Hypoxia-mediated EMT and stemness (Homo sapiens)

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1HypoxiaPre-miRNAEpithelial-Mesenchymal Transition (EMT) / StemnessMature miRNAhsa-miR-200b-3pZEB1hsa-miR-200a-3pDICER1hsa-miR-200c-3p


Model of hypoxia mediated EMT and stemness.

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Ontology Terms



  1. van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MH, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG; ''Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.''; Nat Commun, 2014 PubMed Europe PMC Scholia


View all...
117758view12:53, 22 May 2021EweitzModified title
88661view15:19, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
83778view15:12, 4 December 2015SusanAdd IDs miRNAs and changed miRNA names
81089view21:17, 21 July 2015Khanspers
80336view22:30, 5 June 2015KhanspersModified description
80335view22:28, 5 June 2015KhanspersNew pathway

External references


NameTypeDatabase referenceComment
DICER1GeneProduct23405 (Entrez Gene)
ZEB1GeneProduct6935 (Entrez Gene)
hsa-miR-200a-3pRnaMIMAT0000682 (miRBase mature sequence)
hsa-miR-200b-3pRnaMIMAT0000318 (miRBase mature sequence)
hsa-miR-200c-3pRnaMIMAT0000617 (miRBase mature sequence)

Annotated Interactions

No annotated interactions

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