Hair follicle development: cytodifferentiation - part 3 of 3 (Homo sapiens)

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433Hair ShaftPigmentationS100A4DKK3KRT15LGR5JUNNf-kappaBKITLGKLK6FOSLHX2WIF1DSC2NFKB1SFRP1GJB6PERPNR3C1IGFSOX2PROM1ZBRB16NFATC1GSDMACD200RUNX3DSG1NogginBMP6SPINK5SOSTDC1RBPJB-cateninELANETP63Smad1CUX1SOX9FOXE1TCF3FOXQ1BMPPathwayNOTCH1WntPathwayShhPathwayNotchPathwayIGFBP5Gli2GATA3DKK1KRTsSmad4DSG4HOXC12MSX1BMPPathwayNotchPathwayCD34BCL11BLRIG1PHLDA1FSTNotch2SCF/c-kitSignalingEdaPathwaySPINK6GPRC5DKLK4KLK13KLK14KRTAP8-1KRTAP15KRTAP3-3KRTAP6-1KRTAP2-4FOSBADAMTS20TP63ShhPathwayLEF1BMPR1AWntPathwayB-cateninWnt5aWNT5AKRT19DKK4EGFRCTGFFZD1GAS1Bmp4Bmp6FGFTGFBInterferon gammaLEF1Notch1EGR2ADAM17DLX3HOXC13FOXN1MSX2HRCASP14KLK5KLK7ADAM17TCF4LGR5Stem CellCompartment33Hair FollicleDifferentiationHair FollicleShapeHair FollicleDifferentiation


Description

The hair follicle (HF) is the biological unit responsible for producing a single hair shaft. The follicles are arranged with concentric epithelial progenitor layers surrounding the dermal core, which is the dermal papilla (DP). Classically, the development of the follicle itself can be divided into three stages: Induction, Organogenesis and Cytodifferentiation. Hair follicle cytodifferentiation is the third main step in hair follicle development and leads to the formation of the bulbous peg. Source: Notch signaling and the developing hair follicle, by Geneviève Aubin-Houzelstein

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Ontology Terms

 

