Nuclear Receptors Meta-Pathway (Homo sapiens)

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10, 48OtherOtherCAR target genesCAR/PXR LigandOtherOtherOther9501717CYP4A11EPHA2TXNPRDX6ABCB11NRG1InflammationFGF13PPARGC1AEGR1SLC2A10CYP3A5IL1BSERPINB2GCC1ANKRD1UGT2B7TSC22D3UGT2B4BIRC3CYP4A11CYP2A6MGST3SLCO2B1ABCC3HMOX1ADH7SULT2A1ENC1IL11IL12AGGT1bile acidconjugationPDE4BSRXN1NFE2L2JUNABCC2PLK2Cell proliferationand differentiationAGERSREBF1SLC2A7Co-activatorsSCNN1AEPB41L4BTGFB1TranscriptionfactorsPPP1R14CGSTA3SLC2A4ALAS1BLVRBUGT1A3PPARAFTLPGDSLC7A11STOMPRRG4MAFFGCLCTXNRD1RXRAACOX1CYP7A1NCOA2SRCFKBP5CYP2B6UGT1A9FGF19IL17BCUL1MGST2UGT1A9AKAP13FTH1SOD3CBR1UGT1A7CYP2B6CYP2A6Drug and steroidmetabolismGPR153PMP2IRS2TGFB2CYP3A4CYP2C19GPX3GPX2KEAP1UGT1A3SLC26A2SP1SLC27A5CDKN1CCDC42EP3SLC2A1CES3SLC2A2ABCC4Bile acidneosynthesisCYP7A1GSTA4CYP1B1SMARCA1CES4ASULT2A1MAFGFGFBP1HSP90AA1UGT1A1ALOX5APSERPINB9ZIC2IL12BME1NR0B2RGS2GSRSTAT3CYP8B1UGT1A6PCK1FGD4UGT1A7ACAA1NCOA1TranscriptionfactorsPDGFBCES1PTGS2AntioxidantproteinsABHD2PPP2R4CBR3TGFB1SP1LRRC8ANR1I3PPARANR3C1ETNK2ABCB4SLC2A6MYOFSLC2A5MGST1CAP2MGAMNR1H3SERTAD2BIRC2NR0B2ABCC5POU5F1TGFBR2HGFHSP90AB1SMC1AJUNCCL2ALDH3A1SLC2A11TNFAIP3NR0B2CYP2A6ABCG5G6PDNAV3TXNRD3PPARGC1AABCC3GSTT1Bile acid &xenobiotics transportCell proliferationand apoptosisTNS4SERPINA1SDPRHBEGFSLC2A14S100PESR1NFKB2SRGNABCB1CYP3A4UGT1A4NR1H4PDK4ANGPTL4HSP90AA1CYP1A2DNERSLC2A9SNAI2ABCC2UGT1A4GCLMSLC2A3UGT1A1DNAJB1PTGR1CYP3A7PPARDUGT1A4POLKCXCR7CYP1A1MetabolismGSTA2GADD45BGSTT2IP6K3JUNBSEC14L1EHHADHTGFBR3PRDX1GSTA2SLC2A12THBDSLC19A2AMIGO2BAATSLC2A13KAT2BDNAJC7MT1IPNQO1CES3SLC7A5SULT1A1GSTP1DNAJC15TGFAPhase 2metabolismMFGE8CES5AGSTA5EPHA3EP300UGT1A9CCL20SLC2A8UGT1A3KTN1GSTA1CES2CYP7A1SLC10A1CYP2C9EDN2SULT2A1SPINK13NCOA6ABCG8ARL5BB3GNT5FASNUGT1A6HSPA1ASQSTM1SPRY1IFNGGPR115GPAMCPEB4BHLHE40CYP3A4175NR1I34411441352474622531161612389453973828, 4912111212112443293044354233444538451161216164112920132912121212411247163729912122038121612LigandDNAJC7HSP90AA1CoregulatorsGenesTATA boxPBREMRXRANR1I3LigandCo-activatorsNCOA1EGFR pathwayEP300UGT1A612, 16, 40AHRRSRC44CDKN1BAIP44CYP1B116, 20, 40, 44, 45UGT1A112, 16, 40ALDH3A145GSTA216, 40AHRJUND13NQO116, 40IGFBP1NFE2L21540BAX44JUNCYP1A24EGFR16, 20, 40, 44, 45HSP90AA1TNFPTGES3IL251HES1ARNT8CDC37CYP1A116, 20, 40, 44, 45AHRARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxUGT1A9Hepatocyteproliferation11, 12NR1H311SCP2CPT1A1111APOC311FABP111CCND1PLTP11DBI1111APOA211CPT211APOA1CYP4A1111ACADM1111CDK411CYP7A1MYC1111mitochondrialomega-oxidationSLC27A1Cholesterolcatabolism11peroxisomalbeta-oxidationKLK1511APOA511CDK1CYP8B11111PPAR alpha ligandPPARAGenesTATA boxPPREPPARARXRALigandlipoproteinmetabolismfatty acidtransportmitochondrialbeta-oxidationPXR target genes14, 38SLCO1B1HSP90AA114NR1I2SRPX2NCOA3FOXO1CYP4F1232CYP3A414UGT1A116DNAJC714ABCC4NRIP114UnknownCYP2B616GSTA214PSMC5PPARGC1ANCOA1NCOA2ABCB114NR1I2LigandCoregulatorsGenesTATA boxXRERXRANR1I2LigandAhR LigandCo-activatorsGenesTATA boxNR1I3NR1I2NR3C1RXRA28, 49NR1I3NR1I2NR3C1HSP90AA1GR ligandp23HSP90AA1p23NR3C1HSP90AA118, 42p23NR3C1Ligand42NR3C1Ligand42LigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGRECoregulatorsGR inhibitorytarget genesLXR ligandNR1H3LigandRXRA28, 49PTGES3RXRA28, 49NR1H3CYP2B61CYP2C91GenesTATA boxVDREVDR target genesVDR23, 42LigandRXRACYP3A41VDRVDR ligandRXRAVDRLigandER ligandESR1ESR1LigandLigandGenesTATA boxEREESR1LigandESR1LigandESR139ESR1ESR1LigandLigandCoregulatorsER target genes25GenesTATA boxNR1H3LigandLXRERXRALXR target genes28, 49FXR ligandNR1H4RXRA33LigandGenesTATA boxNR1H433RXRALigandFXREBile aciddetoxification5NR1H433LigandUGT1A412UGT1A612UGT1A912UGT1A312CYP2C9CYP3A516CYP2C191616SULT2A131ABCC21ABCC31EHHADHFOXO12932Inflammation17Growth andapoptosisSignaltransduction1717Inflammation17Growth andapoptosis17Signaltransduction17Metabolism17Transport17NuclearreceptorsFXR Target genesGR stimulatorytarget genesMulti-drugresistanceDrug and steroidmetabolismPhase 2metabolismMulti-drugresistancePhase 2metabolismDrug and steroidmetabolismPhase 2metabolismDrug and steroidmetabolismMulti-drugresistanceTranscriptionfactorsDrug and steroidmetabolismTranscriptionfactorsDrug and steroidmetabolismPPAR alphatarget genesAhR target genesGenesTATA boxRXRALigandARENRF2 targetgenesPhase 1proteinsPhase 2proteins99GSTM5GSTM1GSTM2GSTM3GSTM4TransportSLC5A29SLC5A1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SLC5A8SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14Growth factorsand receptors9NFE2L2NRF2 ligandKEAP1NFE2L2LigandNFE2L2NFE2L2SCDOtherOtherOtherOtherOther