Nuclear Receptors Meta-Pathway (Homo sapiens)
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10, 48
Other
Other
CAR target genes
CAR/PXR Ligand
Other
Other
Other
9
50
17
17
CYP4A11
EPHA2
TXN
PRDX6
ABCB11
NRG1
Inflammation
FGF13
PPARGC1A
EGR1
SLC2A10
CYP3A5
IL1B
SERPINB2
GCC1
ANKRD1
UGT2B7
TSC22D3
UGT2B4
BIRC3
CYP4A11
CYP2A6
MGST3
SLCO2B1
ABCC3
HMOX1
ADH7
SULT2A1
ENC1
IL11
IL12A
GGT1
bile acid
conjugation
PDE4B
SRXN1
NFE2L2
JUN
ABCC2
PLK2
Cell proliferation
and differentiation
AGER
SREBF1
SLC2A7
Co-activators
SCNN1A
EPB41L4B
TGFB1
Transcription
factors
PPP1R14C
GSTA3
SLC2A4
ALAS1
BLVRB
UGT1A3
PPARA
FTL
PGD
SLC7A11
STOM
PRRG4
MAFF
GCLC
TXNRD1
RXRA
ACOX1
CYP7A1
NCOA2
SRC
FKBP5
CYP2B6
UGT1A9
FGF19
IL17B
CUL1
MGST2
UGT1A9
AKAP13
FTH1
SOD3
CBR1
UGT1A7
CYP2B6
CYP2A6
Drug and steroid
metabolism
GPR153
PMP2
IRS2
TGFB2
CYP3A4
CYP2C19
GPX3
GPX2
KEAP1
UGT1A3
SLC26A2
SP1
SLC27A5
CDKN1C
CDC42EP3
SLC2A1
CES3
SLC2A2
ABCC4
Bile acid
neosynthesis
CYP7A1
GSTA4
CYP1B1
SMARCA1
CES4A
SULT2A1
MAFG
FGFBP1
HSP90AA1
UGT1A1
ALOX5AP
SERPINB9
ZIC2
IL12B
ME1
NR0B2
RGS2
GSR
STAT3
CYP8B1
UGT1A6
PCK1
FGD4
UGT1A7
ACAA1
NCOA1
Transcription
factors
PDGFB
CES1
PTGS2
Antioxidant
proteins
ABHD2
PPP2R4
CBR3
TGFB1
SP1
LRRC8A
NR1I3
PPARA
NR3C1
ETNK2
ABCB4
SLC2A6
MYOF
SLC2A5
MGST1
CAP2
MGAM
NR1H3
SERTAD2
BIRC2
NR0B2
ABCC5
POU5F1
TGFBR2
HGF
HSP90AB1
SMC1A
JUN
CCL2
ALDH3A1
SLC2A11
TNFAIP3
NR0B2
CYP2A6
ABCG5
G6PD
NAV3
TXNRD3
PPARGC1A
ABCC3
GSTT1
Bile acid &
xenobiotics transport
Cell proliferation
and apoptosis
TNS4
SERPINA1
SDPR
HBEGF
SLC2A14
S100P
ESR1
NFKB2
SRGN
ABCB1
CYP3A4
UGT1A4
NR1H4
PDK4
ANGPTL4
HSP90AA1
CYP1A2
DNER
SLC2A9
SNAI2
ABCC2
UGT1A4
GCLM
SLC2A3
UGT1A1
DNAJB1
PTGR1
CYP3A7
PPARD
UGT1A4
POLK
CXCR7
CYP1A1
Metabolism
GSTA2
GADD45B
GSTT2
IP6K3
JUNB
SEC14L1
EHHADH
TGFBR3
PRDX1
GSTA2
SLC2A12
THBD
SLC19A2
AMIGO2
BAAT
SLC2A13
KAT2B
DNAJC7
MT1IP
NQO1
CES3
SLC7A5
SULT1A1
GSTP1
DNAJC15
TGFA
Phase 2
metabolism
MFGE8
CES5A
GSTA5
EPHA3
EP300
UGT1A9
CCL20
SLC2A8
UGT1A3
KTN1
GSTA1
CES2
CYP7A1
SLC10A1
CYP2C9
EDN2
SULT2A1
SPINK13
NCOA6
ABCG8
ARL5B
B3GNT5
FASN
UGT1A6
HSPA1A
SQSTM1
SPRY1
IFNG
GPR115
GPAM
CPEB4
BHLHE40
CYP3A4
1
7
5
NR1I3
44
11
44
1
3
5
24
7
46
22
5
31
16
16
12
38
9
45
39
7
38
28, 49
12
1
1
12
12
1
12
44
3
29
30
44
35
42
33
44
45
38
45
1
16
12
16
16
41
1
29
20
1
3
29
12
12
12
12
41
12
47
16
37
29
9
12
12
20
38
12
16
12
Ligand
DNAJC7
HSP90AA1
Coregulators
Genes
TATA box
PBREM
RXRA
NR1I3
Ligand
Co-activators
NCOA1
EGFR pathway
EP300
UGT1A6
12, 16, 40
AHRR
SRC
44
CDKN1B
AIP
44
CYP1B1
16, 20, 40, 44, 45
UGT1A1
12, 16, 40
ALDH3A1
45
GSTA2
16, 40
AHR
JUND
13
NQO1
16, 40
IGFBP1
NFE2L2
15
40
BAX
44
JUN
CYP1A2
4
EGFR
16, 20, 40, 44, 45
HSP90AA1
TNF
PTGES3
IL2
51
HES1
ARNT
8
CDC37
CYP1A1
16, 20, 40, 44, 45
AHR
ARNT
AIP
SRC
SRC
CDC37
AHR
ARNT
AHR
Ligand
Ligand
Ligand
XRE
