IL-3 Signaling Pathway (Rattus norvegicus)

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PhosphorylationMethylationExtracellularDMACY->NUDeacetylationMAReaction through unknown mechanisms/moleculesGODInhibitionDEnzyme complexProteolytic cleavageLigandNucleusDephosphorylationMAMolecular AssociationGolgi apparatusENCY->PMDGlycosylationDCY->NUDPMDDPlasma membranePalmitoylationDesumoylationNUEndoplasmic reticulumCYDeubiquitinationSumoylationMAMolecule in the pathwayMitochondrionCY->PMMAAutophosphorylationReceptorMT->CYControl(Protein-protein interaction)MAProteins in a complex interactionMTRecruitmentDUbiquitinationDDAccession Number: NetPath 15DCY->PMDDDDCytoplasmDERActivationEndosomeDemethylationDDAcetylationTranslocationECChek1Rac1Atf2HckBcl2l1CishSykPpp2caSlc2a1Slc2a1YWHAQGnb2l1Mapkapk2YwhabBcl2Nfkb1Mapk14RPS6KB2Vav1RaraPak1SelpJak1Gata1PILRBMapk8IL3KrasCsf2rbIl3raIL3Sfpi1RxraSrcHrasInpp5dFynFcer2IL3MrasMatkGsk3aLckMmp9BadGene SymbolYwhazRac2CrkJak2CDC42Kcnip3IL3Stat6Pik3r2Bcl2l11Rap1aBmxMapk1Ptpn11Akt1Stat5bBadGab2Gata2CblGab1PrkcbCrklDnm1Stat1Map2k1BIRC5Stat3LynRAPGEF1Mapk3Pik3cdFesPtk2Shc1PrkacaGrb2TYK2VclFoxo1Stat5aMmp2Gsk3bMAPK7Nfkb1PrkcaSocs2Mapk9TecId1Creb1Raf1Mapk3PrkcaPxnAtf1Sos1PIK3CACsf2rbIl3raPtpn6Socs3Hspb1Shc1Tnfrsf1bPik3r1Bax


Description

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15

Comments

GenMAPP notes 
NetPath:15 - IL-3 Signaling Pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP286(r21281) with a 87% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69359view18:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
67375view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-3 signaling pathway' added !
41672view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
35790view06:54, 13 February 2010MaintBotAdded description
34064view19:07, 9 December 2009MaintBotAutomatic update of empty xrefs
31430view21:01, 13 August 2009MaintBotFixed text labels
30976view00:51, 30 July 2009MaintBotConverted from Homo sapiens
21351view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:IL-3 NetPath 15]] moved to [[Pathway:WP319]]: Moved to stable identifier
8174view13:46, 7 January 2008MaintBot[[Pathway:Rat:IL-3 NetPath 15]] moved to [[Pathway:Rattus norvegicus:IL-3 NetPath 15]]: Renaming species
7707view16:11, 18 December 2007MaintBotfixed category names
7246view12:41, 4 November 2007MaintBotAdded categories to GPML
6560view22:20, 22 May 2007A.Pandeygpml file for [[Rat:IL-3_NetPath_15]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
Atf1GeneProduct315305 (Entrez Gene)
Atf2GeneProduct81647 (Entrez Gene)
BIRC5GeneProduct64041 (Entrez Gene)
BadGeneProduct64639 (Entrez Gene)
BaxGeneProduct24887 (Entrez Gene)
Bcl2GeneProduct24224 (Entrez Gene)
Bcl2l11GeneProduct64547 (Entrez Gene)
Bcl2l1GeneProduct24888 (Entrez Gene)
BmxGeneProduct367786 (Entrez Gene)
CDC42GeneProduct64465 (Entrez Gene)
CblGeneProduct500985 (Entrez Gene)
Chek1GeneProduct140583 (Entrez Gene)
CishGeneProduct83681 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
CrkGeneProduct54245 (Entrez Gene)
CrklGeneProduct287942 (Entrez Gene)
Csf2rbGeneProduct171081 (Entrez Gene)
Dnm1GeneProduct140694 (Entrez Gene)
Fcer2GeneProduct171075 (Entrez Gene)
FesGeneProduct361597 (Entrez Gene)
Foxo1GeneProduct84482 (Entrez Gene)
FynGeneProduct25150 (Entrez Gene)
Gab1GeneProduct361388 (Entrez Gene)
Gab2GeneProduct84477 (Entrez Gene)
Gata1GeneProduct25172 (Entrez Gene)
Gata2GeneProduct25159 (Entrez Gene)
Gene SymbolGeneProduct
Gnb2l1GeneProduct83427 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Gsk3aGeneProduct50686 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
HckGeneProduct25734 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
Hspb1GeneProduct24471 (Entrez Gene)
IL3GeneProduct24495 (Entrez Gene)
Id1GeneProduct25261 (Entrez Gene)
Il3raGeneProduct246144 (Entrez Gene)
Inpp5dGeneProduct54259 (Entrez Gene)
Jak1GeneProduct84598 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
Kcnip3GeneProduct65199 (Entrez Gene)
KrasGeneProduct24525 (Entrez Gene)
LckGeneProduct313050 (Entrez Gene)
LynGeneProduct81515 (Entrez Gene)
MAPK7GeneProduct114509 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
Mapkapk2GeneProduct289014 (Entrez Gene)
MatkGeneProduct60450 (Entrez Gene)
Mmp2GeneProduct81686 (Entrez Gene)
Mmp9GeneProduct81687 (Entrez Gene)
MrasGeneProduct25482 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
PIK3CAGeneProduct170911 (Entrez Gene)
PILRBGeneProduct288554 (Entrez Gene)
Pak1GeneProduct29431 (Entrez Gene)
Pik3cdGeneProduct366508 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Ppp2caGeneProduct24672 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
Ptk2GeneProduct25614 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
Ptpn6GeneProduct116689 (Entrez Gene)
PxnGeneProduct360820 (Entrez Gene)
RAPGEF1GeneProduct63881 (Entrez Gene)
RPS6KB2GeneProduct361696 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene)
Rac2GeneProduct366957 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
Rap1aGeneProduct295347 (Entrez Gene)
RaraGeneProduct24705 (Entrez Gene)
RxraGeneProduct25271 (Entrez Gene)
SelpGeneProduct25651 (Entrez Gene)
Sfpi1GeneProduct366126 (Entrez Gene)
Shc1GeneProduct85385 (Entrez Gene)
Slc2a1GeneProduct24778 (Entrez Gene)
Socs2GeneProduct84607 (Entrez Gene)
Socs3GeneProduct89829 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
Stat6GeneProduct362896 (Entrez Gene)
SykGeneProduct25155 (Entrez Gene)
TYK2GeneProduct298706 (Entrez Gene)
TecGeneProduct84492 (Entrez Gene)
Tnfrsf1bGeneProduct156767 (Entrez Gene)
Vav1GeneProduct25156 (Entrez Gene)
VclGeneProduct305679 (Entrez Gene)
YWHAQGeneProduct25577 (Entrez Gene)
YwhabGeneProduct56011 (Entrez Gene)
YwhazGeneProduct25578 (Entrez Gene)

Annotated Interactions

No annotated interactions
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