Fas ligand pathway and stress induction of heat shock proteins (Homo sapiens)

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Cytoplasm12LegendROSMitochondria PathwayActinNFK-B PathwayCell SurvivalStressNecrosisApoptosomeProteasomeNucleusSelf-activationExtracellularInhibitionActivate3x-P3x-PFAS PathwayStress Induction of HSP regulationCut3x-PDNA presentationMAP3K1MAPKAPK2DFFBPhosphateCeramideDAXXLMNB1HSPB1FADDMAPK8APAF1DFFBCASP8HSPB1APAF1FASPhosphateCASP9JUNSPTAN1CASP10CASP3CASP3LMNB2GlutathioneFAP1DFFALMNAMAP3K7HSPB1CASP7PhosphateCYCSMIR34CDAXXHSPB1IL1APARP1CASP6HSPB1MAP2K4FAF1HSPB1PAK1MAPKAPK3CFLARRIPK2ARHGDIBApoptosisFAF1ACTA1PhosphateHSPB1HSPB1RB1PRKDCPhosphateTNFBCL2PhosphateCASP8PAK2PhosphatePhosphateFASLGACTBACTG1


This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress.

More info: BioCarta.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000 PubMed Europe PMC Scholia
  2. Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, Xu L; ''Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres.''; BMC Cancer, 2008 PubMed Europe PMC Scholia


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121827view07:27, 7 March 2022EgonwMade a pathway clickable
116694view15:33, 9 May 2021EweitzModified title
109375view15:04, 16 March 2020L DupuisRemoved graphical line under cell membrane
106414view21:58, 28 August 2019KhanspersModified description
106186view12:08, 16 August 2019MaintBotHMDB identifier normalization
105594view04:47, 10 August 2019KhanspersModified description
94814view02:30, 6 October 2017Khanspersremoved old GenMAPP comments
94813view02:29, 6 October 2017Khanspersconnected interactions and updated layout
87381view11:05, 22 July 2016MaintBotadded missing graphids
86072view08:43, 29 June 2016MirellaKalafatiModified title
80438view20:50, 22 June 2015KhanspersReverted to version '00:30, 2 May 2015' by Khanspers
80436view20:43, 22 June 2015Khanspersfixed unconnected edges
80435view20:41, 22 June 2015KhanspersAdded mir21 targeting of FASLG
80039view00:30, 2 May 2015KhanspersAdded MIR34C
79967view15:22, 28 April 2015ZariAnnotated Actin and FAP1
71366view18:37, 17 October 2013MaintBotAutomated update of data sources
68923view17:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67221view10:22, 26 June 2013Christine ChichesterOntology Term : 'FasL mediated signaling pathway' added !
45253view18:39, 7 October 2011AlexanderPicoOntology Term : 'stress response pathway' added !
41070view23:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
38813view08:54, 24 September 2010Jildaucompartments
38672view14:59, 23 September 2010Bassetfrogadded pathway link
38234view21:13, 27 August 2010KhanspersRemoved receptor and protein complex graphics
35551view14:57, 12 February 2010Thomasadded literature
35550view14:56, 12 February 2010ThomasModified description
35549view14:54, 12 February 2010ThomasModified description
34453view18:23, 10 December 2009MaintBotAutomatic update of empty xrefs
32396view17:00, 15 August 2009MaintBotFixed text labels
32044view13:29, 14 August 2009MaintBotFixed group labels
21341view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:WP314]]: Moved to stable identifier
15405view23:05, 27 May 2008Khanspersconnectors
14467view23:47, 22 May 2008KhanspersAdded connectors, groups, metabolites
14465view23:45, 22 May 2008KhanspersPeriodical save, work in progress
14461view23:35, 22 May 2008KhanspersPeriodical save, work in progress
14455view23:24, 22 May 2008KhanspersAdded connectors
14453view23:23, 22 May 2008KhanspersPeriodical save, work in progress
14451view23:13, 22 May 2008KhanspersPeriodical save, work in progress
13064view11:12, 17 May 2008MaintBotautomated metabolite conversion
13020view11:06, 17 May 2008MaintBotSticky edges patch by Sjoerd
8016view13:46, 7 January 2008MaintBot[[Pathway:Human:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:Homo sapiens:Fas Pathway and Stress Induction of HSP Regulation Biocarta]]: Renaming species
7631view16:06, 18 December 2007MaintBotfixed category names
7219view12:41, 4 November 2007MaintBotAdded categories to GPML
6312view22:17, 22 May 2007169.230.77.174gpml file for [[Human:Fas_Pathway_and_Stress_Induction_of_HSP_Regulation_Biocarta]]

External references


View all...
NameTypeDatabase referenceComment
ACTA1GeneProduct58 (Entrez Gene)
ACTBGeneProduct60 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
APAF1GeneProduct317 (Entrez Gene)
ARHGDIBGeneProduct397 (Entrez Gene) Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
ApoptosisPathwayWP254 (WikiPathways)
BCL2GeneProduct596 (Entrez Gene)
CASP10GeneProduct843 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP6GeneProduct839 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP8GeneProduct841 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CFLARGeneProduct8837 (Entrez Gene)
CYCSGeneProduct54205 (Entrez Gene)
CeramideMetabolite104404-17-3 (CAS)
DAXXGeneProduct1616 (Entrez Gene)
DFFAGeneProduct1676 (Entrez Gene)
DFFBGeneProduct1677 (Entrez Gene)
FADDGeneProduct8772 (Entrez Gene)
FAF1GeneProduct11124 (Entrez Gene)
FAP1GeneProduct4799 (Entrez Gene)
FASGeneProduct355 (Entrez Gene)
FASLGGeneProduct356 (Entrez Gene)
GlutathioneMetaboliteHMDB0000125 (HMDB)
HSPB1GeneProduct3315 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LMNAGeneProduct4000 (Entrez Gene)
LMNB1GeneProduct4001 (Entrez Gene)
LMNB2GeneProduct84823 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
MAPKAPK3GeneProduct7867 (Entrez Gene)
MIR34CRnaENSG00000207562 (Ensembl)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PARP1GeneProduct142 (Entrez Gene)
PRKDCGeneProduct5591 (Entrez Gene)
PhosphateMetaboliteHMDB0001429 (HMDB)
RB1GeneProduct5925 (Entrez Gene)
RIPK2GeneProduct8767 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 2
SPTAN1GeneProduct6709 (Entrez Gene) Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TNFGeneProduct7124 (Entrez Gene)

Annotated Interactions

No annotated interactions

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