Vascular smooth muscle contraction (Bos taurus)

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CrossbreidgeContraction+pIntravasal pressure/stretchHyperpolarizationReduction of contractile system Ca2+ sensitivityVasoconstrictors+pDepolarizationMyofilamentsRELAXCATIONReduction of intracellular Ca2+ concentration-pPPP1CCGNA12PKGPRKCGPRKCEPRKCAMYLK4ADCY4RhOAADCY1KCNU1CALML5GNAQCYP4A11cGMPACTA2EETNPR-ARAMP3PLA2G12BPRKCQACTG2phospholipase A2PLCB3BRAFPLCB1GUCY1B3PRKACBArachidonic acid metabolismITPR1ADORA2BPLA2G6ITPR2MYL6BADCY9ROCK1EndothelinMYLKMYL9MYLK3Adrenomedullinphospholipase A2AdenosinePGI2ADCY6ADORA2AARHGEF11vasopressinCYP4A22KCNMA1PLA2G2APPP1R12A20-HETEGNA11AVPR1APPP1CANOGNA13PRKCDPLA2G2CPLA2G2D1MAPK3PRKCBPPP1CBPLA2G4BKCNMB4PLA2G4FCa2+CACNA1SPLA2G4ACPI-17PLA2G4DARHGEF12PRKXPLCB2PLA2G5PLA2G3CALM2Angiotensin IIGsAGTR1Ca2+PLA2G1BMYL6ADRA1APLA2G4EAVPR1BCALCRLADCY8ITPR3BNPNPR-BPLA2G10ADCY2CALM3GUCY1A2RAF1IP3RAMP1K+PLA2G12AMAP2K1PRKACAGUCY1A3ADRA1BCACNA1CCAMPCACNA1FPLCB4ANPCaDMAP2K2ARAFPPP1R12CMHCPTGIRKCNMB2ROCK2ArachidonateCALMKCNMB3PPP1R12BCalcium signal PathwayCACNA1DPLA2G2EADCY7CNPPLA2G2D4ADCY3ARHGEF1CALM1PLA2G2AMYLK2NorepinephrinePLA2G2FEDNRAK+DAGADCY5CGRPKCNMB1CALML6Ca2+IRAGRAMP2PRKCHMAPK1ADRA1DCACNA1FCACNA1DCACNA1SCACNA1CKCNMB2KCNU1KCNMB3KCNMB4KCNMB1KCNMA1ITPR2ITPR1ITPR3MYLK2MYLKMYLK4MYLK3MyosinACTG2MYL6MHCMYL9ACTA2MYL6BMyosinPPP1CCPPP1CBPPP1R12CPPP1CAPPP1R12BPPP1R12AVasodilators+p+p+p+p+p+p+p+p-p


Description

Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels. The main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to high blood pressure, while excessive vasodilation as in shock leads to low blood pressure (http://en.wikipedia.org/wiki/Vascular_smooth_muscle).

