exp Med, 2005 PubMed Europe PMC
  75. Chen Y, Dennis EA; ''Expression and characterization of human group V phospholipase A2.''; Biochim Biophys Acta, 1998 PubMed Europe PMC
  76. Cuebas DA, Phillips C, Schmitz W, Conzelmann E, Novikov DK; ''The role of alpha-methylacyl-CoA racemase in bile acid synthesis.''; Biochem J, 2002 PubMed Europe PMC
  77. Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A; ''Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.''; J Biol Chem, 2007 PubMed Europe PMC
  78. Horrobin DF; ''Fatty acid metabolism in health and disease: the role of delta-6-desaturase.''; Am J Clin Nutr, 1993 PubMed Europe PMC
  79. Setty BN, Stuart MJ, Walenga RW; ''Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase.''; Biochim Biophys Acta, 1985 PubMed Europe PMC
  80. Hooper PL, Hooper EM, Hunt WC, Garry PJ, Goodwin JS; ''Vitamins, lipids and lipoproteins in a healthy elderly population.''; Int J Vitam Nutr Res, 1983 PubMed Europe PMC
  81. Hansel A, Heinemann SH, Hoshi T; ''Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.''; Biochim Biophys Acta, 2005 PubMed Europe PMC
  82. Minkes M, Stanford N, Chi MM, Roth GJ, Raz A, Needleman P, Majerus PW; ''Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.''; J Clin Invest, 1977 PubMed Europe PMC
  83. Semnani RT, Venugopal PG, Leifer CA, Mostböck S, Sabzevari H, Nutman TB; ''Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.''; Blood, 2008 PubMed Europe PMC
  84. Singh S, Madzelan P, Banerjee R; ''Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.''; Nat Prod Rep, 2007 PubMed Europe PMC
  85. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  86. Bierbach H; ''Studies on long chain fatty acid:CoA ligase from human small intestine.''; Gut, 1980 PubMed Europe PMC
  87. McCay PB; ''Vitamin E: interactions with free radicals and ascorbate.''; Annu Rev Nutr, 1985 PubMed Europe PMC
  88. Ho AW, Wong CK, Lam CW; ''Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways.''; Immunobiology, 2008 PubMed Europe PMC
  89. Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M; ''Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.''; Biochim Biophys Acta, 1999 PubMed Europe PMC
  90. Ahlberg J, Angelin B, Björkhem I, Einarsson K, Leijd B; ''Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.''; J Lipid Res, 1979 PubMed Europe PMC
  91. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC
  92. Abate A, Yang G, Dennery PA, Oberle S, Schröder H; ''Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin.''; Free Radic Biol Med, 2000 PubMed Europe PMC
  93. Bowser PA, Gray GM; ''Sphingomyelinase in pig and human epidermis.''; J Invest Dermatol, 1978 PubMed Europe PMC
  94. Schaap D, de Widt J, van der Wal J, Vandekerckhove J, van Damme J, Gussow D, Ploegh HL, van Blitterswijk WJ, van der Bend RL; ''Purification, cDNA-cloning and expression of human diacylglycerol kinase.''; FEBS Lett, 1990 PubMed Europe PMC
  95. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev V; ''Structure-function relationships, physiological roles and evolution of mammalian ER-resident selenoproteins.''; Antioxid Redox Signal, 2009 PubMed Europe PMC
  96. Engels F, Nijkamp FP; ''Pharmacological inhibition of leukotriene actions.''; Pharm World Sci, 1998 PubMed Europe PMC
  97. Zetterberg H, Nexö E, Regland B, Minthon L, Boson R, Palmér M, Rymo L, Blennow K; ''The transcobalamin (TC) codon 259 genetic polymorphism influences holo-TC concentration in cerebrospinal fluid from patients with Alzheimer disease.''; Clin Chem, 2003 PubMed Europe PMC
  98. Agaugué S, Perrin-Cocon L, Coutant F, André P, Lotteau V; ''1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity.''; J Immunol, 2006 PubMed Europe PMC
  99. Bates CJ, Schneede J, Mishra G, Prentice A, Mansoor MA; ''Relationship between methylmalonic acid, homocysteine, vitamin B12 intake and status and socio-economic indices, in a subset of participants in the British National Diet and Nutrition Survey of people aged 65 y and over.''; Eur J Clin Nutr, 2003 PubMed Europe PMC
  100. Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, Zhu H, Hou M, Ma J, Tang Z, Ling W; ''Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.''; J Nutr, 2008 PubMed Europe PMC
