mRNA processing (Mus musculus)

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YYYYSR-repressor proteins(2a)UG(2b)AGGene Ontology: RNA BindingFormation of pre-mRNPsFormation of the active Spliceosomal C complexU4 snRNPCF IIexon 2Cleavage at the 3’-Splice-Site and Exon LigationSR-binding sitesexon 2GMP5U2CPSFCstFU2 snRNPCstFProcessing of Intron-Containing Pre-mRNAexon 2snRNP Sm core complexPoly(A)pb II(3)5splicing factor SF3BCPSFSR-proteins3Primary RNA transcriptAdditional SR proteinsCAAGA(2)5 G capmRNA polyadenylationexon 1hnRNPs35P-SF3b14bPiSpt5Additional FactorsInternal methylation of mRNAU4Serine/Argenine Rich Proteins(SR)AG5Formation of the Spliceosomal A complexRngtt (capping enzyme)U2 snRNPsexon 25Regulation ofSR protein phosphatasesU6 snRNPmRNA Cappingexon 1AAUAAAAdditional FactorsA3RNA-binding region RNP-1 (RNA recognition motif)53533Formation of the Spliceosomal E complexAGpre-mRNAexon 25AYYYYCF IIAPsnRNP Sm core complexmRNA splice site selectionRegulatorsAU4:U5:U6 tri-snRNP complexAccessory ProteinsSR-binding sitesU5 snRNPU1iPodegradedFormation of the Spliceosomal B complexexon 1heterogeneous nuclear ribonucleoproteinsAAAAAAAsplicesome associated helicasesYYYYGU(1)exon 2Poly(A) polsplicing factor SF3AFormation of the Spliceosomal A complexhnRNP regulatorssnRNP Sm core complex3Internal methylation of mRNASR-phosphatases5U1 snRNP3YYYYmRNA 3’-end processingMethylation of mRNASR-proteinsAlternative SplicingPolr2amRNA splicing (major pathway)U4/U6YYYYexon 1U2AFright click on blue text for detailed information5Additional FactorsFormation of the Spliceosomal C complexSR protein kinasesPutative Alternative SplicingLariat Formation and 5’-Splice Site CleavageU5Misc.AG(2c)5RNA helicaseRNAi pathway3AGRnmt (methyltransferase)53Formation of pre-mRNPsU5Poly(A)-binding protein IIKinases Phosphorylating RS domains?Formation of the Spliceosomal B complex65SR-kinasesCFISR-proteinsU2 snRNPATPCleavage of mRNA at the 3’-endCF IInterPro Domain Containing:exon 1YYYYUG3U2AFPoly(A) polymerase alphaFormation of the Spliceosomal E complexU6RNA helicase ACap BindingmRNA cappingintronAU1 snRNPexon 13Note: New participating members shown at each step2610027L16RikSfrs7AI2552155330419I02RikPapolb8030431D03RikAI255207Fxr1hNufip1Ppm1gAW260507Fmr11810035L17RikPabpn1Rps4xHnrpa3D330023I21RikRpl8Matr3-ps14930562C03RikSfrs12Ncbp2Snrpd12810028N01RikRalyGrsf1LSMD1_MOUSEExosc42700088M22RikPcolceHrmt1l1Hnrpa0Rps27Rbm12Tsn5730555F13RikAI255230Pum1U2af2Rbed1Taf15SnrpbAfg3l2Rnu1b62010300K22Rik9630048M01RikAdarNxf1B930007L02RikRbms3Sfrs11Brunol6D12Mgi40SonBrca1Sfrs10Rnu1a1Rbm16Snrpd3Nsap1l-pendingHrmt1l21110037F02RikRbmy1a11200009B18RikSf3b1Ddx48Dnajc8FblRnu108IlkapCstf2t2410112D09RikRnps1Zbp1Cstf2Rnpc2Prpf18Sf3b4Pabpc1Prpf3Srp68AA589495DazlRbmxCugbp2Ddx19bSbno1Rpl26Pskh1Msi1hRbm15bLsm8Akap12610031L17RikMrps28Sf3b2AA522010Srpk1Dhx8Rps13Rps9Mrpl230710005M24RikTardbpHnrprRbpmsSnrpa15730557H03RikH2-BfD11Ertd730e1110034O07Rik1700025B16RikEif4ePrpf4Ddx19aOas2SnrpnCpeb4Pspc1Rbm10SsbHnrpdClk3Sfrs5Sca1Cdk9Oas1g4921506I22RikRbpms2D12Mgi43C79783Sfrs60610033I05RikAuh2410013L13RikAdarb22010319N22RikDdx391600023H17RikRps20Rad21Rnaset2Imp4Cstf3SlbpRnu2ZfmlC230097K14RikLsm7Park72400002F11RikRnmtPabpc4Smn1Nhp2l1Srp143110061K15RikAI256346B230118G17RikBicc1QkFnbp3C80672Ssa2Tiaf1Xrn22010003O18RikAI2552194930422M05RikRbms2Pcbp2Aco1Cpsf2AW553050Prpf8Rpl37Rnu112410003C20RikDdx56Eif4e2Rnu1b2Rpl11Rpl381700012H05Rik2600011C06RikDdx20Eral1Zmat24932422E22RikU4 snRNAPcbp4Ddx244932702K14RikCsad4930534J06RikRbm11Sart3Hnrpa3Rps23D1Pas1Safb2Srp94930554P13RikPRP17_MOUSEDhx16AU023006PrkrDdx3xTial10610009D07RikCpeb1Bat1aExosc9Myef2Ilf3Polr2a2810036M01RikBrunol4Matr3-ps2Rps29Ptbp1SnrpfRps24Ppargc1bRnu6MGI:2661424AI314192RngttSfpqPrpf4b1700009P03Rik9530027K23RikRbmxrt1810036A22RikFxr2hAI043106AI8447801500012C14RikTnrc4Snrpb2Ddx25Elavl2D15Ertd119eFusBard1Rnu1b1AI255212SnrpeTtc14Rpl192610102M01RikLsm2Cnot4Rbm4D1Pas1-rs1U5 snRNAMGI:1336880Zfp385Eif3s9AI4621714930565A21RikPhf5aRbmxrtMGI:13514653100004P22RikSf4Prpf8Npm1RnaselSnrpaG430095G15RikAW049977Rps281190002L16RikPabpc2Nol8Rbm18Hnrph2Elavl4Rbm17Rbm9Sfrs4AI467299Dkc1Rpp143830425H19RikRbm13Sf3a12610024A01RikMGI:19262245730557B15RikAL022933A130095G20RikPtbp2SyncripRbm3Adat1Tdrd7Cpsf4Wdr55Hnrpa2b1Tmed10Trim215031411E02RikU2af1-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-pendingAA407033Rbm7Thoc41110017C15Rik2810055E05RikLsm11HnrpllGgcxOasl2Exosc8Tia12610317D23RikHnrph11810036E18RikAcin1Srpk23200001K10Rik2810442I21RikSfrs11B230333C21RikSf3b3AI504630AI5030512610020N02RikCova1Rae1Cugbp1AI462438Igf2bp1Rbm28SnrpgSf3a3Supt5hRbm8aAI843301Dhx15Hnrpa1Htatsf1Rpl7Poldip3Mrpl11AI255847Rpl12AI256354Clk2PapolaAU045931Prpf4Fusip1Smc1l1Zfp622Cpeb31110033J19Rik4930429A22RikSfrs9Ddx6Cyp4f18Uhmk1Htf9cMki67ipWbscr1Spop1300006N24RikHnrpfU2af1RnpepRnu1a1Secisbp22610015J01RikDazap1Srp54Snrpd2V1rc17Elavl1Rbm142210008M09RikClk1Cstf2tZfp346Ppargc1aOas3Cpsf3MGI:2387367Cdc40BC013481Cd2bp22810411C16RikU2af1-rs1Scye1Pabpc53000004N20RikLsm2Rnu1b10610009C03RikSfrs3Sf3a21500011J06RikAI255183Nhp2l1SRrp40Matr3PpieRpl39Rbm6AI255840Cstf1Rad52bSlc25a4LgtnSpenExosc52610209F03RikSlc6a8BollSrp19Sfrs16D8Ertd233eStau12600016F06RikRnmtl1Msi2hRbm17Lrrn6a4930506D01RikOas1bPpp1r8HnrplC430048L16RikAfg3l1Rbm19D9Mgi24Eif4g2Sfrs14Elavl3AI642080Ncbp1Abcb4D5Ertd700eCol4a3D830027H13Rik9130414A06RikDicer1Sfrs24632417O19RikRps14TenrLsm1Eif4a2C330027G06Rik4922503N01Rik4932422M17RikNcl1700095D18RikCiz1Rnu1b2Cpsf5Tlr5Adam5Pcbp3Igf2bp3C85084Rbm52410104I19RikPpil4Polr2gSfrs1Tarbp29430070C08Rik5730453I16RikEwsr1HnrpuRod1Hdp2610023M21RikSnrp1c