Gonadotropin-releasing hormone (GnRH) signaling (Bos taurus)

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1, 2ER+p+pGonadothropins gene expression & Secration+pMAP3K2CDC42GsGNRH2PRKACBCa+2PLA2G4AMAP2K4ITPR3MAPK12DNAGNA11MAPK3CALM3GNRH1Cytokine-cytokine receptor interaction pathwayMAP2K1PLCB3MEKKCALM1GNAQMAP2K2ADCY8ADCY2SOS2MAPK13ADCY1CALM2ADCY5MAP2K6KRASITPR2cAMPCACNA1CBMKPLCB1MAPK8CREBPRKACAADCY9MAPK1PRKXPKCCAMK2GPLA2G4FMAP3K1AAEGFRMAP3K3PLCB4DAGPLA2G4BPLD2FSH-βMAPK14α-GSUPLD1ADCY4NRASLH-βHB-EGFPLCB2GNRHRCALML5HRASADCY6ADCY7PLA2G4DPLA2G4ECa+2ITPR1CALML6MAPK10CACNA1DMAP2K7Pyk2ADCY3DNARAF1CAMK2BMAPK9IP3MAPK Signaling PathwayMMP2ELK1Calcium signaling pathwayNeuroactive ligand-receptor interactionPathwayMAP2K3MT1CALMCAMK2DGrb2MAPK11DNACACNA1SSOS1CAMK2Ac-JUNCACNA1FSRCMAP3K4PA,PE+pLH-β+p+p+p+p


Description

Gonadotropin-releasing hormones (GnRH) are the key factors stimulating gonadotropin release from the pituitary. GnRHs are decapeptides that act via G-protein coupled receptors (gonadotropin-releasing hormone receptors, GnRH-R). To date, several molecular forms of GnRH and GnRH-R have been identified in vertebrates. In most species, two forms of GnRH are present. one that is hypophysiotropic, stimulating gonadotropin release from the pituitary, and one that plays a neuromodulatory role in the central nervous system. The pituitary gonadotropins are heterodimeric glycoprotein-hormones consisting of a non-covalently linked common glycoprotein-hormone α-subunit and a specific β-subunit (FSHβ or LHβ) conferring their biological activity(2)

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Ontology Terms

 

