Cytosolic sensors of pathogen-associated DNA (Homo sapiens)

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21, 86, 1057, 10157, 8316167, 13, 1469, 9946, 53, 55, 77565663, 81, 923, 10, 12, 25, 41...17, 63, 9045814, 719, 47, 77, 8427, 9862, 89, 92, 9735, 71, 8833, 63, 8130, 7353, 1007, 29563, 9, 11, 15, 34...4669, 9957, 83457, 268343, 9662, 89, 92, 97163, 6739, 46, 5145, 72, 76, 9150, 10224, 7346169816520, 24, 7356461, 78, 85endoplasmic reticulum(perinuclear vesicle)endosomenucleoplasmcytosolcytoplasmic vesicle lumenp-S552-CTNNB1CREBBP TICAM1 TLR3 UBB(77-152) p-S172-TBK1 DHX36:CpGPOLR2F TRIM56 HSV2 dsDNA HSV1 dsDNA UBC(1-76) NFkB ComplexDTX4 STING:STINGK63polyUb-STING TRIM32/TRIM56DHX36 K48polyUb-DDX41 POLR1C UBC(533-608) IRF3 HBV dsDNA ATPHCMV dsDNA HCMV dsDNA PPiUBC(457-532) ADPTRIM21DHX36:CpG:MyD88beta-catenin:IRF3:p300UBC(1-76) TMEM173 K48polyUb-DDX41:TRIM21IRF3 POLR2L POLR3A p-S407,Y641-STAT6dimerUBB(1-76) K63polyUb-STING STING:cGAMPp-S407-STAT6CRCP RPS27A(1-76) HCMV dsDNA DTX4XRCC5 CHUK ZBP1TBK1 DDX41:c-di-AMP,c-di-GMPSTING:p-S172-TBK1:STAT6HCV dsDNA HSV2 dsDNA CTNNB1CREBBP c-di-AMP NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1viral plus strand DNA with sticky 3' end UBC(153-228) CTNNB1 XRCC5 ZBP1 RIPK1Rotavirus dsRNA VACV dsDNA viral plus strand DNA with sticky 3' end MYD88 PRKDC UBB(1-76) DDX41 Influenza A dsRNA intermediate form DTX4 IRF3POLR2H dsDNA:ZBP1Phospho-NF-kappaBInhibitorSTING:TRIM32/TRIM56p-T,4S-IRF3:p-T,4S-IRF3ATPUBB(1-76) UBC(153-228) UBC(609-684) RIPK3UbATPL. monocytogenes dsDNA Unmethylated CpG DNA UBC(229-304) DHX9/DHX36:CpGDDX41 viral ligandHSV1 dsDNA IKBKG RNA Polymerase IIIHoloenzymeSTING:c-di-GMPK63polyUb-STING Double-stranded DNA POLR3E LRRFIP1 viral plus strand DNA with sticky 3' end p-S552-CTNNB1 STAT6 IRF3HBV dsRNA intermediate form p-S172-TBK1 DHX9 K63polyUb-STING c-GMP-AMPVACV dsDNA ADPK63polyUb-STING ATPMg2+ MYD88 2'-deoxyadenosine5'-monophosphateRPS27A(1-76) UBB(77-152) p-4S,T404-IRF3RIPK1 ADPUBC(457-532) NFKB1(1-433) K63polyUb-STING TREX1 dimerADPNLRP4 RIPK1 UBB(77-152) 5'-ppp-AU-rich dsRNAUBC(1-76) POLR3D DHX9 viral minus strand DNA with sticky 3' end DHX36 viraldsRNA:TLR3:TICAM1:RIPK1NFKB1(1-433) POLR2K POLR3F dsDNA:ZBP1:pS-172-TBK:IRF3NLRP4HSV2 dsDNA POLR3G DDX41 p-T,4S-IRF3:p-T,4S-IRF3MB21D1UBB(1-76) DHX9:CpG:MyD88p-S407,Y641-STAT6 DHX36 UBA52(1-76) UBC(533-608) UBC(381-456) TBK1L.pneumophila dsDNA H2ORPS27A(1-76) UBC(305-380) HSV1 dsDNA UBC(305-380) cGAS:dsDNATREX1:viral DNAHCMV dsDNA POLR3H HCV dsDNAL. monocytogenes dsDNA UBB(153-228) p-S172-TBK1 NFKB2(1-454) UBC(609-684) IRF3 TRIM32 K63polyUb-STING M. tuberculosis dsDNA LRRFIP1 EBV dsDNA DNA-PK:microbialdsDNACHUK:IKBKB:IKBKGADPHCMV dsDNA UBC(77-152) IFI16c-di-AMP ADPRELA NFKBIB ATPIKBKG viral minus strand DNA with sticky 3' end cGAS ligandsdsDNA:LRRFLII-interactingprotein 1dimerL. monocytogenes dsDNA