Biotin biosynthesis II (Oryza sativa)

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cytosolpimeloyl-CoAbiotin synthase(LOC_OS08G42730.1)S-adenosyl-4-methylthio-2-oxobutanoatean unsulfuratedsulfur acceptorAdoMetPiADPATP8-amino-7-oxononanoatesynthasebiotin synthase(LOC_OS08G42730.1)a sulfur donor7-keto-8-aminopelargonateAlaBtnadenosylmethionine--8-amino-7-oxononanoatetransaminase7,8-diaminopelargonateCO2dethiobiotinCoA-SHCO2a sulfurated sulfurdonor


Description

Developed by Gramene.org Source:Plant Reactome.

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History

CompareRevisionActionTimeUserComment
118128view10:34, 25 May 2021EweitzModified title
86999view14:41, 15 July 2016MkutmonOntology Term : 'biotin metabolic pathway' added !
82002view14:39, 8 September 2015Anweshafixing title, data source, & tagging incomplete pathways
80497view14:48, 25 June 2015AnweshaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Metabolite
7,8-diaminopelargonateMetaboliteCHEBI:2247 (ChEBI)
7-keto-8-aminopelargonateMetaboliteCHEBI:15830 (ChEBI)
8-amino-7-oxononanoate synthaseProtein1122039 (Reactome) Facilitates the combination of L-alanine and pimeloyl-CoA to form 7-keto-8-aminopelargonate.
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
AdoMetMetaboliteCHEBI:15414 (ChEBI)
AlaMetaboliteCHEBI:16977 (ChEBI)
BtnMetaboliteCHEBI:15956 (ChEBI)
CO2MetaboliteCHEBI:16526 (ChEBI)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
PiMetaboliteCHEBI:18367 (ChEBI)
S-adenosyl-4-methylthio-2-oxobutanoateMetaboliteCHEBI:8944 (ChEBI)
a sulfur donor1131485 (Reactome)
a sulfurated sulfur donor1131438 (Reactome)
adenosylmethionine--8-amino-7-oxononanoate transaminaseProtein1121777 (Reactome) Facilitates the conversion of 7-keto-8-aminopelargonate to 7,8-diaminopelargonate.
an unsulfurated sulfur acceptor1132100 (Reactome)
biotin synthase (LOC_OS08G42730.1)ProteinQ69U93 (Uniprot-TrEMBL) Facilitates the conversion of dethiobiotin to 9-mercaptodethiobiotin.
dethiobiotinMetaboliteCHEBI:16691 (ChEBI)
pimeloyl-CoAMetaboliteCHEBI:15504 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
1119870 (Reactome) 7-keto-8-aminopelargonate is converted to 7,8-diaminopelargonate by adenosylmethionine--8-amino-7-oxononanoate aminotransferase.
1120139 (Reactome)
1120881 (Reactome) L-alanine and pimeloyl-CoA are combined by enzymatic activity of 8-amino-7-oxononanoate synthase to form 7-keto-8-aminopelargonate.
1121121 (Reactome) Dethiobiotin is converted to 9-mercaptodethiobiotin by enzymatic activity of biotin synthase.
1121531 (Reactome) 7,8-diaminopelargonate is converted to dethiobiotin by enzymatic activity of an unknown enzyme.
7,8-diaminopelargonate1121531 (Reactome)
7,8-diaminopelargonateArrow1119870 (Reactome)
7-keto-8-aminopelargonate1119870 (Reactome)
7-keto-8-aminopelargonateArrow1120881 (Reactome)
8-amino-7-oxononanoate synthasemim-catalysis1120881 (Reactome)
ADPArrow1121531 (Reactome)
ATP1121531 (Reactome)
AdoMet1119870 (Reactome)
Ala1120881 (Reactome)
Arrow1121121 (Reactome)
BtnArrow1120139 (Reactome)
CO21121531 (Reactome)
CO2Arrow1120881 (Reactome)
CoA-SHArrow1120881 (Reactome)
PiArrow1121531 (Reactome)
S-adenosyl-4-methylthio-2-oxobutanoateArrow1119870 (Reactome)
a sulfur donor1121121 (Reactome)
a sulfurated sulfur donor1121121 (Reactome)
adenosylmethionine--8-amino-7-oxononanoate transaminasemim-catalysis1119870 (Reactome)
an unsulfurated sulfur acceptorArrow1121121 (Reactome)
biotin synthase (LOC_OS08G42730.1)mim-catalysis1120139 (Reactome)
biotin synthase (LOC_OS08G42730.1)mim-catalysis1121121 (Reactome)
dethiobiotin1121121 (Reactome)
dethiobiotinArrow1121531 (Reactome)
pimeloyl-CoA1120881 (Reactome)
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