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History

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CompareRevisionActionTimeUserComment
107057view14:14, 17 September 2019MaintBotChEBI identifier normalization
87857view11:54, 25 July 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
82870view16:22, 10 November 2015JmeliusCorrect outdated id
80970view12:08, 6 July 2015Mkutmonfixed graphid problem
80968view12:00, 6 July 2015Mkutmonfixed unconnected lines
79750view08:51, 9 April 2015Zarichanged identyfier for CACNA1C
79732view11:42, 7 April 2015ZariModified description
79731view11:34, 7 April 2015ZariNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
20-HETEMetaboliteCHEBI:34306 (ChEBI)
ACTA2GeneProduct515610 (Entrez Gene)
ACTG2GeneProduct281595 (Entrez Gene)
ADCY1GeneProduct281601 (Entrez Gene)
ADCY2GeneProduct510708 (Entrez Gene)
ADCY3GeneProduct535603 (Entrez Gene)
ADCY4GeneProduct788151 (Entrez Gene)
ADCY5GeneProduct505740 (Entrez Gene)
ADCY6GeneProduct509936 (Entrez Gene)
ADCY7GeneProduct281603 (Entrez Gene)
ADCY8GeneProduct535017 (Entrez Gene)
ADCY9GeneProduct525482 (Entrez Gene)
ADORA2AGeneProduct617828 (Entrez Gene)
ADORA2BGeneProduct529760 (Entrez Gene)
ADRA1AGeneProduct282134 (Entrez Gene)
ADRA1BGeneProduct407140 (Entrez Gene)
ADRA1DGeneProduct539543 (Entrez Gene)
AGTR1GeneProduct281607 (Entrez Gene)
ANPMetaboliteCHEBI:80233 (ChEBI)
ARAFGeneProduct540421 (Entrez Gene)
ARHGEF11GeneProduct511220 (Entrez Gene)
ARHGEF12GeneProduct503575 (Entrez Gene)
ARHGEF1GeneProduct513377 (Entrez Gene)
AVPR1AGeneProduct538439 (Entrez Gene)
AVPR1BGeneProduct282861 (Entrez Gene)
AdenosineMetabolite
AdrenomedullinMetaboliteCHEBI:80339 (ChEBI)
Angiotensin IIMetaboliteCHEBI:2719 (ChEBI)
ArachidonateMetaboliteCHEBI:15843 (ChEBI)
Arachidonic acid metabolismPathway
BNPMetaboliteCHEBI:80234 (ChEBI)
BRAFGeneProduct536051 (Entrez Gene)
CACNA1CGeneProduct408015 (Entrez Gene)
CACNA1CGeneProductENSBTAG00000010660 (Ensembl)
CACNA1DGeneProduct408013 (Entrez Gene)
CACNA1FGeneProduct509779 (Entrez Gene)
CACNA1SGeneProduct100337204 (Entrez Gene)
CACNA1SGeneProductENSBTAG00000047491 (Ensembl)
CALCRLGeneProduct527140 (Entrez Gene)
CALM1GeneProduct617095 (Entrez Gene)
CALM2GeneProduct100297344 (Entrez Gene)
CALMGeneProduct326597 (Entrez Gene)
CALM3GeneProduct520277 (Entrez Gene)
CALML5GeneProduct520404 (Entrez Gene)
CALML6GeneProduct617412 (Entrez Gene)
CAMPMetaboliteCHEBI:17489 (ChEBI)
CGRPMetaboliteCHEBI:80337 (ChEBI)
CNPMetaboliteCHEBI:80235 (ChEBI)
CPI-17GeneProduct615348 (Entrez Gene)
CYP4A11GeneProduct511890 (Entrez Gene)
CYP4A22GeneProduct516085 (Entrez Gene)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CaDGeneProduct281660 (Entrez Gene)
Calcium signal PathwayPathway
DAGMetaboliteCHEBI:18035 (ChEBI)
EDNRAGeneProduct281749 (Entrez Gene)
EETMetaboliteCHEBI:34157 (ChEBI)
EndothelinMetaboliteCHEBI:80240 (ChEBI)
GNA11GeneProduct281788 (Entrez Gene)
GNA12GeneProduct515159 (Entrez Gene)
GNA13GeneProduct505611 (Entrez Gene)
GNAQGeneProduct536654 (Entrez Gene)
