p38 MAPK Signaling Pathway (Rattus norvegicus)

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1-8DNA transcriptionTranslation??FASL, InflammatoryCytokines, UV, etc.Cytokines Production,Apoptosis, etc.???Growth Factors, UVTrophic Factors, etc.Stress: Osmotic shockg-radiation, AnisomycinLOC100910771Mapkapk2Creb1Rasgrf1Rac1Ddit3Mknk1Tgfb2ApoptosisTraf2MaxElk1LOC100912399Pla2g4aHspb1Shc1Grb2HrasMapkapk2Map3k9LOC100911295Mef2dCdc42Map2k4DaxxMapkapk5TraddStat1Mapk14Mapk14Ripk1Atf2Tgfbr1Rps6ka5Map3k5Map2k6MycTranscription factors


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP400 (r95117) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  2. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia
  3. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  4. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  5. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  6. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  7. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  8. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
95743view13:49, 19 January 2018MkutmonHomology conversion update
95113view14:52, 16 November 2017Mkutmonadded missing comment source for HomologyConverter
69442view19:05, 8 July 2013MaintBotUpdated to 2013 gpml schema
67569view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
41768view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
38233view21:12, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38232view21:11, 27 August 2010Khanspers
35699view23:09, 12 February 2010KhanspersDescription and Bibliography
34135view19:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32388view16:58, 15 August 2009MaintBotFixed text labels
32032view13:26, 14 August 2009MaintBotFixed group labels
31423view20:59, 13 August 2009MaintBotFixed text labels
30979view00:52, 30 July 2009MaintBotConverted from Homo sapiens
21299view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:p38 MAPK signaling pathway]] moved to [[Pathway:WP294]]: Moved to stable identifier
8328view13:46, 7 January 2008MaintBot[[Pathway:Rat:p38 MAPK signaling pathway]] moved to [[Pathway:Rattus norvegicus:p38 MAPK signaling pathway]]: Renaming species
7782view16:17, 18 December 2007MaintBotfixed category names
7324view12:42, 4 November 2007MaintBotAdded categories to GPML
6612view22:20, 22 May 2007S.Burelgpml file for [[Rat:p38_MAPK_signaling_pathway]]

External references

DataNodes

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NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
Atf2GeneProductENSRNOG00000001597 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1386
Cdc42GeneProductENSRNOG00000013536 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:998
Creb1GeneProductENSRNOG00000013412 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1385
DaxxGeneProductENSRNOG00000000477 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1616
Ddit3GeneProductENSRNOG00000006789 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1649
Elk1GeneProductENSRNOG00000010171 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2002
Grb2GeneProductENSRNOG00000003990 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2885
HrasGeneProductENSRNOG00000016611 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3265
Hspb1GeneProductENSRNOG00000023546 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3315
LOC100910771GeneProductENSRNOG00000005724 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6885
LOC100911295GeneProductENSRNOG00000050978 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3150
LOC100912399GeneProductENSRNOG00000013177 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4214
Map2k4GeneProductENSRNOG00000003834 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6416
Map2k6GeneProductENSRNOG00000004437 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5608
Map3k5GeneProductENSRNOG00000031700 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4217
Map3k9GeneProductENSRNOG00000007271 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4293
Mapk14GeneProductENSRNOG00000000513 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1432
Mapkapk2GeneProductENSRNOG00000004726 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9261
Mapkapk5GeneProductENSRNOG00000001345 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8550
MaxGeneProductENSRNOG00000008049 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4149
Mef2dGeneProductENSRNOG00000031778 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4209
Mknk1GeneProductENSRNOG00000010381 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8569
MycGeneProductENSRNOG00000004500 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609
Pla2g4aGeneProductENSRNOG00000002657 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5321
Rac1GeneProductENSRNOG00000001068 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5879
Rasgrf1GeneProductENSRNOG00000014025 (Ensembl)
  • PDZ domain containing guanine nucleotide exchange
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5923
Ripk1GeneProductENSRNOG00000017787 (Ensembl)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8737
Rps6ka5GeneProductENSRNOG00000004362 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9252
Shc1GeneProductENSRNOG00000020657 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6464
Stat1GeneProductENSRNOG00000014079 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6772
Tgfb2GeneProductENSRNOG00000002418 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7042
Tgfbr1GeneProductENSRNOG00000007036 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7046
TraddGeneProductENSRNOG00000015179 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8717
Traf2GeneProductENSRNOG00000006238 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7186

Annotated Interactions

No annotated interactions
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