Cytosolic sensors of pathogen-associated DNA (Homo sapiens)

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10, 89, 995, 16, 41, 52, 54...40, 7448, 9820, 9856, 9839, 60, 69, 97571222, 3031, 803, 28495, 102849, 84, 871, 76945, 10024, 62, 745711, 98724, 74578, 42, 64, 87126931, 34, 49, 611, 71215, 35, 77128318, 78, 9838, 46, 47, 59, 66...43, 49, 5321, 34, 71, 9523, 8350, 864, 9, 84499, 76, 79125745, 10049448, 42, 64, 87endoplasmic reticulumendosomecytosol(perinuclear vesicle)nucleoplasmcytoplasmic vesicle lumenviral minus strand DNA with sticky 3' end XRCC6 p-S477,S479-IRF7 K63polyUb-STING 2xp-S477,S479-IRF7TBK1 STAT6NLRC3MYD88 VACV dsDNA XRCC6 IRF3 Promotor region ofinterferon betaCREBBP DHX36:CpG:MyD88HCMV dsDNA p-S172-TBK1 UBC(305-380) L. monocytogenes dsDNA RELA UBC(533-608) ADPHSV1 dsDNA c-GMP-AMPDHX9 CREBBP, EP300UBC(1-76) HSV1 dsDNA MB21D1 p-T,4S-IRF3:p-T,4S-IRF3Rotavirus dsRNA TMPDDX41 viral ligandUBC(609-684) UBC(153-228) RIPK1 UBC(381-456) TRIM21NKIRAS1 CREBBP NFKB2(1-454) MRE11:dsDNASTING:p-S172-TBK1:IRF3UBC(1-76) HCMV dsDNA POLR2L UBB(77-152) POLR1D TMEM173 p-S172-TBK1 L. monocytogenes dsDNA NFKB1(1-433) POLR3F ADPNKIRAS2 UbSTING:c-di-GMPTREX1 HSV2 dsDNA MRE11A TRIM32 HSV2 dsDNA HSV1 dsDNA PRKDC XRCC5 UBB(77-152) HCV dsDNAATPUBC(77-152) viral plus strand DNA with sticky 3' end c-di-GMP DDX41HSV1 dsRNA intermediate form POLR1C Unmethylated CpG DNA UBC(533-608) HCMV dsDNA viral minus strand DNA with sticky 3' end HSV1 dsDNA c-di-GMPp-S176,S180-CHUK DHX36 LRRFIP1 LRR FLII-interactingprotein 1 dimerZBP1 ligandUBC(533-608) HSV2 dsDNA UBB(1-76) RPS27A(1-76) DHX36 p-S172-TBK1 POLR3E DHX9p-S477,S479-IRF7 DHX36:CpGRELA HSV1 dsDNA LRRFIP1 p-2S-IRF7:p-2S-IRF7p-T,4S-IRF3:p-T,4S-IRF3UBC(229-304) EBV dsDNA UBC(1-76) ATPDDX41 ZBP1IRF3 DTX4 RNA Polymerase IIIHoloenzymep-S407,Y641-STAT6 TRIM32/TRIM56Pol-III ligandsUnmethylated CpG DNA DHX36 p-S172-TBK1 beta-catenin:IRF3:p300NFKB2(1-454) K63polyUb-STING L.pneumophila dsDNA ZBP1 TRIM56 DHX9/DHX36:CpG:MyD88K63polyUb-STING NFKB2(1-454) DHX9 Unmethylated CpG DNA ADPMRE11A DNA-PK:microbialdsDNADTX4cGAS:dsDNAUBC(77-152) p-S407-STAT6ZBP1 IRF3 ZBP1 L. monocytogenes dsDNA HSV1 dsDNA UBC(305-380) HCV dsRNA intermediate form dsDNA:LRRFLII-interactingprotein 1dimerATPUBC(153-228) STING:STINGc-di-AMP, c-di-GMPHSV2 dsDNA Unmethylated CpG DNA dsDNA:LRRFIP1:beta-cateninDDX41:c-di-AMP,c-di-GMPHBV dsDNA DDX41 ATPSTING activatorsHCV dsDNA STING:p-S172-TBK1:STAT6Influenza A dsRNA intermediate form IRF3 pS-172,K48polyUb-TBK1 DHX9:CpGMg2+UBC(229-304) pS-172,K48polyUb-TBK1 Double-stranded DNA K63polyUb-STING UBC(153-228) 2'-deoxycytosine5'-monophosphatePOLR3B DHX36dsDNA:ZBP1:pS-172-TBK1CTNNB1 c-di-AMP TICAM1 PPiPOLR3GL IRF3GTPdsDNA:ZBP1:pS-172-TBK:IRF3viral plus strand DNA with sticky 3' end UbPhospho-NF-kappaBInhibitorK63polyUb-STING STING:TRIM32/TRIM56L. monocytogenes dsDNA dsDNA:ZBP1:pS-172,K48polyUb-TBK1RIPK3 viral minus strand DNA with sticky 3' end K63polyUb-STINGPOLR3K ATPSTING:TBK1:STAT6VACV dsDNA