Differentiation Pathway (Homo sapiens)

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1Endodermal3D matrigel cultureAnterior endodermSerumFP6SortDefinitive endodermCyclopamineRAAscorbic acidNT5EDAPTSB431542SeleniumBMP4FGF2TGFB1A-83-01BMP4NOGNiacinamideSHHCXCR1ES/IPS cellsKITEGFVEGFAFGF4IGF1HGFNOTCH1EGFBMP4NOGWNT3AMultipotent LungProgenitorsHindgut endodermMultipotent endodermalprogenitor cellsHGFFGF4EGFNODALFGF10RAFGF10Intestinal Tissueخ² cellsPancreatic progenitorsHepatocytesHepaticprogenitorsBMP4VEGFASCFTPOFLT3LGSCFCSF1IL6IL3VEGFABMP4SCFTPOIL3EPOINHBAFGF2BMP4FLT3LGTPOFGF2VEGFAFGF2SB431542TGFB1PDGFBIL3IL6VEGFASCFIL11DKK1VEGFAWNT1DKK1WNT1VEGFATGFB3NTF4FGF2BMP4FSTNTF4BMP4FGF2GDF5HemangioblastErythropoietic cellsLymphoid progenitorsOsteoclastsEndothelial cellsCardiomyocytesSmooth muscle cellsSkeletal myoblastsOsteogenic cellsMesenchymal stem/precursor cellsAscorbic acidBeta-Glycerophosphoric acidDexamethasoneDexamethasoneINSINSTFOP-9cocultureOP-9 coculture Semisolid cultureOP-9 orMS-5cocultureSortSemisolid cultureMesenchymo-angioblastAdipogenicCellHematopoieticprogenitorsMonocyte/macrophageprogenitorChondrogeniccellsCardiovascular colonyforming cellsVEGFATPOEPOIL6IL3IL11CSF1RTNFSF11Primitive streakMesodermBMP4WNT2BWNT5A47WNT7BWNT2FGF2IL6IL6RBMP4OP-9 coculture MesodermalGABA neuronsEpidermisPA6/MS-5cocultureCortical layersOptic cupNeural progenitorsDA neuronsSort P75+, HNK1Cortical neuronsKeratinocytesAdherent cultureOligodendrocytesNueral retina(NR)Retinal Pigment epithelium (RPE)Neural crest stem cellsSpinal motor neuronsPhotoreceptorsculture on artificialmatrixUtriclestromacultureKSR or adherantcultureRetinal pigment epitheliumOctic hair cells3D matrigel cultureNeuroectodermAstrocytesSFEBq cultureEctodermFGF2INHBASHHNiacinamideTaurineIGF1FGF8WNT1ALKVitamin ALEFTY1SHHBMP4CNTFNaltrexoneFGF2NODALDKK1PDGFARetinoic acidEGFFGF1FGF2NOGVitamin ASHHSHHINHBAINHBABMP4EctodermalIGF143TPOEPOFLT3LGFGF2