UBC(457-532) p-4S,T404-IRF3 POLR3C TBK1 ADPHSV1 dsDNA MRE11A ADPTREX1 UBC(609-684) GTPMB21D1 viral minus strand DNA with sticky 3' end UBC(229-304) p-S172-TBK1 viral minus strand DNA with sticky 3' end ATPZBP1 UBC(153-228) UBC(77-152) 2xp-S477,S479-IRF7p-2S-IRF7:p-2S-IRF7CREBBP,EP300NFKB1(1-433),NFKB2(1-454):RELAPOLR3GL p-S407,Y641-STAT6 TMEM173 UBC(381-456) RELA NKIRAS2 RELA UBC(533-608) dsDNA:IFI16UbSTING:p-S172-TBK1UBC(533-608) p-S477,S479-IRF7 LRR FLII-interactingprotein 1 dimerUBC(305-380) EP300 PRKDCSTING:STINGATPc-GMP-AMP TMEM173POLR3B Double-stranded DNAHCV dsRNA intermediate form TRIM56 ZBP1 K63polyUb-STING Unmethylated CpG DNA Mg2+NKIRASHCMV dsDNA viral plus strand DNA with sticky 3' end MYD88 UBC(381-456) dCMPUBC(381-456) VACV dsDNA MRE11:dsDNAviral plus strand DNA with sticky 3' end UBC(153-228) IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKBHCMV dsDNA p-S176,S180-CHUK HBV dsDNA p-S552-CTNNB1ATPUBB(153-228) DHX36HSV2 dsDNA MRE11AM. tuberculosis dsDNA ZBP1 UBC(229-304) DHX9HSV1 dsRNA intermediate form IFI16 ligandsUnmethylated CpG DNA p-S177,S181-IKBKB HSV1 dsDNA DHX9/DHX36:CpG:MyD88NLRP4:DTX4:STING:p-S172-TBK1:IRF3VACV dsDNA IRF3 UBB(153-228) UBC(229-304) ATPUBB(77-152) Pol-III ligandsIFI16 Unmethylated CpG DNA viral plus strand DNA with sticky 3' end NKIRAS1 2'-deoxyguanosine5'-monophosphateNLRP4TRIM21 STAT6 HSV2 dsDNA DHX9:CpGDDX58/IFIH1-mediatedinductionofinterferon-alpha/betaTRIM32 viral minus strand DNA with sticky 3' end STING:p-S172,K48polyUb-TBK1:IRF3UBC(305-380) p-4S,T404-IRF3 ZBP1 ligandDHX9 VACV dsDNA NFKB2(1-454) Promotor region ofinterferon betaUBA52(1-76) NFkB inhibitor:NFkBcomplexp-S172-TBK1 DHX9 K63polyUb-STING DHX36 viral minus strand DNA with sticky 3' end DTX4K48polyUb-DDX41 L. monocytogenes dsDNA VACV dsDNA HSV1 dsDNA UbTMPUBC(609-684) NFKB2(1-454) TBK1Unmethylated CpG DNA UBA52(1-76) dsDNA:LRRFIP1:beta-cateninK63polyUb-STING c-di-GMP p-S172-TBK1 STAT6XRCC6 HCV dsDNA p-4S,T404-IRF3 STING:TBK1:IRF3K63polyUb-STINGp-S407,Y641-STAT6RIPK3 c-di-GMP UBC(1-76) IRF3 ZBP1 p-S172-TBK1 ZBP1 UbSTING:p-S172-TBK1:IRF3p-S32,S36-NFKBIA LRRFIP1 NFKB1(1-433) HSV2 dsDNA NLRC3Ku70:Ku80heterodimerHSV1 dsDNA Promotor region of interferon beta c-di-GMP EP300 DDX41:DDX41 ligandPOLR1D UBC(457-532) UBC(77-152) POLR3K UBA52(1-76) pS-172,K48polyUb-TBK1 NLRP4 viral DNA with 3'sticky endsRPS27A(1-76) dsDNA:ZBP1:pS-172,K48polyUb-TBK1POLR2E HSV2 dsDNA IKBKB DNA-PK ligandsMYD88ATPADPUBC(77-152) DDX41c-di-GMPUBB(153-228) XRCC6 dsDNA:ZBP1:pS-172-TBK1pS-172,K48polyUb-TBK1 p-S477,S479-IRF7 TREX1 STING:TBK1:STAT6c-di-AMP, c-di-GMPUnmethylated CpG DNANFKBIA ADPp-S407,Y641-STAT6dimerdsDNA:ZBP1:RIP1:RIP3ATPUnmethylated CpG DNA p-S19,S23-NFKBIB 8773564, 8232096244654, 70397, 382332, 5731654, 70, 946, 57, 59, 66, 75562, 59, 61, 1039218, 36, 37, 48, 68...92838016249922, 4244, 9528, 49, 6531, 984654464620, 2492508, 47, 52