IGF-1 Signaling (Bos taurus)

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1, 2Cell SurvivalProtein SynthesisTranscription of target genesAKT1RAF1IRS1AKT2MAPK4AKT3MAPK8PIK3MAPK10MAPK12KRASSHC1MAPK9SHC2ARAFMAPK1MAPK15MAPK7MAPK13MTORIRS2NRASIGF1RBRAFMAPK6BADSHC4HRASMAPK11IGF1SHC3MAPK14MAPK3PPPPPMitogenesis/Differentiation


Description

The activated IGF-1R (Insulin-like growth factor 1 receptor) regulates cellular adhesion, cytoskeletal organization and migration through interaction with adhesion molecules and integrin. In normal physiology the IGF-1R stimulates linear body growth, promotes neuronal survival and myelination, postnatal mammary gland development and lactation and is implicated in bone formation and renal function (Fortes et al,2013).

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Ontology Terms

 

Bibliography

  1. Jones JI, Clemmons DR; ''Insulin-like growth factors and their binding proteins: biological actions.''; Endocr Rev, 1995 PubMed Europe PMC Scholia
  2. Fortes MR, Li Y, Collis E, Zhang Y, Hawken RJ; ''The IGF1 pathway genes and their association with age of puberty in cattle.''; Anim Genet, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
88665view15:26, 12 August 2016JmeliusOntology Term : 'signaling pathway' added !
79671view18:08, 3 April 2015KhanspersAdded phoshorylation label for states
79664view08:51, 2 April 2015EgonwCorrected the ENSBT* identifier data sources for three identifiers.
79647view21:21, 31 March 2015Evelotypo fixes
79646view21:21, 31 March 2015Evelotypo fixes
78860view08:35, 9 February 2015MkutmonModified description
78853view20:26, 5 February 2015Zari
78852view20:19, 5 February 2015ZariModified description
78847view16:19, 5 February 2015ZariNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl)
AKT2GeneProduct534923 (Entrez Gene)
AKT3GeneProduct100137872 (Entrez Gene)
ARAFGeneProduct540421 (Entrez Gene)
BADGeneProduct615013 (Entrez Gene)
BRAFGeneProductENSBTAG00000021761 (Ensembl)
HRASGeneProduct100298939 (Entrez Gene)
IGF1GeneProduct281239 (Entrez Gene)
IGF1RGeneProduct281848 (Entrez Gene)
IRS1GeneProductENSBTAG00000021308 (Ensembl)
IRS2GeneProductENSBTAG00000012019 (Ensembl)
KRASGeneProduct541140 (Entrez Gene)
MAPK10GeneProduct537631 (Entrez Gene)
MAPK11GeneProduct618906 (Entrez Gene)
MAPK12GeneProduct512943 (Entrez Gene)
MAPK13GeneProduct535327 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK15GeneProduct512125 (Entrez Gene)
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
MAPK3GeneProduct531391 (Entrez Gene)
MAPK4GeneProductENSBTAG00000009907 (Ensembl)
MAPK6GeneProduct538094 (Entrez Gene)
MAPK7GeneProduct537703 (Entrez Gene)
MAPK8GeneProductENSBTAG00000007876 (Ensembl)
MAPK9GeneProduct534125 (Entrez Gene)
MTORGeneProduct100139219 (Entrez Gene)
NRASGeneProduct506322 (Entrez Gene)
PIK3GeneProduct
RAF1GeneProduct521196 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
SHC2GeneProductENSBTAG00000016072 (Ensembl)
SHC3GeneProduct512696 (Entrez Gene)
SHC4GeneProduct524734 (Entrez Gene)

Annotated Interactions

No annotated interactions

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