Cytokinin signaling (Arabidopsis thaliana)

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6NucleusPlant CellHistidinePhosphotransmitter (HP)PO4Type-A ARRCytosolmembrane(Endoplasmic reticulum or plasma membrane)AHK1AHK2Cytokinin1, 2, 4, 7, 9AHK3AHK466AHK5PO4PO4AHP6AHP3AHP2AHP4AHP5AHP1AHP-LikePO4Histidine Phosphotransmitter(HP)ARR3ARR4ARR5ARR6ARR8ARR15ARR16ARR9ARR7ARR1710PO4Type-B ARRARR1ARR2ARR10ARR11ARR13ARR18ARR19ARR14ARR12ARR20ARR21PO4CytokininreceptorHis(H)His(H)Asp(D)Asp(D)


Description

Cytokinin signaling pathway starts from receiving of the ligand (cytokinin) by the cytokinin receptors (a dimer), followed by a phosphate relay by acceptor and donor domains of the receptors and then the histidine phosphotransmitters (HPs). HPs activate the type-A and type-B Arabidopsis response regulators (ARRs) to initiate the downstream events in cytokinin mediated response. Caesar et al (2011) show receptor location in the endoplasmic reticulum membrane, though all the classical models show them on plasma membrane. Paralogs from the A. thaliana genome for AHKs, AHPs, Type-A and Type-B ARRs were added as group members (not as members of complex) on the pathway diagram.

