Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
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21, 86, 105
7, 101
57, 83
16
16
7, 13, 14
69, 99
46, 53, 55, 77
56
56
63, 81, 92
3, 10, 12, 25, 41...
17, 63, 90
45
81
4, 7
19, 47, 77, 84
27, 98
62, 89, 92, 97
35, 71, 88
33, 63, 81
30, 73
53, 100
7, 29
56
3, 9, 11, 15, 34...
46
69, 99
57, 83
45
7, 26
83
43, 96
62, 89, 92, 97
16
3, 67
39, 46, 51
45, 72, 76, 91
50, 102
24, 73
46
16
98
16
5
20, 24, 73
56
46
1, 78, 85
endoplasmic reticulum
(perinuclear vesicle)
endosome
nucleoplasm
cytosol
cytoplasmic vesicle lumen
p-S552-CTNNB1
CREBBP
TICAM1
TLR3
UBB(77-152)
p-S172-TBK1
DHX36:CpG
POLR2F
TRIM56
HSV2 dsDNA
HSV1 dsDNA
UBC(1-76)
NFkB Complex
DTX4
STING:STING
K63polyUb-STING
TRIM32/TRIM56
DHX36
K48polyUb-DDX41
POLR1C
UBC(533-608)
IRF3
HBV dsDNA
ATP
HCMV dsDNA
HCMV dsDNA
PPi
UBC(457-532)
ADP
TRIM21
DHX36:CpG:MyD88
beta-catenin:IRF3:p300
UBC(1-76)
TMEM173
K48polyUb-DDX41:TRIM21
IRF3
POLR2L
POLR3A
p-S407,Y641-STAT6
dimer
UBB(1-76)
K63polyUb-STING
STING:cGAMP
p-S407-STAT6
CRCP
RPS27A(1-76)
HCMV dsDNA
DTX4
XRCC5
CHUK
ZBP1
TBK1
DDX41:c-di-AMP,
c-di-GMP
STING:p-S172-TBK1:STAT6
HCV dsDNA
HSV2 dsDNA
CTNNB1
CREBBP
c-di-AMP
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1
viral plus strand DNA with sticky 3' end
UBC(153-228)
CTNNB1
XRCC5
ZBP1
RIPK1
Rotavirus dsRNA
VACV dsDNA
viral plus strand DNA with sticky 3' end
MYD88
PRKDC
UBB(1-76)
DDX41
Influenza A dsRNA intermediate form
DTX4
IRF3
POLR2H
dsDNA:ZBP1
Phospho-NF-kappaB
Inhibitor
STING:TRIM32/TRIM56
p-T,4S-IRF3:p-T,4S-IRF3
ATP
UBB(1-76)
UBC(153-228)
UBC(609-684)
RIPK3
Ub
ATP
L. monocytogenes dsDNA
Unmethylated CpG DNA
UBC(229-304)
DHX9/DHX36:CpG
DDX41 viral ligand
HSV1 dsDNA
IKBKG
RNA Polymerase III
Holoenzyme
STING:c-di-GMP
K63polyUb-STING
Double-stranded DNA
POLR3E
LRRFIP1
viral plus strand DNA with sticky 3' end
p-S552-CTNNB1
STAT6
IRF3
HBV dsRNA intermediate form
p-S172-TBK1
DHX9
K63polyUb-STING
c-GMP-AMP
VACV dsDNA
ADP
K63polyUb-STING
ATP
Mg2+
MYD88
2'-deoxyadenosine
5'-monophosphate
RPS27A(1-76)
UBB(77-152)
p-4S,T404-IRF3
RIPK1
ADP
UBC(457-532)
NFKB1(1-433)
K63polyUb-STING
TREX1 dimer
ADP
NLRP4
RIPK1
UBB(77-152)
5'-ppp-AU-rich dsRNA
UBC(1-76)
POLR3D
DHX9
viral minus strand DNA with sticky 3' end
DHX36
viral
dsRNA:TLR3:TICAM1:RIPK1
NFKB1(1-433)
POLR2K
POLR3F
dsDNA:ZBP1:pS-172-TBK:IRF3
NLRP4
HSV2 dsDNA
POLR3G
DDX41
p-T,4S-IRF3:p-T,4S-IRF3
MB21D1
UBB(1-76)
DHX9:CpG:MyD88
p-S407,Y641-STAT6
DHX36
UBA52(1-76)
UBC(533-608)
UBC(381-456)
TBK1
L.pneumophila dsDNA
H2O
RPS27A(1-76)
UBC(305-380)
HSV1 dsDNA
UBC(305-380)
cGAS:dsDNA
TREX1:viral DNA
HCMV dsDNA
POLR3H
HCV dsDNA
L. monocytogenes dsDNA
UBB(153-228)
p-S172-TBK1
NFKB2(1-454)
UBC(609-684)
IRF3
TRIM32
K63polyUb-STING
M. tuberculosis dsDNA
LRRFIP1
EBV dsDNA
DNA-PK:microbial
dsDNA
CHUK:IKBKB:IKBKG
ADP
HCMV dsDNA
UBC(77-152)
IFI16
c-di-AMP
ADP
RELA
NFKBIB
ATP
IKBKG
viral minus strand DNA with sticky 3' end
cGAS ligands
dsDNA:LRR
FLII-interacting
protein 1dimer
L. monocytogenes dsDNA
