Eicosanoid Synthesis (Rattus norvegicus)

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112-Hydroperoxy Eicosatetraenoic AcidThromboxane A3Prostaglandin E26-Keto-Prostaglandin F2-alpha15-Hydroperoxy Eicosatetraenoic AcidCell MembraneLtc4sAlox5apPla2g65-HETEPtgs2Leukotriene C4Prostaglandin F2aPGE2 9-ketoreducAlox5apGGT1Peroxidase?Tbxas1Pla2g6Thromboxane A2Leukotriene E4Alox515-HETELta4hPnpla8Prostaglandin D2Leukotriene A412-HETEPtgdsThromboxane B2PGD2 11-ketoreducAlox12Leukotriene B4Leukotriene D4Alox15Dpep1PtgesPtgs1Peroxidase?Prostaglandin I25-HPETEArachidonic acidAlox15bPeroxidase?Ptges2Pla2g2aPtgisAlox5Alox15Prostaglandin H2


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 70% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106975view13:43, 17 September 2019MaintBotHMDB identifier normalization
89523view11:02, 16 September 2016Mkutmonontology tag fix
89481view13:39, 15 September 2016Mkutmonremove space from ontology term id
77414view08:20, 7 September 2014EgonwConfirmed two more Labels as metabolites.
77388view09:45, 5 September 2014EgonwConverted two labels into metabolite DataNodes but without an identifier.
71781view20:31, 17 October 2013MaintBotAutomated update of data sources
71298view16:57, 17 October 2013MaintBotAutomated update of data sources
69362view18:54, 8 July 2013MaintBotUpdated to 2013 gpml schema
67185view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62846view05:04, 3 May 2013MaintBotUpdated UniProt data source
41676view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
35472view12:09, 12 February 2010ThomasModified description
35470view12:09, 12 February 2010Thomasadded literature
34066view19:08, 9 December 2009MaintBotAutomatic update of empty xrefs
32031view13:26, 14 August 2009MaintBotFixed group labels
30921view00:34, 30 July 2009MaintBotConverted from Homo sapiens
21297view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Eicosanoid Synthesis]] moved to [[Pathway:WP293]]: Moved to stable identifier
8006view13:46, 7 January 2008MaintBot[[Pathway:Rat:Eicosanoid Synthesis]] moved to [[Pathway:Rattus norvegicus:Eicosanoid Synthesis]]: Renaming species
7626view16:05, 18 December 2007MaintBotfixed category names
7339view12:42, 4 November 2007MaintBotAdded categories to GPML
19421view22:20, 22 May 2007M.Ramirezgpml file for [[Rat:Eicosanoid_Synthesis]]
6533view22:20, 22 May 2007A.Kwagpml file for [[Rat:Eicosanoid_Synthesis]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
12-Hydroperoxy Eicosatetraenoic AcidMetabolite
15-HETEMetabolite
15-Hydroperoxy Eicosatetraenoic AcidMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB0001193 (HMDB)
Alox12GeneProduct287454 (Entrez Gene)
Alox15GeneProduct81639 (Entrez Gene)
Alox15bGeneProduct266604 (Entrez Gene)
Alox5GeneProduct25290 (Entrez Gene)
Alox5apGeneProduct29624 (Entrez Gene)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
Dpep1GeneProduct94199 (Entrez Gene)
GGT1GeneProduct116568 (Entrez Gene)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
Lta4hGeneProduct299732 (Entrez Gene)
Ltc4sGeneProduct114097 (Entrez Gene)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
Peroxidase?GeneProduct
Pla2g2aGeneProduct29692 (Entrez Gene)
Pla2g6GeneProduct360426 (Entrez Gene)
Pnpla8GeneProduct314075 (Entrez Gene)
Prostaglandin D2MetaboliteHMDB0001403 (HMDB)
Prostaglandin E2MetaboliteCHEBI:15551 (ChEBI)
Prostaglandin F2aMetaboliteHMDB0001139 (HMDB)
Prostaglandin H2MetaboliteHMDB0001381 (HMDB)
Prostaglandin I2MetaboliteHMDB0001335 (HMDB)
PtgdsGeneProduct25526 (Entrez Gene)
Ptges2GeneProduct311865 (Entrez Gene)
PtgesGeneProduct59103 (Entrez Gene)
PtgisGeneProduct25527 (Entrez Gene)
Ptgs1GeneProduct24693 (Entrez Gene)
Ptgs2GeneProduct29527 (Entrez Gene)
Tbxas1GeneProduct24886 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane A3Metabolite4946013 (Chemspider)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)

Annotated Interactions

No annotated interactions
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