Sphingolipid metabolism (Homo sapiens)

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14, 29, 6230, 97, 10538, 13792, 109, 13549, 54, 84, 112, 118...15, 9935, 1112, 4, 18, 64, 81...2816, 11649, 84, 107, 112, 11867, 12423, 876, 10, 9511741, 43, 10321, 55, 56, 96, 98...1138, 17, 6546, 52, 61, 75, 88...1, 17, 31, 57, 1204022, 243, 3576, 11583, 13216, 116591441, 43, 10326, 72, 7939, 78, 94, 101, 1281023747, 58, 13113453, 85, 1062114, 63, 68, 89827719, 5011, 42, 7412667, 135, 34, 66, 731411444, 70, 1306376, 11527, 33, 80, 10045, 11948, 11011714, 36, 63, 68121, 12751609, 12, 20, 32, 71...6925, 86, 90, 93, 122cytosolendoplasmic reticulum lumenlipid dropletlysosomal lumenGolgi lumenSTEAO2ADPNADP+UDPHEXB(122-311) CERALASS proteinsNeu5AcPPM1L UGT8O2GlcSMPD2,3:Mg2+B4GALNT1 dimerGM3 ARSE DEGS1Gb3CerCERS3 STEACERASPGGM1NAD(P)HOxA-STS VAPA SPGOxA-ARSA(19-444) S1PMg2+ H2OUDPHEXB(315-556) CoA-SHPRKD1 SPHMH2OH+UGCGDAGsNeu5AcH2OADPceramide:CERT:PPM1L:VAPA/B trimerPRKD2 HXALADPOxA-ARSF CERS1 GD3,GM3OxA-ARSJ NEU2GBA 3-ketosphinganineATPGLA GLB1 UDP-GalH2OLacCerDHCEH2ONAD+ FA2Hactive STS dimerGalNAcGalASAH1(143-395) phytosphingosineGM2 HEXB(315-556) CERAST-CoAACER3ACER2PSAP(311-391) ARSK GM2 VAPA H2OGM2A:GM2ORMDL2 Ca2+ GM2SPTSSB H2OPXLP-SPTLC3 PPM1L ESYT2 NADHSO4(2-)HEXA,BARSA(448-507) LacCerGlobosideCO2OSBPSO4(2-)ARSI NADPHGPLASAH2-like proteinsARSF CSNK1G2OxA-ARSA(19-444) CERAPPAP2SMPD4:Mg2+SPHK1 Gb4CerH2OASAH2 VAPB SPHK2 ARSG COL4A3BP-2 COL4A3BP-2 ACER1H2OBGALVAPB VAPA Ca2+ ATPPALMUDP-GlcOxA-ARSE Ca2+ GM3CERT:PPM1L:VAPA/BtrimerPPAP2ADHEA-SO4DEGS2H2OLacCerSPHMGSLSPAPOxA-STS ARSH2SASAH1ESYT1 H2OARSH SPHMSUMF1NADHORMDL3 ATPALDH3B2KDSRSGPP1 GM3H+SPGH+GlucosylceramideL-SerPALMSUMF2 H2OSPHKH+GLTPALDH3B1PCOxA-ARSK B3GALNT1PPAP2A NADHRCOOHOxA-ARSI ATPSPAPXLP-SGPL1H2OH2OCa2+ NEU3SPGGLB1L H2OGlucosylceramideSPTLC1 active ARSA:Ca2+GALC2HCERASTEASMPD4 multiphospho-CERT:PPM1L:VAPA/B trimerC1PGlucosylceramideSMPD3 NEU4-2 GLB1 OxA-STS SPAPHEXB(122-311) ChoPPiH+CTSA(29-326) UDPGalCerNADPHARSJ GM2A(32-193)NAD+NEU1 Mg2+ PPAP2C PiSUMF1 ATPactive ARSORMDL1 HD2NALNAD+ASAH1(22-142) PRKD3 GD3 CoA-SHGD2 PCGBA2PPM1L:VAPA/B dimerORMDL1,ORMDL2,ORMDL3OxA-ARSA(19-444) SPTSSA SGPP2 OxA-ARSG PiH2OH2OH2ON-acylsphingosineH2OGalH2OCERKHEXA ARSA(448-507) p-S,S132,T-COL4A3BP-2ESYT3 GalCerPPAP2B C1PCTSA(327-480) SUMF1:SUMF2CPEGD2,GM2HXALCERASPGUDP-GalNAcPXLP-SPTLC2 ADPALDH3A2-1 dimerENPP7ESYT1:ESYT2:ESYT3H2OSPHMARSA(19-444) 2xPalmC-SGMS2NAD+DAGsPPM1L B4GALNT1 H2OCERS5 H2OCa2+ SMPD1SUMF2VAPA OxA-ARSD PRKD1,2,3ARSB GSLNADP+ CERA PENEU1,4active ARSA:Ca2+ALDH3A2-1 GLTPD1PALM-CoAOxA-ARSH ADPS1PCa2+GlcChoPGM2A(32-193) NADH SAMD8ChoPCERS4 ARSA(448-507) p-S,S132,T-COL4A3BP-2 PETAGPLDHEAGBA:SAPCNADPH SPAH2OVAPB bHEXPip-S132-COL4A3BP-2SPTLC complexesARSA(448-507) SMPD2 NADP+RCOOHGalactive STS dimerGb3CerSGMS1GLA dimerSPGN-acylphytosphingosineGBA3GM3STS CERAPPM1L CERACERS6 SulfatideSGPPH2OGlucosylceramideVAPB OxA-ARSB COL4A3BP-2HEXA NAD(P)+ARSD CERS2 3235, 111359