Bibliography

  1. Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom AR, Chung CY, Cai X, Cai CL, Pevny L, Nicolis S, Ma'ayan A, Rendl M; ''Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors.''; Dev Cell, 2012 PubMed Europe PMC Scholia
  2. Fantauzzo KA, Kurban M, Levy B, Christiano AM; ''Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.''; PLoS Genet, 2012 PubMed Europe PMC Scholia
  3. Collu GM, Hidalgo-Sastre A, Brennan K; ''Wnt-Notch signalling crosstalk in development and disease.''; Cell Mol Life Sci, 2014 PubMed Europe PMC Scholia
  4. Aubin-Houzelstein G; ''Notch signaling and the developing hair follicle.''; Adv Exp Med Biol, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117745view12:45, 22 May 2021EweitzModified title
115444view11:19, 19 February 2021DeSlChanged "PW nodes" in blue to textlabels (since they're not PWs)
115443view11:11, 19 February 2021DeSlAdded lit. ref on book (in description) as PW ref.
115442view11:09, 19 February 2021DeSlAnnotated ZFP145 with Human ortholog iD (name was only know for Rat).
115441view11:01, 19 February 2021DeSlRemoved email address + last modified item ; small textual change in title
115440view10:59, 19 February 2021DeSlAdded linkouts to other PWs in description
110704view14:12, 28 May 2020LaurentFixed interactions
104845view14:36, 20 June 2019Fehrhartadded crosstalk between Wnt and Notch pathways
104841view14:25, 20 June 2019Fehrhart
97324view19:05, 9 May 2018KhanspersModified description
97323view19:00, 9 May 2018Khanspersupdated xrefs, connected interactions
96296view16:13, 7 March 2018Fehrhartconnected lines
88632view14:41, 12 August 2016JmeliusOntology Term : 'PW:0000003' removed !
88631view14:41, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
88628view14:36, 12 August 2016JmeliusOntology Term : 'signaling pathway' added !
78512view10:29, 7 January 2015MaintBotadded missing graphIds
77665view07:44, 4 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
77312view22:14, 14 August 2014DanieltrinunesMinimal gene name corretion
77311view22:08, 14 August 2014DanieltrinunesModified title
77310view22:08, 14 August 2014DanieltrinunesModified title
77309view22:07, 14 August 2014DanieltrinunesNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM17GeneProductP78536 (Uniprot-TrEMBL)
ADAMTS20GeneProductP59510 (Uniprot-TrEMBL)
B-cateninGeneProductP35222 (Uniprot-TrEMBL)
BCL11BGeneProductQ9C0K0 (Uniprot-TrEMBL)
BMP PathwayPathwayWP1425 (WikiPathways)
BMP6ProteinP22004 (Uniprot-TrEMBL)
BMPR1AGeneProductP36894 (Uniprot-TrEMBL)
Bmp4ProteinP12644 (Uniprot-TrEMBL)
Bmp6ProteinP22004 (Uniprot-TrEMBL)
CASP14GeneProductP31944 (Uniprot-TrEMBL)
CD200GeneProductP41217 (Uniprot-TrEMBL)
CD34ProteinP28906 (Uniprot-TrEMBL)
CTGFProteinP29279 (Uniprot-TrEMBL)
CUX1GeneProductP39880 (Uniprot-TrEMBL)
DKK1GeneProductO94907 (Uniprot-TrEMBL)
DKK3ProteinQ9UBP4 (Uniprot-TrEMBL)
DKK4ProteinQ9UBT3 (Uniprot-TrEMBL)
DLX3GeneProductO60479 (Uniprot-TrEMBL)
DSC2ProteinQ02487 (Uniprot-TrEMBL)
DSG1ProteinQ02413 (Uniprot-TrEMBL)
DSG4ProteinQ86SJ6 (Uniprot-TrEMBL)
EGFRProteinP00533 (Uniprot-TrEMBL)
EGR2ProteinP11161 (Uniprot-TrEMBL)
ELANEGeneProductP08246 (Uniprot-TrEMBL)
Eda PathwayPathway
FGFGeneProduct
FOSBProteinP53539 (Uniprot-TrEMBL)
FOSProteinP01100 (Uniprot-TrEMBL)
FOXE1ProteinO00358 (Uniprot-TrEMBL)
FOXN1ProteinO15353 (Uniprot-TrEMBL)
FOXQ1GeneProductQ9C009 (Uniprot-TrEMBL)
FSTProteinP19883 (Uniprot-TrEMBL)
FZD1ProteinQ9UP38 (Uniprot-TrEMBL)
GAS1ProteinP54826 (Uniprot-TrEMBL)
GATA3GeneProductP23771 (Uniprot-TrEMBL)
GJB6GeneProductO95452 (Uniprot-TrEMBL)
