p53 signaling (Mus musculus)

From WikiPathways

Jump to: navigation, search
1DNA damageInhibition of IGF-1/mTOR pathwayCell cycle arrestInhibition ofangiogenesisand metastasisG2 arrest (sustained)ApoptosisExosome mediated secretionStress signalsTarget genesGenotoxic stressG1 arrest (sustained)EndpointDNA repair and damagepreventionp53 negative feedbackAtrCasp3mmu-miR-291a-3pmmu-miR-124-3pCdk6mmu-miR-103a-3pIgfbp3Ccng1mmu-miR-17-5pCcnb2BidChek1mmu-miR-302d-3pPmaip1Gm5593mmu-miR-181b-5pPpm1dThbs1Ccng2Gtse1Rchy1mmu-miR-149-5pBaxSesn3mmu-miR-503-5pCcne2Serpinb5Cdkn2ammu-miR-291b-3pSteap3mmu-miR-19b-3pIgf1Ccnd3CyctCasp9Ccnb3mmu-miR-297a-5pBbc3Gadd45bmmu-miR-181a-5pRrm2Ccnd2mmu-miR-217-5pCdk2Cd82mmu-miR-362-5pmmu-miR-9-5pCdkn1aCdk4mmu-miR-294-3pZmat3mmu-miR-223-3pBai1Mdm4mmu-miR-301b-3pGadd45gPerpCycsAtmmmu-miR-29b-3pmmu-miR-21-5pmmu-miR-15a-5pmmu-miR-449a-5pmmu-miR-425-5pSiah1bSesn2Trp73Fasmmu-miR-758-3pCcnd1Apaf1Ccne1Ccnb1mmu-miR-30e-5pmmu-miR-295-3pShisa5mmu-miR-145a-5pTrp53mmu-miR-20a-5pEi24Rrm2bSesn1Pidd1mmu-miR-34b-5pmmu-miR-18a-5pmmu-miR-122-5pSfnmmu-miR-7b-5pmmu-miR-1a-3pCdk1Rfwd2mmu-miR-16-5pDdb2Chek2Gadd45aSiah1aCasp8mmu-miR-21a-5pmmu-let-7b-5pmmu-miR-195a-5pmmu-miR-486-5pTsc2mmu-miR-216a-5pMdm2mmu-miR-24-3pRprmSerpine1mmu-miR-340-5pPtenGadd45gGadd45bGadd45aIgfbp3Mdm2Siah1aSiah1bmmu-miR-425-5pmmu-miR-16-5pmmu-miR-17-5pmmu-miR-301b-3pmmu-miR-301b-3pmmu-miR-301b-3pmmu-miR-19b-3pmmu-miR-19b-3pmmu-miR-19b-3pmmu-miR-503-5pmmu-let-7b-5pmmu-miR-19b-3pmmu-miR-340-5pmmu-miR-34b-5pmmu-miR-149-5pmmu-miR-362-5pmmu-miR-15a-5pmmu-miR-362-5pmmu-miR-15a-5pmmu-miR-15a-5pmmu-miR-24-3p


Description

http://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.

Quality Tags

Ontology Terms

 

