Aryl hydrocarbon receptor pathway (Homo sapiens)

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8, 13, 34, 43TranscriptionfactorsDrug and steroid metabolismTranscriptionPhase 2 metabolismOtherCo-activatorsCell proliferation and differentiationInflammationEP300EGFR pathwayHSP90AA1LigandSRCAIPAHREGFRHSP90AA1TNFARNTCDC37AHRARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxPTGES3PTGES3NCOA1UGT1A3SLC7A55128UGT1A4MYOF51IFNG2823SERPINB224TGFB124CAP2UGT1A92951POLKUGT1A72451IL12A23CES3IL17B2928IL1B24JUNB24IL12B23MGST133UGT1A6AHRR14, 16, 5124CDKN1BCYP1B12414, 16, 24, 28, 29UGT1A114, 16, 51ALDH3A1GSTA228JUND14, 16NQO11014, 16IGFBP147NFE2L214BAX24JUN40CYP1A2IL214, 16, 24, 28, 29HES1449CYP1A114, 16, 24, 28, 29


Description

The aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic metabolism, e.g. cytochrome P450 enzymes. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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  32. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  33. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
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  43. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
123110view05:44, 4 July 2022EgonwMade a pathway clickable
120645view15:08, 22 December 2021EweitzNudge group up
120644view15:07, 22 December 2021EweitzStraighten arrow
120643view15:06, 22 December 2021EweitzTighten graphics, align
120640view01:25, 22 December 2021EweitzModified description
117655view11:46, 22 May 2021EweitzModified title
106304view17:45, 20 August 2019KhanspersModified description
105535view06:04, 9 August 2019KhanspersModified description
95229view18:54, 26 November 2017DeSlModified description
95226view18:52, 26 November 2017DeSlOntology Term : 'aryl hydrocarbon receptor signaling pathway' added !
95142view02:47, 17 November 2017AlexanderPicoadded graphical lines
95141view02:45, 17 November 2017AlexanderPicoremoved bad interactions
95140view02:41, 17 November 2017AlexanderPicoupdated node label
95139view02:38, 17 November 2017MaintBotremoved odd charactes from node lable
88902view08:20, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79696view11:00, 5 April 2015EgonwFixed the references section.
79690view20:11, 4 April 2015AlexanderPicoModified title
79597view05:34, 27 March 2015EgonwUpdated the Ensembl data source.
79544view15:12, 24 March 2015RiannefijtenModified description
79543view15:10, 24 March 2015Riannefijtenfixed unconnected line
79516view07:53, 24 March 2015Riannefijtenadded reference
79486view13:14, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for 'aryl hydrocarbon receptor agonist'.
79481view13:00, 23 March 2015RiannefijtenUpdated connections and the annotations
78579view14:50, 7 January 2015MaintBotadded missing graphIds
78253view22:04, 17 December 2014KhanspersModified title
78212view14:51, 14 December 2014EgonwChanged GPML schema.
78211view14:46, 14 December 2014MaintBotModified title
78086view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AHRGeneProductENSG00000106546 (Ensembl)
AHRRGeneProductENSG00000063438 (Ensembl)
AIPGeneProductENSG00000110711 (Ensembl)
ALDH3A1GeneProductENSG00000108602 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
BAX GeneProductENSG00000087088 (Ensembl)
CAP2GeneProductENSG00000112186 (Ensembl)
CDC37GeneProductENSG00000105401 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CES3GeneProductENSG00000172828 (Ensembl)
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP1B1GeneProductENSG00000138061 (Ensembl)
EGFR pathwayPathwayWP1910 (WikiPathways)
EGFRGeneProductENSG00000146648 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
HES1GeneProductENSG00000114315 (Ensembl)
HSP90AA1 GeneProductENSG00000080824 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IGFBP1 GeneProductENSG00000146678 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL17BGeneProductENSG00000127743 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL2 GeneProductENSG00000109471 (Ensembl)
JUNBGeneProductENSG00000171223 (Ensembl)
JUNDGeneProductENSG00000130522 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LigandMetaboliteCHEBI:72768 (ChEBI) Omeprazole, TCDD, PCB
MGST1GeneProductENSG00000008394 (Ensembl)
MYOFGeneProductENSG00000138119 (Ensembl)
NCOA1GeneProductENSG00000084676 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NQO1GeneProductENSG00000181019 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
PTGES3GeneProductENSG00000110958 (Ensembl)
SERPINB2GeneProductENSG00000197632 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)
SRC GeneProductENSG00000197122 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A7GeneProductENSG00000244122 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)

Annotated Interactions

No annotated interactions

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