UBC(457-532)
p-4S,T404-IRF3
POLR3C
TBK1
ADP
HSV1 dsDNA
MRE11A
ADP
TREX1
UBC(609-684)
GTP
MB21D1
viral minus strand DNA with sticky 3' end
UBC(229-304)
p-S172-TBK1
viral minus strand DNA with sticky 3' end
ATP
ZBP1
UBC(153-228)
UBC(77-152)
2xp-S477,S479-IRF7
p-2S-IRF7:p-2S-IRF7
CREBBP,EP300
NFKB1(1-433),
NFKB2(1-454):RELA
POLR3GL
p-S407,Y641-STAT6
TMEM173
UBC(381-456)
RELA
NKIRAS2
RELA
UBC(533-608)
dsDNA:IFI16
Ub
STING:p-S172-TBK1
UBC(533-608)
p-S477,S479-IRF7
LRR FLII-interacting
protein 1 dimer
UBC(305-380)
EP300
PRKDC
STING:STING
ATP
c-GMP-AMP
TMEM173
POLR3B
Double-stranded DNA
HCV dsRNA intermediate form
TRIM56
ZBP1
K63polyUb-STING
Unmethylated CpG DNA
Mg2+
NKIRAS
HCMV dsDNA
viral plus strand DNA with sticky 3' end
MYD88
UBC(381-456)
dCMP
UBC(381-456)
VACV dsDNA
MRE11:dsDNA
viral plus strand DNA with sticky 3' end
UBC(153-228)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB
HCMV dsDNA
p-S176,S180-CHUK
HBV dsDNA
p-S552-CTNNB1
ATP
UBB(153-228)
DHX36
HSV2 dsDNA
MRE11A
M. tuberculosis dsDNA
ZBP1
UBC(229-304)
DHX9
HSV1 dsRNA intermediate form
IFI16 ligands
Unmethylated CpG DNA
p-S177,S181-IKBKB
HSV1 dsDNA
DHX9/DHX36:CpG:MyD88
NLRP4:DTX4:STING:p-S172-TBK1:IRF3
VACV dsDNA
IRF3
UBB(153-228)
UBC(229-304)
ATP
UBB(77-152)
Pol-III ligands
IFI16
Unmethylated CpG DNA
viral plus strand DNA with sticky 3' end
NKIRAS1
2'-deoxyguanosine
5'-monophosphate
NLRP4
TRIM21
STAT6
HSV2 dsDNA
DHX9:CpG
DDX58/IFIH1-mediated
induction
of
interferon-alpha/beta
TRIM32
viral minus strand DNA with sticky 3' end
STING:p-S172,K48polyUb-TBK1:IRF3
UBC(305-380)
p-4S,T404-IRF3
ZBP1 ligand
DHX9
VACV dsDNA
NFKB2(1-454)
Promotor region of
interferon beta
UBA52(1-76)
NFkB inhibitor:NFkB
complex
p-S172-TBK1
DHX9
K63polyUb-STING
DHX36
viral minus strand DNA with sticky 3' end
DTX4
K48polyUb-DDX41
L. monocytogenes dsDNA
VACV dsDNA
HSV1 dsDNA
Ub
TMP
UBC(609-684)
NFKB2(1-454)
TBK1
Unmethylated CpG DNA
UBA52(1-76)
dsDNA:LRRFIP1:beta-catenin
K63polyUb-STING
c-di-GMP
p-S172-TBK1
STAT6
XRCC6
HCV dsDNA
p-4S,T404-IRF3
STING:TBK1:IRF3
K63polyUb-STING
p-S407,Y641-STAT6
RIPK3
c-di-GMP
UBC(1-76)
IRF3
ZBP1
p-S172-TBK1
ZBP1
Ub
STING:p-S172-TBK1:IRF3
p-S32,S36-NFKBIA
LRRFIP1
NFKB1(1-433)
HSV2 dsDNA
NLRC3
Ku70:Ku80
heterodimer
HSV1 dsDNA
Promotor region of interferon beta
c-di-GMP
EP300
DDX41:DDX41 ligand
POLR1D
UBC(457-532)
UBC(77-152)
POLR3K
UBA52(1-76)
pS-172,K48polyUb-TBK1
NLRP4
viral DNA with 3'
sticky ends
RPS27A(1-76)
dsDNA:ZBP1:pS-172,K48polyUb-TBK1
POLR2E
HSV2 dsDNA
IKBKB
DNA-PK ligands
MYD88
ATP
ADP
UBC(77-152)
DDX41
c-di-GMP
UBB(153-228)
XRCC6
dsDNA:ZBP1:pS-172-TBK1
pS-172,K48polyUb-TBK1
p-S477,S479-IRF7
TREX1
STING:TBK1:STAT6
c-di-AMP, c-di-GMP
Unmethylated CpG DNA
NFKBIA
ADP
p-S407,Y641-STAT6
dimer
dsDNA:ZBP1:RIP1:RIP3
ATP
Unmethylated CpG DNA
p-S19,S23-NFKBIB
87
73
56
4, 82
3
20
96
24
46
54, 70
39
7, 38
23
32, 57
3
16
54, 70, 94
6, 57, 59, 66, 75
56
2, 59, 61, 103
92
18, 36, 37, 48, 68...
92
83
80
16
24
99
22, 42
44, 95
28, 49, 65
31, 98
46
5
4
46
46
20, 24
92
50
8, 47, 52