  101. Choi SW, Mason JB; ''Folate and carcinogenesis: an integrated scheme.''; J Nutr, 2000 PubMed Europe PMC
  102. Karthikeyan S, Zhou Q, Osterman AL, Zhang H; ''Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.''; Biochemistry, 2003 PubMed Europe PMC
  103. Bütikofer P, Yee MC, Schott MA, Lubin BH, Kuypers FA; ''Generation of phosphatidic acid during calcium-loading of human erythrocytes. Evidence for a phosphatidylcholine-hydrolyzing phospholipase D.''; Eur J Biochem, 1993 PubMed Europe PMC
  104. Bertran N, Camps J, Fernandez-Ballart J, Arija V, Ferre N, Tous M, Simo D, Murphy MM, Vilella E, Joven J; ''Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study.''; J Lab Clin Med, 2005 PubMed Europe PMC
  105. Taki T, Kanfer JN; ''Phospholipase D from rat brain.''; Methods Enzymol, 1981 PubMed Europe PMC
  106. Guzik TJ, Korbut R, Adamek-Guzik T; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol, 2003 PubMed Europe PMC
  107. Clifton PM, Mackinnon AM, Barter PJ; ''Effects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction.''; J Lipid Res, 1985 PubMed Europe PMC
  108. Bianco AC, Kim BW; ''Deiodinases: implications of the local control of thyroid hormone action.''; J Clin Invest, 2006 PubMed Europe PMC
  109. Shields DJ, Lehner R, Agellon LB, Vance DE; ''Membrane topography of human phosphatidylethanolamine N-methyltransferase.''; J Biol Chem, 2003 PubMed Europe PMC
  110. Fakhrzadeh H, Ghotbi S, Pourebrahim R, Nouri M, Heshmat R, Bandarian F, Shafaee A, Larijani B; ''Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional population based study.''; BMC Public Health, 2006 PubMed Europe PMC
  111. Lavie CJ, Milani RV, Mehra MR, Ventura HO; ''Omega-3 polyunsaturated fatty acids and cardiovascular diseases.''; J Am Coll Cardiol, 2009 PubMed Europe PMC
  112. Helgerud P, Saarem K, Norum KR; ''Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction.''; J Lipid Res, 1981 PubMed Europe PMC
  113. Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar-Uniyal M, Dai W; ''Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.''; J Biol Chem, 2001 PubMed Europe PMC
  114. Banerjee R; ''B12 trafficking in mammals: A for coenzyme escort service.''; ACS Chem Biol, 2006 PubMed Europe PMC
  115. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC
  116. Sica A, Tan TH, Rice N, Kretzschmar M, Ghosh P, Young HA; ''The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.''; Proc Natl Acad Sci U S A, 1992 PubMed Europe PMC
  117. Fowler B, Leonard JV, Baumgartner MR; ''Causes of and diagnostic approach to methylmalonic acidurias.''; J Inherit Metab Dis, 2008 PubMed Europe PMC
  118. Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM; ''Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.''; J Biol Chem, 2006 PubMed Europe PMC
  119. Scalabrino G, Peracchi M; ''New insights into the pathophysiology of cobalamin deficiency.''; Trends Mol Med, 2006 PubMed Europe PMC
  120. Verkleij-Hagoort AC, van Driel LM, Lindemans J, Isaacs A, Steegers EA, Helbing WA, Uitterlinden AG, Steegers-Theunissen RP; ''Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study.''; Mol Genet Metab, 2008 PubMed Europe PMC
  121. Correa-Cerro LS, Porter FD; ''3beta-hydroxysterol Delta7-reductase and the Smith-Lemli-Opitz syndrome.''; Mol Genet Metab, 2005 PubMed Europe PMC
  122. Huijghebaert SM, Hofmann AF; ''Influence of the amino acid moiety on deconjugation of bile acid amidates by cholylglycine hydrolase or human fecal cultures.''; J Lipid Res, 1986 PubMed Europe PMC
  123. Riedel B, Fiskerstrand T, Refsum H, Ueland PM; ''Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase.''; Biochem J, 1999 PubMed Europe PMC
  124. Cheng JB, Jacquemin E, Gerhardt M, Nazer H, Cresteil D, Heubi JE, Setchell KD, Russell DW; ''Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.''; J Clin Endocrinol Metab, 2003 PubMed Europe PMC
  125. Gordon MM, Brada N, Remacha A, Badell I, del Río E, Baiget M, Santer R, Quadros EV, Rothenberg SP, Alpers DH; ''A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency.''; Hum Mutat, 2004 PubMed Europe PMC
  126. Gaughan DJ, Kluijtmans LA, Barbaux S, McMaster D, Young IS, Yarnell JW, Evans A, Whitehead AS; ''The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations.''; Atherosclerosis, 2001 PubMed Europe PMC
