mRNA processing (Mus musculus)

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exon 1SR-proteinsAccessory Proteinsexon 1U1 snRNP35(3)3CAexon 1CstF5SR-binding sitesSR protein phosphatasesPrimary RNA transcriptintron35CstFPutative Alternative SplicingPoly(A) polymerase alphaGUCF IImRNA 3’-end processingU4:U5:U6 tri-snRNP complexU1 snRNPPFormation of the Spliceosomal B complex355SR-phosphatasesKinases Phosphorylating RS domains?3U5hnRNP regulatorsmRNA splicing (major pathway)YYYYexon 2Gene Ontology: RNA BindingsnRNP Sm core complexInterPro Domain Containing:Formation of the Spliceosomal E complexdegradedexon 2U1ATPFormation of the Spliceosomal C complexU2AFexon 2mRNA CappingMisc.CFI(2)Formation of the Spliceosomal B complexAdditional FactorsLariat Formation and 5’-Splice Site Cleavage3YYYY(1)Rnmt (methyltransferase)RNA helicaseNote: New participating members shown at each stepInternal methylation of mRNAAdditional FactorsSerine/Argenine Rich Proteins(SR)mRNA splice site selectioniPoYYYYSR-proteins53YYYYRegulation ofmRNA polyadenylationRegulatorsAGSR-binding sitesCF IAGAGGMPAdditional FactorsU555YYYYCF IIAGU2AFU2 snRNPs5SR protein kinasesFormation of the Spliceosomal E complexexon 1Processing of Intron-Containing Pre-mRNAU6 snRNPASR-kinasesPoly(A) polmRNA capping(2c)55Rngtt (capping enzyme)SR-repressor proteinssnRNP Sm core complex(2a)Spt5U4/U6Internal methylation of mRNAFormation of pre-mRNPsU2YYYYU6(2b)Cleavage at the 3’-Splice-Site and Exon LigationAAAAAAAheterogeneous nuclear ribonucleoproteinsright click on blue text for detailed informationAFormation of pre-mRNPsSF3b14bsplicing factor SF3AFormation of the Spliceosomal A complexCPSFFormation of the Spliceosomal A complexAdditional SR proteinssplicing factor SF3B3AP-RNA helicase Asplicesome associated helicasesMethylation of mRNAUGexon 2U2 snRNPAlternative SplicingU4 snRNPAGRNA-binding region RNP-1 (RNA recognition motif)RNAi pathway3exon 2Cap BindingAAUAAApre-mRNA3Cleavage of mRNA at the 3’-endexon 1AGU4Poly(A)pb IIexon 153U2 snRNPA365UGexon 2Pi5 G capCPSFPolr2asnRNP Sm core complexPoly(A)-binding protein IIFormation of the active Spliceosomal C complexSR-proteinsAhnRNPsAU5 snRNPTdrd7ZfmlA130095G20RikTiaf1Adam5AW049977Snrpd3Cova1Tnrc4Rpl37Eif4a20610033I05RikRnu1b1Sf3b2G430095G15RikRbm31yAI255219Sca1AI255215Prpf8AdarFusip1Mettl3PrkrCdc40Oas1gFnbp3Sfrs7D330023I21RikDdx5Prpf8Htatsf13110061K15RikNpm13830425H19RikRpl26Sfrs1Prpf18Rpl7Lsm7AW107884CirbpPcolceExosc9Dnajc8D830027H13RikRnu2AI2552121700095D18RikMrpl23SsbSecisbp24930562C03RikBrca1Rod1HnrpmRps6Srp68Ddx24Uhmk15730557B15RikIlf3Rbm28AI043106Pabpn1SfpqNcbp2Pcbp1Cugbp2Trim21Rps24Hnrph15730555F13RikPhf5aRnps11110037F02Rik2010300K22RikCpsf3Clk21810036A22RikDdx39Sfrs2TertCd2bp2Rbms2Dhx8Igf2bp3Sf3a3Ppm1gRbm8a2400002F11RikPRP17_MOUSEZfp622Smn1Eif4g3SnrpgExosc4U2af1-rs1Snrpd22410104I19RikPark7Sfrs10RalyPpp1r14bSrrm1Wbp4RbmxrtAI256346C80672B230118G17RikDhx38Rbm18Col4a3D3Jfr1Rnmtl1Lsm12810055E05RikDdx19bRnu1b6D230005D02RikPoldip34932702K14RikSfrs31700012H05RikSyncripDdx25Stau1PapolaC230097K14Rik2310046H11