Hair follicle development: organogenesis - part 2 of 3 (Homo sapiens)

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Dermal CondensatePlacodeHair BudShapeoverexpressionRUNX2NCAMTP63FOXI3CCND1CDH1LEF1SNAI1Activin AFZD1NF-kBWntPathwayEDAREDAEdaPathwayShhPathwaySHHEDARB-cateninEDASHHLRP5/6BMP sPTCHSMOShhPathwaySHHPTCH1SMONOGPDGFRAPDGFPDGFNogginPTCH1CCND1GJB6LEF1FGFR2GLI2CCND2ITGB1PrimaryCiliaRas-MAPKPathwayTgf-B2PathwayGLI1GLI sFGFWNT5AWNT5AMYCLaminin-511PlacodeDowngrowth


The hair follicle (HF) is the biological unit responsible for producing a single hair shaft. The follicles are arranged with concentric epithelial progenitor layers surrounding the dermal core, which is the dermal papilla (DP). Classically, the development of the follicle itself can be divided into three stages: Induction, Organogenesis and Cytodifferentiation. Hair follicle development is a process dependent on epithelial-mesenchymal transitions orchestrated by many signaling pathways. Here we find one of three complex regulatory pathways assembled from a text mining approach portraying the development of this key mammal-specific structure.

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Ontology Terms



  1. Nowak JA, Polak L, Pasolli HA, Fuchs E; ''Hair follicle stem cells are specified and function in early skin morphogenesis.''; Cell Stem Cell, 2008 PubMed Europe PMC Scholia
  2. Fantauzzo KA, Kurban M, Levy B, Christiano AM; ''Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.''; PLoS Genet, 2012 PubMed Europe PMC Scholia
  3. Hammerschmidt B, Schlake T; ''Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs.''; Dev Biol, 2007 PubMed Europe PMC Scholia


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117746view12:46, 22 May 2021EweitzModified title
115446view11:29, 19 February 2021DeSlChanged two "PW nodes" to textlabels (since these aren't PWs).
115445view11:24, 19 February 2021DeSlAdded PW ID for primary cilia
115439view10:58, 19 February 2021DeSlSmall textual change in title
115438view10:57, 19 February 2021DeSlOntology Term : 'hair follicle cell' added !
115437view10:56, 19 February 2021DeSlAdded annotations for some PW nodes
115435view10:52, 19 February 2021DeSlConnected last unconnected line
115434view10:51, 19 February 2021DeSlAdded ID for Activin A (aka inhibin beta A)
115433view10:49, 19 February 2021DeSlRemoved email address + last modified item
115432view10:48, 19 February 2021DeSlAdded linkouts to other two PWs
90188view19:51, 21 October 2016Khanspersfixed unconnected
88630view14:41, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
82284view23:10, 23 September 2015AlexanderPicochaging Rectangle to RoundedRectangle to resolve pvjs errors
82273view23:35, 22 September 2015AlexanderPicoReverted to version '03:29, 7 January 2015' by AlexanderPico
82272view23:35, 22 September 2015AlexanderPicochanging double lined nuclei for pvjs compatibility
82271view23:27, 22 September 2015AlexanderPicochanging double line to solid for pvjs compatibility
78519view10:29, 7 January 2015MaintBotadded missing graphIds
77664view07:43, 4 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
77315view22:29, 14 August 2014DanieltrinunesModified description
77308view22:06, 14 August 2014DanieltrinunesModified title
77307view22:05, 14 August 2014DanieltrinunesNew pathway

External references


View all...
NameTypeDatabase referenceComment
Activin AGeneProductP08476 (Uniprot-TrEMBL)
B-cateninGeneProductP35222 (Uniprot-TrEMBL)
BMP sProteinP12644 (Uniprot-TrEMBL)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CCND2ProteinP30279 (Uniprot-TrEMBL)
CDH1GeneProductP12830 (Uniprot-TrEMBL)
EDAProteinQ92838 (Uniprot-TrEMBL)
EDARProteinQ9UNE0 (Uniprot-TrEMBL)
Eda PathwayPathway
FGFProteinP05230 (Uniprot-TrEMBL)
FGFR2ProteinP21802 (Uniprot-TrEMBL)
FOXI3GeneProductA8MTJ6 (Uniprot-TrEMBL)
FZD1ProteinQ9UP38 (Uniprot-TrEMBL)
GJB6GeneProductO95452 (Uniprot-TrEMBL)
GLI sProteinP08151 (Uniprot-TrEMBL)
GLI1ProteinP08151 (Uniprot-TrEMBL)
GLI2ProteinP10070 (Uniprot-TrEMBL)
ITGB1ProteinP05556 (Uniprot-TrEMBL)
LEF1ProteinQ9UJU2 (Uniprot-TrEMBL)
LRP5/6ProteinO75197 (Uniprot-TrEMBL)
Laminin-511ProteinO15230 (Uniprot-TrEMBL)
MYCProteinP01106 (Uniprot-TrEMBL)
NCAMProteinP13591 (Uniprot-TrEMBL)
NF-kBProteinP19838 (Uniprot-TrEMBL)
NOGProteinQ9BZE4 (Uniprot-TrEMBL)
NogginProteinQ9BZE4 (Uniprot-TrEMBL)
PDGFProteinP04085 (Uniprot-TrEMBL)
PDGFRAProteinP16234 (Uniprot-TrEMBL)
PTCH1ProteinQ13635 (Uniprot-TrEMBL)
PTCHProteinQ13635 (Uniprot-TrEMBL)
Primary CiliaPathwayWP4536 (WikiPathways)
RUNX2GeneProductQ13950 (Uniprot-TrEMBL)
Ras-MAPK PathwayPathway
SHHProteinQ15465 (Uniprot-TrEMBL)
SMOProteinQ99835 (Uniprot-TrEMBL)
SNAI1ProteinO95863 (Uniprot-TrEMBL)
Shh PathwayPathwayWP4249 (WikiPathways)
TP63GeneProductQ9H3D4 (Uniprot-TrEMBL)
Tgf-B2 PathwayPathway
WNT5AProteinP41221 (Uniprot-TrEMBL)
Wnt PathwayPathwayWP428 (WikiPathways)

Annotated Interactions

No annotated interactions

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