Eicosanoid Synthesis (Mus musculus)

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16-Keto-Prostaglandin F2-alphaThromboxane A3Prostaglandin E2Cell Membrane15-Hydroperoxy Eicosatetraenoic Acid12-Hydroperoxy Eicosatetraenoic AcidPeroxidase?5-HPETELeukotriene A4Prostaglandin H212-HETEPtgs2Lta4hAlox155-HETEArachidonic acidPtgdsAlox8Pnpla8Prostaglandin I2Leukotriene C4Alox12Ltc4sThromboxane B2Thromboxane A2Alox15Peroxidase?Pla2g6Alox5Alox5apPtges2Prostaglandin D2Tbxas1PtgesAlox5apPla2g2aProstaglandin F2aGgt1PGD2 11-ketoreducPGE2 9-ketoreducDpep1Leukotriene B4Pla2g6Ptgs1Leukotriene D4Peroxidase?Alox5Leukotriene E415-HETEPtgis


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 70% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106877view13:35, 17 September 2019MaintBotHMDB identifier normalization
89525view11:03, 16 September 2016Mkutmonontology tag fix
89477view13:39, 15 September 2016Mkutmonremove space from ontology term id
71719view20:16, 17 October 2013MaintBotAutomated update of data sources
71313view17:15, 17 October 2013MaintBotAutomated update of data sources
69076view18:09, 8 July 2013MaintBotUpdated to 2013 gpml schema
67186view10:18, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62829view04:44, 3 May 2013MaintBotUpdated UniProt data source
41263view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35469view12:08, 12 February 2010ThomasModified description
35468view12:08, 12 February 2010Thomasadded literature
34376view22:44, 9 December 2009MaintBotAutomatic update of empty xrefs
32690view23:04, 31 August 2009Khanspersupdated xrefs
32047view13:30, 14 August 2009MaintBotFixed group labels
30816view23:56, 29 July 2009MaintBotConverted from Homo sapiens
21349view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:Eicosanoid Synthesis]] moved to [[Pathway:WP318]]: Moved to stable identifier
8004view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Eicosanoid Synthesis]] moved to [[Pathway:Mus musculus:Eicosanoid Synthesis]]: Renaming species
7625view16:05, 18 December 2007MaintBotfixed category names
7338view12:42, 4 November 2007MaintBotAdded categories to GPML
6434view22:18, 22 May 2007A.Kwagpml file for [[Mouse:Eicosanoid_Synthesis]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite70608-72-9 (CAS)
5-HPETEMetaboliteHMDB0001193 (HMDB)
Alox12GeneProduct11684 (Entrez Gene)
Alox15GeneProduct11687 (Entrez Gene)
Alox5GeneProduct11689 (Entrez Gene)
Alox5apGeneProduct11690 (Entrez Gene)
Alox8GeneProduct11688 (Entrez Gene)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
Dpep1GeneProduct13479 (Entrez Gene)
Ggt1GeneProduct14598 (Entrez Gene)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
Lta4hGeneProduct16993 (Entrez Gene)
Ltc4sGeneProduct17001 (Entrez Gene)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
Peroxidase?GeneProduct
Pla2g2aGeneProduct18780 (Entrez Gene)
Pla2g6GeneProduct53357 (Entrez Gene)
Pnpla8GeneProduct67452 (Entrez Gene)
Prostaglandin D2MetaboliteHMDB0001403 (HMDB)
Prostaglandin F2aMetaboliteHMDB0001139 (HMDB)
Prostaglandin H2MetaboliteHMDB0001381 (HMDB)
Prostaglandin I2MetaboliteHMDB0001335 (HMDB)
PtgdsGeneProduct19215 (Entrez Gene)
Ptges2GeneProduct96979 (Entrez Gene)
PtgesGeneProduct64292 (Entrez Gene)
PtgisGeneProduct19223 (Entrez Gene)
Ptgs1GeneProduct19224 (Entrez Gene)
Ptgs2GeneProduct19225 (Entrez Gene)
Tbxas1GeneProduct21391 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)

Annotated Interactions

No annotated interactions
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