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Bibliography

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  1. Wohlbach DJ, Quirino BF, Sussman MR; ''Analysis of the Arabidopsis histidine kinase ATHK1 reveals a connection between vegetative osmotic stress sensing and seed maturation.''; Plant Cell, 2008 PubMed Europe PMC
  2. Urao T, Yamaguchi-Shinozaki K, Shinozaki K; ''Plant histidine kinases: an emerging picture of two-component signal transduction in hormone and environmental responses.''; Sci STKE, 2001 PubMed Europe PMC
  3. To JP, Haberer G, Ferreira FJ, Deruère J, Mason MG, Schaller GE, Alonso JM, Ecker JR, Kieber JJ; ''Type-A Arabidopsis response regulators are partially redundant negative regulators of cytokinin signaling.''; Plant Cell, 2004 PubMed Europe PMC
  4. Hao GP, Wu ZY, Chen MS, Cao MQ, Pelletier G, Huang CL, Yang Q; ''[ATHK1 gene regulates signal transduction of osmotic stress in Arabidopsis thaliana].''; Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao, 2004 PubMed Europe PMC
  5. Kim J; ''Phosphorylation of A-Type ARR to function as negative regulator of cytokinin signal transduction.''; Plant Signal Behav, 2008 PubMed Europe PMC
  6. Caesar K, Thamm AM, Witthöft J, Elgass K, Huppenberger P, Grefen C, Horak J, Harter K; ''Evidence for the localization of the Arabidopsis cytokinin receptors AHK3 and AHK4 in the endoplasmic reticulum.''; J Exp Bot, 2011 PubMed Europe PMC
  7. Tran LS, Urao T, Qin F, Maruyama K, Kakimoto T, Shinozaki K, Yamaguchi-Shinozaki K; ''Functional analysis of AHK1/ATHK1 and cytokinin receptor histidine kinases in response to abscisic acid, drought, and salt stress in Arabidopsis.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC
  8. Hill K, Mathews DE, Kim HJ, Street IH, Wildes SL, Chiang YH, Mason MG, Alonso JM, Ecker JR, Kieber JJ, Schaller GE; ''Functional characterization of type-B response regulators in the Arabidopsis cytokinin response.''; Plant Physiol, 2013 PubMed Europe PMC
  9. Urao T, Yakubov B, Satoh R, Yamaguchi-Shinozaki K, Seki M, Hirayama T, Shinozaki K; ''A transmembrane hybrid-type histidine kinase in Arabidopsis functions as an osmosensor.''; Plant Cell, 1999 PubMed Europe PMC
  10. Lee DJ, Park JY, Ku SJ, Ha YM, Kim S, Kim MD, Oh MH, Kim J; ''Genome-wide expression profiling of ARABIDOPSIS RESPONSE REGULATOR 7(ARR7) overexpression in cytokinin response.''; Mol Genet Genomics, 2007 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
107045view14:13, 17 September 2019MaintBotChEBI identifier normalization
104053view20:29, 28 April 2019EgonwAdded two missing metabolite identifiers.
87212view14:19, 19 July 2016SusanOntology Term : 'hormone signaling pathway' added !
80364view23:26, 9 June 2015Pjaiswalfixed elbow to straight line conenctions in nucleus
80363view23:24, 9 June 2015Pjaiswalfixing AHP6 connectors
80362view23:23, 9 June 2015Pjaiswalconnectors not showing properly on live site. trying to fix them.
80361view23:21, 9 June 2015Pjaiswalchanged line type from elbow to curved for AHP6 inhibitor roles
80354view23:03, 9 June 2015PjaiswalModified description
80353view22:54, 9 June 2015Pjaiswalmoved PO4 and some connectors
80352view22:52, 9 June 2015Pjaiswalmoved anchor
80351view22:48, 9 June 2015Pjaiswalfixed broken connections
80350view22:43, 9 June 2015Pjaiswalfixed broken connections
80349view22:38, 9 June 2015PjaiswalNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AHK1GeneProductAT2G17820 (Ensembl Plants) Histidine Kinase 1
AHK2GeneProductAT5G35750 (Ensembl Plants) Histidine Kinase 2
AHK3GeneProductAT1G27320 (Ensembl Plants) Histidine Kinase 3
AHK4GeneProductAT2G01830 (Ensembl Plants) Histidine Kinase 4
AHK5GeneProductAT5G10720 (Ensembl Plants) Histidine Kinase 5
AHP-LikeGeneProductAT4G04402 (Ensembl Plants) histidine phosphotransfer protein like
AHP1GeneProductAT3G21510 (Ensembl Plants) histidine phosphotransfer protein 1
AHP2GeneProductAT3G29350 (Ensembl Plants) histidine phosphotransfer protein 2
AHP3GeneProductAT5G39340 (Ensembl Plants) histidine phosphotransfer protein 3
AHP4GeneProductAT3G16360 (Ensembl Plants) histidine phosphotransfer protein 4
AHP5GeneProductAT1G03430 (Ensembl Plants) histidine phosphotransfer protein 5
AHP6GeneProductAT1G80100 (Ensembl Plants) histidine phosphotransfer protein 6
ARR10GeneProductAt4g31920 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 10
ARR11GeneProductAt1g67710 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 11
ARR12GeneProductAt2g25180 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 12
ARR13GeneProductAt2g27070 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 13
ARR14GeneProductAt2g01760 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 14
ARR15GeneProductAT1G74890 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 15
ARR16GeneProductAT2G40670 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 16
ARR17GeneProductAT3G56380 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 17
ARR18GeneProductAt5g58080 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 18
ARR19GeneProductAt1g49190 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 19
ARR1GeneProductAt3g16857 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 1
ARR20GeneProductAt3g62670 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 20
ARR21GeneProductAt5g07210 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 21
ARR2GeneProductAt4g16110 (Ensembl Plants) Type-B Arabidopsis (Arabidopsis thaliana) response regulator 2
ARR3GeneProductAt1g59940 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 3
ARR4GeneProductAt1g10470 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 4
ARR5GeneProductAt3g48100 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 3
ARR6GeneProductAt5g62920 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 6
ARR7GeneProductAT1G19050 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 7
ARR8GeneProductAt2g41310 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 8
ARR9GeneProductAt3g57040 (Ensembl Plants) Type-A Arabidopsis (Arabidopsis thaliana) response regulator 9
Asp (D)CHEBI:17053 (ChEBI)
CytokininMetaboliteCHEBI:23530 (ChEBI)
His (H)CHEBI:15971 (ChEBI)

Annotated Interactions

No annotated interactions

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