Genes
TATA box
UGT1A9
Hepatocyte
proliferation
11, 12
NR1H3
11
SCP2
CPT1A
11
11
APOC3
11
FABP1
11
CCND1
PLTP
11
DBI
11
11
APOA2
11
CPT2
11
APOA1
CYP4A11
11
ACADM
11
11
CDK4
11
CYP7A1
MYC
11
11
mitochondrial
omega-oxidation
SLC27A1
Cholesterol
catabolism
11
peroxisomal
beta-oxidation
KLK15
11
APOA5
11
CDK1
CYP8B1
11
11
PPAR alpha ligand
PPARA
Genes
TATA box
PPRE
PPARA
RXRA
Ligand
lipoprotein
metabolism
fatty acid
transport
mitochondrial
beta-oxidation
PXR target genes
14, 38
SLCO1B1
HSP90AA1
14
NR1I2
SRPX2
NCOA3
FOXO1
CYP4F12
32
CYP3A4
14
UGT1A1
16
DNAJC7
14
ABCC4
NRIP1
14
Unknown
CYP2B6
16
GSTA2
14
PSMC5
PPARGC1A
NCOA1
NCOA2
ABCB1
14
NR1I2
Ligand
Coregulators
Genes
TATA box
XRE
RXRA
NR1I2
Ligand
AhR Ligand
Co-activators
Genes
TATA box
NR1I3
NR1I2
NR3C1
RXRA
28, 49
NR1I3
NR1I2
NR3C1
HSP90AA1
GR ligand
p23
HSP90AA1
p23
NR3C1
HSP90AA1
18, 42
p23
NR3C1
Ligand
42
NR3C1
Ligand
42
Ligand
Ligand
NR3C1
NR3C1
Ligand
Ligand
GRE
Genes
TATA box
NR3C1
NR3C1
Ligand
Ligand
nGRE
Coregulators
GR inhibitory
target genes
LXR ligand
NR1H3
Ligand
RXRA
28, 49
PTGES3
RXRA
28, 49
NR1H3
CYP2B6
1
CYP2C9
1
Genes
TATA box
VDRE
VDR target genes
VDR
23, 42
Ligand
RXRA
CYP3A4
1
VDR
VDR ligand
RXRA
VDR
Ligand
ER ligand
ESR1
ESR1
Ligand
Ligand
Genes
TATA box
ERE
ESR1
Ligand
ESR1
Ligand
ESR1
39
ESR1
ESR1
Ligand
Ligand
Coregulators
ER target genes
25
Genes
TATA box
NR1H3
Ligand
LXRE
RXRA
LXR target genes
28, 49
FXR ligand
NR1H4
RXRA
33
Ligand
Genes
TATA box
NR1H4
33
RXRA
Ligand
FXRE
Bile acid
detoxification
5
NR1H4
33
Ligand
UGT1A4
12
UGT1A6
12
UGT1A9
12
UGT1A3
12
CYP2C9
CYP3A5
16
CYP2C19
16
16
SULT2A1
31
ABCC2
1
ABCC3
1
EHHADH
FOXO1
29
32
Inflammation
17
Growth and
apoptosis
Signal
transduction
17
17
Inflammation
17
Growth and
apoptosis
17
Signal
transduction
17
Metabolism
17
Transport
17
Nuclear
receptors
FXR Target genes
GR stimulatory
target genes
Multi-drug
resistance
Drug and steroid
metabolism
Phase 2
metabolism
Multi-drug
resistance
Phase 2
metabolism
Drug and steroid
metabolism
Phase 2
metabolism
Drug and steroid
metabolism
Multi-drug
resistance
Transcription
factors
Drug and steroid
metabolism
Transcription
factors
Drug and steroid
metabolism
PPAR alpha
target genes
AhR target genes
Genes
TATA box
RXRA
Ligand
ARE
NRF2 target
genes
Phase 1
proteins
Phase 2
proteins
9
9
GSTM5
GSTM1
GSTM2
GSTM3
GSTM4
Transport
SLC5A2
9
SLC5A1
SLC5A4
SLC5A10
SLC5A9
SLC5A6
SLC5A11
SLC5A12
SLC5A3
SLC5A7
SLC5A8
SLC5A5
SLC6A2
SLC6A1
SLC6A4
SLC6A11
SLC6A9
SLC6A6
SLC6A13
SLC6A14
SLC6A3
SLC6A7
SLC6A8
SLC6A5
SLC6A16
SLC6A15
SLC6A18
SLC6A20
SLC6A17
SLC6A19
SLC39A2
SLC39A1
SLC39A4
SLC39A10
SLC39A9
SLC39A6
SLC39A11
SLC39A12
SLC39A3
SLC39A7
SLC39A8
SLC39A5
SLC39A13
SLC39A14
Growth factors
and receptors
9
NFE2L2
NRF2 ligand
KEAP1
NFE2L2
Ligand
NFE2L2
NFE2L2
SCD
Other
Other
Other
Other
Other