Nuclear receptors meta-pathway (Homo sapiens)

From WikiPathways

Jump to: navigation, search
10, 48CAR/PXR LigandCAR target genesOtherOtherOtherOtherOther5017179CES3FGF19CES5ACYP2A6PTGS2AntioxidantproteinsSLC2A12EHHADHZIC2UGT2B7CYP4A11SEC14L1SLC2A8RGS2Bile acid &xenobiotics transportPDE4BPPP1R14CUGT1A7PDK4ABCB11PPP2R4PPARGC1ASRGNPTGR1PRRG4CYP1B1CYP2B6CYP2C9SLC2A13UGT1A6SULT2A1IL12AG6PDABCC2CES2PRDX6EP300DNAJB1GPX3NRG1TSC22D3ETNK2DNERUGT1A9MT1IPFTLTGFACell proliferationand apoptosisALDH3A1PCK1NR0B2UGT1A4THBDSLC2A1PPARDCYP2A6GCLMUGT1A9CYP3A4CCL20PRDX1CBR3GPR115TGFB1ALAS1CYP8B1EPB41L4BCYP3A5ABCG5SERPINB2NR3C1CDKN1CBHLHE40IL12BHSP90AB1AKAP13GSTP1MFGE8UGT1A1GADD45BSLC2A2KTN1FGFBP1NR0B2CYP3A4DNAJC7CYP7A1UGT1A3CCL2CXCR7ARL5BSLC19A2MAFFGPR153SLC2A3GSTA4SLC2A6ABCC3NCOA2CBR1IRS2ABHD2ABCC5Co-activatorsACOX1ABCG8EPHA3AMIGO2TranscriptionfactorsUGT1A3TXNRD3PPARAUGT1A9SCNN1AGSTA2SNAI2EGR1HGFSTOMCES4AABCB4SLC2A14NAV3UGT1A3MGST3SLC2A10CYP2B6SLC2A5UGT1A7HSP90AA1SDPRPOLKSP1DNAJC15SLC2A9CYP2C19BIRC2CAP2NR1I3SLCO2B1SLC26A2SULT1A1CYP1A1STAT3ABCB1CYP2A6ANGPTL4HBEGFGPX2SLC2A7BLVRBSMC1ASRXN1PDGFBFGF13NFKB2MGST2EDN2GPAMFGD4FTH1MGST1SLC7A11SERPINB9SP1CYP1A2GCC1NCOA6CES3SERTAD2PGDTranscriptionfactorsGSTA2SLC27A5LRRC8ATGFB2SOD3BAATUGT1A6TNFAIP3SPINK13UGT2B4IL1BGSRGGT1AGERCell proliferationand differentiationCYP3A4FKBP5MYOFPPARAACAA1PMP2Bile acidneosynthesisRXRAMAFGPOU5F1ABCC3ABCC4MetabolismTXNRD1GSTA5FASNNR1H4SRCMGAMDrug and steroidmetabolismCES1SQSTM1InflammationB3GNT5GSTA3PLK2ME1NCOA1CYP3A7CDC42EP3NR1H3IFNGIL11HMOX1GSTT1JUNBIP6K3KAT2BCUL1CYP7A1UGT1A4ANKRD1bile acidconjugationSREBF1SLC7A5SLC10A1SPRY1ENC1GSTA1CYP4A11TGFB1KEAP1TXNSMARCA1EPHA2TGFBR2JUNABCC2UGT1A1SULT2A1JUNALOX5APCPEB4S100PTNS4GCLCNFE2L2SULT2A1SERPINA1UGT1A4SLC2A4GSTT2PPARGC1ASLC2A11TGFBR3ADH7NR0B2HSP90AA1IL17BCYP7A1BIRC3ESR1HSPA1APhase 2metabolismNQO141167294428, 4916443512164116173712241391212121212716121116551381254512331293453312946932045122947111444412938124420NR1I338121423016221238LigandDNAJC7HSP90AA1CoregulatorsGenesTATA boxPBREMRXRANR1I3LigandCo-activatorsNCOA1EGFR pathwayEP300UGT1A6AHRR12, 16, 4044SRCCDKN1B44AIPCYP1B116, 20, 40, 44, 45UGT1A112, 16, 40ALDH3A1GSTA245AHR16, 40JUND13NQO116, 40IGFBP115NFE2L240BAX44JUNCYP1A2416, 20, 40, 44, 45EGFRHSP90AA1TNFPTGES3IL251HES18ARNTCDC37CYP1A1AHR16, 20, 40, 44, 45ARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxUGT1A9Hepatocyteproliferation11, 12NR1H311SCP211CPT1A11APOC311FABP1CCND11111PLTP11DBI11APOA2CPT21111APOA111CYP4A1111ACADM11CDK411CYP7A111MYCmitochondrialomega-oxidation11SLC27A111Cholesterolcatabolismperoxisomalbeta-oxidationKLK1511APOA511CDK111CYP8B111PPAR alpha ligandPPARAGenesTATA boxPPREPPARARXRALigandlipoproteinmetabolismfatty acidtransportmitochondrialbeta-oxidationPXR target genes14, 38SLCO1B114HSP90AA1NR1I2SRPX2NCOA3FOXO132CYP4F1214CYP3A4UGT1A11614DNAJC7ABCC4NRIP114UnknownCYP2B616GSTA214PSMC5PPARGC1ANCOA1NCOA2ABCB1NR1I214LigandCoregulatorsGenesTATA boxXRERXRANR1I2LigandAhR LigandCo-activatorsGenesTATA boxNR1I3NR1I2NR3C1RXRA28, 49NR1I3NR1I2NR3C1HSP90AA1GR ligandp23HSP90AA1p23NR3C118, 42HSP90AA1p23NR3C1Ligand42NR3C142LigandLigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGRECoregulatorsGR inhibitorytarget genesLXR ligandNR1H3LigandRXRA28, 49PTGES3RXRA28, 49NR1H3CYP2B6CYP2C911GenesTATA boxVDREVDR target genes23, 42VDRLigandRXRACYP3A41VDRVDR ligandRXRAVDRLigandER ligandESR1ESR1LigandLigandGenesTATA boxEREESR1LigandESR1LigandESR139ESR1ESR1LigandLigandCoregulatorsER target genes25GenesTATA boxNR1H3LigandLXRERXRA28, 49LXR target genesFXR ligandNR1H4RXRA33LigandGenesTATA boxNR1H433RXRALigandFXREBile aciddetoxification5NR1H433LigandUGT1A4UGT1A61212UGT1A912UGT1A312CYP2C916CYP3A516CYP2C1916SULT2A131ABCC2ABCC31EHHADH1FOXO129Inflammation32Growth andapoptosis17Signaltransduction1717InflammationGrowth andapoptosis1717SignaltransductionMetabolism1717Transport17NuclearreceptorsFXR Target genesGR stimulatorytarget genesMulti-drugresistanceDrug and steroidmetabolismPhase 2metabolismMulti-drugresistancePhase 2metabolismDrug and steroidmetabolismPhase 2metabolismDrug and steroidmetabolismMulti-drugresistanceTranscriptionfactorsDrug and steroidmetabolismTranscriptionfactorsDrug and steroidmetabolismPPAR alphatarget genesAhR target genesGenesTATA boxRXRALigandARENRF2 targetgenesPhase 1proteins9Phase 2proteins9GSTM5GSTM1GSTM2GSTM3GSTM4Transport9SLC5A2SLC5A1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SLC5A8SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14Growth factorsand receptors9NFE2L2NRF2 ligandKEAP1NFE2L2LigandNFE2L2NFE2L2SCDOtherOtherOtherOtherOther