UBB(153-228) STAT6 DHX9/DHX36:CpGPOLR3H TBK1 p-S407,Y641-STAT6dimerCRCP IFI16 Promotor region of interferon beta UBC(457-532) ADPCHUK:IKBKB:IKBKGATPUBA52(1-76) dsDNA:ZBP1UBC(77-152) ADPNLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1POLR2E ZBP1 HBV dsDNA DTX4p-4S,T404-IRF3 ZBP1 K48polyUb-DDX41 M. tuberculosis dsDNA IFI16 ligandsHCMV dsDNA HCMV dsDNA c-di-GMP NFKBIA UbNLRP4 UBB(1-76) UBC(153-228) NLRP4 M. tuberculosis dsDNA STING:cGAMPc-di-AMP IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKBRPS27A(1-76) K63polyUb-STING HCV dsDNA DHX9 STING:TBK1:IRF3UBC(305-380) p-S407,Y641-STAT6 c-di-GMP POLR2K 5'-ppp-AU-rich dsRNAATPUBC(229-304) NFkB ComplexRIPK1 EP300 DNA-PK ligandsUBB(1-76) IFI16 UBC(305-380) K48polyUb-DDX41 NLRP4:DTX4:STING:p-S172-TBK1:IRF3ATPRELA K63polyUb-STING XRCC6 DDX58/IFIH1-mediatedinductionofinterferon-alpha/betaviral plus strand DNA with sticky 3' end RIPK1Unmethylated CpG DNAHSV2 dsDNA K63polyUb-STING p-S177,S181-IKBKB NKIRASADPDHX9 TMEM173 EP300 UBC(1-76) UBB(77-152) IkBs:NFkBHSV1 dsDNA NLRP4UBC(457-532) POLR3C viral plus strand DNA with sticky 3' end NFKB1(1-433):NFKB2(1-454):RELAPOLR3G HSV2 dsDNA STING:p-S172,K48polyUb-TBK1:IRF3UBC(609-684) cGAS ligandsPOLR3D UBA52(1-76) Unmethylated CpG DNA UBC(229-304) ZBP1 UBC(609-684) c-GMP-AMP NFKBIB Mg2+ DTX4 RPS27A(1-76) Ku70:Ku80heterodimerUBC(381-456) viral minus strand DNA with sticky 3' end MRE11AADPp-4S,T404-IRF3 p-S552-CTNNB1 UBC(381-456) UBB(153-228) c-di-AMP ADPviral minus strand DNA with sticky 3' end HBV dsDNA LRRFIP1 UBC(609-684) ATPMB21D1VACV dsDNA ADPMYD88 K63polyUb-STING IKBKG K63polyUb-STING TRIM21 VACV dsDNA TREX1 p-S407,Y641-STAT6dimerp-S172-TBK1 Double-stranded DNAp-S552-CTNNB1UBB(153-228) UBC(457-532) viral minus strand DNA with sticky 3' end TBK1XRCC5 Ub2'-deoxyguanosine5'-monophosphate2'-deoxyadenosine5'-monophosphateSTING:STINGp-S552-CTNNB1UBA52(1-76) TLR3 CTNNB1POLR2F K48polyUb-DDX41:TRIM21XRCC5 viral minus strand DNA with sticky 3' end IKBKG p-S172-TBK1 UBA52(1-76) HBV dsRNA intermediate form DHX36 TREX1 dimerRIPK3TMEM173IFI16PRKDC CHUK HSV2 dsDNA STAT6 ADPUBC(533-608) VACV dsDNA viral plus strand DNA with sticky 3' end L. monocytogenes dsDNA p-4S,T404-IRF3ATPHCMV dsDNA ATPdsDNA:IFI16RPS27A(1-76) NFKB1(1-433) UBC(457-532) PRKDCDDX41:DDX41 ligandp-S32,S36-NFKBIA viral plus strand DNA with sticky 3' end IRF3MYD88 NLRP4c-GMP-AMP DDX41 TBK1TREX1:viral DNAH2OUBB(1-76) DHX9:CpG:MyD88VACV dsDNA TRIM56 Double-stranded DNA p-S19,S23-NFKBIB UBB(77-152) IRF3 UBC(381-456) dsDNA:ZBP1:RIP1:RIP3viral plus strand DNA with sticky 3' end p-S172-TBK1 viraldsRNA:TLR3:TICAM1:RIPK1Unmethylated CpG DNA HCMV dsDNA IKBKB POLR3A viral DNA with 3'sticky endsPOLR2H p-S407,Y641-STAT6UBB(153-228) TRIM32 VACV dsDNA p-4S,T404-IRF3 UBC(77-152) NFKB1(1-433) HSV1 dsDNA MYD88c-di-GMP STING:p-S172-TBK11294, 101493213, 751, 272436, 8320, 557424, 621, 2, 14, 72, 88625787102244475312573086498737, 90, 922019, 26, 51, 58, 63...874517, 33, 88, 9668, 10425, 982949496, 67, 7168, 81, 104102