Bibliography

  1. Rieswijk L, Brauers KJ, Coonen ML, van Breda SG, Jennen DG, Kleinjans JC; ''Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.''; Mutagenesis, 2015 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
88290view14:54, 1 August 2016FehrhartOntology Term : 'p53 signaling pathway' added !
87396view11:05, 22 July 2016MaintBotadded missing graphids
85041view08:42, 10 April 2016EgonwRemoved an incorrect mim-conversion annotation.
82881view12:20, 11 November 2015JmeliusCorrect outdated id
82354view11:33, 27 September 2015EgonwAdded GraphIDs to DataNodes that had none.
80199view22:15, 20 May 2015MaintBotconnected interactions and added literature ref
79094view09:20, 2 March 2015LindarieswijkModified description
79093view09:19, 2 March 2015LindarieswijkModified description
79092view09:15, 2 March 2015LindarieswijkNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apaf1GeneProduct11783 (Entrez Gene)
AtmGeneProduct11920 (Entrez Gene)
AtrGeneProduct245000 (Entrez Gene)
Bai1GeneProduct107831 (Entrez Gene)
BaxGeneProduct12028 (Entrez Gene)
Bbc3GeneProduct170770 (Entrez Gene)
BidGeneProduct12122 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp8GeneProduct12370 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
Ccnb1GeneProduct268697 (Entrez Gene)
Ccnb2GeneProduct12442 (Entrez Gene)
Ccnb3GeneProduct209091 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Ccnd3GeneProduct12445 (Entrez Gene)
Ccne1GeneProduct12447 (Entrez Gene)
Ccne2GeneProduct12448 (Entrez Gene)
Ccng1GeneProduct12450 (Entrez Gene)
Ccng2GeneProduct12452 (Entrez Gene)
Cd82GeneProduct12521 (Entrez Gene)
Cdk1GeneProduct12534 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdk4GeneProduct12567 (Entrez Gene)
Cdk6GeneProduct12571 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn2aGeneProduct12578 (Entrez Gene)
Chek1GeneProduct12649 (Entrez Gene)
Chek2GeneProduct50883 (Entrez Gene)
CycsGeneProduct13063 (Entrez Gene)
CyctGeneProduct13067 (Entrez Gene)
Ddb2GeneProduct107986 (Entrez Gene)
Ei24GeneProduct13663 (Entrez Gene)
FasGeneProduct14102 (Entrez Gene)
Gadd45aGeneProduct13197 (Entrez Gene)
Gadd45bGeneProduct17873 (Entrez Gene)
Gadd45gGeneProduct23882 (Entrez Gene)
Gm5593GeneProductENSMUSG00000048574 (Ensembl)
Gtse1GeneProduct29870 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Igfbp3GeneProduct16009 (Entrez Gene)
Mdm2GeneProduct17246 (Entrez Gene)
Mdm4GeneProduct17248 (Entrez Gene)
PerpGeneProduct64058 (Entrez Gene)
Pidd1GeneProduct57913 (Entrez Gene)
Pmaip1GeneProduct58801 (Entrez Gene)
Ppm1dGeneProduct53892 (Entrez Gene)
PtenGeneProduct19211 (Entrez Gene)
Rchy1GeneProduct68098 (Entrez Gene)
Rfwd2GeneProduct26374 (Entrez Gene)
RprmGeneProduct67874 (Entrez Gene)
Rrm2GeneProduct20135 (Entrez Gene)
Rrm2bGeneProduct382985 (Entrez Gene)
Serpinb5GeneProduct20724 (Entrez Gene)
Serpine1GeneProduct18787 (Entrez Gene)
Sesn1GeneProduct140742 (Entrez Gene)
Sesn2GeneProduct230784 (Entrez Gene)
Sesn3GeneProduct75747 (Entrez Gene)
SfnGeneProduct55948 (Entrez Gene)
Shisa5GeneProduct66940 (Entrez Gene)