  127. Kim YI; ''Role of the MTHFR polymorphisms in cancer risk modification and treatment.''; Future Oncol, 2009 PubMed Europe PMC
  128. Krishnaveni GV, Hill JC, Veena SR, Bhat DS, Wills AK, Karat CL, Yajnik CS, Fall CH; ''Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes.''; Diabetologia, 2009 PubMed Europe PMC
  129. Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J; ''Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.''; Cell Immunol, 2007 PubMed Europe PMC
  130. Cipollone F, Cicolini G, Bucci M; ''Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.''; Pharmacol Ther, 2008 PubMed Europe PMC
  131. Pyne S, Pyne NJ; ''Sphingosine 1-phosphate signalling in mammalian cells.''; Biochem J, 2000 PubMed Europe PMC
  132. Yun J, Kim JY, Kim OY, Jang Y, Chae JS, Kwak JH, Lim HH, Park HY, Lee SH, Lee JH; ''Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men.''; Nutr Metab Cardiovasc Dis, 2009 PubMed Europe PMC
  133. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.''; Circulation, 2000 PubMed Europe PMC
  134. Sneddon AA, Wu HC, Farquharson A, Grant I, Arthur JR, Rotondo D, Choe SN, Wahle KW; ''Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants.''; Atherosclerosis, 2003 PubMed Europe PMC
  135. Bose R, Kolesnick R; ''Measurement of ceramide synthase activity.''; Methods Enzymol, 2000 PubMed Europe PMC
  136. Zhai XY, Nielsen R, Birn H, Drumm K, Mildenberger S, Freudinger R, Moestrup SK, Verroust PJ, Christensen EI, Gekle M; ''Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.''; Kidney Int, 2000 PubMed Europe PMC
  137. Watanabe F, Oki Y, Nakano Y, Kitaoka S; ''Occurrence and characterization of cyanocobalamin reductase (NADPH; CN-eliminating) involved in decyanation of cyanocobalamin in Euglena gracilis.''; J Nutr Sci Vitaminol (Tokyo), 1988 PubMed Europe PMC
  138. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.''; J Immunol, 1991 PubMed Europe PMC
  139. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.''; Am J Clin Nutr, 2009 PubMed Europe PMC
  140. Kypreos KE, van Dijk KW, van Der Zee A, Havekes LM, Zannis VI; ''Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion.''; J Biol Chem, 2001 PubMed Europe PMC
  141. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  142. Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA; ''Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.''; J Am Diet Assoc, 2009 PubMed Europe PMC
  143. Häberle J, Pauli S, Berning C, Koch HG, Linnebank M; ''TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations.''; J Hum Genet, 2009 PubMed Europe PMC
  144. van der Westhuyzen DR, Cai L, de Beer MC, de Beer FC; ''Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.''; J Biol Chem, 2005 PubMed Europe PMC
  145. Salem N Jr, Pawlosky R, Wegher B, Hibbeln J; ''In vivo conversion of linoleic acid to arachidonic acid in human adults.''; Prostaglandins Leukot Essent Fatty Acids, 1999 PubMed Europe PMC
  146. Refsum H, Johnston C, Guttormsen AB, Nexo E; ''Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults.''; Clin Chem, 2006 PubMed Europe PMC
  147. Gao Y, Hannan NR, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, Jowett JB, Kim KH, Walder K, Collier GR; ''Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.''; Cytokine, 2006 PubMed Europe PMC
  148. Ganji V, Kafai MR; ''Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994.''; Am J Clin Nutr, 2003 PubMed Europe PMC
  149. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ; ''Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.''; Am J Hum Genet, 2001 PubMed Europe PMC
  150. Peters-Golden M, Brock TG; ''5-lipoxygenase and FLAP.''; Prostaglandins Leukot Essent Fatty Acids, 2003 PubMed Europe PMC
  151. Burk RF, Hill KE, Motley AK; ''Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P.''; J Nutr, 2003 PubMed Europe PMC
  152. Joensen AM, Schmidt EB, Dethlefsen C, Johnsen SP, Tjønneland A, Rasmussen LH, Overvad K; ''Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.''; Br J Nutr, 2009 PubMed Europe PMC
  153. Basu S; ''F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  154. Stoffel W, LeKim D, Sticht G; ''Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one).''; Hoppe Seylers Z Physiol Chem, 1968 PubMed Europe PMC