Rik4922503N01RikElavl4Ppargc1bRpl9Rnpc1Nhp2l1Rbm141300006N24RikThoc4Sf3b1Pum1Srp14Ptbp1Rbmx2Sfrs64930506D01RikDdx56Adat1Pcbp2Cstf2tRbm4Prpf3SonFxr1hSpopDdx1C85084Sf3b5Nufip1Rbm30710005M24RikSynj2Eif3s4Rbm9Afg3l2Pabpc4Rbm17Zfp346AW260507Rnaseh2aTraf6Nsep1Ptbp2FusDazap1Xrn2Rad21RbmxMyef2Sfrs5HnrpdSfrs8Nsap1l-pendingSnrpnSlc25a49630048M01RikRbm113100004P22RikEif4g2D12Mgi40Sfrs12AA407033Rbm5AI255750AI467299Tia1AU045931Tlr5Ciz11700009P03RikTarbp23200001K10RikSfrs16Rbms1Matr3-ps1Hrmt1l2Hnrpa0AI194270Refbp2Snrpa1Snrpd1Dicer1Rpl12Rnu1b1D5Ertd700e1700047G05RikBollDdx3x2610102M01RikRps13Snrp70Supt5hMGI:2661424Oas1bRbmxrtRps14D1Pas1-rs16720478K01RikTnrc6cRnpc24930565A21RikSbno12410013L13RikD11Ertd730eRbed1HdpRnu1a2Srp54Papolg2600016C11RikRpl39Eif3s9Akap1Rnu1b2Hnrph2SnrpaSf3a2Clk3SnrpeMGI:13368801810036E18RikC797834930554P13RikBclaf1Fmr1Srpk1Clk14930534J06RikAco1IlkapMrpl11CsadRbm7AI843301D15Ertd119e1110033J19RikOas2Rpl82410112D09RikBB131279Afg3l1Prpf4Matr32810028N01RikRbm17Cstf3Sfrs4Lsm8Rbm16Slc6a8AI255840AI255230Cstf1Rbmy1a1Rpl38Rpl192010003O18RikV1rc175730557H03Rik2610101N10RikImp4Cpsf4Elavl2Tial1Srp9Htf9cAI6420808030431D03RikD12Mgi43DazlAA589495MGI:1926224Pskh1Hnrpr2210008M09RikTsnDdx6Nhp2l1Rbm12Pcbp4Cpeb42610031L17RikPspc1Srpk2Rbm10Zmat22810036M01RikWdr551190005F20RikSfrs10Hrmt1l1Brunol4Rps23Mrps28U2af1-rs24930422M05Rik1190002L16Rik1700003D06RikRnu1a12810411C16RikHnrpabU5 snRNANhp2l1BC013481RdbpSfrs11HnrplPpie2610023M21Rik2700077B20Rik0610009D07RikLrrn6aHnrpuRps28MGI:1351465Msi1hD9Mgi24Ssa2Hnrpa1Clk4RbpmsSf3b3Cpeb1Rnpepl1AL022933Acin1Ddx20Prpf4bSRrp40Sf4Prpf4C330027G06RikTenrH2-BfAI255183AA522010Rbm15bZbp1G3bp2-pendingExosc52700028P07RikMsi2hCstf2AI447568Pum2Ppp1r8Rnu108Ddx48TardbpAU0230066330548G22RikU2af2Rnu6Rps11HnrpcSf3b4Sfrs11Adarb2AuhBicc1Exosc75031411E02Rik1500011J06RikRngttSpenAI2558474921506I22RikRnu11Nxf71110034O07RikPolr2gRps4xAI504630Sfrs14Polr2aAI314192Oas3RnmtMatr3-ps25330419I02RikMbnl1Igf2bp1Rae1Snrpb2Lsm2Ddx41Cpsf22410003C20RikCdk9MGI:23873679130414A06RikTmed10Rpl22B230333C21RikFxr2h4930429A22RikRbm21Eral11110017C15RikRnu2Rpp14Srp19Cyp4f18Taf151200009B18RikPpil4Ddx44632417O19RikEif4eGrsf1Snrp1cDhx15Scye1Dhx9HnrpdlPrpf18Rnu12Ddx19aU4 snRNASmc1l1Brunol6QkRbms3HnrpkRps292610027L16RikSnrpf2610020N02RikRbm19Rad52bRnu1a1Nxf1Safb2Lsm43000004N20RikRps27AI4624382600011C06RikCstf2t1700025B16RikCnot4Elavl1RnaselBard1SlbpHnrpf2610209F03RikWdr92610024A01RikAI255207Ppargc1aLsm2Hnrpa3D19Bwg1357eRnpepPabpc55730453I16Rik0610009J05RikEwsr1Ggcx0610009C03RikAbcb4Hnrpll9430070C08RikWbscr1Mki67ipD1Pas1AI844780Lsm11LgtnDdx21Cpeb34932422M17RikNhp2l1U2af1Dhx16Exosc8Dnd1Cugbp1Sart3Rps7NonoAI503051Papolb4930517K11RikC430048L16Rik2700088M22RikTtc14Rps20D8Ertd233eDkc1Sf3a1Zfp3852600016F06Rik1810035L17RikOasl2Cpsf52610015J01RikHnrpa2b12810441O16RikB930007L02RikNcbp1Pcbp3Rnu1b2Cpsf1AI256354Pabpc2Rpl32Sfrs9SnrpbRbm6Sfrs12Rps9LSMD1_MOUSERbm13Rnaset2Hnrpa3Bat1aTxnl4FblOas1a2610317D23Rik1600023H17RikAW5530504932422E22RikElavl31500012C14RikRbpms2Eif4e3Rbm22Nol89530027K23RikNclRpl11AI462171Pabpc1Eif4e22010319N22Rik2810442I21Rik