Bibliography

  1. Kim HH; ''Regulation of gonadotropin-releasing hormone gene expression.''; Semin Reprod Med, 2007 PubMed Europe PMC
  2. Widmann P, Reverter A, Fortes MR, Weikard R, Suhre K, Hammon H, Albrecht E, Kuehn C; ''A systems biology approach using metabolomic data reveals genes and pathways interacting to modulate divergent growth in cattle.''; BMC Genomics, 2013 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
107056view14:14, 17 September 2019MaintBotChEBI identifier normalization
87581view02:24, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87580view02:24, 25 July 2016AlexanderPicoOntology Term : 'gonadotropin releasing neuron' added !
87360view09:39, 22 July 2016MaintBotadded missing graphids
87329view11:26, 21 July 2016MkutmonReverted to version '11:22, 21 July 2016' by Mkutmon
87328view11:25, 21 July 2016MaintBotadded missing graphids
87327view11:22, 21 July 2016MkutmonReverted to version '16:21, 10 November 2015' by Mkutmon
87326view11:16, 21 July 2016MaintBotadded missing graphids
82869view16:21, 10 November 2015JmeliusCorrect outdated id
82851view20:18, 9 November 2015EgonwRemoved a non-numeric Entrez gene (and MEKK is not found in Entrez Gene for cow).
79023view08:25, 25 February 2015Mkutmonfixed xref for MAPK1
79022view08:23, 25 February 2015Mkutmonfixed special character
79021view08:22, 25 February 2015Mkutmonfixed xrefs and special characters
79015view14:28, 24 February 2015ZariModified description
79014view14:27, 24 February 2015ZariModified description
79013view14:25, 24 February 2015ZariNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AAMetaboliteCHEBI:15843 (ChEBI)
ADCY1GeneProduct281601 (Entrez Gene)
ADCY2GeneProduct510708 (Entrez Gene)
ADCY3GeneProduct535603 (Entrez Gene)
ADCY4GeneProduct788151 (Entrez Gene)
ADCY5GeneProduct505740 (Entrez Gene)
ADCY6GeneProduct509936 (Entrez Gene)
ADCY7GeneProduct281603 (Entrez Gene)
ADCY8GeneProduct535017 (Entrez Gene)
ADCY9GeneProduct525482 (Entrez Gene)
BMKGeneProduct537703 (Entrez Gene)
CACNA1CGeneProduct408015 (Entrez Gene)
CACNA1DGeneProduct408013 (Entrez Gene)
CACNA1FGeneProduct509779 (Entrez Gene)
CACNA1SGeneProductENSBTAG00000047491 (Ensembl)
CALM1GeneProduct617095 (Entrez Gene)
CALM2GeneProduct100297344 (Entrez Gene)
CALMGeneProduct326597 (Entrez Gene)
CALM3GeneProduct520277 (Entrez Gene)
CALML5GeneProduct520404 (Entrez Gene)
CALML6GeneProduct617412 (Entrez Gene)
CAMK2AGeneProduct530719 (Entrez Gene)
CAMK2BGeneProduct525416 (Entrez Gene)
CAMK2DGeneProduct532713 (Entrez Gene)
CAMK2GGeneProduct282162 (Entrez Gene)
CDC42GeneProduct532712 (Entrez Gene)
CREBGeneProduct509107 (Entrez Gene)
Ca+2MetaboliteCHEBI:29108 (ChEBI)
Calcium signaling pathwayPathway
Cytokine-cytokine receptor interaction pathwayPathway
DAGMetaboliteCHEBI:18035 (ChEBI)
DNAMetabolite
EGFRGeneProduct407217 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
FSH-βGeneProduct281171 (Entrez Gene)
GNA11GeneProduct281788 (Entrez Gene)
GNAQGeneProduct536654 (Entrez Gene)
GNRH1GeneProduct768325 (Entrez Gene)
GNRH2GeneProduct100848664 (Entrez Gene)
GNRHRGeneProduct281798 (Entrez Gene)
Grb2GeneProduct535298 (Entrez Gene)
GsGeneProduct281793 (Entrez Gene)
HB-EGFGeneProduct522921 (Entrez Gene)
HRASGeneProduct100298939 (Entrez Gene)
IP3MetaboliteCHEBI:16595 (ChEBI)
ITPR1GeneProduct317697 (Entrez Gene)
ITPR2GeneProduct281878 (Entrez Gene)
ITPR3GeneProduct281879 (Entrez Gene)
KRASGeneProduct541140 (Entrez Gene)
LH-βGeneProduct280839 (Entrez Gene)
LH-βGeneProduct786429 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAP2K3GeneProduct516039 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP2K6GeneProduct286883 (Entrez Gene)
MAP2K7GeneProduct787278 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP3K2GeneProduct504592 (Entrez Gene)
MAP3K3GeneProduct508943 (Entrez Gene)
MAP3K4GeneProduct511779 (Entrez Gene)
MAPK Signaling PathwayPathwayWP998 (WikiPathways)
MAPK10GeneProduct534125 (Entrez Gene)
MAPK11GeneProduct618906 (Entrez Gene)
MAPK12GeneProduct512943 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK13GeneProduct535327 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MAPK9GeneProduct537631 (Entrez Gene)
MEKKGeneProduct
MMP2GeneProduct4313 (Entrez Gene)
MT1GeneProduct4323 (Entrez Gene)
NRASGeneProduct506322 (Entrez Gene)
Neuroactive ligand-receptor interactionPathwayPathway
PA,PEMetaboliteCHEBI:16337 (ChEBI)
PKCGeneProduct
PLA2G4AGeneProduct525072 (Entrez Gene)
PLA2G4BGeneProduct505485 (Entrez Gene)
PLA2G4DGeneProduct531209 (Entrez Gene)
PLA2G4EGeneProduct526364 (Entrez Gene)
PLA2G4FGeneProduct522866 (Entrez Gene)
PLCB1GeneProduct287026 (Entrez Gene)
PLCB2GeneProduct508888 (Entrez Gene)
PLCB3GeneProduct515669 (Entrez Gene)
PLCB4GeneProduct281985 (Entrez Gene)
PLD1GeneProduct522159 (Entrez Gene)
PLD2GeneProduct514554 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PRKACBGeneProduct282323 (Entrez Gene)
PRKXGeneProduct505773 (Entrez Gene)
Pyk2GeneProduct541008 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
SOS1GeneProduct537682 (Entrez Gene)
SOS2GeneProduct100138040 (Entrez Gene)
SRCGeneProduct535742 (Entrez Gene)
c-JUNGeneProduct280831 (Entrez Gene)
cAMPMetaboliteCHEBI:17489 (ChEBI)
α-GSUGeneProduct280749 (Entrez Gene)

Annotated Interactions

No annotated interactions

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