GPRC5DProteinQ9NZD1 (Uniprot-TrEMBL)
GSDMAGeneProductQ96QA5 (Uniprot-TrEMBL)
Gli2ProteinP10070 (Uniprot-TrEMBL)
HOXC12GeneProductP31275 (Uniprot-TrEMBL)
  • (1, 2, 3 & 4) mx, cuticle, cx and md
  • (1) As embryonic hf morphogenesis reaches completion (P9), expression of the Hoxc13 is detected in the hair-shaft forming compartments of the matrix, cuticle, cortex and medulla.
  • (1) Hoxc13 directly regulates expression of the hair keratin genes such as K32, K35 and K37, and of the transcription factor Foxq1.
HOXC13GeneProductO60479 (Uniprot-TrEMBL)
  • (1, 2, 3 & 4) mx, cuticle, cx and md
  • (1) As embryonic hf morphogenesis reaches completion (P9), expression of the Hoxc13 is detected in the hair-shaft forming compartments of the matrix, cuticle, cortex and medulla.
  • (1) Hoxc13 directly regulates expression of the hair keratin genes such as K32, K35 and K37, and of the transcription factor Foxq1.
HRGeneProductO43593 (Uniprot-TrEMBL) Mx,Cx,Bulb
IGFBP5GeneProductP24593 (Uniprot-TrEMBL)
IGFProteinP05019 (Uniprot-TrEMBL)
Interferon gammaProteinP01579 (Uniprot-TrEMBL)
JUNProteinP05412 (Uniprot-TrEMBL)
KITLGGeneProductP21583 (Uniprot-TrEMBL)
KLK13ProteinQ9UKR3 (Uniprot-TrEMBL)
KLK14ProteinQ9P0G3 (Uniprot-TrEMBL)
KLK4ProteinQ9Y5K2 (Uniprot-TrEMBL)
KLK5ProteinQ9Y337 (Uniprot-TrEMBL)
KLK6ProteinQ92876 (Uniprot-TrEMBL)
KLK7ProteinP49862 (Uniprot-TrEMBL)
KRT15GeneProductP19012 (Uniprot-TrEMBL)
KRT19GeneProductP08727 (Uniprot-TrEMBL)
KRTAP15ProteinQ3LI76 (Uniprot-TrEMBL)
KRTAP2-4ProteinQ9BYR9 (Uniprot-TrEMBL)
KRTAP3-3GeneProductQ9BYR6 (Uniprot-TrEMBL)
KRTAP6-1ProteinQ3LI64 (Uniprot-TrEMBL)
KRTAP8-1ProteinQ8IUC2 (Uniprot-TrEMBL)
KRTsGeneProduct(1) Hoxc13 directly regulates expression of the hair keratin genes such as K32, K35 and K37, and of the transcription factor Foxq1
LEF1ProteinQ9UJU2 (Uniprot-TrEMBL)
LGR5ProteinO75473 (Uniprot-TrEMBL)
LHX2ProteinP50458 (Uniprot-TrEMBL)
LRIG1ProteinQ96JA1 (Uniprot-TrEMBL)
MSX1ProteinP28360 (Uniprot-TrEMBL) Mx,Cx,Bulb
MSX2ProteinP35548 (Uniprot-TrEMBL) Mx,Cx,Bulb
NFATC1GeneProductO95644 (Uniprot-TrEMBL)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NOTCH1GeneProduct
NR3C1GeneProductP04150 (Uniprot-TrEMBL)
Nf-kappaBProteinP19838 (Uniprot-TrEMBL)
NogginProteinQ9BZE4 (Uniprot-TrEMBL)
Notch PathwayPathwayWP268 (WikiPathways)
Notch1GeneProductP46531 (Uniprot-TrEMBL)
Notch2GeneProductQ04721 (Uniprot-TrEMBL)
PERPProteinQ96FX8 (Uniprot-TrEMBL)
PHLDA1GeneProductQ8WV24 (Uniprot-TrEMBL)
PROM1ProteinO43490 (Uniprot-TrEMBL)
RBPJGeneProductQ06330 (Uniprot-TrEMBL)
RUNX3ProteinQ13761 (Uniprot-TrEMBL)
S100A4GeneProductP26447 (Uniprot-TrEMBL)
SCF/c-kit SignalingPathway
SFRP1ProteinQ8N474 (Uniprot-TrEMBL)
SOSTDC1GeneProductQ6X4U4 (Uniprot-TrEMBL)
SOX2ProteinP48431 (Uniprot-TrEMBL)
SOX9GeneProductP48436 (Uniprot-TrEMBL)
SPINK5GeneProductQ9NQ38 (Uniprot-TrEMBL)
SPINK6GeneProductQ6UWN8 (Uniprot-TrEMBL)
Shh PathwayPathwayWP4249 (WikiPathways)
Smad1ProteinQ15797 (Uniprot-TrEMBL)
Smad4ProteinQ13485 (Uniprot-TrEMBL)
Stem Cell Compartment
TCF3GeneProductP15923 (Uniprot-TrEMBL)
TCF4GeneProductP15884 (Uniprot-TrEMBL)
TGFBProteinP01137 (Uniprot-TrEMBL)
TP63ProteinQ9H3D4 (Uniprot-TrEMBL)
WIF1ProteinQ9Y5W5 (Uniprot-TrEMBL)
WNT5AProteinP41221 (Uniprot-TrEMBL)
Wnt PathwayPathwayWP428 (WikiPathways)
Wnt5aProteinP41221 (Uniprot-TrEMBL)
ZBRB16GeneProductENSG00000109906 (Ensembl) Name of GeneProduct (ZFP145) is only know for Rattus norv.; found ortholog through Ensemble (1-to-1 mapping, name is ZBRB16 for Homo sap. )

Annotated Interactions

No annotated interactions

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