Pluripotent stem cell differentiation pathway (Homo sapiens)
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3D matrigel
culture
Serum
FP6
Endodermal
Definitive
endoderm
Anterior endoderm
Sort
SB431542
CXCR1
Cyclopamine
BMP4
A-83-01
DAPT
NOG
Ascorbic acid
NT5E
BMP4
FGF2
Niacinamide
TGFB1
SHH
RA
Selenium
ES/IPS cells
KIT
EGF
VEGFA
FGF4
IGF1
HGF
NOTCH1
EGF
BMP4
NOG
WNT3A
Multipotent Lung
Progenitors
Hindgut
endoderm
Multipotent endodermal
progenitor cells
HGF
FGF4
EGF
NODAL
FGF10
RA
FGF10
Intestinal Tissue
خ² cells
Pancreatic
progenitors
Hepatocytes
Hepatic
progenitors
BMP4
VEGFA
SCF
TPO
FLT3LG
SCF
CSF1
IL6
IL3
VEGFA
BMP4
SCF
TPO
IL3
EPO
INHBA
FGF2
BMP4
FLT3LG
TPO
FGF2
VEGFA
FGF2
SB431542
TGFB1
PDGFB
IL3
IL6
VEGFA
SCF
IL11
DKK1
VEGFA
WNT1
DKK1
WNT1
VEGFA
TGFB3
NTF4
FGF2
BMP4
FST
NTF4
BMP4
FGF2
GDF5
Hemangioblast
Erythropoietic
cells
Lymphoid
progenitors
Osteoclasts
Endothelial cells
Cardiomyocytes
Smooth
muscle cells
Skeletal
myoblasts
Osteogenic cells
Mesenchymal stem/
precursor cells
Ascorbic acid
Beta-Glycerophosphoric acid
Dexamethasone
Dexamethasone
INS
INS
TF
OP-9
coculture
OP-9 coculture
Semisolid culture
OP-9 or
MS-5
coculture
Sort
Semisolid culture
Mesenchymo-
angioblast
Adipogenic
Cell
Hematopoietic
progenitors
Monocyte/
macrophage
progenitor
Chondrogenic
cells
Cardiovascular colony
forming cells
VEGFA
TPO
EPO
IL6
IL3
IL11
CSF1R
TNFSF11
Primitive streak
Mesoderm
BMP4
WNT2B
47
WNT5A
WNT7B
WNT2
FGF2
IL6
IL6R
BMP4
OP-9 coculture
Mesodermal
GABA neurons
Epidermis
PA6/MS-5
coculture
Cortical layers
Optic cup
Neural
progenitors
DA neurons
Sort P75+, HNK1
Cortical neurons
Keratinocytes
Adherent
culture
Oligodendrocytes
Nueral retina(NR)
Retinal Pigment
epithelium (RPE)
Neural crest
stem cells
Spinal motor neurons
Photoreceptors
culture on
artificial
matrix
Utricle
stroma
culture
KSR or adherant
culture
Retinal pigment
epithelium
Octic hair cells
3D matrigel
culture
Neuroectoderm
Astrocytes
SFEBq culture
Ectoderm
FGF2
INHBA
SHH
Niacinamide
Taurine
IGF1
FGF8
WNT1
ALK
Vitamin A
LEFTY1
SHH
BMP4
CNTF
Naltrexone
FGF2
NODAL
DKK1
PDGFA
Retinoic acid
EGF
FGF1
FGF2
NOG
Vitamin A
SHH
SHH
INHBA
INHBA
BMP4
Ectodermal
IGF1
43
TPO
EPO
FLT3LG
FGF2