IL1 and megakaryotyces in obesity (Bos taurus)

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1Increased adhesionIncreased ploidyTranscripts increased in mouse data(Human homologs)Platelets with increased inflammatoryand thrombotic transcriptsHigh Fat DietTranscripts increased inFramingham Heart Studyp38/MAPK pathwayIL1R1F2RICAM1IL1BTIMP2SELENBP1MMP9PLA2G7IRAK1TLR1IL18MYD88TIMP1CCR3PIK3CANLRP3FCER1AMYD88F2IFNGS100A9HBEGFCCL2TLR2ERKpathwayMMP9Active integrinsPlateletWhite Blood CellAdhesionAggregationHeterotypic AggregateFormationMegakaryocyteIL1R1NFKB1IL1BIL1R1


Description

Schematic of the effects of interleukin (IL)1-beta/IL1R1 on megakaryocyte and platelet function. A high fat diet will cause megakaryocytes to produce platelets with an increase in both inflammatory and thrombotic genes.

IL1-beta in circulation as a result of increased body weight will bind IL1R1 on megakaryocytes. This interaction leads to the activation of the nuclear factor (NF)kB, PI3K/Akt, and mitogen activated protein kinase (MAPK) (ERK and p38) pathways. As a result, there is an increase in megakarycoyte maturation, including increased adhesion, increases in ploidy, and increases in mRNA production of inflammatory and thrombotic genes. IL1-beta can also bind IL1R1 on platelets and either enhance aggregation induced by agonists or promote adhesion and heterotypic aggregate formation.

Some of the data used to create the pathway was generated in mouse (noted in pathway), however the pathway represents human homologs of those genes.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2865(78483) with a 96.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE; ''Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.''; Arterioscler Thromb Vasc Biol, 2014 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
88663view15:22, 12 August 2016JmeliusOntology Term : 'obesity disease pathway' added !
80728view15:23, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCL2GeneProductENSBTAG00000037811 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6347
CCR3GeneProductENSBTAG00000001338 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1232
ERK pathwayPathway
F2GeneProductENSBTAG00000007148 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2147
F2RGeneProductENSBTAG00000020199 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2149
FCER1AGeneProductENSBTAG00000012887 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2205
HBEGFGeneProductENSBTAG00000021766 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1839
ICAM1GeneProductENSBTAG00000010303 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3383
IFNGGeneProductENSBTAG00000012529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
IL18GeneProductENSBTAG00000000277 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3606
IL1BGeneProductENSBTAG00000001321 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL1R1GeneProductENSBTAG00000005273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554
IRAK1GeneProductENSBTAG00000016085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3654
MMP9GeneProductENSBTAG00000020676 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4318
MYD88GeneProductENSBTAG00000000563 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4615
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NLRP3GeneProductENSBTAG00000001273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114548
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PLA2G7GeneProductENSBTAG00000019315 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7941
S100A9GeneProductENSBTAG00000006505 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6280
SELENBP1GeneProductENSBTAG00000008091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8991
TIMP1GeneProductENSBTAG00000005043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7076
TIMP2GeneProductENSBTAG00000010899 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7077
TLR1GeneProduct
TLR2GeneProductENSBTAG00000008008 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7097
p38/MAPK pathwayPathwayWP400 (WikiPathways)

Annotated Interactions

No annotated interactions
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