  155. Erickson SK, Bösterling B; ''Cholesterol 7 alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles.''; J Lipid Res, 1981 PubMed Europe PMC
  156. Ho TC, Chen SL, Yang YC, Chen CY, Feng FP, Hsieh JW, Cheng HC, Tsao YP; ''15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.''; J Biol Chem, 2008 PubMed Europe PMC
  157. Kimura T, Nakanishi K, Nakagawa T, Shibukawa A, Matsuzaki K; ''Simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection.''; J Pharm Biomed Anal, 2005 PubMed Europe PMC
  158. Labunskyy VM, Hatfield DL, Gladyshev VN; ''The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.''; IUBMB Life, 2007 PubMed Europe PMC
  159. Sniderman AD; ''How, when, and why to use apolipoprotein B in clinical practice.''; Am J Cardiol, 2002 PubMed Europe PMC
  160. Wang LH, Kulmacz RJ; ''Thromboxane synthase: structure and function of protein and gene.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC
  161. Johnson MR, Barnes S, Diasio RB; ''Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.''; Anal Biochem, 1989 PubMed Europe PMC
  162. Skacel N, Menon LG, Mishra PJ, Peters R, Banerjee D, Bertino JR, Abali EE; ''Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.''; J Biol Chem, 2005 PubMed Europe PMC
  163. Liu YY, Han TY, Giuliano AE, Cabot MC; ''Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.''; J Biol Chem, 1999 PubMed Europe PMC
  164. Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W; ''Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study.''; Eur J Clin Nutr, 2008 PubMed Europe PMC
  165. Cali JJ, Russell DW; ''Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.''; J Biol Chem, 1991 PubMed Europe PMC
  166. Bosschaerts T, Guilliams M, Noel W, Hérin M, Burk RF, Hill KE, Brys L, Raes G, Ghassabeh GH, De Baetselier P, Beschin A; ''Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.''; J Immunol, 2008 PubMed Europe PMC
  167. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN; ''Characterization of mammalian selenoproteomes.''; Science, 2003 PubMed Europe PMC
  168. Chanarin I; ''Cobalamins and nitrous oxide: a review.''; J Clin Pathol, 1980 PubMed Europe PMC
  169. Guimarães MJ, Peterson D, Vicari A, Cocks BG, Copeland NG, Gilbert DJ, Jenkins NA, Ferrick DA, Kastelein RA, Bazan JF, Zlotnik A; ''Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC
  170. Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo J Jr; ''Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy.''; Biol Trace Elem Res, 2008 PubMed Europe PMC
  171. Shigenaga MK, Gimeno CJ, Ames BN; ''Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.''; Proc Natl Acad Sci U S A, 1989 PubMed Europe PMC
  172. Lööf L, Wengle B; ''Enzymatic sulphation of bile salts in human liver.''; Biochim Biophys Acta, 1978 PubMed Europe PMC
  173. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, Harrison DG, Fukai T; ''Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.''; Arterioscler Thromb Vasc Biol, 2002 PubMed Europe PMC
  174. Lewis GF, Rader DJ; ''New insights into the regulation of HDL metabolism and reverse cholesterol transport.''; Circ Res, 2005 PubMed Europe PMC
  175. Maccarrone M, Meloni C, Manca-di-Villahermosa S, Cococcetta N, Casciani CU, Finazzi-Agrò A, Taccone-Gallucci M; ''Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route.''; Am J Kidney Dis, 2001 PubMed Europe PMC
  176. Aksoy E, Vanden Berghe W, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M, Willems F; ''Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.''; Eur J Immunol, 2005 PubMed Europe PMC
  177. Bailey SW, Ayling JE; ''The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC
  178. Fernandes-Costa F, Metz J; ''Vitamin B12 binders (transcobalamins) in serum.''; Crit Rev Clin Lab Sci., 1982 PubMed Europe PMC
  179. Schwarz M, Wright AC, Davis DL, Nazer H, Björkhem I, Russell DW; ''The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.''; J Clin Invest, 2000 PubMed Europe PMC
  180. Abu Khaled M, Watkins CL, Krumdieck CL; ''Inactivation of B12 and folate coenzymes by butyl nitrite as observed by NMR: implications on one-carbon transfer mechanism.''; Biochem Biophys Res Commun, 1986 PubMed Europe PMC
  181. Giera M, Renard D, Plössl F, Bracher F; ''Lathosterol side chain amides: a new class of human lathosterol oxidase inhibitors.''; Steroids, 2008 PubMed