GUCY1A2GeneProduct613600 (Entrez Gene)
GUCY1A3GeneProduct281216 (Entrez Gene)
GUCY1B3GeneProduct282433 (Entrez Gene)
GsGeneProduct281793 (Entrez Gene)
IP3MetaboliteCHEBI:16595 (ChEBI)
IRAGGeneProduct281918 (Entrez Gene)
ITPR1GeneProduct317697 (Entrez Gene)
ITPR2GeneProduct281878 (Entrez Gene)
ITPR3GeneProduct281879 (Entrez Gene)
K+MetaboliteCHEBI:29103 (ChEBI)
KCNMA1GeneProduct282573 (Entrez Gene)
KCNMB1GeneProduct407176 (Entrez Gene)
KCNMB2GeneProduct534568 (Entrez Gene)
KCNMB3GeneProduct539609 (Entrez Gene)
KCNMB4GeneProduct520448 (Entrez Gene)
KCNU1GeneProduct524144 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MHCGeneProduct
MYL6GeneProduct281341 (Entrez Gene)
MYL6BGeneProduct515421 (Entrez Gene)
MYL9GeneProduct505964 (Entrez Gene)
MYLK2GeneProduct533378 (Entrez Gene)
MYLKGeneProduct338037 (Entrez Gene)
MYLK3GeneProduct526379 (Entrez Gene)
MYLK4GeneProduct518025 (Entrez Gene)
NOMetaboliteCHEBI:16480 (ChEBI)
NPR-AGeneProduct533048 (Entrez Gene)
NPR-BGeneProduct281357 (Entrez Gene)
NorepinephrineMetaboliteCHEBI:18357 (ChEBI)
PGI2MetaboliteCHEBI:15552 (ChEBI)
PKGGeneProduct
PLA2G10GeneProduct613966 (Entrez Gene)
PLA2G12AGeneProduct527214 (Entrez Gene)
PLA2G12BGeneProduct100337447 (Entrez Gene)
PLA2G1BGeneProduct282457 (Entrez Gene)
PLA2G2AGeneProduct507201 (Entrez Gene)
PLA2G2AGeneProduct521383 (Entrez Gene)
PLA2G2CGeneProduct504978 (Entrez Gene)
PLA2G2D1GeneProduct494318 (Entrez Gene)
PLA2G2D4GeneProduct503625 (Entrez Gene)
PLA2G2EGeneProduct506243 (Entrez Gene)
PLA2G2FGeneProduct541294 (Entrez Gene)
PLA2G3GeneProduct527631 (Entrez Gene)
PLA2G4AGeneProduct525072 (Entrez Gene)
PLA2G4BGeneProduct505485 (Entrez Gene)
PLA2G4DGeneProduct531209 (Entrez Gene)
PLA2G4EGeneProduct526364 (Entrez Gene)
PLA2G4FGeneProduct522866 (Entrez Gene)
PLA2G5GeneProduct614911 (Entrez Gene)
PLA2G6GeneProduct535381 (Entrez Gene)
PLCB1GeneProduct287026 (Entrez Gene)
PLCB2GeneProduct508888 (Entrez Gene)
PLCB3GeneProduct515669 (Entrez Gene)
PLCB4GeneProduct281985 (Entrez Gene)
PPP1CAGeneProduct516175 (Entrez Gene)
PPP1CBGeneProduct538829 (Entrez Gene)
PPP1CCGeneProduct282318 (Entrez Gene)
PPP1R12AGeneProduct538606 (Entrez Gene)
PPP1R12BGeneProduct100337338 (Entrez Gene)
PPP1R12BGeneProductENSBTAG00000011772 (Ensembl)
PPP1R12CGeneProduct512431 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PRKACBGeneProduct282323 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCEGeneProduct507041 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKXGeneProduct505773 (Entrez Gene)
PTGIRGeneProduct520278 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAMP1GeneProduct617017 (Entrez Gene)
RAMP2GeneProduct504230 (Entrez Gene)
RAMP3GeneProduct613547 (Entrez Gene)
ROCK1GeneProduct785911 (Entrez Gene)
ROCK2GeneProduct282041 (Entrez Gene)
RhOAGeneProduct338049 (Entrez Gene)
cGMPMetaboliteCHEBI:16356 (ChEBI)
phospholipase A2GeneProduct104974671 (Entrez Gene)
phospholipase A2GeneProduct615045 (Entrez Gene)
vasopressinMetaboliteCHEBI:34543 (ChEBI)

Annotated Interactions

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