Siah1aGeneProduct20437 (Entrez Gene)
Siah1bGeneProduct20438 (Entrez Gene)
Steap3GeneProduct68428 (Entrez Gene)
Thbs1GeneProduct21825 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Trp73GeneProduct22062 (Entrez Gene)
Tsc2GeneProduct22084 (Entrez Gene)
Zmat3GeneProduct22401 (Entrez Gene)
mmu-let-7b-5pGeneProductmmu-let-7b-5p (miRBase mature sequence)
mmu-miR-103a-3pGeneProductmmu-miR-103a-3p (miRBase mature sequence)
mmu-miR-122-5pGeneProductmmu-miR-122-5p (miRBase mature sequence)
mmu-miR-124-3pGeneProductmmu-miR-124-3p (miRBase mature sequence)
mmu-miR-145a-5pGeneProductmmu-miR-145a-5p (miRBase mature sequence)
mmu-miR-149-5pGeneProductmmu-miR-149-5p (miRBase mature sequence)
mmu-miR-15a-5pGeneProductmmu-miR-15a-5p (miRBase mature sequence)
mmu-miR-16-5pGeneProductmmu-miR-16-5p (miRBase mature sequence)
mmu-miR-17-5pGeneProductmmu-miR-17-5p (miRBase mature sequence)
mmu-miR-181a-5pGeneProductmmu-miR-181a-5p (miRBase mature sequence)
mmu-miR-181b-5pGeneProductmmu-miR-181b-5p (miRBase mature sequence)
mmu-miR-18a-5pGeneProductmmu-miR-18a-5p (miRBase mature sequence)
mmu-miR-195a-5pGeneProductmmu-miR-195a-5p (miRBase mature sequence)
mmu-miR-19b-3pGeneProductmmu-miR-19b-3p (miRBase mature sequence)
mmu-miR-1a-3pGeneProductmmu-miR-1a-3p (miRBase mature sequence)
mmu-miR-20a-5pGeneProductmmu-miR-20a-5p (miRBase mature sequence)
mmu-miR-21-5pGeneProductmmu-miR-21-5p (miRBase mature sequence)
mmu-miR-216a-5pGeneProductmmu-miR-216a-5p (miRBase mature sequence)
mmu-miR-217-5pGeneProductmmu-miR-217-5p (miRBase mature sequence)
mmu-miR-21a-5pGeneProductmmu-miR-21a-5p (miRBase mature sequence)
mmu-miR-223-3pGeneProductmmu-miR-223-3p (miRBase mature sequence)
mmu-miR-24-3pGeneProductmmu-miR-24-3p (miRBase mature sequence)
mmu-miR-291a-3pGeneProductmmu-miR-291a-3p (miRBase mature sequence)
mmu-miR-291b-3pGeneProductmmu-miR-291b-3p (miRBase mature sequence)
mmu-miR-294-3pGeneProductmmu-miR-294-3p (miRBase mature sequence)
mmu-miR-295-3pGeneProductmmu-miR-295-3p (miRBase mature sequence)
mmu-miR-297a-5pGeneProductmmu-miR-297a-5p (miRBase mature sequence)
mmu-miR-29b-3pGeneProductmmu-miR-29b-3p (miRBase mature sequence)
mmu-miR-301b-3pGeneProductmmu-miR-301b-3p (miRBase mature sequence)
mmu-miR-302d-3pGeneProductmmu-miR-302d-3p (miRBase mature sequence)
mmu-miR-30e-5pGeneProductmmu-miR-30e-5p (miRBase mature sequence)
mmu-miR-340-5pGeneProductmmu-miR-340-5p (miRBase mature sequence)
mmu-miR-34b-5pGeneProductmmu-miR-34b-5p (miRBase mature sequence)
mmu-miR-362-5pGeneProductmmu-miR-362-5p (miRBase mature sequence)
mmu-miR-425-5pGeneProductmmu-miR-425-5p (miRBase mature sequence)
mmu-miR-449a-5pGeneProductmmu-miR-449a-5p (miRBase mature sequence)
mmu-miR-486-5pGeneProductmmu-miR-486-5p (miRBase mature sequence)
mmu-miR-503-5pGeneProductmmu-miR-503-5p (miRBase mature sequence)
mmu-miR-758-3pGeneProductmmu-miR-758-3p (miRBase mature sequence)
mmu-miR-7b-5pGeneProductmmu-miR-7b-5p (miRBase mature sequence)
mmu-miR-9-5pGeneProductmmu-miR-9-5p (miRBase mature sequence)

Annotated Interactions

No annotated interactions

Personal tools